PubRank

Ruth McPherson

Author PubWeight™ 254.51‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010 28.21
2 Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science 2004 21.65
3 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
4 Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet 2011 13.25
5 Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 2012 12.10
6 Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010 8.55
7 LDL-cholesterol concentrations: a genome-wide association study. Lancet 2008 6.44
8 A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet 2009 6.31
9 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol 2013 5.97
10 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations. Can J Cardiol 2009 5.65
11 Medical sequencing at the extremes of human body mass. Am J Hum Genet 2007 5.61
12 Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 2014 5.47
13 Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med 2014 4.94
14 Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 2010 4.08
15 Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes 2010 4.07
16 Lipid treatment assessment project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals. Circulation 2009 3.98
17 Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med 2016 3.88
18 Recommendations for the management of dyslipidemia and the prevention of cardiovascular disease: summary of the 2003 update. CMAJ 2003 3.85
19 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
20 Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet 2010 3.15
21 Gene dosage of the common variant 9p21 predicts severity of coronary artery disease. J Am Coll Cardiol 2010 3.07
22 Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus. Arterioscler Thromb Vasc Biol 2009 2.79
23 Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD. Sci Transl Med 2011 2.29
24 Genetically determined height and coronary artery disease. N Engl J Med 2015 2.24
25 A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet 2009 2.09
26 Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study. Obesity (Silver Spring) 2009 2.07
27 Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. Sci Transl Med 2010 1.75
28 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
29 Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study. J Am Coll Cardiol 2009 1.64
30 Lack of MEF2A mutations in coronary artery disease. J Clin Invest 2005 1.62
31 Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. Am J Hum Genet 2011 1.60
32 A novel efflux-recapture process underlies the mechanism of high-density lipoprotein cholesteryl ester-selective uptake mediated by the low-density lipoprotein receptor-related protein. Arterioscler Thromb Vasc Biol 2004 1.59
33 Lack of support for the association between GAD2 polymorphisms and severe human obesity. PLoS Biol 2005 1.59
34 Clinical and public health assessment of benefits and risks of statins in primary prevention of coronary events: resolved and unresolved issues. Can J Cardiol 2008 1.59
35 Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke 2013 1.51
36 Discordance between Framingham Risk Score and atherosclerotic plaque burden. Eur Heart J 2013 1.46
37 Genetic and phenotypic architecture of metabolic syndrome-associated components in dyslipidemic and normolipidemic subjects: the GEMS Study. Atherosclerosis 2007 1.36
38 A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet 2012 1.35
39 Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project). Am J Cardiol 2005 1.32
40 Triglycerides and heart disease: still a hypothesis? Arterioscler Thromb Vasc Biol 2011 1.32
41 Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet 2008 1.30
42 Cardiometabolic risk in Canada: a detailed analysis and position paper by the cardiometabolic risk working group. Can J Cardiol 2011 1.24
43 Improved prediction of cardiovascular disease based on a panel of single nucleotide polymorphisms identified through genome-wide association studies. Circ Cardiovasc Genet 2010 1.23
44 Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells. PLoS One 2011 1.19
45 A systems biology framework identifies molecular underpinnings of coronary heart disease. Arterioscler Thromb Vasc Biol 2013 1.18
46 Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk. Arterioscler Thromb Vasc Biol 2012 1.10
47 Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women. Diabetes 2002 1.10
48 Clinical and genetic association of serum ceruloplasmin with cardiovascular risk. Arterioscler Thromb Vasc Biol 2011 1.10
49 Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arterioscler Thromb Vasc Biol 2014 1.08
50 Adipocyte low density lipoprotein receptor-related protein gene expression and function is regulated by peroxisome proliferator-activated receptor gamma. J Biol Chem 2003 1.08
51 Comparative effects of rosuvastatin and atorvastatin across their dose ranges in patients with hypercholesterolemia and without active arterial disease. Am J Cardiol 2003 1.07
52 Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects. Arterioscler Thromb Vasc Biol 2007 1.06
53 Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res 2017 1.06
54 Gene expression profiling in whole blood identifies distinct biological pathways associated with obesity. BMC Med Genomics 2010 1.05
55 Prevalence of dyslipidemia in statin-treated patients in Canada: results of the DYSlipidemia International Study (DYSIS). Can J Cardiol 2010 1.05
56 Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol 2013 1.03
57 Gain-of-function R225W mutation in human AMPKgamma(3) causing increased glycogen and decreased triglyceride in skeletal muscle. PLoS One 2007 1.03
58 ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. Mol Endocrinol 2009 1.02
59 Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity. J Lipid Res 2010 1.01
60 Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia. J Lipid Res 2005 1.00
61 Novel N-terminal mutation of human apolipoprotein A-I reduces self-association and impairs LCAT activation. J Lipid Res 2010 1.00
62 The analysis by Manuel and colleagues creates controversy with headlines, not data. CMAJ 2005 0.97
63 Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary). Can J Cardiol 2011 0.96
64 Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community. J Am Heart Assoc 2015 0.96
65 Genetic predisposition to higher blood pressure increases coronary artery disease risk. Hypertension 2013 0.95
66 Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux. J Biol Chem 2006 0.95
67 Statin therapy in Canadian patients with hypercholesterolemia: the Canadian Lipid Study -- Observational (CALIPSO). Can J Cardiol 2005 0.94
68 Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver. Arterioscler Thromb Vasc Biol 2005 0.94
69 Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. Obesity (Silver Spring) 2007 0.93
70 The transcription factor GATA-2 does not associate with angiographic coronary artery disease in the Ottawa Heart Genomics and Cleveland Clinic GeneBank Studies. Hum Genet 2009 0.92
71 Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice. Arterioscler Thromb Vasc Biol 2007 0.92
72 Statins for primary prevention of coronary artery disease. Lancet 2007 0.91
73 Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy. J Lipid Res 2005 0.91
74 A PYY Q62P variant linked to human obesity. Hum Mol Genet 2005 0.90
75 Identifying genes for coronary artery disease: An idea whose time has come. Can J Cardiol 2007 0.90
76 Secretory vesicular transport from the Golgi is altered during ATP-binding cassette protein A1 (ABCA1)-mediated cholesterol efflux. J Biol Chem 2003 0.89
77 The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts. BMC Med Genet 2009 0.87
78 RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies. PLoS One 2011 0.87
79 Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol. Arterioscler Thromb Vasc Biol 2007 0.86
80 Remnant cholesterol: "Non-(HDL-C + LDL-C)" as a coronary artery disease risk factor. J Am Coll Cardiol 2012 0.85
81 Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity. FEBS J 2013 0.84
82 SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells. J Biol Chem 2006 0.84
83 Scavenger receptor class B type I localizes to a late endosomal compartment. J Lipid Res 2008 0.83
84 Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARgamma and Identification of TUSC5 Coding Variants in Lean and Obese Humans. PPAR Res 2010 0.83
85 Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arterioscler Thromb Vasc Biol 2015 0.83
86 Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk. Circ Cardiovasc Genet 2013 0.83
87 Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes. Biochim Biophys Acta 2013 0.82
88 The metabolic syndrome and type 2 diabetes: role of the adipocyte. Curr Opin Lipidol 2003 0.82
89 Redundancy control in pathway databases (ReCiPa): an application for improving gene-set enrichment analysis in Omics studies and "Big data" biology. OMICS 2013 0.82
90 Role of cholesteryl ester transfer protein in selective uptake of high density lipoprotein cholesteryl esters by adipocytes. J Lipid Res 2004 0.81
91 Blood gene expression reveal pathway differences between diet-sensitive and resistant obese subjects prior to caloric restriction. Obesity (Silver Spring) 2010 0.80
92 ERK1/2 regulates hepatocyte Trib1 in response to mitochondrial dysfunction. Biochim Biophys Acta 2013 0.79
93 A gene-centric approach to elucidating cardiovascular risk. Circ Cardiovasc Genet 2009 0.79
94 Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan. J Biol Chem 2004 0.78
95 Early effects of statin therapy on endothelial function and microvascular reactivity in patients with coronary artery disease. Am Heart J 2005 0.78
96 Partitioning the heritability of Coronary Artery Disease highlights the importance of immune-mediated processes and epigenetic sites associated with transcriptional activity. Cardiovasc Res 2017 0.77
97 Limitations of statin monotherapy for the treatment of dyslipidemia: a projection based on the Canadian lipid study--observational. Curr Med Res Opin 2009 0.77
98 A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution. Eur J Hum Genet 2013 0.77
99 Antibody phenotyping test for the human apolipoprotein E2 isoform. Clin Chem 2003 0.76
100 Lower mitochondrial proton leak and decreased glutathione redox in primary muscle cells of obese diet-resistant versus diet-sensitive humans. J Clin Endocrinol Metab 2014 0.76
101 Gene-environment interaction in dyslipidemia. Curr Opin Lipidol 2015 0.76
102 Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease. Int J Mol Epidemiol Genet 2011 0.75
103 ERRγ Regulates Cardiac, Gastric, and Renal Potassium Homeostasis. Endocr Rev 2009 0.75
104 Do clustered beta-propeller domains within the N-terminus of LRP1 play a functional role? Biochim Biophys Acta 2004 0.75
105 Statin therapy and the management of acute coronary syndromes. Can J Cardiol 2003 0.75
106 Obesity and coronary artery calcification: Can it explain the obesity-paradox? Int J Cardiovasc Imaging 2015 0.75
107 Statin therapy in acute coronary syndrome. Am J Cardiol 2006 0.75