Published in Cell on December 24, 2009
p53 mutations in cancer. Nat Cell Biol (2013) 5.18
Mutant p53: one name, many proteins. Genes Dev (2012) 4.33
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell (2014) 3.68
The endocytic matrix. Nature (2010) 3.15
Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer (2010) 2.94
Translating p53 into the clinic. Nat Rev Clin Oncol (2010) 2.55
Allele-specific p53 mutant reactivation. Cancer Cell (2012) 2.51
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature (2012) 2.46
Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. J Clin Invest (2010) 2.38
Metabolic regulation by p53. J Mol Med (Berl) (2011) 2.26
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol (2011) 2.19
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Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling. Cell (2014) 2.12
A direct role for Met endocytosis in tumorigenesis. Nat Cell Biol (2011) 2.11
Metabolic regulation by p53 family members. Cell Metab (2013) 2.00
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ (2011) 1.94
p53 at a glance. J Cell Sci (2010) 1.88
Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression. Dev Cell (2011) 1.87
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis. Cell Death Differ (2013) 1.77
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis. Cell Death Differ (2011) 1.76
The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration. J Cell Sci (2011) 1.73
Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity. Mol Cell (2013) 1.72
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras. J Pathol (2011) 1.72
The rebel angel: mutant p53 as the driving oncogene in breast cancer. Carcinogenesis (2012) 1.67
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene (2012) 1.62
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Tumour-associated mutant p53 drives the Warburg effect. Nat Commun (2013) 1.52
BRAF(V600E) and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res (2011) 1.47
Mutant p53 cooperates with ETS2 to promote etoposide resistance. Genes Dev (2012) 1.47
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
Links between mutant p53 and genomic instability. J Cell Biochem (2012) 1.41
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Endocytosis and cancer. Cold Spring Harb Perspect Biol (2013) 1.40
Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion. J Mammary Gland Biol Neoplasia (2011) 1.37
Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc Natl Acad Sci U S A (2011) 1.36
Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells. Dev Cell (2012) 1.35
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
p53 Family and Cellular Stress Responses in Cancer. Front Oncol (2014) 1.33
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. J Clin Invest (2014) 1.33
Contribution of p53 to metastasis. Cancer Discov (2014) 1.28
Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration. J Cell Biol (2011) 1.27
Correlation of IDH1 mutation with clinicopathologic factors and prognosis in primary glioblastoma: a report of 118 patients from China. PLoS One (2012) 1.27
Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome. Oncotarget (2011) 1.27
Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions. J Biol Chem (2011) 1.24
Integrin traffic - the update. J Cell Sci (2015) 1.24
Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res (2012) 1.22
Diacylglycerol kinase α controls RCP-dependent integrin trafficking to promote invasive migration. J Cell Biol (2012) 1.21
Integrin trafficking at a glance. J Cell Sci (2012) 1.19
New plays in the p53 theater. Curr Opin Genet Dev (2010) 1.19
Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis. Cell Death Dis (2011) 1.15
RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. J Cell Biol (2013) 1.13
Collagen architecture in pregnancy-induced protection from breast cancer. J Cell Sci (2013) 1.12
p63 regulates glutaminase 2 expression. Cell Cycle (2013) 1.12
p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner. Cancer Res (2010) 1.12
Integrin endosomal signalling suppresses anoikis. Nat Cell Biol (2015) 1.11
Chaperone-mediated autophagy degrades mutant p53. Genes Dev (2013) 1.11
R-Ras regulates migration through an interaction with filamin A in melanoma cells. PLoS One (2010) 1.11
Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2. PLoS One (2012) 1.11
EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours. Sci Rep (2012) 1.10
Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A (2014) 1.09
A central role for vesicle trafficking in epithelial neoplasia: intracellular highways to carcinogenesis. Nat Rev Cancer (2013) 1.09
Steroid receptor coactivator-1 upregulates integrin α₅ expression to promote breast cancer cell adhesion and migration. Cancer Res (2011) 1.08
Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation. Cell Death Dis (2010) 1.08
The consequence of oncomorphic TP53 mutations in ovarian cancer. Int J Mol Sci (2013) 1.07
Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype. J Biol Chem (2013) 1.07
p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Res (2010) 1.06
The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Traffic (2010) 1.04
Cell adhesion and its endocytic regulation in cell migration during neural development and cancer metastasis. Int J Mol Sci (2012) 1.04
Novel functions for Rab GTPases in multiple aspects of tumour progression. Biochem Soc Trans (2012) 1.04
Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle (2013) 1.04
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep (2012) 1.03
Mutant p53: One, No One, and One Hundred Thousand. Front Oncol (2015) 1.02
Escape from p21-mediated oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins. J Biol Chem (2011) 1.02
Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression. Cell Death Dis (2013) 1.01
Endocytosis, signaling, and beyond. Cold Spring Harb Perspect Biol (2014) 1.01
Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β. Sci Rep (2013) 1.00
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Mol Med (2015) 0.99
Mena binds α5 integrin directly and modulates α5β1 function. J Cell Biol (2012) 0.98
A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion. Cancer Biol Ther (2013) 0.98
Role of adhesion receptor trafficking in 3D cell migration. Curr Opin Cell Biol (2013) 0.97
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev (2015) 0.96
MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle (2011) 0.96
Crosstalk between p53 and TGF-β Signalling. J Signal Transduct (2012) 0.95
Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo. Oncogene (2011) 0.95
Effect of NRG1, GDNF, EGF and NGF in the migration of a Schwann cell precursor line. Neurochem Res (2010) 0.95
Doubles game: Src-Stat3 versus p53-PTEN in cellular migration and invasion. Mol Cell Biol (2010) 0.95
The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins. J Biol Chem (2014) 0.94
Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5. Proc Natl Acad Sci U S A (2016) 0.94
Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4. J Biol Chem (2010) 0.94
A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1α in pancreatic ductal adenocarcinoma. Br J Cancer (2014) 0.94
Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression. Cancer Discov (2016) 0.94
DNA damage response genes and the development of cancer metastasis. Radiat Res (2014) 0.93
The impact of p53 in predicting clinical outcome of breast cancer patients with visceral metastasis. Sci Rep (2013) 0.93
Genetically engineered mouse models of pancreatic cancer. Cancer J (2012) 0.93
Transcriptional control of cancer metastasis. Trends Cell Biol (2013) 0.92
Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. J Biol Chem (2011) 0.92
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (2003) 18.51
TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 11.85
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer (2005) 8.70
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A (2006) 8.01
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell (2002) 7.35
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet (2011) 6.89
Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell (2003) 5.44
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature (2009) 5.32
Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell (2007) 5.29
p53 mutations in cancer. Nat Cell Biol (2013) 5.18
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res (2005) 5.07
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol (2005) 5.00
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell (2012) 4.58
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res (2010) 4.44
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol (2003) 4.25
Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol (2002) 4.22
Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A (2003) 4.03
A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell (2007) 3.97
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med (2012) 3.96
Engineering tumors with 3D scaffolds. Nat Methods (2007) 3.96
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell (2007) 3.84
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature (2012) 3.77
Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol (2008) 3.72
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
Integrins: masters and slaves of endocytic transport. Nat Rev Mol Cell Biol (2009) 3.52
Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Gastroenterology (2004) 3.39
p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol (2006) 3.37
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36
p73: Friend or foe in tumorigenesis. Nat Rev Cancer (2002) 3.30
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol (2009) 3.26
A non-genetic route to aneuploidy in human cancers. Nat Cell Biol (2011) 3.25
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08
A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol (2013) 2.98
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol (2002) 2.92
Integrin trafficking and the control of cell migration. Traffic (2006) 2.89
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
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Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice. Science (2002) 2.73
Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med (2009) 2.73
Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron (2005) 2.72
Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell (2012) 2.71
p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem (2003) 2.69
p53: new roles in metabolism. Trends Cell Biol (2007) 2.69
Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. J Cell Biol (2008) 2.61
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res (2007) 2.60
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell (2007) 2.60
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity (2006) 2.57
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A (2004) 2.56
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Mol Cell (2012) 2.51
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
Endocytic recycling pathways: emerging regulators of cell migration. Curr Opin Cell Biol (2006) 2.48
PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol (2004) 2.45
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis. Mol Cell (2011) 2.40
Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature (2012) 2.40
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol (2003) 2.38
The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J (2005) 2.38
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ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell (2013) 2.32
Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO J (2009) 2.31
alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J Cell Biol (2007) 2.31
IL-6 involvement in epithelial cancers. J Clin Invest (2007) 2.29
Metabolic regulation by p53. J Mol Med (Berl) (2011) 2.26
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature (2009) 2.22
MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A (2010) 2.21
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev (2011) 2.20
Common effector processing mediates cell-specific responses to stimuli. Nature (2007) 2.20
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol (2005) 2.20
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell (2005) 2.17
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol (2009) 2.16
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev Cell (2004) 2.13
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J (2006) 2.11
Identifying single-cell molecular programs by stochastic profiling. Nat Methods (2010) 2.11
Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell (2012) 2.11
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A (2010) 2.10
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol (2011) 2.07
TIGAR is required for efficient intestinal regeneration and tumorigenesis. Dev Cell (2013) 2.03
Metabolic regulation by p53 family members. Cell Metab (2013) 2.00
Mechanisms of integrin activation and trafficking. Curr Opin Cell Biol (2011) 2.00
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96
The cell biology of cell-in-cell structures. Nat Rev Mol Cell Biol (2008) 1.96
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. Nat Cell Biol (2007) 1.94