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1
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Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.
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Mol Cells
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2012
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1.13
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2
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Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation.
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Mol Cells
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2007
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1.08
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3
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Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.
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J Alzheimers Dis
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2012
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1.05
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4
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Functional interaction of neuronal Cav1.3 L-type calcium channel with ryanodine receptor type 2 in the rat hippocampus.
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J Biol Chem
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2007
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1.05
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5
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Effects of ginsenosides and their metabolites on voltage-dependent Ca(2+) channel subtypes.
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Mol Cells
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2006
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0.99
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6
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17Beta-estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism.
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Life Sci
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2002
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0.99
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7
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Neuroprotective effects of ginsenoside Rg3 against homocysteine-induced excitotoxicity in rat hippocampus.
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Brain Res
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2006
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0.97
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8
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Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: involvement of LPA receptors.
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Mol Cells
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2012
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0.97
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9
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Prevention of ginsenoside-induced desensitization of Ca2+-activated Cl- current by microinjection of inositol hexakisphosphate in Xenopus laevis oocytes: involvement of GRK2 and beta-arrestin I.
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J Biol Chem
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2003
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0.96
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10
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Cloning and expression of Ca2+-activated chloride channel from rat brain.
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Biochem Biophys Res Commun
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2005
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0.94
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11
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Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons.
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Biochem Biophys Res Commun
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2002
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0.94
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12
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Characteristics of ginsenoside Rg3-mediated brain Na+ current inhibition.
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Mol Pharmacol
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2005
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0.93
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13
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A simple method for the preparation of crude gintonin from ginseng root, stem, and leaf.
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J Ginseng Res
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2011
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0.93
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14
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Transient receptor potential melastatin 7 channels are involved in ginsenoside Rg3-induced apoptosis in gastric cancer cells.
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Basic Clin Pharmacol Toxicol
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2011
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0.93
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15
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Suppression of metastasis of intravenously-inoculated B16/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: involvement of autotaxin inhibition.
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Int J Oncol
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2012
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0.92
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16
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Ginsenoside Rg3 antagonizes NMDA receptors through a glycine modulatory site in rat cultured hippocampal neurons.
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Biochem Biophys Res Commun
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2004
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0.92
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17
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Ginsenoside Rg3 activates human KCNQ1 K+ channel currents through interacting with the K318 and V319 residues: a role of KCNE1 subunit.
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Eur J Pharmacol
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2010
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0.91
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18
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Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction.
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Eur J Pharmacol
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2011
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0.91
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19
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Stereospecificity of ginsenoside Rg3 action on ion channels.
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Mol Cells
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2004
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0.91
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20
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Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue.
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Mol Pharmacol
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2007
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0.90
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21
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Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors.
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J Pharmacol Exp Ther
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2002
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0.90
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22
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Mutations Leu427, Asn428, and Leu431 residues within transmembrane domain-I-segment 6 attenuate ginsenoside-mediated L-type Ca(2+) channel current inhibitions.
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Biol Pharm Bull
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2009
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0.90
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23
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Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes.
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Arch Pharm Res
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2003
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0.89
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24
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Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
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Neuropsychopharmacology
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2013
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0.89
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25
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Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration.
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Neurochem Int
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2009
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0.89
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26
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Quercetin inhibits the 5-hydroxytryptamine type 3 receptor-mediated ion current by interacting with pre-transmembrane domain I.
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Mol Cells
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2005
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0.89
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27
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Evidence that the tertiary structure of 20(S)-ginsenoside Rg(3) with tight hydrophobic packing near the chiral center is important for Na(+) channel regulation.
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Biochem Biophys Res Commun
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2005
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0.88
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28
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An edible gintonin preparation from ginseng.
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J Ginseng Res
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2011
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0.87
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29
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Quercetin enhances human α7 nicotinic acetylcholine receptor-mediated ion current through interactions with Ca(2+) binding sites.
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Mol Cells
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2010
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0.87
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30
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Cloning and heterologous expression of a Ca2+-activated chloride channel isoform from rat brain.
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Biol Pharm Bull
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2006
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0.87
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31
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Effects of Korean red ginseng extract on cisplatin-induced nausea and vomiting.
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Arch Pharm Res
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2005
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0.87
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32
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Ginsenoside Rg3 enhances large conductance Ca2+-activated potassium channel currents: a role of Tyr360 residue.
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Mol Cells
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2010
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0.86
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33
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Characteristics of gintonin-mediated membrane depolarization of pacemaker activity in cultured interstitial cells of Cajal.
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Cell Physiol Biochem
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2014
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0.86
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34
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Differential effect of ginsenoside metabolites on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.
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Mol Cells
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2004
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0.86
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35
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Inhibitory Effects of Quercetin on Muscle-type of Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes.
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Korean J Physiol Pharmacol
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2011
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0.86
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36
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Differential effects of ginsenoside metabolites on HERG k channel currents.
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J Ginseng Res
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2011
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0.86
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37
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Stereospecific effects of ginsenoside Rg3 epimers on swine coronary artery contractions.
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Biol Pharm Bull
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2006
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0.86
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38
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Genistein-induced apoptosis of human breast cancer MCF-7 cells involves calpain-caspase and apoptosis signaling kinase 1-p38 mitogen-activated protein kinase activation cascades.
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Anticancer Drugs
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2007
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0.86
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39
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Vascular smooth muscle dysfunction induced by monomethylarsonous acid (MMA III): a contributing factor to arsenic-associated cardiovascular diseases.
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Environ Res
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2008
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0.85
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40
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Neuroprotective effects of ginseng saponins against L-type Ca2+ channel-mediated cell death in rat cortical neurons.
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Biochem Biophys Res Commun
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2007
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0.85
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41
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Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.
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Brain Res
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2010
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0.85
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42
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Activation of lysophosphatidic acid receptor by gintonin inhibits Kv1.2 channel activity: involvement of tyrosine kinase and receptor protein tyrosine phosphatase α.
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Neurosci Lett
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2013
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0.84
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43
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Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes.
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Mol Cells
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2003
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0.84
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44
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Quercetin Inhibits α3β4 Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes.
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Korean J Physiol Pharmacol
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2011
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0.84
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45
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Protective effects of ginseng saponins on 3-nitropropionic acid-induced striatal degeneration in rats.
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Neuropharmacology
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2005
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0.84
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46
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Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes.
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Arch Pharm Res
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2003
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0.84
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47
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Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans.
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Biol Pharm Bull
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2007
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0.83
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48
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Effects of protopanaxatriol-ginsenoside metabolites on rat N-methyl-d-aspartic Acid receptor-mediated ion currents.
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Korean J Physiol Pharmacol
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2012
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0.83
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49
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Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells.
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Free Radic Biol Med
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2006
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0.83
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50
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Effects of quercetin on α9α10 nicotinic acetylcholine receptor-mediated ion currents.
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Eur J Pharmacol
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2010
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0.83
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51
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A role for the carbohydrate portion of ginsenoside Rg3 in Na+ channel inhibition.
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Mol Cells
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2005
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0.82
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52
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Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents.
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J Ginseng Res
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2012
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0.82
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53
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Ginseng saponins induce store-operated calcium entry in Xenopus oocytes.
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Br J Pharmacol
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2004
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0.82
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54
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The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
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Br J Pharmacol
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2005
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0.82
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55
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Ginsenoside Rg₃ regulates GABAA receptor channel activity: involvement of interaction with the γ₂ subunit.
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Eur J Pharmacol
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2013
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0.82
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56
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Dietary supplementation of chardonnay grape seed flour reduces plasma cholesterol concentration, hepatic steatosis, and abdominal fat content in high-fat diet-induced obese hamsters.
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J Agric Food Chem
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2014
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0.81
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57
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Involvement of batrachotoxin binding sites in ginsenoside-mediated voltage-gated Na+ channel regulation.
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Brain Res
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2008
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0.81
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58
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Modulation of the intestinal microbiota is associated with lower plasma cholesterol and weight gain in hamsters fed chardonnay grape seed flour.
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J Agric Food Chem
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2015
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0.81
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59
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Identification of ginsenoside interaction sites in 5-HT3A receptors.
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Neuropharmacology
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2006
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0.81
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60
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Human glycine alpha1 receptor inhibition by quercetin is abolished or inversed by alpha267 mutations in transmembrane domain 2.
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Brain Res
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2007
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0.81
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61
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Resveratrol Inhibits GABAC ρ Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes.
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Korean J Physiol Pharmacol
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2013
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0.81
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62
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Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats.
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Neurochem Int
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2007
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0.81
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63
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Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, potentiates ATP-gated P2X₁ receptor channel currents.
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Mol Cells
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2013
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0.81
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64
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The biochemical activation of T-type Ca2+ channels in HEK293 cells stably expressing alpha1G and Kir2.1 subunits.
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Biochem Biophys Res Commun
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2004
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0.81
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65
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Role of Korean red ginseng total saponins in rat infertility induced by polycystic ovaries.
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Fertil Steril
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2005
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0.81
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66
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Effects of ginsenoside on pacemaker potentials of cultured interstitial cells of Cajal clusters from the small intestine of mice.
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Mol Cells
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2012
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0.81
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67
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Effects of ginsenosides on glycine receptor alpha1 channels expressed in Xenopus oocytes.
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Mol Cells
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2003
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0.80
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68
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The IL-6/sIL-6R treatment of a malignant melanoma cell line enhances susceptibility to TNF-alpha-induced apoptosis.
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Biochem Biophys Res Commun
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2007
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0.80
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69
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Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans.
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J Ginseng Res
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2011
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0.80
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70
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Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes.
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Eur J Pharmacol
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2009
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0.80
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71
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Repeated intracerebroventricular infusion of nicotine prevents kainate-induced neurotoxicity by activating the alpha7 nicotinic acetylcholine receptor.
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Epilepsy Res
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2006
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0.80
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72
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HYP-1, a novel diamide compound, relieves inflammatory and neuropathic pain in rats.
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Pharmacol Biochem Behav
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2012
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0.79
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73
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Induction of apoptotic cell death by synthetic naringenin derivatives in human lung epithelial carcinoma A549 cells.
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Biol Pharm Bull
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2007
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0.79
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74
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Resveratrol enhances 5-hydroxytryptamine type 3A receptor-mediated ion currents: the role of arginine 222 residue in pre-transmembrane domain I.
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Biol Pharm Bull
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2011
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0.79
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75
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Plant Lysophosphatidic Acids: A Rich Source for Bioactive Lysophosphatidic Acids and Their Pharmacological Applications.
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Biol Pharm Bull
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2016
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0.79
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76
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Modifications of aliphatic side chain of 20(S)-ginsenoside RG3 cause an enhancement or loss of brain Na+ channel current inhibitions.
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Biol Pharm Bull
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2008
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0.79
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77
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A role for Leu247 residue within transmembrane domain 2 in ginsenoside-mediated alpha7 nicotinic acetylcholine receptor regulation.
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Mol Cells
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2009
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0.78
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78
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Differential effects of quercetin glycosides on GABAC receptor channel activity.
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Arch Pharm Res
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2014
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0.78
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79
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Differential regulations of quercetin and its glycosides on ligand-gated ion channels.
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Biol Pharm Bull
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2008
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0.78
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80
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Involvement of 5-HT receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT receptor channel and binding study.
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J Neurochem
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2006
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0.78
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81
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Effects of ginsenosides on carbachol-stimulated formation of inositol phosphates in rat cortical cell cultures.
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Neurochem Res
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2003
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0.78
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82
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The effects of ginsenoside Rg(3) on human Kv1.4 channel currents without the N-terminal rapid inactivation domain.
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Biol Pharm Bull
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2009
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0.77
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83
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Quinazolindione derivatives as potent 5-HT3A receptor antagonists.
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Bioorg Med Chem
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2009
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0.77
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84
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A role for the Val291 residue within the transmembrane domain 2 in diltiazem- and TMB-8 [3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester]-mediated 5-hydroxytryptamine type 3A receptor regulations.
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Biol Pharm Bull
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2009
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0.77
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85
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Effects of dextrorotatory morphinans on brain Na+ channels expressed in Xenopus oocytes.
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Eur J Pharmacol
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2007
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0.77
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86
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Ginsenosides regulate ligand-gated ion channels from the outside.
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Mol Cells
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2004
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0.77
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87
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Expression and characterization of recombinant kurtoxin, an inhibitor of T-type voltage-gated calcium channels.
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Biochem Biophys Res Commun
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2011
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0.77
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88
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Ginsenoside Re rescues methamphetamine-induced oxidative damage, mitochondrial dysfunction, microglial activation, and dopaminergic degeneration by inhibiting the protein kinase Cδ gene.
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Mol Neurobiol
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2014
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0.77
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89
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Resveratrol inhibits glycine receptor-mediated ion currents.
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Biol Pharm Bull
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2014
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Antimicrobial effect of 7-O-butylnaringenin, a novel flavonoid, and various natural flavonoids against Helicobacter pylori strains.
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Int J Environ Res Public Health
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2013
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0.76
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Effects of ginsenoside Rg3 on α9α10 nicotinic acetylcholine receptor-mediated ion currents.
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Biol Pharm Bull
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2013
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0.76
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Functional expression of a novel ginsenoside Rf binding protein from rat brain mRNA in Xenopus laevis oocytes.
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Mol Pharmacol
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2002
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0.76
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93
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Effects of dextrorotatory morphinans on alpha3beta4 nicotinic acetylcholine receptors expressed in Xenopus oocytes.
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Eur J Pharmacol
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2006
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0.76
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94
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Effect of ginseng saponins on a rat visceral hypersensitivity model.
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Biol Pharm Bull
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2005
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95
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Differential effects of ginsenoside metabolites on slowly activating delayed rectifier K(+) and KCNQ1 K(+) channel currents.
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J Ginseng Res
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2013
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0.75
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96
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Activation of lysophosphatidic Acid receptor is coupled to enhancement of ca(2+)-activated potassium channel currents.
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Korean J Physiol Pharmacol
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2013
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0.75
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97
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Inhibitory Effects of Ginsenoside Metabolites, Compound K and Protopanaxatriol, on GABAC Receptor-Mediated Ion Currents.
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Korean J Physiol Pharmacol
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2013
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98
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Functional expression and characterization in Xenopus laevis oocytes of the ABCG2 transporter derived from A549 human lung adenocarcinoma cells.
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Oncol Rep
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2011
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0.75
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99
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Effect of calmodulin on ginseng saponin-induced Ca2+-activated Cl- channel activation in Xenopus laevis oocytes.
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Arch Pharm Res
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2005
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0.75
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100
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Ginseng saponins diminish adverse vascular effects associated with chronic methionine-induced hyperhomocysteinemia.
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Biol Pharm Bull
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2006
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0.75
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101
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Inhibitory effects of dextrorotatory morphinans on the human 5-HT(3A) receptor expressed in Xenopus oocytes: Involvement of the N-terminal domain of the 5-HT(3A) receptor.
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Eur J Pharmacol
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2012
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0.75
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Effects of quercetin on human α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated ion currents.
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Biol Pharm Bull
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2010
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0.75
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103
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Mutations of arginine 222 in pre-transmembrane domain I of mouse 5-HT(3A) receptor abolish 20(R)- but not 20(S)-ginsenoside Rg(3) inhibition of 5-HT-mediated ion currents.
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Biol Pharm Bull
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2007
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0.75
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Gintonin Administration is Safe and Potentially Beneficial in Cognitively Impaired Elderly.
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Alzheimer Dis Assoc Disord
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2017
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Preparation of a Monoclonal Antibody against Gintonin and Its Use in an Enzyme Immunoassay.
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Biol Pharm Bull
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2015
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Secretory expression of active clostripain in Escherichia coli.
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J Biotechnol
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2007
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107
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Effect of dextromethorphan on human K(v)1.3 channel activity: involvement of C-type inactivation.
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Eur J Pharmacol
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2010
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0.75
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Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA.
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Clin Exp Pharmacol Physiol
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2015
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0.75
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