Published in J Biol Chem on September 06, 2007
CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. Prog Neurobiol (2012) 1.40
PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ Health Perspect (2012) 1.12
Plasticity of L-type Ca2+ channels after cocaine withdrawal. Synapse (2009) 0.96
Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons. J Neurosci (2011) 0.95
Homer and the ryanodine receptor. Eur Biophys J (2009) 0.91
Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels. Mol Cells (2011) 0.90
Genetics of hypertension and cardiovascular disease and their interconnected pathways: lessons from large studies. Curr Hypertens Rep (2011) 0.87
Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node. J Physiol (2012) 0.87
Ryanodine modification of RyR1 retrogradely affects L-type Ca(2+) channel gating in skeletal muscle. J Muscle Res Cell Motil (2009) 0.86
Functional role of voltage gated Ca(2+) channels in heart automaticity. Front Physiol (2015) 0.86
Three dimensional neuronal cell cultures more accurately model voltage gated calcium channel functionality in freshly dissected nerve tissue. PLoS One (2012) 0.85
Ryanodine receptors selectively contribute to the formation of taste-evoked calcium signals in mouse taste cells. Eur J Neurosci (2010) 0.85
Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography. Hum Genet (2013) 0.84
Surface L-type Ca2+ channel expression levels are increased in aged hippocampus. Aging Cell (2013) 0.84
Distinct Components of Retrograde CaV1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1. Biophys J (2016) 0.82
Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett (2014) 0.79
Ryanodine Receptors Selectively Interact with L Type Calcium Channels in Mouse Taste Cells. PLoS One (2013) 0.78
FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation? Eur J Pharmacol (2013) 0.78
Levels of Ca(V)1.2 L-Type Ca(2+) Channels Peak in the First Two Weeks in Rat Hippocampus Whereas Ca(V)1.3 Channels Steadily Increase through Development. J Signal Transduct (2012) 0.78
Direct interaction and functional coupling between human 5-HT6 receptor and the light chain 1 subunit of the microtubule-associated protein 1B (MAP1B-LC1). PLoS One (2014) 0.77
Ryanodine receptor patents. Recent Pat Biotechnol (2012) 0.76
Voltage-Induced Ca2+ Release in Postganglionic Sympathetic Neurons in Adult Mice. PLoS One (2016) 0.75
Chronic alcohol consumption from adolescence-to-adulthood in mice--hypothalamic gene expression changes in the dilated cardiomyopathy signaling pathway. BMC Neurosci (2014) 0.75
Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J Biol Chem (2003) 1.55
Function and regulation of Dyrk1A: towards understanding Down syndrome. Cell Mol Life Sci (2009) 1.44
Ginsenosides: are any of them candidates for drugs acting on the central nervous system? CNS Drug Rev (2007) 1.42
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. J Biol Chem (2008) 1.37
Molecular interaction between parkin and PINK1 in mammalian neuronal cells. Mol Cell Neurosci (2009) 1.36
Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2. Neuron (2003) 1.35
Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behçet's disease. Arthritis Rheum (2003) 1.33
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases. J Biol Chem (2005) 1.25
Enhanced hypothalamic leptin signaling in mice lacking dopamine D2 receptors. J Biol Chem (2010) 1.23
Parkin ubiquitinates and promotes the degradation of RanBP2. J Biol Chem (2005) 1.19
β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation. Cancer Lett (2011) 1.18
The dopamine D2 receptor regulates the development of dopaminergic neurons via extracellular signal-regulated kinase and Nurr1 activation. J Neurosci (2006) 1.16
Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways. Eur J Biochem (2003) 1.15
Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity. Mol Cells (2012) 1.13
Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. BMB Rep (2009) 1.09
On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft. J Neurochem (2009) 1.08
Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation. Mol Cells (2007) 1.08
Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle. J Biol Chem (2006) 1.08
alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J Biol Chem (2002) 1.06
The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn. J Biol Chem (2006) 1.06
CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Proc Natl Acad Sci U S A (2009) 1.06
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing. J Alzheimers Dis (2012) 1.05
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. J Biol Chem (2006) 1.03
Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. J Neurochem (2006) 1.03
Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem (2010) 1.02
Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells. J Cell Sci (2007) 1.00
Effects of ginsenosides and their metabolites on voltage-dependent Ca(2+) channel subtypes. Mol Cells (2006) 0.99
17Beta-estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism. Life Sci (2002) 0.99
Pyrrolidine dithiocarbamate and zinc inhibit proteasome-dependent proteolysis. Exp Cell Res (2004) 0.99
Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome. Mol Cell Neurosci (2007) 0.98
Parkin directly modulates 26S proteasome activity. J Neurosci (2010) 0.98
Inhibition of recombinant Ca(v)3.1 (alpha(1G)) T-type calcium channels by the antipsychotic drug clozapine. Eur J Pharmacol (2009) 0.98
Synthesis and biological evaluation of novel T-type Ca2+ channel blockers. Bioorg Med Chem (2004) 0.98
Neuroprotective effects of ginsenoside Rg3 against homocysteine-induced excitotoxicity in rat hippocampus. Brain Res (2006) 0.97
Functional modulation of parkin through physical interaction with SUMO-1. J Neurosci Res (2006) 0.97
Increased production of tumor necrosis factor-alpha induces apoptosis after traumatic spinal cord injury in rats. J Neurotrauma (2003) 0.97
Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: involvement of LPA receptors. Mol Cells (2012) 0.97
NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. J Biol Chem (2010) 0.96
Prevention of ginsenoside-induced desensitization of Ca2+-activated Cl- current by microinjection of inositol hexakisphosphate in Xenopus laevis oocytes: involvement of GRK2 and beta-arrestin I. J Biol Chem (2003) 0.96
Cloning and expression of Ca2+-activated chloride channel from rat brain. Biochem Biophys Res Commun (2005) 0.94
Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor. J Biol Chem (2003) 0.94
NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1. J Biol Chem (2007) 0.94
Inhibitory effect of ginsenosides on NMDA receptor-mediated signals in rat hippocampal neurons. Biochem Biophys Res Commun (2002) 0.94
Distinct regulation of internalization and mitogen-activated protein kinase activation by two isoforms of the dopamine D2 receptor. Mol Endocrinol (2003) 0.94
A simple method for the preparation of crude gintonin from ginseng root, stem, and leaf. J Ginseng Res (2011) 0.93
Characteristics of ginsenoside Rg3-mediated brain Na+ current inhibition. Mol Pharmacol (2005) 0.93
Transient receptor potential melastatin 7 channels are involved in ginsenoside Rg3-induced apoptosis in gastric cancer cells. Basic Clin Pharmacol Toxicol (2011) 0.93
A novel role of hippocalcin in bFGF-induced neurite outgrowth of H19-7 cells. J Neurosci Res (2008) 0.92
Suppression of metastasis of intravenously-inoculated B16/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: involvement of autotaxin inhibition. Int J Oncol (2012) 0.92
Ginsenoside Rg3 antagonizes NMDA receptors through a glycine modulatory site in rat cultured hippocampal neurons. Biochem Biophys Res Commun (2004) 0.92
Ginsenoside Rg3 activates human KCNQ1 K+ channel currents through interacting with the K318 and V319 residues: a role of KCNE1 subunit. Eur J Pharmacol (2010) 0.91
Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction. Eur J Pharmacol (2011) 0.91
Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of alpha-synuclein. Biochemistry (2004) 0.91
Stereospecificity of ginsenoside Rg3 action on ion channels. Mol Cells (2004) 0.91
Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. J Biol Chem (2010) 0.91
Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol (2007) 0.90
Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. J Biol Chem (2004) 0.90
Phospholipase D1 is associated with amyloid precursor protein in Alzheimer's disease. Neurobiol Aging (2006) 0.90
Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors. J Pharmacol Exp Ther (2002) 0.90
A hexane fraction of guava Leaves (Psidium guajava L.) induces anticancer activity by suppressing AKT/mammalian target of rapamycin/ribosomal p70 S6 kinase in human prostate cancer cells. J Med Food (2012) 0.90
Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels. Mol Cells (2011) 0.90
Mutations Leu427, Asn428, and Leu431 residues within transmembrane domain-I-segment 6 attenuate ginsenoside-mediated L-type Ca(2+) channel current inhibitions. Biol Pharm Bull (2009) 0.90
Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes. Arch Pharm Res (2003) 0.89
Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells. J Biol Chem (2003) 0.89
Potentiation of methamphetamine neurotoxicity by intrastriatal lipopolysaccharide administration. Neurochem Int (2009) 0.89
cAMP-responding element-binding protein and c-Ets1 interact in the regulation of ATP-dependent MUC5AC gene expression. J Biol Chem (2008) 0.89
Quercetin inhibits the 5-hydroxytryptamine type 3 receptor-mediated ion current by interacting with pre-transmembrane domain I. Mol Cells (2005) 0.89
ASK1 negatively regulates the 26 S proteasome. J Biol Chem (2010) 0.89
Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology (2013) 0.89
Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells. J Neurosci Res (2005) 0.88
Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain. J Biol Chem (2003) 0.88
Anti-proliferative effects and cell death mediated by two isoforms of dopamine D2 receptors in pituitary tumor cells. Mol Cell Endocrinol (2003) 0.88
Evidence that the tertiary structure of 20(S)-ginsenoside Rg(3) with tight hydrophobic packing near the chiral center is important for Na(+) channel regulation. Biochem Biophys Res Commun (2005) 0.88
Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10. Cancer Res (2006) 0.88
An edible gintonin preparation from ginseng. J Ginseng Res (2011) 0.87
LIM kinase 1 activates cAMP-responsive element-binding protein during the neuronal differentiation of immortalized hippocampal progenitor cells. J Biol Chem (2003) 0.87
Effects of Korean red ginseng extract on cisplatin-induced nausea and vomiting. Arch Pharm Res (2005) 0.87
Direct interaction and functional coupling between voltage-gated CaV1.3 Ca2+ channel and GABAB receptor subunit 2. FEBS Lett (2010) 0.87
Bimolecular fluorescence complementation; lighting-up tau-tau interaction in living cells. PLoS One (2013) 0.87
Evidence that alpha-synuclein functions as a negative regulator of Ca(++)-dependent alpha-granule release from human platelets. Blood (2002) 0.87
Quercetin enhances human α7 nicotinic acetylcholine receptor-mediated ion current through interactions with Ca(2+) binding sites. Mol Cells (2010) 0.87
Cloning and heterologous expression of a Ca2+-activated chloride channel isoform from rat brain. Biol Pharm Bull (2006) 0.87