Published in Stem Cell Rev on June 01, 2007
Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol (2008) 2.87
Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocr Rev (2013) 1.91
The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. Cell Stem Cell (2009) 1.81
Breast cancer stem cells: implications for therapy of breast cancer. Breast Cancer Res (2008) 1.26
The biology of progesterone receptor in the normal mammary gland and in breast cancer. Mol Cell Endocrinol (2011) 1.19
p53 in stem cells. World J Biol Chem (2011) 0.95
A requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 mice. Oncogene (2013) 0.91
Relationship of CD44+CD24-/low breast cancer stem cells and axillary lymph node metastasis. J Transl Med (2012) 0.90
Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells. Development (2014) 0.86
CD271 is an imperfect marker for melanoma initiating cells. Oncotarget (2014) 0.86
Gene expression in murine mammary epithelial stem cell-like cells shows similarities to human breast cancer gene expression. Breast Cancer Res (2009) 0.85
Vitamin D compounds reduce mammosphere formation and decrease expression of putative stem cell markers in breast cancer. J Steroid Biochem Mol Biol (2014) 0.81
Breast cancer stem cells, pathways and therapeutic perspectives 2011. Indian J Surg (2012) 0.77
Non-enzymatic, serum-free tissue culture of pre-invasive breast lesions for spontaneous generation of mammospheres. J Vis Exp (2014) 0.75
Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. Oncogene (2016) 0.75
Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer (2008) 18.08
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
Purification and unique properties of mammary epithelial stem cells. Nature (2006) 15.98
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol (2006) 7.11
Control of mammary stem cell function by steroid hormone signalling. Nature (2010) 5.38
Cancer stem cells: current status and evolving complexities. Cell Stem Cell (2012) 5.07
Breast-cancer risk in families with mutations in PALB2. N Engl J Med (2014) 4.97
Steroid hormone receptor status of mouse mammary stem cells. J Natl Cancer Inst (2006) 4.47
Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell (2008) 4.45
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell (2010) 3.70
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res (2010) 3.40
The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res (2008) 3.23
ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics (2010) 2.86
Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans. Proc Natl Acad Sci U S A (2004) 2.80
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe (2011) 2.59
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell (2011) 2.49
Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow. Blood (2010) 2.23
The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes Dev (2008) 2.13
Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Res Treat (2013) 2.05
MDM4 is a key therapeutic target in cutaneous melanoma. Nat Med (2012) 1.93
LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins. EMBO Rep (2003) 1.86
FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (2010) 1.86
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem (2001) 1.82
A role for common genomic variants in the assessment of familial breast cancer. J Clin Oncol (2012) 1.80
Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer. Cancer Cell (2013) 1.74
Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol (2004) 1.68
Socs2 and elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol (2006) 1.65
Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J (2005) 1.52
Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. Oncogene (2004) 1.51
Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737. Proc Natl Acad Sci U S A (2011) 1.45
Patient-derived xenograft models of breast cancer and their predictive power. Breast Cancer Res (2015) 1.43
Mammary stem cells and mammopoiesis. Cancer Res (2006) 1.43
Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer. Proc Natl Acad Sci U S A (2005) 1.41
Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. Hum Mutat (2011) 1.38
Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2. Cell Rep (2013) 1.33
Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Mol Cell Biol (2011) 1.29
Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex. EMBO J (2004) 1.28
Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer. Gastroenterology (2009) 1.27
Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells. Stem Cells (2012) 1.25
Investigation of the transcriptional changes underlying functional defects in the mammary glands of prolactin receptor knockout mice. Recent Prog Horm Res (2003) 1.20
Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Sci Transl Med (2012) 1.18
Isolation of mouse mammary epithelial subpopulations: a comparison of leading methods. J Mammary Gland Biol Neoplasia (2012) 1.17
StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein. J Biol Chem (2005) 1.15
Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif. J Biol Chem (2004) 1.15
Transcriptional regulators in mammary gland development and cancer. Int J Biochem Cell Biol (2003) 1.10
Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4. EMBO J (2003) 1.09
Phase I trial of the oral PARP inhibitor olaparib in combination with paclitaxel for first- or second-line treatment of patients with metastatic triple-negative breast cancer. Breast Cancer Res (2013) 1.08
Resident macrophages influence stem cell activity in the mammary gland. Breast Cancer Res (2009) 1.07
Predictors of participation in clinical and psychosocial follow-up of the kConFab breast cancer family cohort. Fam Cancer (2005) 1.04
Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer. Breast Cancer Res (2005) 1.03
Insights into the cell of origin in breast cancer and breast cancer stem cells. Asia Pac J Clin Oncol (2010) 1.02
The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine. PLoS One (2010) 1.01
Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. J Biol Chem (2012) 1.00
The Angelina Jolie effect. Med J Aust (2013) 0.99
Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells. J Exp Med (2011) 0.98
Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland. BMC Dev Biol (2008) 0.98
c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3. EMBO J (2006) 0.97