Published in Science on November 06, 1987
Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes. Nature (1984) 8.65
Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements. Science (1985) 8.44
Recommendations for the establishment of primary stroke centers. Brain Attack Coalition. JAMA (2000) 7.25
Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus. Proc Natl Acad Sci U S A (1986) 6.57
Photosynthesis by isolated protoplasts, protoplast extracts, and chloroplasts of wheat: influence of orthophosphate, pyrophosphate, and adenylates. Plant Physiol (1978) 6.55
Role of land-surface changes in arctic summer warming. Science (2005) 5.54
The isolation of spinach chloroplasts in pyrophosphate media. Plant Physiol (1968) 5.53
The reduction of 3-phosphoglycerate by reconstituted chloroplasts and by chloroplast extracts. Biochim Biophys Acta (1974) 4.93
Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med (1980) 4.90
Effects of mannose on photosynthetic gas exchange in spinach leaf discs. Plant Physiol (1983) 4.73
Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg (1978) 4.55
Some effects of sugars and sugar phosphates on carbon dioxide fixation by isolated chloroplasts. Biochem J (1966) 4.16
Carbon dioxide assimilation by leaves, isolated chloroplasts, and ribulose bisphosphate carboxylase from spinach. Plant Physiol (1975) 4.11
Photosynthesis by isolated chloroplasts. Inhibition by DL-glyceraldehyde of carbon dioxide assimilation. Biochem J (1972) 3.80
Cost-effectiveness of tissue plasminogen activator for acute ischemic stroke. NINDS rt-PA Stroke Study Group. Neurology (1998) 3.62
Some effects of inorganic phosphate on O2 evolution by isolated chloroplasts. Biochim Biophys Acta (1967) 3.16
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. Proc Natl Acad Sci U S A (1987) 3.08
Rapid separation of the chloroplast and cytoplasmic fractions from intact leaf protoplasts. Arch Biochem Biophys (1979) 2.93
An improved spectrophotometric assay for ribulosebisphosphate carboxylase. Biochim Biophys Acta (1974) 2.93
Calvin-cycle intermediates in relation to induction phenomena in photosynthetic carbon dioxide fixation by isolated chloroplasts. Biochem J (1966) 2.71
Photosynthesis. Annu Rev Biochem (1970) 2.64
Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells. Proc Natl Acad Sci U S A (1986) 2.57
Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation. Cell (1983) 2.54
An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys (1979) 2.54
Effects of carbon dioxide on mitochondrial enzymes from Ricinus. Biochem J (1960) 2.48
The Role of Glycolic Acid Metabolism in Opening of Leaf Stomata. Plant Physiol (1964) 2.42
Simultaneous measurement of oxygen evolution and chlorophyll fluorescence from leaf pieces. Plant Physiol (1983) 2.42
Measurement of CO(2) and H(2)O Vapor Exchange in Spinach Leaf Discs : Effects of Orthophosphate. Plant Physiol (1983) 2.38
Huntington's Chorea in South Wales. A genetic and epidemiological study. Clin Genet (1981) 2.31
The relation of oxygen evolution to carbon assimilation with isolated chloroplasts. Biochim Biophys Acta (1967) 2.29
Photosynthesis by isolated chloroplasts. Reversal of orthophosphate inhibition by Calvin-cycle intermediates. Biochem J (1968) 2.27
Gaining patients' consent. Telling parents all relevant details might reduce recruitment of children to trials. BMJ (1996) 2.14
Ribulose bisphosphate carboxylase--lack of dark inactivation of the enzyme in experiments with protoplasts. FEBS Lett (1979) 2.07
Inorganic pyrophosphatase and photosynthesis by isolated chloroplasts. II. The controlling influence of orthophosphate. Biochim Biophys Acta (1973) 2.05
Intracellular metabolite gradients and flow of carbon during photosynthesis of leaf protoplasts. Arch Biochem Biophys (1980) 1.98
Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein. Proc Natl Acad Sci U S A (1991) 1.97
Inhibition of Chlorophyll Synthesis by High Concentrations of Carbon Dioxide. Plant Physiol (1965) 1.96
The control of 3-phosphoglycerate reduction in isolated chloroplasts by the concentrations of ATP, ADP and 3-phosphoglycerate. Biochim Biophys Acta (1979) 1.93
Oxygen evolution by isolated chloroplasts with carbon dioxide as the hydrogen acceptor. A requirement for orthophosphate or pyrophosphate. Biochim Biophys Acta (1967) 1.89
Pyocyanine and Phosphorylation with Chloroplasts. Plant Physiol (1959) 1.88
High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury. J Neurosurg (1988) 1.87
Huntington's chorea. The basis for long-term prevention. Lancet (1979) 1.87
Improved rates of carbon dioxide fixation by illuminated chloroplasts. Biochem J (1964) 1.85
The site of sucrose synthesis in isolated leaf protoplasts. FEBS Lett (1979) 1.83
Autocatalysis and light activation of enzymes in relation to photosynthetic induction in wheat chloroplasts. Arch Biochem Biophys (1980) 1.82
Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer Treat Rep (1983) 1.81
Factors influencing age at onset and duration of survival in Huntington's chorea. Ann Hum Genet (1981) 1.79
Neurotoxicity of commonly used antineoplastic agents (second of two parts). N Engl J Med (1974) 1.77
The significance of light activation of enzymes during the induction phase of photosynthesis in isolated chloroplasts. Arch Biochem Biophys (1980) 1.70
Temperature and photosynthesis. I. Some effects of temperature on carbon dioxide fixation by isolated chloroplasts. Biochim Biophys Acta (1966) 1.68
The E2A gene product contains two separable and functionally distinct transcription activation domains. Proc Natl Acad Sci U S A (1993) 1.63
Rich and cold: diversity, distribution and drivers of fungal communities in patterned-ground ecosystems of the North American Arctic. Mol Ecol (2014) 1.62
Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcription. Mol Cell Biol (1989) 1.61
Phosphoglycerate as a hill oxidant in a reconstituted chloroplast system. Plant Physiol (1971) 1.60
The production of cerebrospinal fluid in man and its modification by acetazolamide. J Neurosurg (1966) 1.58
Assay of parathyroid hormone in human serum and its uses. Ann Clin Biochem (1976) 1.58
Clinical studies with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037). Cancer Res (1971) 1.57
Photosynthesis by isolated pea chloroplasts: some effects of adenylates and inorganic pyrophosphate. Plant Physiol (1977) 1.56
Tori mandibularis: a case report and review of the literature. J Can Dent Assoc (1995) 1.56
Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes. Nucleic Acids Res (1991) 1.51
Transient inhibition by ribose 5-phosphate of photosynthetic O2 evolution in a reconstituted chloroplast system. Biochim Biophys Acta (1976) 1.50
Identifying brain tumours in children and young adults. BMJ (2013) 1.48
Regulation of ribulose-1,5-bisphosphate carboxylase activity by the activase system in lysed spinach chloroplasts. Plant Physiol (1988) 1.47
Effect of low intensity monochromatic light therapy (890 nm) on a radiation-impaired, wound-healing model in murine skin. Lasers Surg Med (1998) 1.46
Inhibition of spinach phosphoribulokinase by DL-glyceraldehyde. Biochem J (1976) 1.45
Similarity of Ribulose-1,5-bisphosphate Carboxylases of Isogenic Diploid and Tetraploid Ryegrass (Lolium perenne L.) Cultivars. Plant Physiol (1981) 1.44
Localization of inhibition by adenosine diphosphate of phosphoglycerate-dependent oxygen evolution in a reconstituted chloroplast system. Biochem J (1976) 1.44
Flash pulmonary oedema. Lancet (2001) 1.43
Physical studies of phospholipids. II. Monolayer studies of some synthetic 2,3-diacyl-DL-phosphatidylethanolamines and phosphatidylcholines containing trans double bonds. Biochim Biophys Acta (1966) 1.42
Inorganic pyrophospatase and photosynthesis by isolated chloroplasts. I. Characterisation of chloroplast pyrophosphatase and its relation to the response to exogenous pyrophosphate. Biochim Biophys Acta (1973) 1.37
Relationship between Steady-State Fluorescence Yield and Photosynthetic Efficiency in Spinach Leaf Tissue. Plant Physiol (1988) 1.37
Brain tubulin and actin cDNA sequences: isolation of recombinant plasmids. Nucleic Acids Res (1980) 1.35
Activation of wheat chloroplast sedoheptulose bisphosphatase: a continuous spectrophotometric assay. Arch Biochem Biophys (1982) 1.35
A review of quality of life in Alzheimer's disease. Part 2: Issues in assessing drug effects. Pharmacoeconomics (1998) 1.34
A requirement for chelation in obtaining functional chloroplasts of sunflower and wheat. Arch Biochem Biophys (1978) 1.31
Thermal uncoupling in chloroplasts. Inhibition of photophosphorylation without depression of light-induced pH change. Arch Biochem Biophys (1973) 1.28
Inhibition, by sulphate, of the oxygen evolution associated with photosynthetic carbon assimilation. Biochim Biophys Acta (1968) 1.27
Mixed monolayers of phospholipids and cholesterol. Biochim Biophys Acta (1969) 1.25
CO 2 -dependent oxygen evolution by envelope-free chloroplasts. Nature (1971) 1.25
Neurotoxicity of commonly used antineoplastic agents (first of two parts). N Engl J Med (1974) 1.20
Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter. J Biol Chem (2000) 1.20
A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model. Proc Natl Acad Sci U S A (1996) 1.19
Subunit structure of cell-specific E box-binding proteins analyzed by quantitation of electrophoretic mobility shift. J Biol Chem (1992) 1.17
Carbon Dioxide-Induced Oscillations in Fluorescence and Photosynthesis: Role of Thylakoid Membrane Energization in Regulation of Photosystem II Activity. Plant Physiol (1988) 1.16
Atrial fibrillation and antithrombotic prophylaxis: a prospective meta-analysis. Lancet (1989) 1.16
Assessment of health status in survivors of cancer. Arch Dis Child (1994) 1.16
The effect of magnesium and other ions on the distribution of ribulose 1,5-bisphosphate carboxylase in chloroplast extracts. Arch Biochem Biophys (1981) 1.14
The relationship between light scattering and chlorophyll a fluorescence during oscillations in photosynthetic carbon assimilation. Arch Biochem Biophys (1985) 1.14
Applicability of the Health Utilities Index to a population of childhood survivors of central nervous system tumours in the U.K. Eur J Cancer (1999) 1.13
Activation of fructose 1,6-bisphosphatase in darkened intact chloroplasts by NADPH. Arch Biochem Biophys (1981) 1.12
Parathyroid carcinoma in familial hyperparathyroidism. J Clin Pathol (1977) 1.08
Regulation of fructose-1,6-biphosphatase activity in intact chloroplasts. Studies of the mechanism of inactivation. Biochim Biophys Acta (1980) 1.07
NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells. J Autoimmun (1996) 1.07
Huntington's chorea in South Wales: mutation, fertility, and genetic fitness. J Med Genet (1983) 1.06
NF-kappa B activates the HIV promoter in neurons. EMBO J (1993) 1.06
Photosynthesis in a reconstituted chloroplast system from spinach. Some factors affecting CO2-dependent oxygen evolution with fructose-1,6-bisphosphate as substrate. Biochim Biophys Acta (1976) 1.05
An illuminated constant-temperature water bath for the study of photochemical reactions in biological systems. Anal Biochem (1966) 1.04
Methotrexate pneumonitis induced by intrathecal methotrexate therapy: a case report with pharmacokinetic data. Cancer (1976) 1.03
Regulatory mechanisms in photosynthetic carbon metabolism. Curr Top Cell Regul (1976) 1.02
Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. Eur J Cancer (2010) 1.02