Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.

FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A (2008) 5.71

Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell (2008) 5.34

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85

Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J (2004) 4.57

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest (2009) 4.29

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93

The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J (2004) 3.92

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84

FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol (2008) 3.70

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest (2005) 3.66

Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab (2008) 3.35

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc Natl Acad Sci U S A (2003) 3.28

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci (2010) 3.17

Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem (2005) 2.94

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability. J Clin Invest (2008) 2.68

Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J (2004) 2.50

Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest (2007) 2.39

Regulation of superoxide dismutase genes: implications in disease. Free Radic Biol Med (2009) 2.35

A new fork for clinical application: targeting forkhead transcription factors in cancer. Clin Cancer Res (2009) 2.27

A Drosophila model for age-associated changes in sleep:wake cycles. Proc Natl Acad Sci U S A (2006) 2.27

Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit Care Med (2011) 2.24

Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling. Nat Rev Immunol (2009) 2.19

Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J (2006) 2.18

SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12

FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J (2009) 2.11

β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med (2012) 2.02

Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol (2005) 2.00

FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem (2010) 2.00

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med (2011) 1.97

Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol (2007) 1.96

Caloric restriction and intermittent fasting: two potential diets for successful brain aging. Ageing Res Rev (2006) 1.94

Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA. PLoS One (2010) 1.94

Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol (2003) 1.92

The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol (2009) 1.91

Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91

Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct (2011) 1.89

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest (2012) 1.82

Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxid Redox Signal (2008) 1.81

miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev (2010) 1.80

Free radicals and senescence. Exp Cell Res (2008) 1.79

Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages. J Immunol (2008) 1.77

MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival. Blood (2011) 1.76

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood (2010) 1.75

Redox control of the cell cycle in health and disease. Antioxid Redox Signal (2009) 1.72

FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature (2016) 1.66

Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem (2010) 1.65

Current understanding of klotho. Ageing Res Rev (2008) 1.64

Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest (2012) 1.63

Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. EMBO J (2006) 1.63

The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J Clin Invest (2006) 1.62

Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol (2009) 1.61

Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons. J Neurosci (2014) 1.59

Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death Differ (2011) 1.59

Functional interaction between FOXO3a and ATM regulates DNA damage response. Nat Cell Biol (2008) 1.58

Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis. Int J Oncol (2006) 1.58

Klotho and aging. Biochim Biophys Acta (2009) 1.58

Mitochondrial dysfunction in cancer. Front Oncol (2013) 1.57

Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem (2009) 1.50

In control of biology: of mice, men and Foxes. Biochem J (2006) 1.50

Retracted The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners. BMC Physiol (2010) 1.47

Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury. Histol Histopathol (2005) 1.47

Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth. Aging Cell (2008) 1.47

Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Mol Cell Biol (2006) 1.45

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev (2007) 1.43

p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A (2004) 1.43

Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease. PLoS Comput Biol (2012) 1.41

Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One (2010) 1.41

Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener (2015) 1.41

Oxidative stress and ageing: is ageing a cysteine deficiency syndrome? Philos Trans R Soc Lond B Biol Sci (2005) 1.41

Cardiac aging: from molecular mechanisms to significance in human health and disease. Antioxid Redox Signal (2012) 1.40

Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes. J Biol Chem (2009) 1.40

Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. Diabetes (2009) 1.39

Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucleic Acids Res (2007) 1.38

p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. Mol Cell Biol (2004) 1.38

DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature (2014) 1.37

FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc Natl Acad Sci U S A (2007) 1.37

FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Mol Cell Biol (2009) 1.35

Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. J Clin Invest (2004) 1.34

The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33

FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Proc Natl Acad Sci U S A (2009) 1.32

Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress. Mol Biol Cell (2004) 1.32

The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol Cell Biol (2008) 1.31

Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis. Breast Cancer Res (2008) 1.30

Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice. PLoS One (2009) 1.28

Forkhead transcription factors and cardiovascular biology. Circ Res (2008) 1.28

Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets. Drug Discov Today Dis Mech (2010) 1.28

Role of forkhead transcription factors in diabetes-induced oxidative stress. Exp Diabetes Res (2012) 1.27

Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proc Natl Acad Sci U S A (2011) 1.26

Control of Bcl-2 expression by reactive oxygen species. Proc Natl Acad Sci U S A (2003) 1.26

FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts. J Biol Chem (2008) 1.25

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBO J (2010) 1.24

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol (2013) 1.24

Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro. Cell Cycle (2012) 1.23

JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span. J Biol Chem (2009) 1.21

CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med (2004) 1.20

Mirk regulates the exit of colon cancer cells from quiescence. J Biol Chem (2009) 1.20

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A (2005) 7.21

FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol (2005) 7.02

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell (2003) 6.76

The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol (2002) 4.85

Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol (2007) 4.73

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol (2002) 4.68

Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science (2005) 4.61

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J (2004) 4.57

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature (2008) 4.33

FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat Cell Biol (2006) 4.14

Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer (2010) 3.74

FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell (2011) 3.58

The decision to enter mitosis: feedback and redundancy in the mitotic entry network. J Cell Biol (2009) 3.48

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem (2003) 3.41

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem (2004) 3.39

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment. Cell (2008) 3.38

Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations. Science (2011) 3.29

cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. J Biol Chem (2003) 3.24

Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol (2002) 3.20

Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol (2010) 3.01

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep (2004) 2.98

FoxM1: at the crossroads of ageing and cancer. Biochim Biophys Acta (2006) 2.98

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol (2003) 2.90

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol (2002) 2.86

Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol Cell Biol (2002) 2.84

FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol (2013) 2.83

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene (2005) 2.80

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension. EMBO J (2003) 2.70

Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell (2004) 2.64

Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol (2004) 2.62

Polo-like kinases: a team in control of the division. Cell Cycle (2006) 2.62

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood (2009) 2.49

Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett (2005) 2.45

Rap1: a key regulator in cell-cell junction formation. J Cell Sci (2007) 2.44

Getting in and out of mitosis with Polo-like kinase-1. Oncogene (2005) 2.44

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis. J Biol Chem (2004) 2.37

Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins. EMBO J (2004) 2.19

Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. Cancer Res (2006) 2.13

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem (2002) 2.12

Structure and regulation of the cAMP-binding domains of Epac2. Nat Struct Biol (2003) 2.11

Kif15 cooperates with eg5 to promote bipolar spindle assembly. Curr Biol (2009) 2.10

The chromosomal passenger complex: guiding Aurora-B through mitosis. J Cell Biol (2006) 2.07

Capturing cyclic nucleotides in action: snapshots from crystallographic studies. Nat Rev Mol Cell Biol (2007) 2.07

Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol (2010) 2.07

Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. J Cell Biol (2003) 2.07

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity (2013) 2.05

The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem (2009) 2.05

Unravelling the tumor-suppressive functions of FOXO proteins. Trends Cell Biol (2008) 2.05

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci U S A (2009) 2.04

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. Curr Biol (2006) 2.02

Rap1 regulates E-cadherin-mediated cell-cell adhesion. J Biol Chem (2004) 1.98

Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity. J Biol Chem (2008) 1.93

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature (2006) 1.88

Cyclic nucleotide analogs as probes of signaling pathways. Nat Methods (2008) 1.84

Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody. EMBO Rep (2006) 1.82

Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. EMBO J (2008) 1.81

Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity (2013) 1.75

Rap2A links intestinal cell polarity to brush border formation. Nat Cell Biol (2012) 1.71

Mechanisms of centrosome separation and bipolar spindle assembly. Dev Cell (2010) 1.70

Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain. Mol Cell Biol (2008) 1.67

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature (2008) 1.66

Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol (2012) 1.63

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol Cell Biol (2004) 1.63

Specificity in Ras and Rap signaling. J Biol Chem (2008) 1.62

Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy. Blood (2012) 1.61

The survivin/Aurora B complex: its role in coordinating tension and attachment. Cell Cycle (2003) 1.61

Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. EMBO J (2002) 1.60

MAPK signaling pathways in the regulation of hematopoiesis. J Leukoc Biol (2009) 1.60

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis. Nat Commun (2011) 1.59

The case for Survivin as mitotic regulator. Curr Opin Cell Biol (2006) 1.59

The role of the PI3K-PKB signaling module in regulation of hematopoiesis. Cell Cycle (2009) 1.55

HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood (2008) 1.54

Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. J Biol Chem (2003) 1.53

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. J Cell Biol (2011) 1.53

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. J Cell Biol (2013) 1.52

FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol (2004) 1.51

Ablation of the spindle assembly checkpoint by a compound targeting Mps1. EMBO Rep (2005) 1.49

The extending network of FOXO transcriptional target genes. Antioxid Redox Signal (2010) 1.49

Evolution of the Ras-like small GTPases and their regulators. Small GTPases (2011) 1.48

CLIP-170 facilitates the formation of kinetochore-microtubule attachments. EMBO J (2005) 1.47

Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis. J Clin Invest (2014) 1.45

FOXO transcription factors as regulators of immune homeostasis: molecules to die for? J Immunol (2003) 1.44

RAMA1 is a novel kinetochore protein involved in kinetochore-microtubule attachment. J Cell Sci (2009) 1.44

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS One (2008) 1.43

Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes. Mol Cancer Res (2006) 1.42

Regulating Rap small G-proteins in time and space. Trends Cell Biol (2011) 1.42

FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1. J Biol Chem (2006) 1.40

Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism. J Immunol (2006) 1.40

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons. Proc Natl Acad Sci U S A (2007) 1.40