Published in Immunity on August 01, 2003
The bone marrow niche for haematopoietic stem cells. Nature (2014) 5.06
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature (2013) 4.11
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood (2005) 3.76
Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev (2008) 2.95
The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood (2009) 2.85
CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest (2010) 2.38
Circulation and chemotaxis of fetal hematopoietic stem cells. PLoS Biol (2004) 2.18
The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol (2009) 1.95
A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones. Nat Cell Biol (2014) 1.49
Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. J Clin Invest (2005) 1.36
Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis. Mol Cancer (2010) 1.36
Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin. Dev Cell (2013) 1.35
What does the concept of the stem cell niche really mean today? BMC Biol (2012) 1.32
Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage. Dev Cell (2014) 1.28
The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function. Elife (2014) 1.28
Making sense of hematopoietic stem cell niches. Blood (2015) 1.23
Chronic AMD3100 antagonism of SDF-1alpha-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction. J Mol Cell Cardiol (2010) 1.23
Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J Exp Med (2013) 1.21
SHIP is required for a functional hematopoietic stem cell niche. Blood (2008) 1.20
CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood (2006) 1.14
Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice. J Gerontol A Biol Sci Med Sci (2009) 1.13
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth. Proc Natl Acad Sci U S A (2006) 1.12
MiR-886-3p down regulates CXCL12 (SDF1) expression in human marrow stromal cells. PLoS One (2010) 1.09
SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation. Blood (2006) 1.08
Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis. Expert Rev Hematol (2009) 1.06
Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease. Exp Hematol (2008) 1.02
Hematopoietic progenitor migration to the adult thymus. Ann N Y Acad Sci (2011) 1.01
Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron (2014) 1.00
CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis. Arthritis Res Ther (2010) 0.99
CXCR4 promotes B cell egress from Peyer's patches. J Exp Med (2013) 0.99
The long road to the thymus: the generation, mobilization, and circulation of T-cell progenitors in mouse and man. Semin Immunopathol (2008) 0.98
beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells. Stem Cells (2009) 0.97
Induction of a tumor-metastasis-receptive microenvironment as an unwanted and underestimated side effect of treatment by chemotherapy or radiotherapy. J Ovarian Res (2013) 0.95
Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo. Blood (2008) 0.93
Bone marrow niches for hematopoietic stem cells and immune cells. Inflamm Allergy Drug Targets (2012) 0.92
Genome-wide analysis of miRNA-mRNA interactions in marrow stromal cells. Stem Cells (2014) 0.92
Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol (2015) 0.91
The expanding family of bone marrow homing factors for hematopoietic stem cells: stromal derived factor 1 is not the only player in the game. ScientificWorldJournal (2012) 0.89
CXCL12/SDF-1 and CXCR4. Front Immunol (2015) 0.89
Oval cell response in 2-acetylaminofluorene/partial hepatectomy rat is attenuated by short interfering RNA targeted to stromal cell-derived factor-1. Am J Pathol (2006) 0.88
Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis. PLoS One (2011) 0.88
Hematopoietic stem cell development, niches, and signaling pathways. Bone Marrow Res (2012) 0.87
T and B lymphocyte differentiation from hematopoietic stem cell. Semin Immunol (2008) 0.86
Downregulation of the CXCR4 receptor inhibits cervical carcinoma metastatic behavior in vitro and in vivo. Int J Oncol (2014) 0.85
The chemokine system in innate immunity. Cold Spring Harb Perspect Biol (2015) 0.85
Bone marrow vascular niche: home for hematopoietic stem cells. Bone Marrow Res (2014) 0.84
Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments. Birth Defects Res C Embryo Today (2010) 0.84
Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling. Differentiation (2013) 0.83
Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells. Stem Cell Rev (2016) 0.82
Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow. Oncotarget (2015) 0.82
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells. J Immunol (2015) 0.82
Expression of migration-related genes is progressively upregulated in murine Lineage-Sca-1+c-Kit+ population from the fetal to adult stages of development. Stem Cell Res Ther (2010) 0.82
Regulatory System for Stem/Progenitor Cell Niches in the Adult Rodent Pituitary. Int J Mol Sci (2016) 0.82
MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development. Blood (2015) 0.81
Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model. Cell Mol Immunol (2012) 0.80
Localized CCR2 Activation in the Bone Marrow Niche Mobilizes Monocytes by Desensitizing CXCR4. PLoS One (2015) 0.80
SDF-1α in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules (2013) 0.80
Bloodlines of haematopoietic stem cell research in Japan. Philos Trans R Soc Lond B Biol Sci (2008) 0.79
Dynamic Cross Talk between S1P and CXCL12 Regulates Hematopoietic Stem Cells Migration, Development and Bone Remodeling. Pharmaceuticals (Basel) (2013) 0.79
Reciprocal upregulation of Notch signaling molecules in hematopoietic progenitor and mesenchymal stromal cells. J Stem Cells Regen Med (2011) 0.79
Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity (2016) 0.78
Primary marrow-derived stromal cells: isolation and manipulation. Methods Mol Biol (2013) 0.78
The role of the marrow microenvironment in hematopoietic stem cell transplantation. Cell Ther Transplant (2010) 0.78
CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. J Exp Med (2017) 0.78
The role of CD44 in fetal and adult hematopoietic stem cell regulation. Haematologica (2015) 0.77
Single-cell analysis of murine long-term hematopoietic stem cells reveals distinct patterns of gene expression during fetal migration. PLoS One (2012) 0.77
Are neural crest stem cells the missing link between hematopoietic and neurogenic niches? Front Cell Neurosci (2015) 0.77
Adult haematopoietic stem cell niches. Nat Rev Immunol (2017) 0.77
C/EBPβ mediates osteoclast recruitment by regulating endothelial progenitor cell expression of SDF-1α. PLoS One (2014) 0.76
Microenvironmental regulation of hematopoietic stem cells and its implications in leukemogenesis. Curr Opin Hematol (2016) 0.76
Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities. World J Stem Cells (2016) 0.76
The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. Stem Cell Rev (2016) 0.75
Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling. Ann N Y Acad Sci (2016) 0.75
CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer. Mol Cancer Ther (2015) 0.75
AML1/ETO accelerates cell migration and impairs cell-to-cell adhesion and homing of hematopoietic stem/progenitor cells. Sci Rep (2016) 0.75
EMT Involved in Migration of Stem/Progenitor Cells for Pituitary Development and Regeneration. J Clin Med (2016) 0.75
Boosting Hematopoietic Engraftment after in Utero Transplantation through Vascular Niche Manipulation. Stem Cell Reports (2016) 0.75
Enhanced in utero allogeneic engraftment in mice after mobilizing fetal HSCs by α4β1/7 inhibition. Blood (2016) 0.75
Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases. Wiley Interdiscip Rev Dev Biol (2017) 0.75
CXCL12a/CXCR4b acts to retain neutrophils in caudal hematopoietic tissue and to antagonize recruitment to an injury site in the zebrafish larva. Immunogenetics (2017) 0.75
Current Developments in Mobilization of Hematopoietic Stem and Progenitor Cells and Their Interaction with Niches in Bone Marrow. Transfus Med Hemother (2017) 0.75
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity (2006) 11.28
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07
The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity (2010) 4.13
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature (2013) 4.04
Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity (2004) 3.75
CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells. Nature (2008) 2.72
Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis Rheum (2009) 2.64
CXCR4 regulates interneuron migration in the developing neocortex. J Neurosci (2003) 2.44
Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell (2013) 2.19
Bone marrow graft-versus-host disease: early destruction of hematopoietic niche after MHC-mismatched hematopoietic stem cell transplantation. Blood (2010) 2.04
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 2.02
The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol (2009) 1.95
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med (2011) 1.87
Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol (2006) 1.86
Random walk behavior of migrating cortical interneurons in the marginal zone: time-lapse analysis in flat-mount cortex. J Neurosci (2009) 1.83
Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system. Nat Neurosci (2012) 1.77
Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proc Natl Acad Sci U S A (2003) 1.69
Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nat Neurosci (2002) 1.69
Paranodal junction formation and spermatogenesis require sulfoglycolipids. Proc Natl Acad Sci U S A (2002) 1.68
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol (2009) 1.64
Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Mol Ther (2011) 1.61
Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells. J Immunol (2005) 1.57
A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol (2003) 1.52
Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice. Blood (2005) 1.51
The role of CXCL12 in the organ-specific process of artery formation. Blood (2004) 1.47
Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4. J Exp Med (2009) 1.46
Reconstitution of mouse spermatogonial stem cell niches in culture. Cell Stem Cell (2012) 1.41
Stromal niches, plasma cell differentiation and survival. Curr Opin Immunol (2006) 1.35
Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin. Dev Cell (2013) 1.35
A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron (2005) 1.33
C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells. Proc Natl Acad Sci U S A (2010) 1.30
Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. J Hepatol (2012) 1.28
Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity (2013) 1.27
Perivascular epithelioid cell tumor of the jejunum. Pathol Res Pract (2003) 1.27
Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc Natl Acad Sci U S A (2012) 1.26
The polycomb protein Ezh2 regulates differentiation and plasticity of CD4(+) T helper type 1 and type 2 cells. Immunity (2013) 1.25
Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow. J Exp Med (2013) 1.21
3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials (2012) 1.19
The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3. J Leukoc Biol (2003) 1.17
Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, alphav integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity. Hum Gene Ther (2006) 1.16
miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy. Mol Ther (2008) 1.13
Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors. Hum Gene Ther (2007) 1.13
Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol Ther (2010) 1.13
Efficient adipocyte and osteoblast differentiation from mouse induced pluripotent stem cells by adenoviral transduction. Stem Cells (2009) 1.12
Innate immune response induced by gene delivery vectors. Int J Pharm (2007) 1.11
Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes. Stem Cell Reports (2013) 1.10
Fiber-modified adenovirus vectors decrease liver toxicity through reduced IL-6 production. J Immunol (2007) 1.10
Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1. BMC Dev Biol (2009) 1.09
Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis. J Pharmacol Exp Ther (2008) 1.08
Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3. Immunity (2011) 1.08
Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells. Trends Immunol (2011) 1.08
Memory CD8(+) T cells colocalize with IL-7(+) stromal cells in bone marrow and rest in terms of proliferation and transcription. Eur J Immunol (2015) 1.08
IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation. J Allergy Clin Immunol (2011) 1.06
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood (2012) 1.06
DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4. Circ Res (2010) 1.02
Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8+ T cells. Proc Natl Acad Sci U S A (2011) 1.01
Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells. Int J Cancer (2007) 1.00
RNA interference of PPARgamma using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells. Gene (2005) 0.99
Regulation of muscle protein degradation, not synthesis, by dietary leucine in rats fed a protein-deficient diet. Amino Acids (2008) 0.99
Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction. PLoS One (2011) 0.99
CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice. Blood (2010) 0.98
Induction of type I interferon by adenovirus-encoded small RNAs. Proc Natl Acad Sci U S A (2010) 0.95
The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets. Biomaterials (2012) 0.95
Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells. Cell Reprogram (2010) 0.94
SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation. Development (2009) 0.93
Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences. Clin Cancer Res (2011) 0.93
Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7- and CXCR4-mediated signaling. J Immunol (2012) 0.92
Bone marrow niches for hematopoietic stem cells and immune cells. Inflamm Allergy Drug Targets (2012) 0.92
CXCR4 is required for proper regional and laminar distribution of cortical somatostatin-, calretinin-, and neuropeptide Y-expressing GABAergic interneurons. Cereb Cortex (2010) 0.92
A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure. Blood (2013) 0.91
Effects of dietary protein of Korean foxtail millet on plasma adiponectin, HDL-cholesterol, and insulin levels in genetically type 2 diabetic mice. Biosci Biotechnol Biochem (2005) 0.91
Adenovirus vectors composed of subgroup B adenoviruses. Curr Gene Ther (2007) 0.91
Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates. Mol Ther (2008) 0.91
Persistence of effector memory Th1 cells is regulated by Hopx. Eur J Immunol (2010) 0.91
Adenovirus vector-mediated doxycycline-inducible RNA interference. Hum Gene Ther (2004) 0.91
Development of mammalian cell-enclosing subsieve-size agarose capsules (<100 microm) for cell therapy. Biomaterials (2005) 0.91
Mixed adenoneuroendocrine carcinoma of the gallbladder with squamous cell carcinomatous and osteosarcomatous differentiation: report of a case. Pathol Int (2013) 0.90
The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35. J Control Release (2006) 0.90
Efficient adenovirus vector-mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation. J Gene Med (2008) 0.90
Spi-B is critical for plasmacytoid dendritic cell function and development. Blood (2012) 0.90
Solitary rectal ulcer syndrome associated with ulcerative colitis. Gastrointest Endosc (2006) 0.90
Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune responses. J Immunol (2008) 0.89