Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine.

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Published in Arterioscler Thromb Vasc Biol on March 27, 2014

Authors

Jaana Hartiala, Brian J Bennett, W H Wilson Tang, Zeneng Wang, Alexandre F R Stewart, Robert Roberts, Ruth McPherson, Aldons J Lusis1, Stanley L Hazen1, Hooman Allayee2, CARDIoGRAM Consortium

Author Affiliations

1: From the Department of Preventive Medicine (J.H., H.A.) and Institute for Genetic Medicine (J.H., H.A.), Keck School of Medicine of the University of Southern California, Los Angeles; Department of Genetics (B.J.B.) and Nutrition Research Institute (B.J.B.), University of North Carolina, Chapel Hill, Kannapolis; Departments of Cardiovascular Medicine (W.H.W.T., Z.W., S.L.H.) and Cellular and Molecular Medicine (W.H.W.T., Z.W., S.L.H.) and Center for Cardiovascular Diagnostics and Prevention (W.H.W.T., Z.W., S.L.H.), Cleveland Clinic, OH; John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (A.F.R.S., R.R., R.M.); and Departments of Medicine (A.J.L.), Human Genetics (A.J.L.), and Microbiology, Immunology, and Molecular Genetics (A.J.L.), David Geffen School of Medicine of UCLA.
2: From the Department of Preventive Medicine (J.H., H.A.) and Institute for Genetic Medicine (J.H., H.A.), Keck School of Medicine of the University of Southern California, Los Angeles; Department of Genetics (B.J.B.) and Nutrition Research Institute (B.J.B.), University of North Carolina, Chapel Hill, Kannapolis; Departments of Cardiovascular Medicine (W.H.W.T., Z.W., S.L.H.) and Cellular and Molecular Medicine (W.H.W.T., Z.W., S.L.H.) and Center for Cardiovascular Diagnostics and Prevention (W.H.W.T., Z.W., S.L.H.), Cleveland Clinic, OH; John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (A.F.R.S., R.R., R.M.); and Departments of Medicine (A.J.L.), Human Genetics (A.J.L.), and Microbiology, Immunology, and Molecular Genetics (A.J.L.), David Geffen School of Medicine of UCLA. hallayee@usc.edu.

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