Published in Nature on January 04, 2006
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88
Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31
Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell (2009) 8.33
Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res (2009) 7.98
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res (2006) 7.91
Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci U S A (2009) 7.24
Interactions between cancer stem cells and their niche govern metastatic colonization. Nature (2011) 6.94
Distinct stem cells contribute to mammary gland development and maintenance. Nature (2011) 6.32
Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell (2008) 5.76
Control of mammary stem cell function by steroid hormone signalling. Nature (2010) 5.38
WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci U S A (2007) 4.97
Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77
Progesterone induces adult mammary stem cell expansion. Nature (2010) 4.69
The CD44+/CD24- phenotype is enriched in basal-like breast tumors. Breast Cancer Res (2008) 4.63
Cancer stem cells: an evolving concept. Nat Rev Cancer (2012) 4.57
Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A (2006) 4.54
Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol (2006) 4.32
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29
Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell (2010) 4.25
Epithelial stem cells: turning over new leaves. Cell (2007) 4.10
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med (2009) 4.03
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature (2010) 4.01
Metastasis: recent discoveries and novel treatment strategies. Lancet (2007) 3.93
Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol (2007) 3.76
Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol (2009) 3.67
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. Proc Natl Acad Sci U S A (2007) 3.58
Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res (2008) 3.45
GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell (2008) 3.44
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res (2010) 3.40
Breast cancer: origins and evolution. J Clin Invest (2007) 3.31
Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci U S A (2008) 3.26
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland. J Cell Biol (2006) 3.24
CD49f and CD61 identify Her2/neu-induced mammary tumor-initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling. Oncogene (2011) 3.08
Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell (2010) 3.03
Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells. Breast Cancer Res (2008) 2.96
ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A (2009) 2.93
Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol (2008) 2.87
ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A (2007) 2.85
In situ identification of bipotent stem cells in the mammary gland. Nature (2014) 2.71
Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS One (2008) 2.70
Hormonal and local control of mammary branching morphogenesis. Differentiation (2006) 2.60
Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res (2009) 2.49
A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev (2007) 2.48
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells. Nat Cell Biol (2008) 2.46
Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol (2009) 2.45
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol (2008) 2.41
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci U S A (2007) 2.39
Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. J Clin Invest (2010) 2.38
Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair. Cell (2012) 2.35
Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res (2008) 2.29
Circulating tumor cells predict survival in early average-to-high risk breast cancer patients. J Natl Cancer Inst (2014) 2.28
Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell (2008) 2.24
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland. Breast Cancer Res (2012) 2.18
CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell (2009) 2.17
The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes Dev (2008) 2.13
Evaluation of the current knowledge limitations in breast cancer research: a gap analysis. Breast Cancer Res (2008) 2.06
Stem cells and the niche: a dynamic duo. Cell Stem Cell (2010) 2.06
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res (2009) 2.04
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression. Nat Cell Biol (2013) 2.03
Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype. Environ Health Perspect (2009) 2.02
Patterning mechanisms of branched organs. Science (2008) 2.00
Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science (2014) 1.99
Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells--implications for pregnancy-induced protection against breast cancer. Stem Cells (2008) 1.96
Genomic analysis at the single-cell level. Annu Rev Genet (2011) 1.96
Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell (2010) 1.92
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature (2015) 1.91
Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer Progression. Trends Cell Biol (2015) 1.87
A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell (2013) 1.86
Mammary stem cells and the differentiation hierarchy: current status and perspectives. Genes Dev (2014) 1.86
The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage. PLoS One (2009) 1.83
The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis. Genes Dev (2009) 1.82
GATA3 in development and cancer differentiation: cells GATA have it! J Cell Physiol (2010) 1.80
Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell. PLoS Biol (2012) 1.79
Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep (2013) 1.78
Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc Natl Acad Sci U S A (2006) 1.77
Cancer stem cells in breast: current opinion and future challenges. Pathobiology (2008) 1.77
Regulation of transgenes in three-dimensional cultures of primary mouse mammary cells demonstrates oncogene dependence and identifies cells that survive deinduction. Genes Dev (2009) 1.76
Stem cells in prostate cancer initiation and progression. J Clin Invest (2007) 1.76
Tracing the cellular origin of cancer. Nat Cell Biol (2013) 1.75
Targeting breast cancer stem cells. Mol Oncol (2010) 1.72
Minireview: hormones and mammary cell fate--what will I become when I grow up? Endocrinology (2008) 1.71
Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics (2008) 1.70
Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland. Dev Cell (2014) 1.70
Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. Genes Dev (2009) 1.69
GATA-3 and the regulation of the mammary luminal cell fate. Curr Opin Cell Biol (2008) 1.68
BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells. Nat Commun (2015) 1.67
Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. J Clin Invest (2009) 1.67
Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype. Environ Health Perspect (2012) 1.66
A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell (2012) 1.65
Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol (2009) 1.65
Mammary gland development. Wiley Interdiscip Rev Dev Biol (2013) 1.64
Murine mammary epithelial stem cells: discovery, function, and current status. Cold Spring Harb Perspect Biol (2011) 1.63
Sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells. Am J Physiol Gastrointest Liver Physiol (2010) 1.60
Three differentiation states risk-stratify bladder cancer into distinct subtypes. Proc Natl Acad Sci U S A (2012) 1.60
Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proc Natl Acad Sci U S A (2006) 1.60
Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett (2009) 1.59
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42
Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35
The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature (2012) 11.91
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res (2008) 10.18
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol (2006) 7.11
Control of mammary stem cell function by steroid hormone signalling. Nature (2010) 5.38
Alternative expression analysis by RNA sequencing. Nat Methods (2010) 5.02
Cancer stem cells: an evolving concept. Nat Rev Cancer (2012) 4.57
Steroid hormone receptor status of mouse mammary stem cells. J Natl Cancer Inst (2006) 4.47
Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell (2008) 4.45
Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell (2010) 3.70
A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med (2008) 3.64
Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res (2010) 3.40
Oligonucleotide microarray analysis of genomic imbalance in children with mental retardation. Am J Hum Genet (2006) 3.29
The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res (2008) 3.23
ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics (2010) 2.86
Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans. Proc Natl Acad Sci U S A (2004) 2.80
Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest (2006) 2.79
The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood (2005) 2.79
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell (2011) 2.68
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells. Cell Host Microbe (2011) 2.59
Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood (2009) 2.41
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland. Breast Cancer Res (2012) 2.18
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. EMBO Mol Med (2011) 2.07
Interspinous distractor devices for the management of lumbar spinal stenosis: a miracle cure for a common problem? Br J Neurosurg (2012) 2.03
Hematopoietic stem cell heterogeneity takes center stage. Cell Stem Cell (2012) 1.94
MDM4 is a key therapeutic target in cutaneous melanoma. Nat Med (2012) 1.93
High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays. Nat Methods (2011) 1.93
Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Res (2008) 1.88
Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex. J Natl Cancer Inst (2013) 1.75
Epithelial progenitors in the normal human mammary gland. J Mammary Gland Biol Neoplasia (2005) 1.74
Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell (2012) 1.71
Alkaline phosphatase-positive colony formation is a sensitive, specific, and quantitative indicator of undifferentiated human embryonic stem cells. Stem Cells (2008) 1.69
Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics. Exp Hematol (2003) 1.69
Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proc Natl Acad Sci U S A (2007) 1.68
The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat Cell Biol (2013) 1.67
Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells. Proc Natl Acad Sci U S A (2002) 1.61
Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Res (2006) 1.46
Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737. Proc Natl Acad Sci U S A (2011) 1.45
Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood (2011) 1.44
Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance. Cancer Res (2010) 1.38
High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells. J Clin Invest (2004) 1.35
Deciphering the mammary epithelial cell hierarchy. Cell Cycle (2006) 1.34
Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2. Cell Rep (2013) 1.33
Cancer stem cells: Here, there, everywhere? Nature (2008) 1.32
Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood (2002) 1.30
Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14. Mol Cell Biol (2011) 1.29
Steel factor responsiveness regulates the high self-renewal phenotype of fetal hematopoietic stem cells. Blood (2007) 1.26
Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells. Stem Cells (2012) 1.25
Characterization of mouse hematopoietic stem and progenitor cells. Curr Protoc Immunol (2008) 1.21
Human melanoma metastasis in NSG mice correlates with clinical outcome in patients. Sci Transl Med (2012) 1.18
BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair. Cancer Res (2008) 1.17
Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors. Blood (2012) 1.16
Supernumerary humeral heads of the biceps brachii muscle revisited. Clin Anat (2003) 1.16
Isotope ratios of H, C, and O in CO2 and H2O of the martian atmosphere. Science (2013) 1.15
LongSAGE profiling of nine human embryonic stem cell lines. Genome Biol (2007) 1.15
Overexpression of a dominant negative form of STAT3 selectively impairs hematopoietic stem cell activity. Oncogene (2002) 1.15
Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions. Exp Hematol (2007) 1.13
Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice. Blood (2013) 1.13
Enzymatic dissociation and culture of normal human mammary tissue to detect progenitor activity. Methods Mol Biol (2005) 1.12
The pathophysiology of symptomatic propriospinal myoclonus. Mov Disord (2014) 1.09
Unique effects of Stat3 on the early phase of hematopoietic stem cell regeneration. Blood (2006) 1.07
Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic stem cells. Blood (2008) 1.05
Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita. Blood (2008) 1.04
Genomic instability of human mammary epithelial cells overexpressing a truncated form of EMSY. J Natl Cancer Inst (2005) 1.03
The emerging picture of the mouse mammary stem cell. Stem Cell Rev (2007) 1.03
Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted β-thalassemia patient. Stem Cells (2013) 1.01
Common and distinct features of cytokine effects on hematopoietic stem and progenitor cells revealed by dose-response surface analysis. Biotechnol Bioeng (2002) 1.00
Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set. PLoS Comput Biol (2006) 0.98
c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3. EMBO J (2006) 0.97
Liver and marrow of adult mdr-1a/1b(-/-) mice show normal generation, function, and multi-tissue trafficking of primitive hematopoietic cells. Exp Hematol (2002) 0.97
The marrow homing efficiency of murine hematopoietic stem cells remains constant during ontogeny. Exp Hematol (2003) 0.97
Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development. Oncogene (2005) 0.96
Enhanced generation of hematopoietic cells from human hepatocarcinoma cell-stimulated human embryonic and induced pluripotent stem cells. Exp Hematol (2009) 0.95
Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA). Blood (2009) 0.95
The BRG1 chromatin remodeler protects against ovarian cysts, uterine tumors, and mammary tumors in a lineage-specific manner. PLoS One (2012) 0.94
Use of walking data in assessing operative results for cervical spondylotic myelopathy: long-term follow-up and comparison with controls. Spine (Phila Pa 1976) (2009) 0.93
Heterogeneity in hematopoietic stem cell populations: implications for transplantation. Curr Opin Hematol (2013) 0.93
Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays? Breast Cancer Res (2011) 0.93
Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors. Blood (2012) 0.93
Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors. PLoS One (2012) 0.92
Novel strategies in brachial plexus repair after traumatic avulsion. Br J Neurosurg (2010) 0.92
The omics of triple-negative breast cancers. Clin Chem (2013) 0.92
Quantitation of human mammary epithelial stem cells with in vivo regenerative properties using a subrenal capsule xenotransplantation assay. Nat Protoc (2010) 0.91
Lineage enforcement by inductive mesenchyme on adult epithelial stem cells across developmental germ layers. Stem Cells (2009) 0.91
Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domain. Gene (2004) 0.90
C1-C2 posterior fixation: are 4 screws better than 2? Neurosurgery (2012) 0.89
Developmental changes in hematopoietic stem cell properties. Exp Mol Med (2013) 0.89
Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells. PLoS Biol (2013) 0.89