Published in Proc Natl Acad Sci U S A on August 09, 2007
Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun (2013) 2.29
Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Metabolism (2011) 1.27
Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9. Mol Biol Cell (2008) 1.10
The role of hyperosmotic stress in inflammation and disease. Biomol Concepts (2012) 1.05
Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins. Mol Cell Biol (2009) 1.00
Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol (2010) 0.98
Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus. J Biol Chem (2008) 0.94
The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. J Biol Chem (2010) 0.92
Cell models for studying renal physiology. Pflugers Arch (2008) 0.90
Hypertonic stress increases claudin-4 expression and tight junction integrity in association with MUPP1 in IMCD3 cells. Proc Natl Acad Sci U S A (2008) 0.89
ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells. J Biol Chem (2009) 0.85
Osmotic stress regulates mineralocorticoid receptor expression in a novel aldosterone-sensitive cortical collecting duct cell line. Mol Endocrinol (2009) 0.83
Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice. Nat Commun (2017) 0.83
MUPP1 complexes renal K+ channels to alter cell surface expression and whole cell currents. Am J Physiol Renal Physiol (2009) 0.82
Effects of 2-bromoethanamine on TonEBP expression and its possible role in induction of renal papillary necrosis in mice. Toxicol Sci (2010) 0.77
Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase. PLoS One (2016) 0.76
The hypertonic environment differentially regulates wild-type CFTR and TNR-CFTR chloride channels. Cell Physiol Biochem (2010) 0.76
How do kidney cells adapt to survive in hypertonic inner medulla? Trans Am Clin Climatol Assoc (2009) 0.75
Aging-associated renal disease in mice is fructokinase dependent. Am J Physiol Renal Physiol (2016) 0.75
Effects of exogenous desmopressin on a model of heat stress nephropathy in mice. Am J Physiol Renal Physiol (2016) 0.75
Claudins and epithelial paracellular transport. Annu Rev Physiol (2006) 4.79
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell (2006) 4.61
Tight junctions and cell polarity. Annu Rev Cell Dev Biol (2006) 4.39
Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Am J Hum Genet (2006) 2.96
An osmotically tolerant inner medullary collecting duct cell line from an SV40 transgenic mouse. Am J Physiol (1993) 2.89
Regulation of gene expression by hypertonicity. Annu Rev Physiol (1997) 2.21
Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem (2001) 1.96
PATJ regulates tight junction formation and polarity in mammalian epithelial cells. J Cell Biol (2005) 1.92
Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci (2004) 1.77
Loss of PALS1 expression leads to tight junction and polarity defects. Mol Biol Cell (2004) 1.60
Cloning and characterization of MUPP1, a novel PDZ domain protein. FEBS Lett (1998) 1.48
A novel claudin 16 mutation associated with childhood hypercalciuria abolishes binding to ZO-1 and results in lysosomal mistargeting. Am J Hum Genet (2003) 1.47
Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31. J Virol (2004) 1.35
Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. J Biol Chem (2001) 1.27
Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption. Am J Physiol Gastrointest Liver Physiol (2005) 1.26
Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells. J Cell Sci (2005) 1.22
The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stability. J Membr Biol (2004) 1.19
Claudins--key pieces in the tight junction puzzle. Cell Commun Adhes (2006) 1.10
Claudin-8 interacts with multi-PDZ domain protein 1 (MUPP1) and reduces paracellular conductance in epithelial cells. Cell Mol Biol (Noisy-le-grand) (2003) 1.07
Urea stress is more akin to EGF exposure than to hypertonic stress in renal medullary cells. Am J Physiol Renal Physiol (2002) 0.99
Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response. J Biol Chem (2007) 0.99
Long-term adaptation of renal cells to hypertonicity: role of MAP kinases and Na-K-ATPase. Am J Physiol Renal Physiol (2001) 0.97
Cell and molecular biology of organic osmolyte accumulation in hypertonic renal cells. Nephron (2001) 0.97
Protein expression changes in spinal muscular atrophy revealed with a novel antibody array technology. Brain (2003) 0.93
Uncovering functionally relevant signaling pathways using microarray-based expression profiling. Oncologist (2000) 0.92
Tonicity-dependent regulation of osmoprotective genes in mammalian cells. Contrib Nephrol (2006) 0.92
Adaptation of murine inner medullary collecting duct (IMCD3) cell cultures to hypertonicity. Ann N Y Acad Sci (2003) 0.91
DNA damage and osmotic regulation in the kidney. Am J Physiol Renal Physiol (2005) 0.90
Regulation of the myo-inositol and betaine cotransporters by tonicity. Kidney Int (1996) 0.88
Mre11-Rad50-Nbs1 complex is activated by hypertonicity. Am J Physiol Renal Physiol (2006) 0.86
The application of DIGE-based proteomics to renal physiology. Nephron Physiol (2006) 0.81
Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med (2006) 10.63
Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med (2007) 6.97
Sulodexide for kidney protection in type 2 diabetes patients with microalbuminuria: a randomized controlled trial. Am J Kidney Dis (2011) 3.81
Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur Heart J (2009) 3.52
Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis. Kidney Int (2010) 2.47
Vasopressin antagonists. N Engl J Med (2015) 2.13
Pyridorin in type 2 diabetic nephropathy. J Am Soc Nephrol (2011) 1.79
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A (2012) 1.72
Sulodexide fails to demonstrate renoprotection in overt type 2 diabetic nephropathy. J Am Soc Nephrol (2011) 1.66
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology (2013) 1.56
Efficacy and safety of oral tolvaptan therapy in patients with the syndrome of inappropriate antidiuretic hormone secretion. Eur J Endocrinol (2011) 1.54
Abnormal angiogenesis in diabetic nephropathy. Diabetes (2009) 1.53
Care of undocumented individuals with ESRD: a national survey of US nephrologists. Am J Kidney Dis (2009) 1.48
Serum uric acid predicts vascular complications in adults with type 1 diabetes: the coronary artery calcification in type 1 diabetes study. Acta Diabetol (2014) 1.48
Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study. Nephrol Dial Transplant (2010) 1.45
Serum cystatin C predicts progression of subclinical coronary atherosclerosis in individuals with type 1 diabetes. Diabetes (2007) 1.44
Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes. J Clin Hypertens (Greenwich) (2014) 1.41
A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study of AST-120 (Kremezin) in patients with moderate to severe CKD. Am J Kidney Dis (2006) 1.38
Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem J (2004) 1.36
Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Metabolism (2011) 1.27
Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. PLoS One (2012) 1.24
Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-κB-dependent pathway. Nephrol Dial Transplant (2011) 1.23
Definition and classification of Cardio-Renal Syndromes: workgroup statements from the 7th ADQI Consensus Conference. Nephrol Dial Transplant (2010) 1.22
Cardiorenal syndromes: an executive summary from the consensus conference of the Acute Dialysis Quality Initiative (ADQI). Contrib Nephrol (2010) 1.20
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism (2011) 1.15
Predictors of cardiovascular events in patients with type 2 diabetic nephropathy and hypertension: a case for albuminuria. Kidney Int Suppl (2004) 1.12
Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver. PLoS One (2012) 1.12
Epidemiology of cardio-renal syndromes: workgroup statements from the 7th ADQI Consensus Conference. Nephrol Dial Transplant (2010) 1.07
Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery. Crit Care (2010) 1.06
Circulating IL-6 mediates lung injury via CXCL1 production after acute kidney injury in mice. Am J Physiol Renal Physiol (2012) 1.05
Molecular mechanisms of angiotensin II stimulation on aquaporin-2 expression and trafficking. Am J Physiol Renal Physiol (2011) 1.00
Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response. J Biol Chem (2007) 0.99
Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury. Am J Physiol Renal Physiol (2011) 0.98
Different ways to die: cell death modes of the unicellular chlorophyte Dunaliella viridis exposed to various environmental stresses are mediated by the caspase-like activity DEVDase. J Exp Bot (2009) 0.96
Differential diagnosis of hyponatraemia. Best Pract Res Clin Endocrinol Metab (2012) 0.95
Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus. J Biol Chem (2008) 0.94
Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-α antibodies. PLoS One (2013) 0.94
Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation. Nephron Exp Nephrol (2009) 0.94
Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse. Am J Physiol Renal Physiol (2012) 0.93
Pathogenesis of diabetic nephropathy. Rev Endocr Metab Disord (2004) 0.93
The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. J Biol Chem (2010) 0.92
Adaptation of murine inner medullary collecting duct (IMCD3) cell cultures to hypertonicity. Ann N Y Acad Sci (2003) 0.91
Hypertonic stress increases claudin-4 expression and tight junction integrity in association with MUPP1 in IMCD3 cells. Proc Natl Acad Sci U S A (2008) 0.89
Relationship between cystatin C and coronary artery atherosclerosis progression differs by type 1 diabetes. Diabetes Technol Ther (2010) 0.88
Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes. Pediatr Nephrol (2013) 0.88
An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials. J Hypertens (2012) 0.87
Chloride, not sodium, stimulates expression of the gamma subunit of Na/K-ATPase and activates JNK in response to hypertonicity in mouse IMCD3 cells. Proc Natl Acad Sci U S A (2003) 0.86
Clinically unrecognized Q-wave myocardial infarction in patients with diabetes mellitus, systemic hypertension, and nephropathy. Am J Cardiol (2004) 0.86
ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells. J Biol Chem (2009) 0.85
Efficacy and safety of carvedilol in treatment of heart failure with chronic kidney disease: a meta-analysis of randomized trials. Circ Heart Fail (2010) 0.84
The Adrogue-Madias formula revisited. Clin J Am Soc Nephrol (2007) 0.84
Lower progression rate of end-stage renal disease in patients with peripheral arterial disease using statins or Angiotensin-converting enzyme inhibitors. J Am Soc Nephrol (2007) 0.84
A colorimetric assay for determination of cell viability in algal cultures. Biomol Eng (2003) 0.84
Cell division in the unicellular microalga Dunaliella viridis depends on phosphorylation of extracellular signal-regulated kinases (ERKs). J Exp Bot (2007) 0.83
Vasopressin antagonists in the treatment of water-retaining disorders. Semin Nephrol (2008) 0.83
A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity. Nephron Physiol (2008) 0.82
Mortality and serum sodium in CKD--yet another U‑shaped curve. Nat Rev Nephrol (2012) 0.82
Phosphorylation of MAP kinase-like proteins mediate the response of the halotolerant alga Dunaliella viridis to hypertonic shock. Biochim Biophys Acta (2004) 0.82
Prevention of cardio-renal syndromes: workgroup statements from the 7th ADQI Consensus Conference. Nephrol Dial Transplant (2010) 0.82
EphA2: expression in the renal medulla and regulation by hypertonicity and urea stress in vitro and in vivo. Am J Physiol Renal Physiol (2004) 0.82
Where vaptans do and do not fit in the treatment of hyponatremia. Kidney Int (2012) 0.81
Synthesis of the Na-K-ATPase gamma-subunit is regulated at both the transcriptional and translational levels in IMCD3 cells. Am J Physiol Renal Physiol (2004) 0.80
Biomarkers in kidney and heart disease. Nephrol Dial Transplant (2010) 0.80
Silencing and overexpression of the gamma-subunit of Na-K-ATPase directly affect survival of IMCD3 cells in response to hypertonic stress. Am J Physiol Renal Physiol (2006) 0.80
Long-term outcomes after coronary artery bypass grafting: preoperative kidney function is prognostic. J Thorac Cardiovasc Surg (2007) 0.79
Vasopressin Antagonists. N Engl J Med (2015) 0.78
The gamma-subunit of Na-K-ATPase is incorporated into plasma membranes of mouse IMCD3 cells in response to hypertonicity. Am J Physiol Renal Physiol (2004) 0.78
Is osmotic demyelination a concern dialyzing hyponatremic patients? Semin Dial (2011) 0.77
The gamma subunit of Na/K-ATPase: an exceptional, small transmembrane protein. Front Biosci (2005) 0.77
Umami: the taste that drives purine intake. J Rheumatol (2013) 0.77
Effects of 2-bromoethanamine on TonEBP expression and its possible role in induction of renal papillary necrosis in mice. Toxicol Sci (2010) 0.77