Published in Nat Methods on September 02, 2007
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc Natl Acad Sci U S A (2009) 3.29
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation. BMC Biol (2012) 2.70
Can cancer be reversed by engineering the tumor microenvironment? Semin Cancer Biol (2008) 2.07
Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement. Proc Natl Acad Sci U S A (2009) 2.07
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov (2009) 1.95
Organs-on-chips at the frontiers of drug discovery. Nat Rev Drug Discov (2015) 1.95
Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitro. Biomaterials (2010) 1.87
Future of personalized medicine in oncology: a systems biology approach. J Clin Oncol (2010) 1.80
Engineering microscale cellular niches for three-dimensional multicellular co-cultures. Lab Chip (2009) 1.77
Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell (2009) 1.77
Anchoring junctions as drug targets: role in contraceptive development. Pharmacol Rev (2008) 1.76
Spherical cancer models in tumor biology. Neoplasia (2015) 1.75
The effect of 3D hydrogel scaffold modulus on osteoblast differentiation and mineralization revealed by combinatorial screening. Biomaterials (2010) 1.71
Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink. Nat Commun (2014) 1.60
Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biol (2008) 1.49
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Biomaterials offer cancer research the third dimension. Nat Mater (2010) 1.45
Three-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic Leukemia. PLoS One (2015) 1.43
The natural and engineered 3D microenvironment as a regulatory cue during stem cell fate determination. Tissue Eng Part B Rev (2009) 1.37
Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells. Biomaterials (2009) 1.37
Hydroxyapatite nanoparticle-containing scaffolds for the study of breast cancer bone metastasis. Biomaterials (2011) 1.32
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Translating tissue engineering technology platforms into cancer research. J Cell Mol Med (2009) 1.29
Manipulating biological agents and cells in micro-scale volumes for applications in medicine. Chem Soc Rev (2013) 1.27
3D in vitro bioengineered tumors based on collagen I hydrogels. Biomaterials (2011) 1.26
Oxygen-controlled three-dimensional cultures to analyze tumor angiogenesis. Tissue Eng Part A (2010) 1.24
Modeling Ewing sarcoma tumors in vitro with 3D scaffolds. Proc Natl Acad Sci U S A (2013) 1.23
Paramagnetic levitational assembly of hydrogels. Adv Mater (2012) 1.18
Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins. BMC Cancer (2009) 1.17
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Self-folding devices and materials for biomedical applications. Trends Biotechnol (2011) 1.16
The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures. BMC Cancer (2010) 1.16
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Chitosan-alginate 3D scaffolds as a mimic of the glioma tumor microenvironment. Biomaterials (2010) 1.14
A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis. PLoS One (2012) 1.12
Tumor engineering: the other face of tissue engineering. Tissue Eng Part A (2010) 1.12
High-content drug screening with engineered musculoskeletal tissues. Tissue Eng Part B Rev (2010) 1.10
Tissue-engineered three-dimensional in vitro models for normal and diseased kidney. Tissue Eng Part A (2010) 1.09
Self-folding polymeric containers for encapsulation and delivery of drugs. Adv Drug Deliv Rev (2012) 1.09
Extraction and assembly of tissue-derived gels for cell culture and tissue engineering. Tissue Eng Part C Methods (2009) 1.09
Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition. Cell Cycle (2013) 1.08
Phenotypic characterization of prostate cancer LNCaP cells cultured within a bioengineered microenvironment. PLoS One (2012) 1.08
The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer. J Transl Med (2012) 1.08
Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner. Gynecol Oncol (2008) 1.07
Emerging technologies for assembly of microscale hydrogels. Adv Healthc Mater (2012) 1.06
Organ-on-a-chip platforms for studying drug delivery systems. J Control Release (2014) 1.06
Bioengineered human tumor within a bone niche. Biomaterials (2014) 1.05
Modeling colon adenocarcinomas in vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction. Am J Pathol (2011) 1.04
Generation of a tumor spheroid in a microgravity environment as a 3D model of melanoma. In Vitro Cell Dev Biol Anim (2009) 1.04
Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. Cancer Res (2013) 1.03
AlgiMatrix™ based 3D cell culture system as an in-vitro tumor model for anticancer studies. PLoS One (2013) 1.03
Three-dimensional in vitro tumor models for cancer research and drug evaluation. Biotechnol Adv (2014) 1.03
Development of an in vitro 3D tumor model to study therapeutic efficiency of an anticancer drug. Mol Pharm (2013) 1.01
A novel 3-D mineralized tumor model to study breast cancer bone metastasis. PLoS One (2010) 1.01
Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics. Transl Oncol (2011) 1.00
Multiplexed, high-throughput analysis of 3D microtissue suspensions. Integr Biol (Camb) (2010) 0.99
Reinforcing silk scaffolds with silk particles. Macromol Biosci (2010) 0.98
Chitosan-alginate scaffold culture system for hepatocellular carcinoma increases malignancy and drug resistance. Pharm Res (2010) 0.98
A 3D fibrous scaffold inducing tumoroids: a platform for anticancer drug development. PLoS One (2013) 0.97
Directed growth of fibroblasts into three dimensional micropatterned geometries via self-assembling scaffolds. Biomaterials (2010) 0.96
Tissue-engineered three-dimensional tumor models to study tumor angiogenesis. Tissue Eng Part A (2010) 0.96
Recreating the tumor microenvironment in a bilayer, hyaluronic acid hydrogel construct for the growth of prostate cancer spheroids. Biomaterials (2012) 0.96
Three-dimensional cell and tissue patterning in a strained fibrin gel system. PLoS One (2007) 0.96
Tissue-engineered models of human tumors for cancer research. Expert Opin Drug Discov (2015) 0.95
Three-dimensional microfluidic collagen hydrogels for investigating flow-mediated tumor-endothelial signaling and vascular organization. Tissue Eng Part C Methods (2013) 0.94
In vivo tibial compression decreases osteolysis and tumor formation in a human metastatic breast cancer model. J Bone Miner Res (2013) 0.93
Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM. Biomaterials (2013) 0.93
DNA-templated assembly of droplet-derived PEG microtissues. Lab Chip (2011) 0.93
Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics. Mol Cancer Res (2015) 0.93
Interactions between human osteoblasts and prostate cancer cells in a novel 3D in vitro model. Organogenesis (2011) 0.93
A hydrogel-based tumor model for the evaluation of nanoparticle-based cancer therapeutics. Biomaterials (2014) 0.92
Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Nat Commun (2015) 0.92
3D porous chitosan-alginate scaffolds: a new matrix for studying prostate cancer cell-lymphocyte interactions in vitro. Adv Healthc Mater (2012) 0.92
A novel three-dimensional culture system of polarized epithelial cells to study endometrial carcinogenesis. Am J Pathol (2010) 0.92
Fibroblast cluster formation on 3D collagen matrices requires cell contraction dependent fibronectin matrix organization. Exp Cell Res (2012) 0.92
Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine. Tissue Eng Part B Rev (2014) 0.92
Multiscale models of breast cancer progression. Ann Biomed Eng (2012) 0.91
Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS One (2012) 0.90
Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations. Biomaterials (2013) 0.90
Review of collagen I hydrogels for bioengineered tissue microenvironments: characterization of mechanics, structure, and transport. Tissue Eng Part B Rev (2014) 0.89
Ex-vivo dynamic 3-D culture of human tissues in the RCCS™ bioreactor allows the study of Multiple Myeloma biology and response to therapy. PLoS One (2013) 0.89
Proliferation and enrichment of CD133(+) glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds. Biomaterials (2014) 0.89
Phosphorescent nanoparticles for quantitative measurements of oxygen profiles in vitro and in vivo. Biomaterials (2012) 0.89
TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer. Nat Commun (2014) 0.88
A three-dimensional in vitro tumor platform for modeling therapeutic irreversible electroporation. Biophys J (2012) 0.88
Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. Lab Chip (2013) 0.88
Biomaterials and emerging anticancer therapeutics: engineering the microenvironment. Nat Rev Cancer (2015) 0.88
A novel three-dimensional stromal-based model for in vitro chemotherapy sensitivity testing of leukemia cells. Leuk Lymphoma (2013) 0.87
Gradient lithography of engineered proteins to fabricate 2D and 3D cell culture microenvironments. Biomed Microdevices (2009) 0.87
The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors. Eur J Pharm Biopharm (2014) 0.87
Multi-lineage MSC differentiation via engineered morphogen fields. J Dent Res (2014) 0.87
Engineering approaches for investigating tumor angiogenesis: exploiting the role of the extracellular matrix. Cancer Res (2012) 0.87
A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype. PLoS One (2013) 0.86
Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer. PLoS One (2014) 0.86
Remodeling Components of the Tumor Microenvironment to Enhance Cancer Therapy. Front Oncol (2015) 0.86
Hyaluronic acid hydrogel stiffness and oxygen tension affect cancer cell fate and endothelial sprouting. Biomater Sci (2014) 0.86
Current approaches in identification and isolation of human renal cell carcinoma cancer stem cells. Stem Cell Res Ther (2015) 0.86
Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids. Nanoscale (2012) 0.86
Designing a binding interface for control of cancer cell adhesion via 3D topography and metabolic oligosaccharide engineering. Biomaterials (2011) 0.86
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (2003) 18.51
Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer (2005) 8.70
Growth factors, matrices, and forces combine and control stem cells. Science (2009) 8.46
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A (2006) 8.01
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell (2002) 7.35
Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials (2003) 7.15
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet (2011) 6.89
Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater (2010) 5.36
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature (2009) 5.32
Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med (2006) 5.10
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res (2005) 5.07
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol (2005) 5.00
Mutant p53 drives invasion by promoting integrin recycling. Cell (2009) 4.75
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol (2003) 4.25
Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol (2002) 4.22
Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A (2003) 4.03
A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell (2007) 3.97
Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol (2008) 3.72
p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol (2006) 3.37
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36
Highly stretchable and tough hydrogels. Nature (2012) 3.34
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol (2009) 3.26
A non-genetic route to aneuploidy in human cancers. Nat Cell Biol (2011) 3.25
Alginate: properties and biomedical applications. Prog Polym Sci (2012) 3.18
Alginate hydrogels as biomaterials. Macromol Biosci (2006) 2.94
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol (2002) 2.92
Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci U S A (2004) 2.81
How practicing dentists can shape dental research: The American Association for Dental Research's vision for the future. J Am Dent Assoc (2012) 2.77
Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron (2005) 2.72
Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell (2012) 2.71
Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J R Soc Interface (2010) 2.69
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell (2007) 2.60
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity (2006) 2.57
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A (2004) 2.56
Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell (2005) 2.47
Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature (2012) 2.40
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol (2003) 2.38
A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A (2005) 2.34
Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol (2012) 2.33
Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors. Proc Natl Acad Sci U S A (2009) 2.29
IL-6 involvement in epithelial cancers. J Clin Invest (2007) 2.29
Inspiration and application in the evolution of biomaterials. Nature (2009) 2.23
MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A (2010) 2.21
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev (2011) 2.20
Common effector processing mediates cell-specific responses to stimuli. Nature (2007) 2.20
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol (2005) 2.20
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol (2012) 2.17
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
Identifying single-cell molecular programs by stochastic profiling. Nat Methods (2010) 2.11
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell (2012) 2.11
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A (2010) 2.10
FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. Proc Natl Acad Sci U S A (2005) 2.07
Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement. Proc Natl Acad Sci U S A (2009) 2.07
Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone (2004) 2.05
Alginate type and RGD density control myoblast phenotype. J Biomed Mater Res (2002) 2.04
Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm Res (2006) 2.03
The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations. Trends Pharmacol Sci (2006) 2.03
Infection-mimicking materials to program dendritic cells in situ. Nat Mater (2009) 2.00
Material-based deployment enhances efficacy of endothelial progenitor cells. Proc Natl Acad Sci U S A (2008) 1.96
The cell biology of cell-in-cell structures. Nat Rev Mol Cell Biol (2008) 1.96
Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration. Biomaterials (2006) 1.88
Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov (2011) 1.88
Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol (2004) 1.87
Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration. J Bone Miner Res (2004) 1.83
Non-viral gene delivery regulated by stiffness of cell adhesion substrates. Nat Mater (2005) 1.83
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc Natl Acad Sci U S A (2007) 1.83
Label-free biomarker detection from whole blood. Nat Nanotechnol (2009) 1.80
Endothelial cell modulation of bone marrow stromal cell osteogenic potential. FASEB J (2005) 1.79
Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Res (2007) 1.77
Engineering growing tissues. Proc Natl Acad Sci U S A (2002) 1.76
Polymeric growth factor delivery strategies for tissue engineering. Pharm Res (2003) 1.74
Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials (2005) 1.74
Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis. J Mammary Gland Biol Neoplasia (2004) 1.71
New materials for tissue engineering: towards greater control over the biological response. Trends Biotechnol (2008) 1.69
Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. J Proteome Res (2006) 1.66
In situ regulation of DC subsets and T cells mediates tumor regression in mice. Sci Transl Med (2009) 1.65
Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects. J Orthop Res (2007) 1.64
Controlled growth factor delivery for tissue engineering. Adv Mater (2009) 1.63
VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects. J Bone Miner Res (2006) 1.63
Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle (2007) 1.62
Engineering vascular networks in porous polymer matrices. J Biomed Mater Res (2002) 1.60
Active scaffolds for on-demand drug and cell delivery. Proc Natl Acad Sci U S A (2010) 1.58
Novel role for PDEF in epithelial cell migration and invasion. Cancer Res (2005) 1.57
The tensile properties of alginate hydrogels. Biomaterials (2004) 1.57
Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech (2003) 1.56
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol (2004) 1.56
Prediction of strength and strain of the proximal femur by a CT-based finite element method. J Biomech (2006) 1.53
Bioinspired growth of crystalline carbonate apatite on biodegradable polymer substrata. J Am Chem Soc (2002) 1.51
Regulating activation of transplanted cells controls tissue regeneration. Proc Natl Acad Sci U S A (2006) 1.46
Regulatory/effector T-cell ratio is reduced in coronary artery disease. Circ J (2014) 1.44
Controlling rigidity and degradation of alginate hydrogels via molecular weight distribution. Biomacromolecules (2004) 1.44
Sustained vascular endothelial growth factor delivery enhances angiogenesis and perfusion in ischemic hind limb. Pharm Res (2005) 1.43
An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. Biomaterials (2010) 1.42
Regulating myoblast phenotype through controlled gel stiffness and degradation. Tissue Eng (2007) 1.40
Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol (2004) 1.40
Role of vascular endothelial growth factor in bone marrow stromal cell modulation of endothelial cells. Tissue Eng (2003) 1.39