Published in Elife on July 19, 2016
Putting a brake on synaptic vesicle endocytosis. Cell Mol Life Sci (2017) 0.75
A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca(2+) cooperativity of vesicle fusion. Elife (2017) 0.75
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell (1994) 7.43
Synaptotagmin I functions as a calcium regulator of release probability. Nature (2001) 5.96
Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Science (1992) 5.00
Intracellular calcium dependence of transmitter release rates at a fast central synapse. Nature (2000) 4.46
Multiple roles of calcium ions in the regulation of neurotransmitter release. Neuron (2008) 4.23
A clamping mechanism involved in SNARE-dependent exocytosis. Science (2006) 3.74
Molecular machines governing exocytosis of synaptic vesicles. Nature (2012) 3.66
Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs. Science (2004) 3.24
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron (2007) 3.18
PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane. Nat Struct Mol Biol (2003) 2.95
Neurotransmitter release: the last millisecond in the life of a synaptic vesicle. Neuron (2013) 2.94
A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth. Nat Neurosci (2007) 2.90
PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins. Cell (2013) 2.72
Presynaptic calcium and control of vesicle fusion. Curr Opin Neurobiol (2005) 2.57
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science (2014) 2.49
Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C. Science (1996) 2.31
Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proc Natl Acad Sci U S A (1994) 2.15
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science (2010) 2.12
Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell (2009) 2.06
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1. Proc Natl Acad Sci U S A (2005) 1.71
Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophys J (2006) 1.52
Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Cell (2011) 1.49
Complexin maintains vesicles in the primed state in C. elegans. Curr Biol (2011) 1.44
Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation. Nat Struct Mol Biol (2011) 1.41
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment. Nat Struct Mol Biol (2013) 1.38
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol (2011) 1.37
Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association. Biochemistry (2007) 1.36
Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity. J Neurosci (2012) 1.36
Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release. Neuron (2013) 1.32
Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion. J Cell Biol (2011) 1.19
Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Nature (2015) 1.16
The Synaptic Vesicle Release Machinery. Annu Rev Biophys (2015) 1.09
Controlling synaptotagmin activity by electrostatic screening. Nat Struct Mol Biol (2012) 1.08
Mechanism of the SDS-resistant synaptotagmin clustering mediated by the cysteine cluster at the interface between the transmembrane and spacer domains. J Biol Chem (2001) 1.07
Cis- and trans-membrane interactions of synaptotagmin-1. Proc Natl Acad Sci U S A (2012) 1.04
Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo. J Neurosci (2011) 1.04
Should I stop or should I go? The role of complexin in neurotransmitter release. Nat Rev Neurosci (2016) 1.02
Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering. EMBO J (2015) 1.01
Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. J Neurosci (2012) 0.99
Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering. J Neurosci (2013) 0.99
Insights into the molecular organization of the neuron by cryo-electron tomography. J Electron Microsc (Tokyo) (2011) 0.94
Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo. Proc Natl Acad Sci U S A (2014) 0.94
Calcium sensitive ring-like oligomers formed by synaptotagmin. Proc Natl Acad Sci U S A (2014) 0.92
Calcium cooperativity of exocytosis as a measure of Ca²+ channel domain overlap. Brain Res (2011) 0.91
Prevalent mechanism of membrane bridging by synaptotagmin-1. Proc Natl Acad Sci U S A (2013) 0.90
SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1. J Biol Chem (2012) 0.90
Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin. Biophys J (2013) 0.89
Role of PI(4,5)P(2) in vesicle exocytosis and membrane fusion. Subcell Biochem (2012) 0.87
The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening. Biochem J (2013) 0.87
Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength. Nat Struct Mol Biol (2015) 0.87
The juxtamembrane linker of full-length synaptotagmin 1 controls oligomerization and calcium-dependent membrane binding. J Biol Chem (2014) 0.85
Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion. Elife (2016) 0.84
Extended-Synaptotagmins (E-Syts); the extended story. Pharmacol Res (2016) 0.81
SMP-domain proteins at membrane contact sites: Structure and function. Biochim Biophys Acta (2015) 0.80
Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening. Sci Rep (2015) 0.79
Different states of synaptotagmin regulate evoked versus spontaneous release. Nat Commun (2016) 0.79
A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells. J Neurosci (2015) 0.77
Supramolecular architecture of endoplasmic reticulum-plasma membrane contact sites. Biochem Soc Trans (2016) 0.76
The synaptotagmin juxtamembrane domain is involved in neuroexocytosis. FEBS Open Bio (2015) 0.76
Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release. Proc Natl Acad Sci U S A (2015) 0.76
Dilation of fusion pores by crowding of SNARE proteins. Elife (2017) 0.75
Circular oligomerization is an intrinsic property of synaptotagmin. Elife (2017) 0.75