Published in J Biol Chem on July 31, 2007
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Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. J Biol Chem (2003) 2.06
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Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals. Proc Natl Acad Sci U S A (2007) 1.84
Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. Proc Natl Acad Sci U S A (2003) 1.83
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X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease. EMBO Rep (2003) 1.70
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Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. Nat Chem Biol (2011) 1.57
A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem (2010) 1.56
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Treatment with miglustat reverses the lipid-trafficking defect in Niemann-Pick disease type C. Neurobiol Dis (2004) 1.50
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. Nat Chem Biol (2012) 1.50
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Assessment of disorder predictions in CASP8. Proteins (2009) 1.44
Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling. Anal Biochem (2004) 1.42
A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem (2010) 1.41
Structural insights into substrate traffic and inhibition in acetylcholinesterase. EMBO J (2006) 1.41
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Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. J Cell Mol Med (2008) 1.33
4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group. Tetrahedron Lett (2011) 1.33
Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. J Biol Chem (2009) 1.32
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. J Biol Chem (2005) 1.31
Ceramide synthases: roles in cell physiology and signaling. Adv Exp Med Biol (2010) 1.30
Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine. FEBS Lett (2007) 1.29
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The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. EMBO J (2004) 1.27
Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. J Biol Chem (2001) 1.26
Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy. Biol Chem (2008) 1.25
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. Mol Cancer Res (2007) 1.25
Characterization of gene-activated human acid-beta-glucosidase: crystal structure, glycan composition, and internalization into macrophages. Glycobiology (2009) 1.25
The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases. Neuromolecular Med (2010) 1.25
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Enhanced calcium release in the acute neuronopathic form of Gaucher disease. Neurobiol Dis (2005) 1.20
Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome. Proteins (2008) 1.20
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A plant-derived recombinant human glucocerebrosidase enzyme--a preclinical and phase I investigation. PLoS One (2009) 1.19
Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. J Biol Chem (2003) 1.18
X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. J Biol Chem (2005) 1.18
Glucosylceramide modulates membrane traffic along the endocytic pathway. J Lipid Res (2002) 1.17
NSAIDs increase survival in the Sandhoff disease mouse: synergy with N-butyldeoxynojirimycin. Ann Neurol (2004) 1.15
Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. J Am Chem Soc (2008) 1.15
Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast. J Biol Chem (2002) 1.14
Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation. J Synchrotron Radiat (2002) 1.12
G protein-coupled receptors show unusual patterns of intrinsic unfolding. Protein Eng Des Sel (2005) 1.12
Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. J Biol Chem (2013) 1.11
Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral Res (2010) 1.09
Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. J Mol Biol (2012) 1.08
New directions in the treatment of Gaucher disease. Trends Pharmacol Sci (2004) 1.07