Published in Proteins on March 01, 2008
Identification, analysis, and prediction of protein ubiquitination sites. Proteins (2010) 2.53
Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48
Determinants of translation efficiency and accuracy. Mol Syst Biol (2011) 2.24
A decade and a half of protein intrinsic disorder: biology still waits for physics. Protein Sci (2013) 1.74
Improved disorder prediction by combination of orthogonal approaches. PLoS One (2009) 1.63
Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits. Biochemistry (2008) 1.50
The nanny model for IDPs. Nat Chem Biol (2009) 1.18
Proteasomes and protein conjugation across domains of life. Nat Rev Microbiol (2011) 1.12
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem (2008) 1.09
Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB. Nature (2011) 1.08
Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3. Biophys J (2008) 1.03
Intrinsically disordered segments affect protein half-life in the cell and during evolution. Cell Rep (2014) 1.01
Describing sequence-ensemble relationships for intrinsically disordered proteins. Biochem J (2013) 1.00
Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response. J Biol Chem (2009) 0.97
Conserved RNA helicase FRH acts nonenzymatically to support the intrinsically disordered neurospora clock protein FRQ. Mol Cell (2013) 0.93
The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1. Mol Cell Biol (2013) 0.92
Reciprocal regulation of metabolic and signaling pathways. BMC Genomics (2010) 0.87
Disordered proteinaceous machines. Chem Rev (2014) 0.86
c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics. Mol Cell Biol (2010) 0.86
Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway. Cell Signal (2009) 0.86
Rapid proteasomal degradation of posttranscriptional regulators of the TIS11/tristetraprolin family is induced by an intrinsically unstructured region independently of ubiquitination. Mol Cell Biol (2014) 0.84
The stability of the small nucleolar ribonucleoprotein (snoRNP) assembly protein Pih1 in Saccharomyces cerevisiae is modulated by its C terminus. J Biol Chem (2012) 0.84
Context-dependent resistance to proteolysis of intrinsically disordered proteins. Protein Sci (2011) 0.84
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators. Front Mol Biosci (2014) 0.82
Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease. Front Genet (2013) 0.79
Nonspecific yet decisive: Ubiquitination can affect the native-state dynamics of the modified protein. Protein Sci (2015) 0.79
A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function. Nat Struct Mol Biol (2017) 0.78
Functional properties and structural requirements of the plasmid pMV158-encoded MobM relaxase domain. J Bacteriol (2013) 0.76
The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening. Front Physiol (2013) 0.75
Paradoxes and wonders of intrinsic disorder: Complexity of simplicity. Intrinsically Disord Proteins (2016) 0.75
Time, space, and disorder in the expanding proteome universe. Proteomics (2017) 0.75
FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded. Bioinformatics (2005) 5.44
Function and structure of inherently disordered proteins. Curr Opin Struct Biol (2008) 4.19
Protein production and purification. Nat Methods (2008) 3.97
Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy. Acta Crystallogr D Biol Crystallogr (2005) 3.13
Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules. Genome Biol (2008) 2.68
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. Nat Struct Mol Biol (2004) 2.46
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell (2008) 2.38
A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73. Genes Dev (2005) 2.21
Assessment of CASP8 structure predictions for template free targets. Proteins (2009) 1.96
Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. Proc Natl Acad Sci U S A (2002) 1.91
Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2. J Immunol (2005) 1.84
Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. Proc Natl Acad Sci U S A (2003) 1.83
Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Plant Biotechnol J (2007) 1.82
NQO1 stabilizes p53 through a distinct pathway. Proc Natl Acad Sci U S A (2002) 1.80
Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology. Curr Opin Pharmacol (2005) 1.71
X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease. EMBO Rep (2003) 1.70
20S proteasomes and protein degradation "by default". Bioessays (2006) 1.63
Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification. Chem Biol (2012) 1.60
Inhibition of hepatitis B virus expression and replication by RNA interference. Hepatology (2003) 1.59
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. Nat Chem Biol (2011) 1.57
A server and database for dipole moments of proteins. Nucleic Acids Res (2007) 1.53
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. Nat Chem Biol (2012) 1.50
Proteomic signatures: amino acid and oligopeptide compositions differentiate among phyla. Proteins (2004) 1.45
Assessment of disorder predictions in CASP8. Proteins (2009) 1.44
Structural insights into substrate traffic and inhibition in acetylcholinesterase. EMBO J (2006) 1.41
Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies. Acta Crystallogr D Biol Crystallogr (2006) 1.39
20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1. Mol Cell (2005) 1.37
The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol. Biochemistry (2006) 1.30
eMovie: a storyboard-based tool for making molecular movies. Trends Biochem Sci (2007) 1.29
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. EMBO J (2004) 1.27
Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy. Biol Chem (2008) 1.25
Characterization of gene-activated human acid-beta-glucosidase: crystal structure, glycan composition, and internalization into macrophages. Glycobiology (2009) 1.25
Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography. Proc Natl Acad Sci U S A (2008) 1.24
Acetylcholinesterase: from 3D structure to function. Chem Biol Interact (2010) 1.22
HalX: an open-source LIMS (Laboratory Information Management System) for small- to large-scale laboratories. Acta Crystallogr D Biol Crystallogr (2005) 1.19
Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription. J Biol Chem (2002) 1.19
The nanny model for IDPs. Nat Chem Biol (2009) 1.18
X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. J Biol Chem (2005) 1.18
The roles of human sucrose nonfermenting protein 2 homologue in the tumor-promoting functions of Rsf-1. Cancer Res (2008) 1.16
PGC-1alpha controls hepatitis B virus through nutritional signals. Proc Natl Acad Sci U S A (2006) 1.16
Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. J Am Chem Soc (2008) 1.15
p53 proteasomal degradation: poly-ubiquitination is not the whole story. Cell Cycle (2005) 1.14
HBXAP, a novel PHD-finger protein, possesses transcription repression activity. Genomics (2002) 1.13
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin. Proc Natl Acad Sci U S A (2005) 1.13
Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation. J Synchrotron Radiat (2002) 1.12
G protein-coupled receptors show unusual patterns of intrinsic unfolding. Protein Eng Des Sel (2005) 1.12
Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease. J Biol Chem (2007) 1.11
Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. J Mol Biol (2012) 1.08
New directions in the treatment of Gaucher disease. Trends Pharmacol Sci (2004) 1.07
Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime. J Med Chem (2009) 1.07
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. J Med Chem (2006) 1.07
P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1. Proc Natl Acad Sci U S A (2003) 1.06
Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design. Protein Sci (2008) 1.05
BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation. J Cell Sci (2011) 1.04
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1. Mol Cell (2012) 1.03
Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3. Biophys J (2008) 1.03
Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease. Acta Crystallogr D Biol Crystallogr (2006) 1.02
Proteopedia: a status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules. J Struct Biol (2011) 1.02
c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association. J Biol Chem (2003) 1.02
Acetylcholinesterase: how is structure related to function? Chem Biol Interact (2008) 1.00
Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography. Acta Crystallogr D Biol Crystallogr (2007) 0.99
Spectral evidence for the presence of tryptophan in the binding site of acetylcholinesterase. FEBS Lett (1973) 0.98
The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded. Proteins (2003) 0.98
Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease. J Mol Neurosci (2003) 0.97