Published in Dig Dis Sci on September 01, 2007
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The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. Genes Dev (2006) 2.76
Modelling how ribavirin improves interferon response rates in hepatitis C virus infection. Nature (2004) 2.74
Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A (2007) 2.67
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Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice. Blood (2004) 2.23
Effects of stellate-ganglion block on hot flushes and night awakenings in survivors of breast cancer: a pilot study. Lancet Oncol (2008) 2.22
A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. Hepatology (2007) 2.16
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol (2002) 2.15
FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J (2009) 2.11
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Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J Clin Invest (2005) 2.10
Polymer particle shape independently influences binding and internalization by macrophages. J Control Release (2010) 2.05
Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res (2006) 2.01
Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. J Cell Biochem (2010) 1.93
Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Mol Cell Biol (2004) 1.85
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci (2012) 1.82
Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc Natl Acad Sci U S A (2008) 1.81
Pharmacodynamics of PEG-IFN-alpha-2a in HIV/HCV co-infected patients: implications for treatment outcomes. J Hepatol (2010) 1.78
Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscle. Diabetes (2007) 1.74
Fuel-powered artificial muscles. Science (2006) 1.69
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Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Exp Cell Res (2005) 1.64
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Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One (2007) 1.56
Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J Biol Chem (2007) 1.52
A randomized crossover trial of a wedged insole for treatment of knee osteoarthritis. Arthritis Rheum (2007) 1.47
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Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis? Arch Pathol Lab Med (2008) 1.42
Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling. J Biol Chem (2006) 1.41
Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer. Proc Natl Acad Sci U S A (2002) 1.41
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Res (2005) 1.41
The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivo. Diabetes Care (2004) 1.40
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Repeated pulse intramuscular injection of pralidoxime chloride in severe acute organophosphorus pesticide poisoning. Am J Emerg Med (2013) 1.39
A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation. J Biol Chem (2006) 1.38
Inhibition of Chk1 by activated PKB/Akt. Cell Cycle (2004) 1.38
Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. Gastroenterology (2006) 1.38
Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells. J Biol Chem (2008) 1.38
Skeletal muscle NAMPT is induced by exercise in humans. Am J Physiol Endocrinol Metab (2009) 1.36
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Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol Cell Biol (2002) 1.36
The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation. Blood (2007) 1.33
Angiotensin-induced defects in renal oxygenation: role of oxidative stress. Am J Physiol Heart Circ Physiol (2005) 1.32
Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death. J Biol Chem (2001) 1.31
Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest (2013) 1.29
Elevated systemic hepcidin and iron depletion in obese premenopausal females. Obesity (Silver Spring) (2009) 1.28
Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis (2008) 1.28
Akt isoforms differentially regulate neutrophil functions. Blood (2010) 1.27
The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol (2005) 1.26
Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res (2004) 1.25
ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging. Lab Invest (2007) 1.22
Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men. J Clin Endocrinol Metab (2007) 1.21
miR-148a regulates osteoclastogenesis by targeting V-maf musculoaponeurotic fibrosarcoma oncogene homolog B. J Bone Miner Res (2013) 1.21
Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Mol Cell Biol (2009) 1.19
Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetes. Diabetes Care (2009) 1.19
An important role for Akt3 in platelet activation and thrombosis. Blood (2011) 1.19
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Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model. Cancer Res (2011) 1.17
Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma. Clin Cancer Res (2008) 1.13
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Marjolin ulcer: an overlooked entity. Int Wound J (2011) 1.13
Acute hypoxia increases the aggressive characteristics and survival properties of prostate cancer cells. Prostate (2003) 1.12
A mathematical model of hepatitis C virus dynamics in patients with high baseline viral loads or advanced liver disease. Gastroenterology (2009) 1.11
Dynamics of alanine aminotransferase during hepatitis C virus treatment. Hepatology (2003) 1.11
Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate. Am J Respir Cell Mol Biol (2009) 1.11
Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses. J Biol Chem (2007) 1.11
MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest (2015) 1.10
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice. Carcinogenesis (2011) 1.10
Mitochondrial hexokinases: guardians of the mitochondria. Cell Cycle (2005) 1.10
Understanding triphasic HCV decline during treatment in the era of IL28B polymorphisms and direct acting antiviral agents via mathematical modeling. J Hepatol (2012) 1.09
Modelling hepatitis C virus kinetics: the relationship between the infected cell loss rate and the final slope of viral decay. Antivir Ther (2009) 1.08
The histologic spectrum of liver disease in African-American, non-Hispanic white, and Hispanic obesity surgery patients. Am J Gastroenterol (2009) 1.08
Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. J Biol Chem (2008) 1.08
FoxM1 regulates mammary luminal cell fate. Cell Rep (2012) 1.08
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice. Cell Metab (2012) 1.07