Published in RNA on October 16, 2007
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Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing. Science (1990) 2.13
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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature (2009) 5.48
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ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96
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A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy. Nat Genet (2003) 3.84
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Cell signalling and the control of pre-mRNA splicing. Nat Rev Mol Cell Biol (2004) 2.78
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The RNA polymerase II CTD coordinates transcription and RNA processing. Genes Dev (2012) 2.55
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination. Genes Dev (2007) 2.49
Strange bedfellows: polyadenylation factors at the promoter. Genes Dev (2003) 2.41
Cotranscriptional processes and their influence on genome stability. Genes Dev (2006) 2.23
The SR protein SRp38 represses splicing in M phase cells. Cell (2002) 2.17
Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease. RNA (2004) 2.10
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Transcriptional activators enhance polyadenylation of mRNA precursors. Mol Cell (2011) 2.01
A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock. Mol Cell (2007) 1.99
The TET family of proteins: functions and roles in disease. J Mol Cell Biol (2009) 1.97
Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J Biol Chem (2002) 1.92
Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Genes Dev (2002) 1.89
Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature (2009) 1.83
R-loop-mediated genomic instability is caused by impairment of replication fork progression. Genes Dev (2011) 1.82
A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev (2010) 1.77
Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation. Genes Dev (2005) 1.76
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. Proc Natl Acad Sci U S A (2009) 1.70
hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing. Hum Mol Genet (2007) 1.69
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. Nature (2004) 1.67
Terminating the transcript: breaking up is hard to do. Genes Dev (2006) 1.67
Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature (2010) 1.58
snRNAs as the catalysts of pre-mRNA splicing. Curr Opin Chem Biol (2005) 1.58
BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. Genes Dev (2005) 1.57
An intronic element contributes to splicing repression in spinal muscular atrophy. Proc Natl Acad Sci U S A (2007) 1.55
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. Science (2011) 1.54
PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins. Mol Cell (2006) 1.51
The search for alternative splicing regulators: new approaches offer a path to a splicing code. Genes Dev (2008) 1.50
Stop codons affect 5' splice site selection by surveillance of splicing. Proc Natl Acad Sci U S A (2002) 1.47
Pin1 modulates the structure and function of human RNA polymerase II. Genes Dev (2003) 1.45
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes Dev (2009) 1.42
Correlation between ankle-brachial index and microalbuminuria in type 2 diabetes mellitus. Iran J Kidney Dis (2013) 1.40
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell (2003) 1.39
Misregulation of pre-mRNA alternative splicing in cancer. Cancer Discov (2013) 1.39
Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors. Mol Cell (2007) 1.38
Requirements of the RNA polymerase II C-terminal domain for reconstituting pre-mRNA 3' cleavage. Mol Cell Biol (2002) 1.37
Characterization of the catalytic activity of U2 and U6 snRNAs. RNA (2003) 1.37
The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex. Genes Dev (2011) 1.37
ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol (2003) 1.34
Regulation of plant developmental processes by a novel splicing factor. PLoS One (2007) 1.34
TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements. Proc Natl Acad Sci U S A (2012) 1.33
Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. Cancer Res (2010) 1.32
Nuclear coupling: RNA processing reaches back to transcription. Nat Struct Biol (2002) 1.30
The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J (2010) 1.28
SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. Dev Cell (2009) 1.23
Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1. Nat Struct Mol Biol (2011) 1.22
Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator. Nat Struct Mol Biol (2008) 1.22
The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription. EMBO J (2005) 1.22
Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins. Nat Struct Mol Biol (2012) 1.22
Hospital mortality and complications of electively clipped or coiled unruptured intracranial aneurysm. Stroke (2010) 1.21
Regulation and substrate specificity of the SR protein kinase Clk/Sty. Mol Cell Biol (2003) 1.20
Pin1 modulates RNA polymerase II activity during the transcription cycle. Genes Dev (2007) 1.20
SUMO functions in constitutive transcription and during activation of inducible genes in yeast. Genes Dev (2010) 1.20
Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function. Genes Dev (2008) 1.19
Multiple roles for polypyrimidine tract binding (PTB) proteins in trypanosome RNA metabolism. RNA (2009) 1.19
Protein-free small nuclear RNAs catalyze a two-step splicing reaction. Proc Natl Acad Sci U S A (2009) 1.16
The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation. Mol Cell (2005) 1.15
TLS inhibits RNA polymerase III transcription. Mol Cell Biol (2010) 1.10
The 3' processing factor CstF functions in the DNA repair response. Nucleic Acids Res (2008) 1.07
Sumoylation modulates the assembly and activity of the pre-mRNA 3' processing complex. Mol Cell Biol (2007) 1.07
Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates. Mol Cell Biol (2003) 1.07
The prolyl isomerase Pin1 functions in mitotic chromosome condensation. Mol Cell (2007) 1.05
PARP1 represses PAP and inhibits polyadenylation during heat shock. Mol Cell (2012) 1.05
Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation. Nucleic Acids Res (2014) 1.04
Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III. Mol Cell Biol (2009) 1.03
Primary mucinous cystadenocarcinoma of renal pelvis: a case report. Cases J (2009) 1.03
Human capping enzyme promotes formation of transcriptional R loops in vitro. Proc Natl Acad Sci U S A (2007) 1.00
The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein. Mol Cell Biol (2005) 1.00
Concurrent splicing and transcription are not sufficient to enhance splicing efficiency. RNA (2007) 0.99
Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast. Genes Dev (2012) 0.98
The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability. RNA (2007) 0.98
Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Mol Cell (2011) 0.98
Far upstream element-binding protein 1 and RNA secondary structure both mediate second-step splicing repression. Proc Natl Acad Sci U S A (2013) 0.96
In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L. J Biol Chem (2003) 0.96
The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nat Commun (2012) 0.96
Splicing of mRNA precursors: the role of RNAs and proteins in catalysis. Mol Biosyst (2009) 0.96
Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery. Mol Cell Biol (2014) 0.96
Establishment of an in vitro trans-splicing system in Trypanosoma brucei that requires endogenous spliced leader RNA. Nucleic Acids Res (2010) 0.93
From transcription to mRNA: PAF provides a new path. Mol Cell (2005) 0.93
A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. Genes Dev (2013) 0.93
Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins. Mol Cell Biol (2005) 0.92
Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol (2009) 0.92
Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation. Mol Cell Biol (2010) 0.91
New talents for an old acquaintance: the SR protein splicing factor ASF/SF2 functions in the maintenance of genome stability. Cell Cycle (2005) 0.91
An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes Dev (2012) 0.90
The hnRNP F/H homologue of Trypanosoma brucei is differentially expressed in the two life cycle stages of the parasite and regulates splicing and mRNA stability. Nucleic Acids Res (2013) 0.90
Is thrombolysis safe in the elderly?: analysis of a national database. Stroke (2010) 0.89