Published in Chem Res Toxicol on August 23, 2007
Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds. Toxicol Appl Pharmacol (2015) 0.85
Integrated Computational Solution for Predicting Skin Sensitization Potential of Molecules. PLoS One (2016) 0.78
QSAR models of human data can enrich or replace LLNA testing for human skin sensitization. Green Chem (2016) 0.77
Prediction of skin sensitization with a particle swarm optimized support vector machine. Int J Mol Sci (2009) 0.77
The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol (2007) 5.16
Determinants of skin sensitisation potential. J Appl Toxicol (2008) 2.11
Routine bone marrow biopsy has little or no therapeutic consequence for positron emission tomography/computed tomography-staged treatment-naive patients with Hodgkin lymphoma. J Clin Oncol (2012) 1.93
The prevalence of plant food allergies: a systematic review. J Allergy Clin Immunol (2008) 1.77
A stepwise approach for defining the applicability domain of SAR and QSAR models. J Chem Inf Model (2005) 1.37
Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis (2005) 1.35
Integrating non-animal test information into an adaptive testing strategy - skin sensitization proof of concept case. ALTEX (2011) 1.24
Stereotyped axon pruning via plexin signaling is associated with synaptic complex elimination in the hippocampus. J Neurosci (2005) 1.21
A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*. ALTEX (2012) 1.15
Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium. Contact Dermatitis (2003) 1.14
Immunotoxicological studies of genetically modified rice expressing PHA-E lectin or Bt toxin in Wistar rats. Toxicology (2007) 1.08
A 21st century roadmap for human health risk assessment. Crit Rev Toxicol (2014) 1.07
Axon pruning in the developing vertebrate hippocampus. Dev Neurosci (2007) 1.00
Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. Chem Res Toxicol (2008) 0.99
Comparative assessment of methods to develop QSARs for the prediction of the toxicity of phenols to Tetrahymena pyriformis. Chemosphere (2002) 0.96
Risk assessment in the 21st century: roadmap and matrix. Crit Rev Toxicol (2014) 0.95
Evidence-based toxicology for the 21st century: opportunities and challenges. ALTEX (2013) 0.94
Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling. Neural Dev (2008) 0.94
A systematic approach to simulating metabolism in computational toxicology. I. The TIMES heuristic modelling framework. Curr Pharm Des (2004) 0.92
Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization. Chem Res Toxicol (2007) 0.92
Making sense of human biomonitoring data: findings and recommendations of a workshop. J Expo Sci Environ Epidemiol (2007) 0.91
Experimental reactivity parameters for toxicity modeling: application to the acute aquatic toxicity of SN2 electrophiles to Tetrahymena pyriformis. Chem Res Toxicol (2010) 0.91
Use and validation of HT/HC assays to support 21st century toxicity evaluations. Regul Toxicol Pharmacol (2013) 0.90
Electrophilic chemistry related to skin sensitization. Reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay. Chem Res Toxicol (2007) 0.90
Description of the electronic structure of organic chemicals using semiempirical and ab initio methods for development of toxicological QSARs. J Chem Inf Model (2005) 0.89
Categorical QSAR Models for skin sensitization based upon local lymph node assay classification measures part 2: 4D-fingerprint three-state and two-2-state logistic regression models. Toxicol Sci (2007) 0.88
Computer-aided knowledge generation for understanding skin sensitization mechanisms: the TOPS-MODE approach. Chem Res Toxicol (2003) 0.87
Immunotoxicity of nucleic acid reduced BioProtein--a bacterial derived single cell protein--in Wistar rats. Toxicology (2002) 0.85
4D-fingerprint categorical QSAR models for skin sensitization based on the classification of local lymph node assay measures. Chem Res Toxicol (2007) 0.84
Quantitative structure-activity relationships for predicting percutaneous absorption rates. Environ Toxicol Chem (2003) 0.83
Bioaccumulation assessment using predictive approaches. Integr Environ Assess Manag (2009) 0.82
A chemical dataset for evaluation of alternative approaches to skin-sensitization testing. Contact Dermatitis (2004) 0.82
An oral Brown Norway rat model for food allergy: comparison of age, sex, dosing volume, and allergen preparation. Toxicology (2004) 0.82
Does the extreme skin sensitization potency of benzoquinone result from special chemistry? Contact Dermatitis (2009) 0.82
Skin sensitization: reaction mechanistic applicability domains for structure-activity relationships. Chem Res Toxicol (2005) 0.82
Non-enzymatic glutathione reactivity and in vitro toxicity: a non-animal approach to skin sensitization. Toxicol In Vitro (2005) 0.81
MetaPath: an electronic knowledge base for collating, exchanging and analyzing case studies of xenobiotic metabolism. Regul Toxicol Pharmacol (2012) 0.81
Structure-based classification of antibacterial activity. J Chem Inf Comput Sci (2002) 0.81
Verification of the structural alerts for Michael acceptors. Chem Res Toxicol (2007) 0.80
Chemical reactivity indices and mechanism-based read-across for non-animal based assessment of skin sensitisation potential. J Appl Toxicol (2008) 0.80
Use of genotoxicity information in the development of integrated testing strategies (ITS) for skin sensitization. Chem Res Toxicol (2010) 0.79
Creating molecular diversity from antioxidants in Brazilian propolis. Combination of TOPS-MODE QSAR and virtual structure generation. Mol Divers (2004) 0.79
Identification of transcription factors and coactivators affected by dibutylphthalate interactions in fetal rat testes. Toxicol Sci (2013) 0.79
ECETOC workshop on the biological significance of DNA adducts: summary of follow-up from an expert panel meeting. Mutat Res (2009) 0.78
From knowledge generation to knowledge archive. A general strategy using TOPS-MODE with DEREK to formulate new alerts for skin sensitization. J Chem Inf Comput Sci (2004) 0.78
Skin sensitization: modeling based on skin metabolism simulation and formation of protein conjugates. Int J Toxicol (2005) 0.78
Predicting drugs and proteins in parasite infections with topological indices of complex networks: theoretical backgrounds, applications, and legal issues. Curr Pharm Des (2010) 0.78
The incorporation of lysine into the peroxidase peptide reactivity assay for skin sensitization assessments. Toxicol Sci (2011) 0.78
A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals. Toxicol Lett (2008) 0.77
Mechanistic applicability domains for non-animal based prediction of toxicological endpoints. QSAR analysis of the schiff base applicability domain for skin sensitization. Chem Res Toxicol (2006) 0.77
Quantitative structure-activity relationships for predicting skin and respiratory sensitization. Environ Toxicol Chem (2003) 0.77
Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59. Altern Lab Anim (2007) 0.77
Categorical QSAR models for skin sensitization based on local lymph node assay measures and both ground and excited state 4D-fingerprint descriptors. J Comput Aided Mol Des (2008) 0.77
Long-term use of antiplatelet drugs by patients with transient ischaemic attack. Eur J Clin Pharmacol (2013) 0.77
Stepwise discrimination between four modes of toxic action of phenols in the Tetrahymena pyriformis assay. Chem Res Toxicol (2003) 0.76
The reduced local lymph node assay: the impact of group size. J Appl Toxicol (2008) 0.76
The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements? Contact Dermatitis (2006) 0.76
Structure-toxicity relationships for aliphatic chemicals evaluated with Tetrahymena pyriformis. Chem Res Toxicol (2002) 0.76
A mechanistic approach to modeling respiratory sensitization. Chem Res Toxicol (2014) 0.76
Toxmatch--a chemical classification and activity prediction tool based on similarity measures. Regul Toxicol Pharmacol (2008) 0.75
Low Incidence of Atrial Fibrillation in Patients with Transient Ischemic Attack. Cerebrovasc Dis Extra (2016) 0.75
Contact allergy to capryloyl salicylic acid: a mechanistic chemistry and structure-activity perspective. Contact Dermatitis (2015) 0.75
Allergic contact dermatitis caused by a skin-lightening agent, 5,5'-dipropylbiphenyl-2,2'-diol. A comment. Contact Dermatitis (2012) 0.75
TIMES-SS--a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity. Regul Toxicol Pharmacol (2007) 0.75
What determines skin sensitization potency-myths, maybes and realities. Part 1. The 500 molecular weight cut-off. Contact Dermatitis (2012) 0.75
Current topics on software use in medicinal chemistry: intellectual property, taxes, and regulatory issues. Curr Top Med Chem (2008) 0.75
Extrapolating local lymph node assay EC3 values to estimate relative sensitizing potency. Cutan Ocul Toxicol (2007) 0.75
Molecular modelling of the mouse cytochrome P450 CYP2F2 based on the CYP102 crystal structure template and selective CYP2F2 substrate interactions. Drug Metabol Drug Interact (2002) 0.75
Food allergy information resources for consumers, industry and regulators. Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M (2006) 0.75
Investigating the relationship between in vitro-in vivo genotoxicity: derivation of mechanistic QSAR models for in vivo liver genotoxicity and in vivo bone marrow micronucleus formation which encompass metabolism. Chem Res Toxicol (2012) 0.75