Published in Nat Neurosci on September 16, 2007
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
Synaptic vesicle fusion. Nat Struct Mol Biol (2008) 4.22
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
Neurotransmitter release: the last millisecond in the life of a synaptic vesicle. Neuron (2013) 2.94
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron (2009) 2.26
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion. Nat Struct Mol Biol (2008) 2.25
Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nat Struct Mol Biol (2008) 2.11
A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse. Nat Neurosci (2009) 2.09
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. Nat Struct Mol Biol (2008) 1.76
Postsynaptic complexin controls AMPA receptor exocytosis during LTP. Neuron (2012) 1.74
Evoked and spontaneous transmission favored by distinct sets of synapses. Curr Biol (2014) 1.71
Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proc Natl Acad Sci U S A (2008) 1.68
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol (2010) 1.63
Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem (2008) 1.59
v-SNARE composition distinguishes synaptic vesicle pools. Neuron (2011) 1.54
The carboxy-terminal domain of complexin I stimulates liposome fusion. Proc Natl Acad Sci U S A (2009) 1.51
Complexin has opposite effects on two modes of synaptic vesicle fusion. Curr Biol (2011) 1.47
Complexin maintains vesicles in the primed state in C. elegans. Curr Biol (2011) 1.44
Synaptobrevin N-terminally bound to syntaxin-SNAP-25 defines the primed vesicle state in regulated exocytosis. J Cell Biol (2010) 1.43
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release. Annu Rev Physiol (2013) 1.41
A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science (2009) 1.40
Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity. J Neurosci (2012) 1.36
Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth. J Neurosci (2008) 1.35
LTP requires a unique postsynaptic SNARE fusion machinery. Neuron (2013) 1.33
Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release. EMBO J (2012) 1.31
A role of complexin-lipid interactions in membrane fusion. FEBS Lett (2009) 1.30
Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming. Proc Natl Acad Sci U S A (2008) 1.28
Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release. Mol Cell Neurosci (2010) 1.27
Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol (2011) 1.26
Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron (2009) 1.24
C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis. J Neurosci (2012) 1.22
Spontaneous and evoked release are independently regulated at individual active zones. J Neurosci (2013) 1.19
Development and plasticity of the Drosophila larval neuromuscular junction. Wiley Interdiscip Rev Dev Biol (2013) 1.15
The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity. Curr Opin Neurobiol (2010) 1.14
A presynaptic endosomal trafficking pathway controls synaptic growth signaling. J Cell Biol (2011) 1.11
Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proc Natl Acad Sci U S A (2013) 1.10
Concurrent binding of complexin and synaptotagmin to liposome-embedded SNARE complexes. Biochemistry (2009) 1.09
Synaptic vesicles position complexin to block spontaneous fusion. Neuron (2013) 1.08
Re-examining how complexin inhibits neurotransmitter release. Elife (2014) 1.07
Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains. J Cell Biol (2009) 1.07
Leaky synapses: regulation of spontaneous neurotransmission in central synapses. Neuroscience (2008) 1.05
Accessory alpha-helix of complexin I can displace VAMP2 locally in the complexin-SNARE quaternary complex. J Mol Biol (2009) 1.05
Should I stop or should I go? The role of complexin in neurotransmitter release. Nat Rev Neurosci (2016) 1.02
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution. Nat Struct Mol Biol (2015) 1.01
Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. J Neurosci (2013) 0.96
Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin. Mol Cell Neurosci (2012) 0.95
Miniature neurotransmission regulates Drosophila synaptic structural maturation. Neuron (2014) 0.95
Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp. Biophys J (2013) 0.95
Membrane curvature sensing by the C-terminal domain of complexin. Nat Commun (2014) 0.95
Novel functions for the anaphase-promoting complex in neurobiology. Semin Cell Dev Biol (2011) 0.94
Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo. Proc Natl Acad Sci U S A (2014) 0.94
Subtle Interplay between synaptotagmin and complexin binding to the SNARE complex. J Mol Biol (2013) 0.94
An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly. J Biol Chem (2014) 0.93
Real-time visualization of complexin during single exocytic events. Nat Neurosci (2010) 0.93
Complexin facilitates exocytosis and synchronizes vesicle release in two secretory model systems. J Physiol (2013) 0.93
Calcium sensitive ring-like oligomers formed by synaptotagmin. Proc Natl Acad Sci U S A (2014) 0.92
Opposing functions of two sub-domains of the SNARE-complex in neurotransmission. EMBO J (2010) 0.92
Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant. Mol Cell Neurosci (2013) 0.90
Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics. J Cell Biol (2014) 0.89
Transmission, Development, and Plasticity of Synapses. Genetics (2015) 0.89
Molecular mechanisms governing Ca(2+) regulation of evoked and spontaneous release. Nat Neurosci (2015) 0.89
Enlightening molecular mechanisms through study of protein interactions. J Mol Cell Biol (2012) 0.88
Re-visiting the trans insertion model for complexin clamping. Elife (2015) 0.87
Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants. J Neurosci (2012) 0.87
The accessory helix of complexin functions by stabilizing central helix secondary structure. Elife (2014) 0.85
Molecular underpinnings of synaptic vesicle pool heterogeneity. Traffic (2015) 0.85
Causes and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee. Genome Biol (2015) 0.84
Pulling force generated by interacting SNAREs facilitates membrane hemifusion. Integr Biol (Camb) (2009) 0.84
Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice. J Neurosci (2014) 0.83
Complexins: small but capable. Cell Mol Life Sci (2015) 0.82
Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex. Elife (2016) 0.82
Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms. Neuron (2015) 0.81
Phosphorylation of Complexin by PKA Regulates Activity-Dependent Spontaneous Neurotransmitter Release and Structural Synaptic Plasticity. Neuron (2015) 0.80
The dendritic SNARE fusion machinery involved in AMPARs insertion during long-term potentiation. Front Cell Neurosci (2014) 0.80
N-terminal domain of complexin independently activates calcium-triggered fusion. Proc Natl Acad Sci U S A (2016) 0.80
Adhesion energy can regulate vesicle fusion and stabilize partially fused states. J R Soc Interface (2012) 0.79
Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. Learn Mem (2011) 0.79
Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation. Cell Rep (2015) 0.78
Complexin arrests a neighbor. Nat Struct Mol Biol (2011) 0.78
C-terminal domain of mammalian complexin-1 localizes to highly curved membranes. Proc Natl Acad Sci U S A (2016) 0.78
Complexin splits the membrane-proximal region of a single SNAREpin. Biochem J (2016) 0.77
Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic. Development (2014) 0.76
Releasing the brake on presynaptic development: Cdc20-APC triggers NeuroD2 degradation to drive presynaptic differentiation. Cell Cycle (2010) 0.76
Investigation of SNARE-Mediated Membrane Fusion Mechanism Using Atomic Force Microscopy. Jpn J Appl Phys (2008) (2009) 0.76
Preincubation of t-SNAREs with Complexin I Increases Content-Mixing Efficiency. Biochemistry (2016) 0.76
Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion. Biophys J (2017) 0.76
Ring-like oligomers of Synaptotagmins and related C2 domain proteins. Elife (2016) 0.75
Complexin Mutants Reveal Partial Segregation between Recycling Pathways That Drive Evoked and Spontaneous Neurotransmission. J Neurosci (2017) 0.75
The Drosophila Postsynaptic DEG/ENaC Channel ppk29 Contributes to Excitatory Neurotransmission. J Neurosci (2017) 0.75
Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion. Biophys J (2016) 0.75
Synaptic activity regulates the abundance and binding of complexin. Biophys J (2015) 0.75
Cortactin Is a Regulator of Activity-Dependent Synaptic Plasticity Controlled by Wingless. J Neurosci (2017) 0.75
Molecular machines in the synapse: overlapping protein sets control distinct steps in neurosecretion. PLoS Comput Biol (2012) 0.75
Role of BMP receptor traffic in synaptic growth defects in an ALS model. Mol Biol Cell (2016) 0.75
Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets. Pharmacol Rev (2017) 0.75
Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function. Front Mol Neurosci (2017) 0.75
Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins. Front Mol Neurosci (2017) 0.75
Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release. Neuron (2002) 2.26
Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila. Neuron (2004) 2.12
Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease. Proc Natl Acad Sci U S A (2004) 2.00
Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth. Science (2005) 1.80
Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity. J Neurosci (2012) 1.36
Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth. J Neurosci (2008) 1.35
Presynaptic N-type calcium channels regulate synaptic growth. J Biol Chem (2003) 1.33
Development of a Drosophila seizure model for in vivo high-throughput drug screening. Eur J Neurosci (2006) 1.29
Genome-wide transcriptional changes associated with enhanced activity in the Drosophila nervous system. Neuron (2005) 1.29
Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release. Mol Cell Neurosci (2010) 1.27
The Drosophila ARC homolog regulates behavioral responses to starvation. Mol Cell Neurosci (2007) 1.20
Spontaneous and evoked release are independently regulated at individual active zones. J Neurosci (2013) 1.19
Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment. J Cell Biol (2004) 1.17
A presynaptic endosomal trafficking pathway controls synaptic growth signaling. J Cell Biol (2011) 1.11
Is synaptotagmin the calcium sensor? Curr Opin Neurobiol (2003) 1.09
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model. Dis Model Mech (2009) 1.09
Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains. J Cell Biol (2009) 1.07
A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function. J Neurosci (2004) 1.02
Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release. J Neurosci (2013) 1.02
Mutation of a NCKX eliminates glial microdomain calcium oscillations and enhances seizure susceptibility. J Neurosci (2013) 1.01
Huntingtin aggregation kinetics and their pathological role in a Drosophila Huntington's disease model. Genetics (2011) 1.00
Automatic robust neurite detection and morphological analysis of neuronal cell cultures in high-content screening. Neuroinformatics (2010) 0.99
Retrograde BMP signaling modulates rapid activity-dependent synaptic growth via presynaptic LIM kinase regulation of cofilin. J Neurosci (2014) 0.99
Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin. Mol Cell Neurosci (2012) 0.95
Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp. Biophys J (2013) 0.95
High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model. PLoS One (2011) 0.95
Synapse development in health and disease. Curr Opin Genet Dev (2011) 0.95
DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. J Neurosci (2010) 0.94
Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release. Proc Natl Acad Sci U S A (2007) 0.93
Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1. Proc Natl Acad Sci U S A (2010) 0.93
The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathology. Curr Trends Neurol (2011) 0.90
Characterization of a hypercontraction-induced myopathy in Drosophila caused by mutations in Mhc. J Cell Biol (2004) 0.87
Abnormal synaptic vesicle biogenesis in Drosophila synaptogyrin mutants. J Neurosci (2012) 0.87
Expression profiling of a hypercontraction-induced myopathy in Drosophila suggests a compensatory cytoskeletal remodeling response. J Biol Chem (2006) 0.83
Synaptic endocytosis: illuminating the role of clathrin assembly. Curr Biol (2008) 0.80
Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. Learn Mem (2011) 0.79
Therapeutic prospects for the prevention of neurodegeneration in Huntington's disease and the polyglutamine repeat disorders. Mini Rev Med Chem (2007) 0.78
Vesicle trafficking: a Rab family profile. Curr Biol (2011) 0.78
Neurobiology: synapses unplugged. Nature (2003) 0.76
Synaptic growth: dancing with adducin. Curr Biol (2011) 0.76