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1
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Myocardial fatty acid metabolism in health and disease.
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Physiol Rev
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2010
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4.49
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2
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Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes.
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Mol Cell Biol
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2011
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2.23
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3
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Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy.
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Am J Physiol Heart Circ Physiol
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2007
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1.86
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4
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Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria.
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J Lipid Res
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2011
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1.79
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5
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Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure.
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Cardiovasc Res
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2005
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1.70
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6
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Role of diet and fuel overabundance in the development and progression of heart failure.
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Cardiovasc Res
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2008
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1.70
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7
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Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure.
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Circulation
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2002
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1.65
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8
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Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids.
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J Lipid Res
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2008
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1.63
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9
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Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.
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Cardiovasc Res
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2008
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1.62
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10
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Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension.
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Hypertension
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2006
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1.56
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11
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Cardiomyocyte deletion of mitofusin-1 leads to mitochondrial fragmentation and improves tolerance to ROS-induced mitochondrial dysfunction and cell death.
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Am J Physiol Heart Circ Physiol
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2011
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1.53
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12
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Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin.
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Am J Physiol Heart Circ Physiol
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2006
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1.52
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13
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Validation of echocardiographic methods for assessing left ventricular dysfunction in rats with myocardial infarction.
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Am J Physiol Heart Circ Physiol
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2004
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1.52
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14
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CVT-4325 inhibits myocardial fatty acid uptake and improves left ventricular systolic function without increasing myocardial oxygen consumption in dogs with chronic heart failure.
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Cardiovasc Drugs Ther
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2007
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1.52
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15
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Cardiac energy metabolism in obesity.
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Circ Res
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2007
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1.51
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16
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Dietary supplementation with omega-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload.
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Cardiovasc Res
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2007
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1.50
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17
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Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure.
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J Mol Cell Cardiol
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2004
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1.49
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18
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Modulating fatty acid oxidation in heart failure.
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Cardiovasc Res
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2011
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1.37
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19
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omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential.
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Cardiovasc Res
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2009
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1.32
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20
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Dietary omega-3 fatty acids alter cardiac mitochondrial phospholipid composition and delay Ca2+-induced permeability transition.
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J Mol Cell Cardiol
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2009
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1.28
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21
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High-fat diet prevents cardiac hypertrophy and improves contractile function in the hypertensive dahl salt-sensitive rat.
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Clin Exp Pharmacol Physiol
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2005
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1.24
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22
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Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart.
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J Lipid Res
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2007
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1.20
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23
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Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.
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Circ Res
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2012
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1.16
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24
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Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure.
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J Card Fail
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2002
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1.16
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25
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Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium.
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J Pharmacol Exp Ther
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2010
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1.15
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26
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Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia.
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Am J Physiol Heart Circ Physiol
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2005
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1.14
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27
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Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition.
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Biochim Biophys Acta
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2010
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1.14
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28
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High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet.
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Am J Hypertens
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2007
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1.14
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29
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Effects of a high saturated fat diet on cardiac hypertrophy and dysfunction in response to pressure overload.
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J Card Fail
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2008
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1.13
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30
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Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure.
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Circ Res
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2002
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1.12
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31
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Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction.
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J Lipid Res
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2013
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1.12
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32
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The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipid remodeling.
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Hypertension
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2009
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1.11
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33
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Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation.
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J Physiol
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2004
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1.10
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34
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Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria.
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Am J Physiol Heart Circ Physiol
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2013
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1.10
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35
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A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload.
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Am J Physiol Heart Circ Physiol
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2009
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1.10
|
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36
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Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation.
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Am J Physiol Heart Circ Physiol
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2004
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1.09
|
|
37
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Effects of chronic activation of peroxisome proliferator-activated receptor-alpha or high-fat feeding in a rat infarct model of heart failure.
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Am J Physiol Heart Circ Physiol
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2005
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1.08
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38
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Preserved protein synthesis in the heart in response to acute fasting and chronic food restriction despite reductions in liver and skeletal muscle.
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Am J Physiol Endocrinol Metab
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2008
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1.08
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39
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Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation.
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Circ Res
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2004
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1.08
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40
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Too much or not enough of a good thing? Cardiac glucolipotoxicity versus lipoprotection.
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J Mol Cell Cardiol
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2010
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1.07
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41
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Low-carbohydrate/high-fat diet attenuates pressure overload-induced ventricular remodeling and dysfunction.
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J Card Fail
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2008
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1.06
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42
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Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure.
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J Am Coll Cardiol
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2007
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1.05
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43
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High intake of saturated fat, but not polyunsaturated fat, improves survival in heart failure despite persistent mitochondrial defects.
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Cardiovasc Res
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2011
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1.05
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44
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Plasma proteome dynamics: analysis of lipoproteins and acute phase response proteins with 2H2O metabolic labeling.
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Mol Cell Proteomics
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2012
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1.05
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45
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The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet.
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Am J Physiol Heart Circ Physiol
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2008
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1.04
|
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46
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Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids.
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PLoS One
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2012
|
1.03
|
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47
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Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure.
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Am J Physiol Heart Circ Physiol
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2008
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1.03
|
|
48
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Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload.
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Am J Physiol Heart Circ Physiol
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2007
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1.03
|
|
49
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Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance.
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Am J Physiol Endocrinol Metab
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2009
|
1.01
|
|
50
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Reverse changes in cardiac substrate oxidation in dogs recovering from heart failure.
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Am J Physiol Heart Circ Physiol
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2008
|
1.01
|
|
51
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Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.
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Am J Physiol Heart Circ Physiol
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2012
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1.00
|
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52
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Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy.
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Cardiovasc Res
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2006
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1.00
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53
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Assessing the reversibility of the anaplerotic reactions of the propionyl-CoA pathway in heart and liver.
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J Biol Chem
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2003
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0.99
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54
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High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets.
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J Hypertens
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2008
|
0.99
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55
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Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs.
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Am J Physiol Endocrinol Metab
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2002
|
0.99
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56
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Fatty acid oxidation in cardiac and skeletal muscle mitochondria is unaffected by deletion of CD36.
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Arch Biochem Biophys
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2007
|
0.99
|
|
57
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Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet.
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Clin Exp Pharmacol Physiol
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2007
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0.98
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58
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Regulation of lactate production at the onset of ischaemia is independent of mitochondrial NADH/NAD+: insights from in silico studies.
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J Physiol
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2005
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0.97
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59
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Dissociation between gene and protein expression of metabolic enzymes in a rodent model of heart failure.
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Eur J Heart Fail
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2006
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0.97
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60
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Mechanistic model of myocardial energy metabolism under normal and ischemic conditions.
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Ann Biomed Eng
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2002
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0.97
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61
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Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo.
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Proc Natl Acad Sci U S A
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2005
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0.96
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62
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Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies.
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Am J Physiol Heart Circ Physiol
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2006
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0.95
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63
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Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion.
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J Mol Cell Cardiol
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2007
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0.95
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64
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Differential effects of heptanoate and hexanoate on myocardial citric acid cycle intermediates following ischemia-reperfusion.
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J Appl Physiol (1985)
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2005
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0.94
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65
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Effects of adiponectin deficiency on structural and metabolic remodeling in mice subjected to pressure overload.
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Am J Physiol Heart Circ Physiol
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2010
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0.94
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66
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Altered expression of the adenine nucleotide translocase isoforms and decreased ATP synthase activity in skeletal muscle mitochondria in heart failure.
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J Mol Cell Cardiol
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2009
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0.93
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67
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Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia.
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J Theor Biol
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2008
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0.92
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68
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Enhanced resistance to permeability transition in interfibrillar cardiac mitochondria in dogs: effects of aging and long-term aldosterone infusion.
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Am J Physiol Heart Circ Physiol
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2012
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0.92
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69
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ω-3 Polyunsaturated fatty acids prevent pressure overload-induced ventricular dilation and decrease in mitochondrial enzymes despite no change in adiponectin.
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Lipids Health Dis
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2010
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0.91
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70
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Chronic activation of peroxisome proliferator-activated receptor-alpha with fenofibrate prevents alterations in cardiac metabolic phenotype without changing the onset of decompensation in pacing-induced heart failure.
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J Pharmacol Exp Ther
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2007
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0.91
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71
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Fatty acid oxidation and its impact on response of spontaneously hypertensive rat hearts to an adrenergic stress: benefits of a medium-chain fatty acid.
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Am J Physiol Heart Circ Physiol
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2004
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0.90
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72
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Quantitative assessment of anaplerosis from propionate in pig heart in vivo.
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Am J Physiol Endocrinol Metab
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2002
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0.90
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73
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Does junk food lead to heart failure? Importance of dietary macronutrient composition in hypertension.
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Hypertension
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2009
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0.90
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74
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Glucose 6-phosphate dehydrogenase deficiency increases redox stress and moderately accelerates the development of heart failure.
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Circ Heart Fail
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2012
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0.88
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75
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Partial inhibition of fatty acid oxidation increases regional contractile power and efficiency during demand-induced ischemia.
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Cardiovasc Res
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2003
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0.87
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76
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Metabolic approaches to the treatment of ischemic heart disease: the clinicians' perspective.
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Heart Fail Rev
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2002
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0.87
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77
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Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK.
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J Mol Cell Cardiol
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2008
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0.86
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78
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Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival.
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Am J Physiol Heart Circ Physiol
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2012
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0.86
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79
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Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity.
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Aging Cell
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2012
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0.86
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80
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High-sugar intake does not exacerbate metabolic abnormalities or cardiac dysfunction in genetic cardiomyopathy.
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Nutrition
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2012
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0.86
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81
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Metabolic therapies for heart disease: fish for prevention and treatment of cardiac failure?
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Cardiovasc Res
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2005
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0.86
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82
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Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.
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Am J Physiol Heart Circ Physiol
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2007
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0.85
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83
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Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power.
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Am J Physiol Heart Circ Physiol
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2005
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0.85
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84
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Increased nonoxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia.
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Am J Physiol Heart Circ Physiol
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2002
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0.84
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85
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Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia.
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Am J Physiol Heart Circ Physiol
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2003
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0.84
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86
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Chronic treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates myocardial respiratory capacity and contractile function.
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Mol Cell Biochem
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2009
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0.84
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87
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Extracellular matrix maturation in the left ventricle of normal and diabetic swine.
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Diabetes Res Clin Pract
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2003
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0.83
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88
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Regulation of malonyl-CoA concentration and turnover in the normal heart.
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J Biol Chem
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2004
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0.83
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89
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Expression of mitochondrial regulatory genes parallels respiratory capacity and contractile function in a rat model of hypoxia-induced right ventricular hypertrophy.
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Mol Cell Biochem
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2008
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0.82
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90
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Acute vagal stimulation attenuates cardiac metabolic response to β-adrenergic stress.
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J Physiol
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2012
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0.82
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91
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Regulation of cardiac energetics: role of redox state and cellular compartmentation during ischemia.
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Ann N Y Acad Sci
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2005
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0.82
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92
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Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia.
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Am J Physiol Heart Circ Physiol
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2008
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0.82
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93
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Chronic hypoxia impairs cytochrome oxidase activity via oxidative stress in selected fetal Guinea pig organs.
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Reprod Sci
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2012
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0.81
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94
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Malonyl-CoA decarboxylase inhibition as a novel approach to treat ischemic heart disease.
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Cardiovasc Drugs Ther
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2006
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0.81
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95
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A radiochemical pyruvate dehydrogenase assay: activity in heart.
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Anal Biochem
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2003
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0.81
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96
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Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation in pigs.
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J Physiol
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2006
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0.80
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97
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Mouse strain-specific differences in cardiac metabolic enzyme activities observed in a model of isoproterenol-induced cardiac hypertrophy.
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Clin Exp Pharmacol Physiol
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2007
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0.78
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98
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Dipropionylcysteine ethyl ester compensates for loss of citric acid cycle intermediates during post ischemia reperfusion in the pig heart.
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Cardiovasc Drugs Ther
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2009
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0.78
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99
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Chronic treatment with trimetazidine reduces the upregulation of atrial natriuretic peptide in heart failure.
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Fundam Clin Pharmacol
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2006
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0.78
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100
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Altered cardiac metabolic phenotype after prolonged inhibition of NO synthesis in chronically instrumented dogs.
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Am J Physiol Heart Circ Physiol
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2006
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0.78
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101
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Assay of the activity of malonyl-coenzyme A decarboxylase by gas chromatography-mass spectrometry.
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Anal Biochem
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2007
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0.77
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102
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Dietary saturated fat and docosahexaenoic acid differentially effect cardiac mitochondrial phospholipid fatty acyl composition and Ca(2+) uptake, without altering permeability transition or left ventricular function.
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Physiol Rep
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2013
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0.77
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103
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Effects of glucose-6-phosphate dehydrogenase deficiency on the metabolic and cardiac responses to obesogenic or high-fructose diets.
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Am J Physiol Endocrinol Metab
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2012
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0.77
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104
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Metabolic therapy for heart disease: impact of trimetazidine.
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Heart Fail Rev
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2005
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0.76
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105
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Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure.
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Cardiovasc Drugs Ther
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2013
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0.76
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106
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Beneficial effects of acute inhibition of the oxidative pentose phosphate pathway in the failing heart.
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Am J Physiol Heart Circ Physiol
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2014
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0.76
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107
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Combining protein ratio p-values as a pragmatic approach to the analysis of multirun iTRAQ experiments.
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J Proteome Res
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2015
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0.76
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108
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Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism.
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Biomed Eng Online
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2004
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0.75
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109
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Partial fatty acid oxidation inhibitors: a potentially new class of drugs for heart failure.
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Eur J Heart Fail
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2002
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0.75
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110
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The role of Ca2+ in coupling cardiac metabolism with regulation of contraction: in silico modeling.
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Ann N Y Acad Sci
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2008
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0.75
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111
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Metabolomic analysis of two different models of delayed preconditioning.
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J Mol Cell Cardiol
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2012
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0.75
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112
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Effect of a high-protein diet on development of heart failure in response to pressure overload.
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Appl Physiol Nutr Metab
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2013
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0.75
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113
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Correction to "Combining Protein Ratio p-Values as a Pragmatic Approach to the Analysis of Multirun iTRAQ Experiments".
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J Proteome Res
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2015
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0.75
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114
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Update on innovative initiatives for the American Journal of Physiology-Heart and Circulatory Physiology.
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Am J Physiol Heart Circ Physiol
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2013
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0.75
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115
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[Potential impact of carbohydrate and fat intake on cardiac hypertrophy].
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Kardiol Pol
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2006
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0.75
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116
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Diabetes and ischaemic heart disease: essential role for metabolic therapies.
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Coron Artery Dis
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2005
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0.75
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117
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[Overview on omega-3 polyunsaturated fatty acids and heart failure].
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Kardiol Pol
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2010
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0.75
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118
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Role of cellular compartmentation in the metabolic response to stress: mechanistic insights from computational models.
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Ann N Y Acad Sci
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2006
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0.75
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119
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Nutrition and cardiovascular disease: putting a pathogenic framework into focus.
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Cardiovasc Res
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2006
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0.75
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