Published in JAMA on September 12, 2007
Patent foramen ovale in cryptogenic stroke: incidental or pathogenic? Stroke (2009) 4.14
Patient-centered care for older adults with multiple chronic conditions: a stepwise approach from the American Geriatrics Society: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. J Am Geriatr Soc (2012) 4.04
Guiding principles for the care of older adults with multimorbidity: an approach for clinicians: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. J Am Geriatr Soc (2012) 3.84
Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials (2010) 3.45
Prognosis Research Strategy (PROGRESS) 3: prognostic model research. PLoS Med (2013) 3.13
Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741. J Clin Oncol (2008) 2.58
Transesophageal echocardiography in cryptogenic stroke and patent foramen ovale: analysis of putative high-risk features from the risk of paradoxical embolism database. Circ Cardiovasc Imaging (2013) 2.56
An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke. Neurology (2013) 2.26
Improving diabetes prevention with benefit based tailored treatment: risk based reanalysis of Diabetes Prevention Program. BMJ (2015) 2.10
Individualized medical decision making: necessary, achievable, but not yet attainable. Arch Intern Med (2010) 2.01
Predicting mortality in incident dialysis patients: an analysis of the United Kingdom Renal Registry. Am J Kidney Dis (2011) 2.01
Current progress in patient-specific modeling. Brief Bioinform (2009) 1.91
Implications of Heterogeneity of Treatment Effect for Reporting and Analysis of Randomized Trials in Critical Care. Am J Respir Crit Care Med (2015) 1.86
Risk of thiazide-induced metabolic adverse events in older adults. J Am Geriatr Soc (2014) 1.85
Is patent foramen ovale a modifiable risk factor for stroke recurrence? Stroke (2010) 1.83
Diabetes and poor disease control: is comorbid depression associated with poor medication adherence or lack of treatment intensification? Psychosom Med (2009) 1.69
High quality care and ethical pay-for-performance: a Society of General Internal Medicine policy analysis. J Gen Intern Med (2009) 1.65
Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials? Philos Ethics Humanit Med (2008) 1.61
No child left behind: Enrolling children and adults simultaneously in critical care randomized trials. Crit Care Med (2009) 1.56
Designing a randomized clinical trial to evaluate personalized medicine: a new approach based on risk prediction. J Natl Cancer Inst (2010) 1.53
Personalised medicine: not just in our genes. BMJ (2012) 1.51
A new taxonomy for stakeholder engagement in patient-centered outcomes research. J Gen Intern Med (2012) 1.47
Secondary failure of metformin monotherapy in clinical practice. Diabetes Care (2009) 1.46
A framework for crafting clinical practice guidelines that are relevant to the care and management of people with multimorbidity. J Gen Intern Med (2014) 1.46
A proposal for integrated efficacy-to-effectiveness (E2E) clinical trials. Clin Pharmacol Ther (2013) 1.45
Dealing with heterogeneity of treatment effects: is the literature up to the challenge? Trials (2009) 1.44
Outcomes and statistical power in adult critical care randomized trials. Am J Respir Crit Care Med (2014) 1.35
Current Status and Future Prospects of Clinical Psychology: Toward a Scientifically Principled Approach to Mental and Behavioral Health Care. Psychol Sci Public Interest (2008) 1.34
Estimating treatment effects for individual patients based on the results of randomised clinical trials. BMJ (2011) 1.32
Support of personalized medicine through risk-stratified treatment recommendations - an environmental scan of clinical practice guidelines. BMC Med (2013) 1.27
Rationalizing prescribing for older patients with multimorbidity: considering time to benefit. Drugs Aging (2013) 1.26
Preclinical Alzheimer disease-the challenges ahead. Nat Rev Neurol (2012) 1.25
Why do so many drugs for Alzheimer's disease fail in development? Time for new methods and new practices? J Alzheimers Dis (2008) 1.20
Multimorbidity and evidence generation. J Gen Intern Med (2014) 1.17
Random treatment assignment using mathematical equipoise for comparative effectiveness trials. Clin Transl Sci (2011) 1.14
Individual and population benefits of daily aspirin therapy: a proposal for personalizing national guidelines. Circ Cardiovasc Qual Outcomes (2011) 1.11
The relative merits of population-based and targeted prevention strategies. Milbank Q (2008) 1.10
Using internally developed risk models to assess heterogeneity in treatment effects in clinical trials. Circ Cardiovasc Qual Outcomes (2014) 1.07
Informing evidence-based decision-making for patients with comorbidity: availability of necessary information in clinical trials for chronic diseases. PLoS One (2012) 1.05
Large-scale international validation of the ADO index in subjects with COPD: an individual subject data analysis of 10 cohorts. BMJ Open (2012) 1.03
Building useful evidence: changing the clinical research paradigm to account for comparative effectiveness research. J Comp Eff Res (2012) 1.01
Competing risk and heterogeneity of treatment effect in clinical trials. Trials (2008) 1.01
Reasons for not prescribing guideline-recommended medications to adults with heart failure. Med Care (2013) 0.98
Addressing multimorbidity in evidence integration and synthesis. J Gen Intern Med (2014) 0.98
General practice by numbers: presentation to final outcome. Br J Gen Pract (2013) 0.97
The predictive value of cancer symptoms in primary care. Br J Gen Pract (2010) 0.96
Are unadjusted analyses of clinical trials inappropriately biased toward the null? Stroke (2009) 0.95
Is personality a key predictor of missing study data? An analysis from a randomized controlled trial. Ann Fam Med (2009) 0.94
Bayesian analysis of heterogeneous treatment effects for patient-centered outcomes research. Health Serv Outcomes Res Methodol (2016) 0.93
In silico vascular modeling for personalized nanoparticle delivery. Nanomedicine (Lond) (2012) 0.93
Systems of service: reflections on the moral foundations of improvement. BMJ Qual Saf (2011) 0.93
Against pragmatism: on efficacy, effectiveness and the real world. Trials (2009) 0.93
Aggregating and disaggregating patients in clinical trials and their subgroup analyses. Ann Intern Med (2010) 0.90
Pathological ventricular remodeling: therapies: part 2 of 2. Circulation (2013) 0.90
Subgroup analyses in randomized controlled trials: the need for risk stratification in kidney transplantation. Am J Transplant (2009) 0.89
Individual differences and evidence-based psychopharmacology. BMC Med (2012) 0.86
Development of an adverse drug reaction risk assessment score among hospitalized patients with chronic kidney disease. PLoS One (2014) 0.84
Rethinking trial strategies for stroke and patent foramen ovale. Curr Opin Neurol (2010) 0.84
Evaluating marker-guided treatment selection strategies. Biometrics (2014) 0.83
Stratifying the risk of venous thromboembolism in otolaryngology. Otolaryngol Head Neck Surg (2012) 0.83
Treating coronary disease and the impact of endothelial dysfunction. Prog Cardiovasc Dis (2014) 0.83
Conceptual and Analytical Considerations toward the Use of Patient-Reported Outcomes in Personalized Medicine. Am Health Drug Benefits (2012) 0.82
Detecting treatment-covariate interactions using permutation methods. Stat Med (2015) 0.82
Caring for patients with kidney disease: shifting the paradigm from evidence-based medicine to patient-centered care. Nephrol Dial Transplant (2015) 0.81
Improved Method to Stratify Elderly Patients With Cancer at Risk for Competing Events. J Clin Oncol (2016) 0.81
Comparative effectiveness of antihypertensive treatment for older children with primary hypertension: study protocol for a series of n-of-1 randomized trials. Trials (2016) 0.80
Mixing nulliparous and multiparous women in randomised controlled trials of preeclampsia prevention is debatable: evidence from a systematic review. PLoS One (2013) 0.80
Limitations of medical research and evidence at the patient-clinician encounter scale. Chest (2013) 0.79
Looking for quality under the lamppost. J Gen Intern Med (2008) 0.79
Computational modeling for bedside application. Heart Fail Clin (2008) 0.79
Predicting response to leuprolide of women with premenstrual dysphoric disorder by daily mood rating dynamics. J Psychiatr Res (2010) 0.79
Is treatment heterogeneity an Achilles' heel for comparative effectiveness research? Pharmacotherapy (2012) 0.79
Value of Donor-Specific Anti-HLA Antibody Monitoring and Characterization for Risk Stratification of Kidney Allograft Loss. J Am Soc Nephrol (2016) 0.79
Pediatric lung transplantation for cystic fibrosis. Transplantation (2008) 0.79
National Trends in Antidepressant, Benzodiazepine, and Other Sedative-Hypnotic Treatment of Older Adults in Psychiatric and Primary Care. J Clin Psychiatry (2017) 0.79
Tiotropium might improve survival in subjects with COPD at high risk of mortality. Respir Res (2014) 0.78
A New MI-Based Visualization Aided Validation Index for Mining Big Longitudinal Web Trial Data. IEEE Access (2016) 0.78
The Lake Wobegon Effect: Why Most Patients Are at Below-Average Risk. Ann Intern Med (2015) 0.78
Distribution of lifespan gain from primary prevention intervention. Open Heart (2016) 0.78
Personalizing evidence-based primary prevention with aspirin: individualized risks and patient preference. Circ Cardiovasc Qual Outcomes (2011) 0.77
Predictability of persistent frequent attendance in primary care: a temporal and geographical validation study. PLoS One (2013) 0.77
Background and design of the profiling biobehavioral responses to mechanical support in advanced heart failure study. J Cardiovasc Nurs (2014) 0.77
Group analysis versus individual response: the inferential limits of randomized controlled trials. Contemp Clin Trials (2010) 0.77
Field Synopsis of the Role of Sex in Stroke Prediction Models. J Am Heart Assoc (2016) 0.77
A predictive enrichment procedure to identify potential responders to a new therapy for randomized, comparative controlled clinical studies. Biometrics (2015) 0.76
Subgroup analyses in confirmatory clinical trials: time to be specific about their purposes. BMC Med Res Methodol (2016) 0.76
The influence of non-clinical patient factors on medical oncologists' decisions to recommend breast cancer adjuvant chemotherapy. Breast Cancer Res Treat (2012) 0.76
A Predictive Model for Diabetic Foot Ulcer Outcome: The Wound Healing Index. Adv Wound Care (New Rochelle) (2016) 0.76
Looking to the future: should 'prognosis' be heard as often as 'diagnosis' in medical education? Educ Prim Care (2015) 0.75
Machine Learning for Treatment Assignment: Improving Individualized Risk Attribution. AMIA Annu Symp Proc (2015) 0.75
No improvement in the reporting of clinical trial subgroup effects in high-impact general medical journals. Trials (2016) 0.75
Estimation of treatment effect in a subpopulation: An empirical Bayes approach. J Biopharm Stat (2015) 0.75
Development of a clinical prediction algorithm for knee osteoarthritis structural progression in a cohort study: value of adding measurement of subchondral bone density. Arthritis Res Ther (2017) 0.75
Individualizing endpoints in randomized clinical trials to better inform individual patient care: the TARGET proposal. Crit Care (2016) 0.75
Treatment benefit and treatment harm rate to characterize heterogeneity in treatment effect. Biometrics (2013) 0.75
Targeted Temperature Management After Cardiac Arrest Due to Drowning: "Frequentist" and "Bayesian" Decision Making. Pediatr Crit Care Med (2016) 0.75
Using clinical trial summary results to establish quality measures. JAMA (2007) 0.75
Artificial Neural Networks for Early Prediction of Mortality in Patients with Non Variceal Upper GI Bleeding (UGIB). Biomed Inform Insights (2008) 0.75
Comparison of quality of care for patients in the Veterans Health Administration and patients in a national sample. Ann Intern Med (2004) 6.86
Duration of resuscitation efforts and survival after in-hospital cardiac arrest: an observational study. Lancet (2012) 6.60
The relative importance of physician communication, participatory decision making, and patient understanding in diabetes self-management. J Gen Intern Med (2002) 4.79
A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med (2012) 4.51
Treatment of hypertension in type 2 diabetes mellitus: blood pressure goals, choice of agents, and setting priorities in diabetes care. Ann Intern Med (2003) 3.81
Adherence to colorectal cancer screening: a randomized clinical trial of competing strategies. Arch Intern Med (2012) 3.79
Lessons from the mammography wars. N Engl J Med (2010) 3.68
Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials (2010) 3.45
Are bad outcomes from questionable clinical decisions preventable medical errors? A case of cascade iatrogenesis. Ann Intern Med (2002) 3.07
Mechanisms for racial and ethnic disparities in glycemic control in middle-aged and older Americans in the health and retirement study. Arch Intern Med (2007) 3.05
Racial disparities in diabetes care processes, outcomes, and treatment intensity. Med Care (2003) 2.88
Patients, privacy and trust: patients' willingness to allow researchers to access their medical records. Soc Sci Med (2006) 2.86
Building a better quality measure: are some patients with 'poor quality' actually getting good care? Med Care (2003) 2.85
Accepting critically ill transfer patients: adverse effect on a referral center's outcome and benchmark measures. Ann Intern Med (2003) 2.75
Pharmacologic lipid-lowering therapy in type 2 diabetes mellitus: background paper for the American College of Physicians. Ann Intern Med (2004) 2.73
Whom should we profile? Examining diabetes care practice variation among primary care providers, provider groups, and health care facilities. Health Serv Res (2002) 2.68
Beyond the randomized clinical trial: the role of effectiveness studies in evaluating cardiovascular therapies. Circulation (2008) 2.45
Case management for patients with poorly controlled diabetes: a randomized trial. Am J Med (2004) 2.41
Brief report: the burden of diabetes therapy: implications for the design of effective patient-centered treatment regimens. J Gen Intern Med (2005) 2.32
Predictors of physician career satisfaction, work-life balance, and burnout. Obstet Gynecol (2007) 2.25
An IV for the RCT: using instrumental variables to adjust for treatment contamination in randomised controlled trials. BMJ (2010) 2.22
Uninsured adults presenting to US emergency departments: assumptions vs data. JAMA (2008) 2.15
Variation in the net benefit of aggressive cardiovascular risk factor control across the US population of patients with diabetes mellitus. Arch Intern Med (2010) 2.06
Progression risk, urinary protein excretion, and treatment effects of angiotensin-converting enzyme inhibitors in nondiabetic kidney disease. J Am Soc Nephrol (2007) 2.00
Impact of the model for end-stage liver disease allocation policy on the use of high-risk organs for liver transplantation. Gastroenterology (2008) 1.95
Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials. J Gen Intern Med (2011) 1.92
How well do patients' assessments of their diabetes self-management correlate with actual glycemic control and receipt of recommended diabetes services? Diabetes Care (2003) 1.81
Does physician communication influence older patients' diabetes self-management and glycemic control? Results from the Health and Retirement Study (HRS). J Gerontol A Biol Sci Med Sci (2007) 1.80
Performance measurement in search of a path. N Engl J Med (2007) 1.78
The impact of diabetes on workforce participation: results from a national household sample. Health Serv Res (2004) 1.70
Incremental benefit and cost-effectiveness of high-dose statin therapy in high-risk patients with coronary artery disease. Circulation (2007) 1.68
Specialty care and the patient-centered medical home. Med Care (2011) 1.68
Proactive case management of high-risk patients with type 2 diabetes mellitus by a clinical pharmacist: a randomized controlled trial. Am J Manag Care (2005) 1.64
What causes pregnancy loss? Preexisting mental illness as an independent risk factor. Gen Hosp Psychiatry (2007) 1.63
All-or-nothing treatment targets make bad performance measures. Am J Manag Care (2007) 1.61
Marriage and cohabitation outcomes after pregnancy loss. Pediatrics (2010) 1.61
New diabetes HEDIS blood pressure quality measure: potential for overtreatment. Am J Manag Care (2010) 1.60
When there is too much to do: how practicing physicians prioritize among recommended interventions. J Gen Intern Med (2004) 1.53
Open-access electronic case report journals: the rationale for case report guidelines. J Clin Epidemiol (2013) 1.51
Comparing clinical automated, medical record, and hybrid data sources for diabetes quality measures. Jt Comm J Qual Improv (2002) 1.48
Shifting views on lipid lowering therapy. BMJ (2010) 1.44
Effect of flexible sigmoidoscopy-based screening on incidence and mortality of colorectal cancer: a systematic review and meta-analysis of randomized controlled trials. PLoS Med (2012) 1.38
Interhospital transfers among Medicare beneficiaries admitted for acute myocardial infarction at nonrevascularization hospitals. Circ Cardiovasc Qual Outcomes (2010) 1.31
Patient-centered performance management: enhancing value for patients and health care systems. JAMA (2013) 1.29
CKD progression and mortality among older patients with diabetes. Am J Kidney Dis (2005) 1.24
Prevalence, diagnosis, and treatment of impaired fasting glucose and impaired glucose tolerance in nondiabetic U.S. adults. Diabetes Care (2010) 1.23
The rheumatoid hand: a predictable disease with unpredictable surgical practice patterns. Arthritis Rheum (2002) 1.20
Informal caregiving for diabetes and diabetic complications among elderly americans. J Gerontol B Psychol Sci Soc Sci (2002) 1.13
Individual and population benefits of daily aspirin therapy: a proposal for personalizing national guidelines. Circ Cardiovasc Qual Outcomes (2011) 1.11
The relative merits of population-based and targeted prevention strategies. Milbank Q (2008) 1.10
Improving eye care for veterans with diabetes: an example of using the QUERI steps to move from evidence to implementation: QUERI Series. Implement Sci (2008) 1.09
Physical activity and mortality across cardiovascular disease risk groups. Med Sci Sports Exerc (2004) 1.07
Using internally developed risk models to assess heterogeneity in treatment effects in clinical trials. Circ Cardiovasc Qual Outcomes (2014) 1.07
Quality by any other name?: a comparison of three profiling systems for assessing health care quality. Health Serv Res (2007) 1.07
The association between three different measures of health status and satisfaction among patients with diabetes. Med Care Res Rev (2003) 1.06
Access to clinically-detailed patient information: a fundamental element for improving the efficiency and quality of healthcare. Med Care (2008) 1.05
Prematurity and low birth weight as potential mediators of higher stillbirth risk in mixed black/white race couples. J Womens Health (Larchmt) (2010) 1.02
Improved cardiovascular risk prediction using nonparametric regression and electronic health record data. Med Care (2013) 1.02
Physician-level P4P--DOA? Can quality-based payment be resuscitated? Am J Manag Care (2007) 1.01
Competing risk and heterogeneity of treatment effect in clinical trials. Trials (2008) 1.01
Performance measurement in chronic kidney disease. J Am Soc Nephrol (2011) 1.01
Can school income and racial/ethnic composition explain the racial/ethnic disparity in adolescent physical activity participation? Pediatrics (2006) 1.00
Does rectal indomethacin eliminate the need for prophylactic pancreatic stent placement in patients undergoing high-risk ERCP? Post hoc efficacy and cost-benefit analyses using prospective clinical trial data. Am J Gastroenterol (2013) 0.96
Diminishing efficacy of combination therapy, response-heterogeneity, and treatment intolerance limit the attainability of tight risk factor control in patients with diabetes. Health Serv Res (2010) 0.95
Physician perceptions of upper extremity reconstruction for the person with tetraplegia. J Hand Surg Am (2005) 0.94
How physicians cope with stillbirth or neonatal death: a national survey of obstetricians. Obstet Gynecol (2008) 0.90
Counting deaths due to medical errors. JAMA (2002) 0.89
Fall-associated difficulty with activities of daily living in functionally independent individuals aged 65 to 69 in the United States: a cohort study. J Am Geriatr Soc (2013) 0.89
Effectiveness of implantable cardioverter-defibrillators in patients with ischemic heart disease and left ventricular dysfunction. Arch Intern Med (2006) 0.89
Physician practices and readiness for medical home reforms: policy, pitfalls, and possibilities. Health Serv Res (2011) 0.88
Profiling quality of care: Is there a role for peer review? BMC Health Serv Res (2004) 0.87
Tissue plasminogen activator was cost-effective compared to streptokinase in only selected patients with acute myocardial infarction. J Clin Epidemiol (2004) 0.87
Influence of study sponsorship on head and neck cancer randomized trial results. Head Neck (2012) 0.87
Improving the reliability of physician "report cards". Med Care (2013) 0.86
Pregnancy intention and birth outcomes: does the relationship differ by age or race? J Womens Health (Larchmt) (2007) 0.86
Providing clinicians with a patient's 10-year cardiovascular risk improves their statin prescribing: a true experiment using clinical vignettes. BMC Cardiovasc Disord (2013) 0.85
What effect does increasing inpatient time have on outpatient-oriented internist satisfaction? J Gen Intern Med (2003) 0.85
The effect of pre-Affordable Care Act (ACA) Medicaid eligibility expansion in New York State on access to specialty surgical care. Med Care (2014) 0.84
Regarding "Risk-adjusted 30-day outcomes of carotid stenting and endarterectomy: results from the SVS Vascular Registry". J Vasc Surg (2009) 0.82
Mortality reduction by implantable cardioverter-defibrillators in high-risk patients with heart failure, ischemic heart disease, and new-onset ventricular arrhythmia: an effectiveness study. J Am Coll Cardiol (2005) 0.81
Why P is not perfect. Am J Med (2012) 0.80
Rosuvastatin in patients with elevated C-reactive protein. N Engl J Med (2009) 0.80
Primary care appointment availability and nonphysician providers one year after Medicaid expansion. Am J Manag Care (2016) 0.80
Interpreting Clinical Trial Outcomes for Optimal Patient Care: A Survey of Clinicians and Trainees. J Grad Med Educ (2016) 0.79
Intensive glucose control in elderly adults. JAMA (2007) 0.78
Association between hospital case volume and the use of bronchoscopy and esophagoscopy during head and neck cancer diagnostic evaluation. Cancer (2013) 0.78
New Studies Do Not Challenge the American College of Cardiology/American Heart Association Lipid Guidelines. Ann Intern Med (2016) 0.77
Follow-up of Glycemic Control and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med (2015) 0.77
How to make market competition work in healthcare. Med Care (2011) 0.75
High-dose statins and the IDEAL study. JAMA (2006) 0.75
Keeping apples and oranges separate: reassessing clinical trials that use composite end points as their primary outcome. J Am Coll Cardiol (2006) 0.75
Will running the numbers first violate the principles of patient-centered care? Ann Intern Med (2008) 0.75
What effect does physician "profiling" have on inpatient physician satisfaction and hospital length of stay? BMC Health Serv Res (2006) 0.75
Adverse events following discharge from the hospital. Ann Intern Med (2004) 0.75
Quality improvement strategies for type 2 diabetes. JAMA (2006) 0.75
Duration of resuscitation efforts and survival after in-hospital cardiac arrest - Authors' reply. Lancet (2013) 0.75
Medicaid managed care: are academic medical centers penalized by attracting patients with high-cost conditions? Am J Manag Care (2003) 0.75
The Veterans Affairs Cardiac Risk Score: Recalibrating the Atherosclerotic Cardiovascular Disease Score for Applied Use. Med Care (2017) 0.75
Concurrent assessment of obstructive/irritative urinary symptoms and incontinence after radical prostatectomy. Urology (2002) 0.75