|
1
|
Epigenetics in human disease and prospects for epigenetic therapy.
|
Nature
|
2004
|
11.46
|
|
2
|
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.
|
Cancer Cell
|
2006
|
8.46
|
|
3
|
Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.
|
Proc Natl Acad Sci U S A
|
2008
|
4.20
|
|
4
|
Rethinking how DNA methylation patterns are maintained.
|
Nat Rev Genet
|
2009
|
4.03
|
|
5
|
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
|
Mol Cancer Ther
|
2009
|
3.56
|
|
6
|
Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island.
|
Cancer Cell
|
2007
|
3.15
|
|
7
|
Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.
|
Cancer Res
|
2002
|
3.02
|
|
8
|
The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.
|
Cancer Res
|
2009
|
2.83
|
|
9
|
DNA methylation screening identifies driver epigenetic events of cancer cell survival.
|
Cancer Cell
|
2012
|
2.45
|
|
10
|
Preferential response of cancer cells to zebularine.
|
Cancer Cell
|
2004
|
2.39
|
|
11
|
Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.
|
Mol Cell Biol
|
2009
|
2.34
|
|
12
|
Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer.
|
PLoS Genet
|
2010
|
2.27
|
|
13
|
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.
|
Proc Natl Acad Sci U S A
|
2006
|
2.25
|
|
14
|
Polycomb-repressed genes have permissive enhancers that initiate reprogramming.
|
Cell
|
2011
|
2.14
|
|
15
|
Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules.
|
Genome Res
|
2012
|
1.95
|
|
16
|
H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes.
|
Mol Cell
|
2010
|
1.85
|
|
17
|
Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.
|
Mol Cancer Ther
|
2005
|
1.85
|
|
18
|
DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter.
|
Hum Mol Genet
|
2011
|
1.83
|
|
19
|
Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells.
|
Biochem Biophys Res Commun
|
2008
|
1.74
|
|
20
|
Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients.
|
Clin Cancer Res
|
2004
|
1.69
|
|
21
|
Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation.
|
Mol Cancer Res
|
2004
|
1.68
|
|
22
|
Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells.
|
Mol Cell Biol
|
2004
|
1.68
|
|
23
|
Examination of IGF2 and H19 loss of imprinting in bladder cancer.
|
Cancer Res
|
2007
|
1.65
|
|
24
|
Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer.
|
Int J Cancer
|
2009
|
1.64
|
|
25
|
Hypomethylation and hypermethylation of DNA in Wilms tumors.
|
Oncogene
|
2002
|
1.59
|
|
26
|
Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance.
|
PLoS Genet
|
2011
|
1.56
|
|
27
|
OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes.
|
Proc Natl Acad Sci U S A
|
2011
|
1.51
|
|
28
|
Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue.
|
Cancer Res
|
2010
|
1.47
|
|
29
|
Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells.
|
Mol Cell Biol
|
2006
|
1.46
|
|
30
|
DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight.
|
Nucleic Acids Res
|
2008
|
1.42
|
|
31
|
Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer.
|
Nat Clin Pract Urol
|
2005
|
1.41
|
|
32
|
Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides.
|
Cancer Res
|
2007
|
1.40
|
|
33
|
Prognostic relevance of methylation markers in patients with non-muscle invasive bladder carcinoma.
|
Eur J Cancer
|
2005
|
1.18
|
|
34
|
Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML.
|
Blood
|
2011
|
1.17
|
|
35
|
Methylation-sensitive single-nucleotide primer extension (Ms-SNuPE) for quantitative measurement of DNA methylation.
|
Nat Protoc
|
2007
|
1.16
|
|
36
|
Functional DNA demethylation is accompanied by chromatin accessibility.
|
Nucleic Acids Res
|
2013
|
1.09
|
|
37
|
Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions.
|
PLoS Genet
|
2012
|
1.07
|
|
38
|
Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome.
|
PLoS One
|
2010
|
1.07
|
|
39
|
RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking.
|
Cancer Res
|
2008
|
1.05
|
|
40
|
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells.
|
Gene
|
2002
|
1.04
|
|
41
|
A panel of three markers hyper- and hypomethylated in urine sediments accurately predicts bladder cancer recurrence.
|
Clin Cancer Res
|
2014
|
0.99
|
|
42
|
The tumor suppressor microRNA-101 becomes an epigenetic player by targeting the polycomb group protein EZH2 in cancer.
|
Cell Cycle
|
2009
|
0.94
|
|
43
|
Tissue inhibitor of metalloproteinase 1 expression associated with gene demethylation confers anoikis resistance in early phases of melanocyte malignant transformation.
|
Transl Oncol
|
2009
|
0.91
|
|
44
|
Diagnostic markers of urothelial cancer based on DNA methylation analysis.
|
BMC Cancer
|
2013
|
0.90
|
|
45
|
SNF5 is an essential executor of epigenetic regulation during differentiation.
|
PLoS Genet
|
2013
|
0.87
|
|
46
|
Epigenetic reprogramming as a key contributor to melanocyte malignant transformation.
|
Epigenetics
|
2011
|
0.86
|
|
47
|
Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review.
|
Clin Rev Allergy Immunol
|
2014
|
0.84
|
|
48
|
Creating a flexible multiple microRNA expression vector by linking precursor microRNAs.
|
Biochem Biophys Res Commun
|
2011
|
0.83
|
|
49
|
Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells.
|
PLoS One
|
2013
|
0.81
|
|
50
|
Reprogramming of the human intestinal epigenome by surgical tissue transposition.
|
Genome Res
|
2014
|
0.80
|
|
51
|
Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model.
|
Urology
|
2013
|
0.78
|
|
52
|
Lysine methyltransferase G9a is not required for DNMT3A/3B anchoring to methylated nucleosomes and maintenance of DNA methylation in somatic cells.
|
Epigenetics Chromatin
|
2012
|
0.78
|
|
53
|
Epigenetic alterations in bladder cancer and their potential clinical implications.
|
Adv Urol
|
2012
|
0.77
|