Published in Hum Mol Genet on September 19, 2007
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A complex network of factors with overlapping affinities represses splicing through intronic elements. Nat Struct Mol Biol (2012) 1.26
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Assays for the identification and prioritization of drug candidates for spinal muscular atrophy. Assay Drug Dev Technol (2014) 1.13
Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice. EMBO Mol Med (2012) 1.09
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Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. Nat Commun (2011) 1.05
Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein. Proc Natl Acad Sci U S A (2010) 1.03
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The secondary structure of the human immunodeficiency virus type 1 transcript modulates viral splicing and infectivity. J Virol (2008) 0.90
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A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele. Pharmacogenet Genomics (2013) 0.85
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Targeting SR proteins improves SMN expression in spinal muscular atrophy cells. PLoS One (2014) 0.83
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SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome. Sci Rep (2015) 0.82
Regulation of androgen receptor splice variant AR3 by PCGEM1. Oncotarget (2016) 0.82
HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA. Sci Rep (2013) 0.82
Presynaptic localization of Smn and hnRNP R in axon terminals of embryonic and postnatal mouse motoneurons. PLoS One (2014) 0.81
A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions. Cell Rep (2014) 0.81
P-coumaric acid regulates exon 12 splicing of the ATP7B gene by modulating hnRNP A1 protein expressions. Biomedicine (Taipei) (2015) 0.80
Starvation actively inhibits splicing of glucose-6-phosphate dehydrogenase mRNA via a bifunctional ESE/ESS element bound by hnRNP K. Biochim Biophys Acta (2013) 0.79
Splicing regulation in spinal muscular atrophy by an RNA structure formed by long-distance interactions. Ann N Y Acad Sci (2015) 0.79
Splicing inhibition of U2AF65 leads to alternative exon skipping. Proc Natl Acad Sci U S A (2015) 0.79
Functional Analysis of Mutations in Exon 9 of NF1 Reveals the Presence of Several Elements Regulating Splicing. PLoS One (2015) 0.77
Optimization of Morpholino Antisense Oligonucleotides Targeting the Intronic Repressor Element1 in Spinal Muscular Atrophy. Mol Ther (2016) 0.77
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Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model. Hum Mol Genet (2012) 0.77
Global identification of hnRNP A1 binding sites for SSO-based splicing modulation. BMC Biol (2016) 0.77
Oxidative Stress Triggers Body-Wide Skipping of Multiple Exons of the Spinal Muscular Atrophy Gene. PLoS One (2016) 0.76
Somatic Therapy of a Mouse SMA Model with a U7 snRNA Gene Correcting SMN2 Splicing. Mol Ther (2016) 0.76
3' Splice site sequences of spinal muscular atrophy related SMN2 pre-mRNA include enhancers for nearby exons. ScientificWorldJournal (2014) 0.75
Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice. Open Biol (2017) 0.75
A rare variant (c.863G>T) in exon 7 of SMN1 disrupts mRNA splicing and is responsible for spinal muscular atrophy. Eur J Hum Genet (2015) 0.75
Multiple effects of curcumin on promoting expression of the exon 7-containing SMN2 transcript. Genes Nutr (2015) 0.75
SRSF2 directly inhibits intron splicing to suppresses cassette exon inclusion. BMB Rep (2017) 0.75
4β-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells. Sci Rep (2017) 0.75
LncRNA-mediated regulation of cell signaling in cancer. Oncogene (2017) 0.75
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Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature (2009) 5.48
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell (2005) 4.91
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev (2010) 4.75
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96
Mechanisms and consequences of alternative polyadenylation. Mol Cell (2011) 3.96
A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy. Nat Genet (2003) 3.84
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Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation. Cell (2004) 3.10
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature (2006) 2.95
Cell signalling and the control of pre-mRNA splicing. Nat Rev Mol Cell Biol (2004) 2.78
Transcription termination by nuclear RNA polymerases. Genes Dev (2009) 2.65
The RNA polymerase II CTD coordinates transcription and RNA processing. Genes Dev (2012) 2.55
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination. Genes Dev (2007) 2.49
Strange bedfellows: polyadenylation factors at the promoter. Genes Dev (2003) 2.41
Cotranscriptional processes and their influence on genome stability. Genes Dev (2006) 2.23
The SR protein SRp38 represses splicing in M phase cells. Cell (2002) 2.17
Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease. RNA (2004) 2.10
Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Mol Cell (2009) 2.10
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Transcriptional activators enhance polyadenylation of mRNA precursors. Mol Cell (2011) 2.01
A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock. Mol Cell (2007) 1.99
The TET family of proteins: functions and roles in disease. J Mol Cell Biol (2009) 1.97
Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J Biol Chem (2002) 1.92
Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Genes Dev (2002) 1.89
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature (2009) 1.83
R-loop-mediated genomic instability is caused by impairment of replication fork progression. Genes Dev (2011) 1.82
A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev (2010) 1.77
Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation. Genes Dev (2005) 1.76
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. Proc Natl Acad Sci U S A (2009) 1.70
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. Nature (2004) 1.67
Terminating the transcript: breaking up is hard to do. Genes Dev (2006) 1.67
Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature (2010) 1.58
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. Genes Dev (2005) 1.57
An intronic element contributes to splicing repression in spinal muscular atrophy. Proc Natl Acad Sci U S A (2007) 1.55
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. Science (2011) 1.54
PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins. Mol Cell (2006) 1.51
The search for alternative splicing regulators: new approaches offer a path to a splicing code. Genes Dev (2008) 1.50
Pin1 modulates the structure and function of human RNA polymerase II. Genes Dev (2003) 1.45
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev (2009) 1.42
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell (2003) 1.39
Misregulation of pre-mRNA alternative splicing in cancer. Cancer Discov (2013) 1.39
Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors. Mol Cell (2007) 1.38
Requirements of the RNA polymerase II C-terminal domain for reconstituting pre-mRNA 3' cleavage. Mol Cell Biol (2002) 1.37
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex. Genes Dev (2011) 1.37
Characterization of the catalytic activity of U2 and U6 snRNAs. RNA (2003) 1.37
ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol (2003) 1.34
Regulation of plant developmental processes by a novel splicing factor. PLoS One (2007) 1.34
TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements. Proc Natl Acad Sci U S A (2012) 1.33
Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. Cancer Res (2010) 1.32
Nuclear coupling: RNA processing reaches back to transcription. Nat Struct Biol (2002) 1.30
The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J (2010) 1.28
SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. Dev Cell (2009) 1.23
Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1. Nat Struct Mol Biol (2011) 1.22
The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription. EMBO J (2005) 1.22
Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator. Nat Struct Mol Biol (2008) 1.22
Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins. Nat Struct Mol Biol (2012) 1.22
Regulation and substrate specificity of the SR protein kinase Clk/Sty. Mol Cell Biol (2003) 1.20
Pin1 modulates RNA polymerase II activity during the transcription cycle. Genes Dev (2007) 1.20
SUMO functions in constitutive transcription and during activation of inducible genes in yeast. Genes Dev (2010) 1.20
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The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation. Mol Cell (2005) 1.15
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Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing. RNA (2007) 1.10
TLS inhibits RNA polymerase III transcription. Mol Cell Biol (2010) 1.10
The 3' processing factor CstF functions in the DNA repair response. Nucleic Acids Res (2008) 1.07
Sumoylation modulates the assembly and activity of the pre-mRNA 3' processing complex. Mol Cell Biol (2007) 1.07
Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates. Mol Cell Biol (2003) 1.07
The prolyl isomerase Pin1 functions in mitotic chromosome condensation. Mol Cell (2007) 1.05
PARP1 represses PAP and inhibits polyadenylation during heat shock. Mol Cell (2012) 1.05
Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation. Nucleic Acids Res (2014) 1.04
Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III. Mol Cell Biol (2009) 1.03
Human capping enzyme promotes formation of transcriptional R loops in vitro. Proc Natl Acad Sci U S A (2007) 1.00
The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein. Mol Cell Biol (2005) 1.00
Concurrent splicing and transcription are not sufficient to enhance splicing efficiency. RNA (2007) 0.99
Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast. Genes Dev (2012) 0.98
The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability. RNA (2007) 0.98
Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Mol Cell (2011) 0.98
Far upstream element-binding protein 1 and RNA secondary structure both mediate second-step splicing repression. Proc Natl Acad Sci U S A (2013) 0.96
The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nat Commun (2012) 0.96
In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L. J Biol Chem (2003) 0.96
Splicing of mRNA precursors: the role of RNAs and proteins in catalysis. Mol Biosyst (2009) 0.96
Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery. Mol Cell Biol (2014) 0.96
From transcription to mRNA: PAF provides a new path. Mol Cell (2005) 0.93
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. Genes Dev (2013) 0.93
Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol (2009) 0.92
Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins. Mol Cell Biol (2005) 0.92
New talents for an old acquaintance: the SR protein splicing factor ASF/SF2 functions in the maintenance of genome stability. Cell Cycle (2005) 0.91
Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation. Mol Cell Biol (2010) 0.91
An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev (2012) 0.90
MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress. Mol Cell Biol (2012) 0.89
Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock. Mol Biol Cell (2005) 0.88
Intrinsic metal binding by a spliceosomal RNA. Nat Struct Biol (2002) 0.88
Pinning down transcription: regulation of RNA polymerase II activity during the cell cycle. Cell Cycle (2004) 0.88
Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila. Development (2002) 0.88