Published in Bioorg Med Chem on August 21, 2007
Synthesis of (+)-cortistatin A. J Am Chem Soc (2008) 1.48
Scalable synthesis of cortistatin A and related structures. J Am Chem Soc (2011) 1.30
Synthesis of cortistatins A, J, K and L. Nat Chem (2010) 1.26
Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives. Mar Drugs (2014) 1.19
Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A (2014) 1.09
Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: application and biological evaluation of D-ring cortistatin analogues. Angew Chem Int Ed Engl (2009) 1.09
An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription. Cell Host Microbe (2012) 1.08
Formal total synthesis of (±)-cortistatin A. Tetrahedron (2010) 1.05
A hypervalent iodine-induced double annulation enables a concise synthesis of the pentacyclic core structure of the cortistatins. Org Lett (2009) 1.04
Marine-derived angiogenesis inhibitors for cancer therapy. Mar Drugs (2013) 0.89
Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance. Chem Soc Rev (2012) 0.84
Marine-derived metabolites of S-adenosylmethionine as templates for new anti-infectives. Mar Drugs (2009) 0.83
Synthetic studies toward (+)-cortistatin A. Tetrahedron (2011) 0.79
Natural product synthesis: clearing the way to cortistatins. Nat Chem (2010) 0.75
Steroidal alkaloids from the marine sponge Corticium niger that inhibit growth of human colon carcinoma cells. J Nat Prod (2014) 0.75
Creation of readily accessible and orally active analogue of cortistatin a. ACS Med Chem Lett (2012) 0.75
Towards a general diastereoselective route to oxabicyclo[3.2.1]octanes via a gold-catalysed cascade reaction. Nat Commun (2015) 0.75
Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nat Med (2002) 5.17
Measurement of spleen stiffness by acoustic radiation force impulse imaging identifies cirrhotic patients with esophageal varices. Gastroenterology (2012) 3.37
Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. Biochem J (2003) 3.29
The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J Clin Invest (2005) 2.80
Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol (2002) 2.57
The atomic structure of rice dwarf virus reveals the self-assembly mechanism of component proteins. Structure (2003) 2.53
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat Med (2006) 2.35
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol (2007) 2.33
Molecular signature of quiescent satellite cells in adult skeletal muscle. Stem Cells (2007) 2.23
A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model. Crit Care Med (2005) 2.15
High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer. Gastric Cancer (2010) 2.11
Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex. J Am Chem Soc (2006) 2.10
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest (2003) 1.95
Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle. J Cell Sci (2011) 1.94
Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes. J Mol Cell Cardiol (2002) 1.86
Purification and cell-surface marker characterization of quiescent satellite cells from murine skeletal muscle by a novel monoclonal antibody. Exp Cell Res (2004) 1.84
Role of premature leptin surge in obesity resulting from intrauterine undernutrition. Cell Metab (2005) 1.83
Two cases of calcified amorphous tumor mimicking mitral valve vegetation. Circulation (2012) 1.79
Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One (2011) 1.73
Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality. Surgery (2009) 1.71
Plasma level of endogenous secretory RAGE is associated with components of the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol (2005) 1.70
Structural elements in the internal ribosome entry site of Plautia stali intestine virus responsible for binding with ribosomes. Nucleic Acids Res (2003) 1.68
The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Res Ther (2006) 1.67
Dramatic changes of the gut flora immediately after severe and sudden insults. Dig Dis Sci (2011) 1.59
CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes (2012) 1.56
Muscle regeneration by reconstitution with bone marrow or fetal liver cells from green fluorescent protein-gene transgenic mice. J Cell Sci (2002) 1.51
Disorders of cochlear blood flow. Brain Res Brain Res Rev (2003) 1.49
Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. Diabetes (2010) 1.48
Increased vascular wall thrombogenicity combined with reduced blood flow promotes occlusive thrombus formation in rabbit femoral artery. Arterioscler Thromb Vasc Biol (2004) 1.48
Low circulating endogenous secretory receptor for AGEs predicts cardiovascular mortality in patients with end-stage renal disease. Arterioscler Thromb Vasc Biol (2006) 1.47
Increased plasma interleukin-6 is associated with the pathogenesis of obstructive sleep apnea syndrome. Chest (2004) 1.47
Long-term effect of body weight-supported treadmill training in Parkinson's disease: a randomized controlled trial. Arch Phys Med Rehabil (2002) 1.45
Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett (2002) 1.45
Differences between right- and left-sided colon cancer in patient characteristics, cancer morphology and histology. J Gastroenterol Hepatol (2007) 1.45
The role of the receptor for advanced glycation end-products in lung fibrosis. Am J Physiol Lung Cell Mol Physiol (2007) 1.45
Increased neutrophils in bronchoalveolar lavage fluids from a patient with pulmonary edema associated with pheochromocytoma. Intern Med (2004) 1.43
RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin. Diabetes (2006) 1.43
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression. Cancer Res (2009) 1.42
Safe and feasible inflow occlusion in laparoscopic liver resection. Surg Endosc (2008) 1.42
Potential benefits of early continuous positive pressure ventilation in patients with rapidly progressive interstitial pneumonia. Respirology (2012) 1.42
Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage. Neurosci Lett (2012) 1.40
Role of gamma delta T cells in the inflammatory response of experimental colitis mice. J Immunol (2003) 1.39
Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells. FASEB J (2010) 1.38
A free-floating left atrial thrombus develops intermittent entrapment in the mid-ventricle during diastole. Heart Vessels (2011) 1.38
Phosphoinositide metabolism during membrane ruffling and macropinosome formation in EGF-stimulated A431 cells. Exp Cell Res (2007) 1.38
Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1. J Appl Physiol (1985) (2002) 1.38
Expression and sub-cellular localization of human ABH family molecules. J Cell Mol Med (2007) 1.36
Advanced glycation end products-induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes. Biochem Biophys Res Commun (2002) 1.36
A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nat Med (2002) 1.35
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. Invest Ophthalmol Vis Sci (2007) 1.32
Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study. BMC Cancer (2010) 1.31
gammadelta T cells: firefighters or fire boosters in the front lines of inflammatory responses. Immunol Rev (2007) 1.31
Identification of histidine kinases that act as sensors in the perception of salt stress in Synechocystis sp. PCC 6803. Proc Natl Acad Sci U S A (2003) 1.30
Septic shock is associated with receptor for advanced glycation end products ligation of LPS. J Immunol (2011) 1.30
Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. Int J Oncol (2002) 1.30
Eukaryotic ribosomal protein RPS25 interacts with the conserved loop region in a dicistroviral intergenic internal ribosome entry site. Nucleic Acids Res (2007) 1.29
Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis. Exp Cell Res (2008) 1.29
Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells. EMBO Rep (2011) 1.28
Serum levels of non-carboxymethyllysine advanced glycation endproducts are correlated to severity of microvascular complications in patients with Type 1 diabetes. J Diabetes Complications (2002) 1.26
Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades. Proc Natl Acad Sci U S A (2005) 1.26
Renal cell carcinoma with unusual metastasis to the gallbladder. J Hepatobiliary Pancreat Surg (2008) 1.26
Trunk deformity is associated with a reduction in outdoor activities of daily living and life satisfaction in community-dwelling older people. Osteoporos Int (2004) 1.24
Structure and biogenesis of the chloroplast NAD(P)H dehydrogenase complex. Biochim Biophys Acta (2010) 1.24
Elongation factor 4 (EF4/LepA) accelerates protein synthesis at increased Mg2+ concentrations. Proc Natl Acad Sci U S A (2011) 1.24
Relative safety of anterior microsurgical decompression versus laminoplasty for cervical myelopathy with a massive ossified posterior longitudinal ligament. Spine (Phila Pa 1976) (2002) 1.24
Expression profiling of endogenous secretory receptor for advanced glycation end products in human organs. Mod Pathol (2005) 1.23
Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes. Diabetes (2006) 1.22
Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer. Cancer Sci (2007) 1.21
Singlet oxygen inhibits the repair of photosystem II by suppressing the translation elongation of the D1 protein in Synechocystis sp. PCC 6803. Biochemistry (2004) 1.21
High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice. J Clin Invest (2010) 1.21
Endogenous secretory receptor for advanced glycation endproducts levels are correlated with serum pentosidine and CML in patients with type 1 diabetes. Arterioscler Thromb Vasc Biol (2007) 1.18
Hepatoid carcinoma of the pancreas producing protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP). J Gastroenterol (2006) 1.17
A novel inhibitory effect of D-allose on production of reactive oxygen species from neutrophils. J Biosci Bioeng (2003) 1.17
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers. Development (2011) 1.16
Circulating concentrations of adiponectin, an endogenous lipopolysaccharide neutralizing protein, decrease in rats with polymicrobial sepsis. J Surg Res (2006) 1.16
Salt stress inhibits the repair of photodamaged photosystem II by suppressing the transcription and translation of psbA genes in synechocystis. Plant Physiol (2002) 1.16
Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice. Proc Natl Acad Sci U S A (2007) 1.15
Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells. FASEB J (2009) 1.15
Genetic background affects properties of satellite cells and mdx phenotypes. Am J Pathol (2010) 1.14
Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization. Biochim Biophys Acta (2004) 1.12
RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases. Mol Med (2007) 1.11
Posture of the trunk in the sagittal plane is associated with gait in community-dwelling elderly population. Clin Biomech (Bristol, Avon) (2004) 1.11
Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells. Chem Pharm Bull (Tokyo) (2004) 1.10
The complex of tmRNA-SmpB and EF-G on translocating ribosomes. Nature (2012) 1.09
The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects. Immunology (2006) 1.09
Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E. J Neurosci (2004) 1.09
Anti-high mobility group box-1 antibody therapy for traumatic brain injury. Ann Neurol (2012) 1.08
Molecular characterization of a high-affinity xylobiose transporter of Streptomyces thermoviolaceus OPC-520 and its transcriptional regulation. J Bacteriol (2004) 1.08
Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury. J Pharmacol Sci (2005) 1.08
Clinical observation of patients with Fabry disease after switching from agalsidase beta (Fabrazyme) to agalsidase alfa (Replagal). Genet Med (2012) 1.07