Inherited mitochondrial diseases of DNA replication.

The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13

Multi-system neurological disease is common in patients with OPA1 mutations. Brain (2010) 5.37

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell (2010) 5.14

Mitochondrial translation and beyond: processes implicated in combined oxidative phosphorylation deficiencies. J Biomed Biotechnol (2010) 2.01

Biochemical diagnosis of mitochondrial disorders. J Inherit Metab Dis (2010) 1.95

Defects in mitochondrial DNA replication and human disease. Crit Rev Biochem Mol Biol (2011) 1.86

Mitochondrial neurogastrointestinal encephalopathy due to mutations in RRM2B. Arch Neurol (2009) 1.85

Expression and maintenance of mitochondrial DNA: new insights into human disease pathology. Am J Pathol (2008) 1.78

The clinical maze of mitochondrial neurology. Nat Rev Neurol (2013) 1.72

Quantitation of cellular deoxynucleoside triphosphates. Nucleic Acids Res (2009) 1.70

Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim Biophys Acta (2009) 1.67

Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance. Brain (2014) 1.49

DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations. Biochim Biophys Acta (2008) 1.43

Next generation sequence analysis for mitochondrial disorders. Genome Med (2009) 1.42

Maintaining genome stability in the nervous system. Nat Neurosci (2013) 1.24

Mitochondrial medicine for aging and neurodegenerative diseases. Neuromolecular Med (2008) 1.22

Clinical, biochemical, cellular and molecular characterization of mitochondrial DNA depletion syndrome due to novel mutations in the MPV17 gene. Eur J Hum Genet (2013) 1.21

MPV17 mutation causes neuropathy and leukoencephalopathy with multiple mtDNA deletions in muscle. Neuromuscul Disord (2012) 1.18

Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53. Nucleic Acids Res (2008) 1.18

OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution. Genome Res (2010) 1.17

Generation of rho0 cells utilizing a mitochondrially targeted restriction endonuclease and comparative analyses. Nucleic Acids Res (2008) 1.17

Gene expression in a Drosophila model of mitochondrial disease. PLoS One (2010) 1.16

Next-generation sequencing reveals DGUOK mutations in adult patients with mitochondrial DNA multiple deletions. Brain (2012) 1.16

Mutations in mitochondrial DNA polymerase-gamma promote breast tumorigenesis. J Hum Genet (2009) 1.15

The importance of mitochondria in age-related and inherited eye disorders. Ophthalmic Res (2010) 1.13

Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53. Nucleic Acids Res (2009) 1.13

Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication. J Biol Chem (2009) 1.11

Mitochondrial biogenesis and turnover. Cell Calcium (2008) 1.10

DNA2 resolves expanding flap in mitochondrial base excision repair. Mol Cell (2008) 1.09

Identification of multiple rate-limiting steps during the human mitochondrial transcription cycle in vitro. J Biol Chem (2010) 1.09

Mitochondrial genome maintenance in health and disease. DNA Repair (Amst) (2014) 1.08

Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Exp Neurol (2008) 1.07

A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells. Nucleosides Nucleotides Nucleic Acids (2011) 1.05

Heterogeneous nuclear ribonucleoprotein A2 is a common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress. Mol Biol Cell (2009) 1.04

Biochemical analysis of human POLG2 variants associated with mitochondrial disease. Hum Mol Genet (2011) 1.04

mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae. Hum Mol Genet (2010) 1.04

The awakening of an advanced malignant cancer: an insult to the mitochondrial genome. Biochim Biophys Acta (2011) 1.02

Late-onset ptosis and myopathy in a patient with a heterozygous insertion in POLG2. J Neurol (2010) 1.01

Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity. J Biol Chem (2010) 1.00

Ribonucleotide discrimination and reverse transcription by the human mitochondrial DNA polymerase. J Biol Chem (2011) 1.00

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity. Aging Cell (2012) 0.99

Physiological and biochemical defects in carboxyl-terminal mutants of mitochondrial DNA helicase. J Biol Chem (2008) 0.98

Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination. J Biol Chem (2011) 0.94

Clinical and molecular features of POLG-related mitochondrial disease. Cold Spring Harb Perspect Biol (2013) 0.94

Spectrum of combined respiratory chain defects. J Inherit Metab Dis (2015) 0.93

Dominant membrane uncoupling by mutant adenine nucleotide translocase in mitochondrial diseases. Hum Mol Genet (2008) 0.93

Loss of mitochondrial DNA under genotoxic stress conditions in the absence of the yeast DNA helicase Pif1p occurs independently of the DNA helicase Rrm3p. Mol Genet Genomics (2009) 0.93

Mitochondrial disease in childhood: mtDNA encoded. Neurotherapeutics (2013) 0.93

Animal models of mitochondrial DNA transactions in disease and ageing. Exp Gerontol (2010) 0.93

Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds. Biochemistry (2011) 0.92

Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance. Hum Mol Genet (2012) 0.91

Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints. BMC Genomics (2014) 0.90

Defects of mitochondrial DNA replication. J Child Neurol (2014) 0.90

Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells. Proc Natl Acad Sci U S A (2010) 0.90

Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels. Mol Pharmacol (2013) 0.89

How can we treat mitochondrial encephalomyopathies? Approaches to therapy. Neurotherapeutics (2008) 0.89

Functional importance of the conserved N-terminal domain of the mitochondrial replicative DNA helicase. Biochim Biophys Acta (2008) 0.89

PCR based determination of mitochondrial DNA copy number in multiple species. Methods Mol Biol (2015) 0.88

Mitochondrial transcription: lessons from mouse models. Biochim Biophys Acta (2011) 0.88

Mitochondrial DNA content varies with pathological characteristics of breast cancer. J Oncol (2011) 0.88

The interface of transcription and DNA replication in the mitochondria. Biochim Biophys Acta (2011) 0.88

Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5. J Virol (2013) 0.87

Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation. Lab Invest (2008) 0.86

Mitochondrial DNA haplogroups in early-onset Alzheimer's disease and frontotemporal lobar degeneration. Mol Neurodegener (2010) 0.86

Maintaining ancient organelles: mitochondrial biogenesis and maturation. Circ Res (2015) 0.85

Costeff optic atrophy syndrome: new clinical case and novel molecular findings. J Inherit Metab Dis (2008) 0.84

Mechanisms of mutagenesis: DNA replication in the presence of DNA damage. Mutat Res Rev Mutat Res (2016) 0.84

Replication intermediates of the linear mitochondrial DNA of Candida parapsilosis suggest a common recombination based mechanism for yeast mitochondria. J Biol Chem (2014) 0.84

Molecular and biochemical characterisation of a novel mutation in POLG associated with Alpers syndrome. BMC Neurol (2011) 0.84

Mitochondrial heat shock protein machinery hsp70/hsp40 is indispensable for proper mitochondrial DNA maintenance and replication. MBio (2015) 0.84

Replicating DNA by cell factories: roles of central carbon metabolism and transcription in the control of DNA replication in microbes, and implications for understanding this process in human cells. Microb Cell Fact (2013) 0.84

Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients. Hum Mol Genet (2012) 0.84

Yeast cells expressing the human mitochondrial DNA polymerase reveal correlations between polymerase fidelity and human disease progression. J Biol Chem (2014) 0.83

An analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitors. PLoS Comput Biol (2009) 0.83

The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease. Hum Genet (2013) 0.83

A257T linker region mutant of T7 helicase-primase protein is defective in DNA loading and rescued by T7 DNA polymerase. J Biol Chem (2011) 0.82

Differential regulation of full-length genome and a single-stranded 7S DNA along the cell cycle in human mitochondria. Nucleic Acids Res (2010) 0.82

Mitochondrial disease in childhood: nuclear encoded. Neurotherapeutics (2013) 0.82

Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1. Nucleic Acids Res (2013) 0.82

Quality assessment of human mitochondrial DNA quantification: MITONAUTS, an international multicentre survey. Mitochondrion (2011) 0.82

Human mitochondrial DNA replication machinery and disease. Curr Opin Genet Dev (2016) 0.82

The neurogenic basic helix-loop-helix transcription factor NeuroD6 enhances mitochondrial biogenesis and bioenergetics to confer tolerance of neuronal PC12-NeuroD6 cells to the mitochondrial stressor rotenone. Exp Cell Res (2012) 0.81

Suppression of mitochondrial DNA instability of autosomal dominant forms of progressive external ophthalmoplegia-associated ANT1 mutations in Podospora anserina. Genetics (2009) 0.81

Polymorphisms in the mitochondrial DNA control region and frailty in older adults. PLoS One (2010) 0.81

De novo mutation in POLG leads to haplotype insufficiency and Alpers syndrome. Mitochondrion (2009) 0.81

Mitochondrial disorders of DNA polymerase γ dysfunction: from anatomic to molecular pathology diagnosis. Arch Pathol Lab Med (2011) 0.80

Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice. Skelet Muscle (2016) 0.80

The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum Mol Genet (2008) 0.80

Mitochondrial DNA impairment in nucleoside reverse transcriptase inhibitor-associated cardiomyopathy. Chem Res Toxicol (2008) 0.80

A novel 154-bp deletion in the human mitochondrial DNA control region in healthy individuals. Hum Mutat (2008) 0.80

Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine. Biochemistry (2014) 0.80

Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. DNA Repair (Amst) (2014) 0.80

Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study. PLoS Comput Biol (2011) 0.79

POLG1 p.R722H mutation associated with multiple mtDNA deletions and a neurological phenotype. BMC Neurol (2010) 0.78

Mitochondrial DNA depletion and fatal infantile hepatic failure due to mutations in the mitochondrial polymerase γ (POLG) gene: a combined morphological/enzyme histochemical and immunocytochemical/biochemical and molecular genetic study. J Cell Mol Med (2011) 0.77

In vitro supplementation with deoxynucleoside monophosphates rescues mitochondrial DNA depletion. Mol Genet Metab (2012) 0.76

Genetic analysis of two Japanese families with progressive external ophthalmoplegia and parkinsonism. J Neurol (2011) 0.76

Mitochondrial DNA Polymerase POLG1 Disease Mutations and Germline Variants Promote Tumorigenic Properties. PLoS One (2015) 0.75

Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. PLoS One (2017) 0.75

Mitochondrial DNA abnormalities in ophthalmological disease. Saudi J Ophthalmol (2011) 0.75

Mitochondrial diseases in man and mouse. Science (1999) 11.67

Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria. Nat Genet (2001) 5.09

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet (2007) 4.99

Systematic identification of human mitochondrial disease genes through integrative genomics. Nat Genet (2006) 4.67

Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Science (1999) 4.05

Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Nat Genet (2001) 3.82

An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region. Nature (1989) 3.75

MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion. Nat Genet (2006) 3.17

Phenotypic spectrum associated with mutations of the mitochondrial polymerase gamma gene. Brain (2006) 3.16

The spectrum of clinical disease caused by the A467T and W748S POLG mutations: a study of 26 cases. Brain (2006) 2.98

Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. Lancet (2004) 2.91

Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. Nat Genet (2001) 2.91

POLG mutations associated with Alpers' syndrome and mitochondrial DNA depletion. Ann Neurol (2004) 2.88

Composition and dynamics of human mitochondrial nucleoids. Mol Biol Cell (2003) 2.74

The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. Nat Genet (2001) 2.71

Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science (2000) 2.66

Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA. Brain (2005) 2.44

Mitochondrial encephalomyopathy with elevated methylmalonic acid is caused by SUCLA2 mutations. Brain (2007) 2.33

Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin. Am J Hum Genet (2005) 2.23

Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lab Invest (2006) 2.14

DNA polymerase gamma in mitochondrial DNA replication and repair. Chem Rev (2006) 2.12

Allogeneic stem cell transplantation corrects biochemical derangements in MNGIE. Neurology (2006) 2.11

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma. J Biol Chem (2001) 2.07

Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion. Am J Hum Genet (2005) 2.06

Mitochondrial DNA polymerase-gamma and human disease. Hum Mol Genet (2006) 2.04

Autosomal recessive mitochondrial ataxic syndrome due to mitochondrial polymerase gamma mutations. Neurology (2005) 2.01

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia. Am J Hum Genet (2006) 1.99

Infusion of platelets transiently reduces nucleoside overload in MNGIE. Neurology (2006) 1.98

The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit. J Biol Chem (2001) 1.92

POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement. Neurology (2004) 1.89

Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc Natl Acad Sci U S A (2005) 1.88

Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia. Nat Struct Mol Biol (2004) 1.87

Cloning and characterization of the human mitochondrial DNA polymerase, DNA polymerase gamma. Genomics (1996) 1.84

Mitochondrial neurogastrointestinal encephalomyopathy: an autosomal recessive disorder due to thymidine phosphorylase mutations. Ann Neurol (2000) 1.82

The common A467T mutation in the human mitochondrial DNA polymerase (POLG) compromises catalytic efficiency and interaction with the accessory subunit. J Biol Chem (2005) 1.81

Recessive POLG mutations presenting with sensory and ataxic neuropathy in compound heterozygote patients with progressive external ophthalmoplegia. Neuromuscul Disord (2003) 1.70

In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells. J Biol Chem (2000) 1.68

Consequences of mutations in human DNA polymerase gamma. Gene (2005) 1.65

Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency. J Clin Invest (2003) 1.60

Functional defects due to spacer-region mutations of human mitochondrial DNA polymerase in a family with an ataxia-myopathy syndrome. Hum Mol Genet (2005) 1.58

Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders. Hum Mol Genet (2006) 1.54

Navajo neurohepatopathy is caused by a mutation in the MPV17 gene. Am J Hum Genet (2006) 1.53

Deoxyribonucleotide pool imbalance stimulates deletions in HeLa cell mitochondrial DNA. J Biol Chem (2003) 1.52

Altered thymidine metabolism due to defects of thymidine phosphorylase. J Biol Chem (2001) 1.52

mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency. Mol Genet Metab (2003) 1.52

Mutations of ANT1, Twinkle, and POLG1 in sporadic progressive external ophthalmoplegia (PEO). Neurology (2003) 1.43

Molecular diagnosis of Alpers syndrome. J Hepatol (2006) 1.38

Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis. J Biol Chem (2002) 1.34

Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility. Nat Genet (2001) 1.31

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a disease of two genomes. Neurologist (2004) 1.30

Mitochondrial DNA polymerase gamma deficiency and mtDNA depletion in a child with Alpers' syndrome. Ann Neurol (1999) 1.28

SUCLA2 mutations are associated with mild methylmalonic aciduria, Leigh-like encephalomyopathy, dystonia and deafness. Brain (2007) 1.27

Mutant deoxynucleotide carrier is associated with congenital microcephaly. Nat Genet (2002) 1.25

Dominant inheritance of premature ovarian failure associated with mutant mitochondrial DNA polymerase gamma. Hum Reprod (2006) 1.25

Elevated plasma deoxyuridine in patients with thymidine phosphorylase deficiency. Biochem Biophys Res Commun (2003) 1.22

Hepatocerebral mitochondrial DNA depletion syndrome caused by deoxyguanosine kinase (DGUOK) mutations. Arch Neurol (2006) 1.22

Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A (2006) 1.21

Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. Arch Biochem Biophys (2002) 1.21

Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. DNA Repair (Amst) (2005) 1.19

Mitochondrial DNA depletion and dGK gene mutations. Ann Neurol (2002) 1.17

Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia. Hum Mol Genet (2005) 1.16

Mitochondrial DNA depletion: mutations in thymidine kinase gene with myopathy and SMA. Neurology (2002) 1.14

Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes. Mol Genet Metab (2005) 1.14

Genetic and chemical rescue of the Saccharomyces cerevisiae phenotype induced by mitochondrial DNA polymerase mutations associated with progressive external ophthalmoplegia in humans. Hum Mol Genet (2006) 1.14

Depletion of mtDNA: syndromes and genes. Mitochondrion (2006) 1.13

New mutations in TK2 gene associated with mitochondrial DNA depletion. Pediatr Neurol (2006) 1.11

Mutations in AAC2, equivalent to human adPEO-associated ANT1 mutations, lead to defective oxidative phosphorylation in Saccharomyces cerevisiae and affect mitochondrial DNA stability. Hum Mol Genet (2004) 1.10

Defects of intergenomic communication: autosomal disorders that cause multiple deletions and depletion of mitochondrial DNA. Semin Cell Dev Biol (2001) 1.09

POLG1, C10ORF2, and ANT1 mutations are uncommon in sporadic progressive external ophthalmoplegia with multiple mitochondrial DNA deletions. Neurology (2006) 1.08

A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family. Neurology (2001) 1.08

Frequent polymorphism of the mitochondrial DNA polymerase gamma gene (POLG) in patients with normal spermiograms and unexplained subfertility. Hum Reprod (2004) 1.08

Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate. EMBO J (2002) 1.05

Mitochondrial myopathy of childhood associated with mitochondrial DNA depletion and a homozygous mutation (T77M) in the TK2 gene. Arch Neurol (2003) 1.02

Sensory ataxic neuropathy due to a novel C10Orf2 mutation with probable germline mosaicism. Neurology (2005) 1.02

Inner ear defect similar to Alport's syndrome in the glomerulosclerosis mouse model Mpv17. Eur Arch Otorhinolaryngol (1996) 1.01

The clinical significance of the POLG gene polymorphism in male infertility. J Clin Endocrinol Metab (2004) 0.98

A novel ANT1 gene mutation with probable germline mosaicism in autosomal dominant progressive external ophthalmoplegia. Neuromuscul Disord (2005) 0.98

Is the CAG repeat of mitochondrial DNA polymerase gamma (POLG) associated with male infertility? A multi-centre French study. Hum Reprod (2005) 0.97

Amish lethal microcephaly: a new metabolic disorder with severe congenital microcephaly and 2-ketoglutaric aciduria. Am J Med Genet (2002) 0.95

Thymidine phosphorylase mutations cause instability of mitochondrial DNA. Gene (2005) 0.89

Mutation analysis in 16 patients with mtDNA depletion. Hum Mutat (2003) 0.88

A polymorphic polymerase. Brain (2006) 0.86

A third locus predisposing to multiple deletions of mtDNA in autosomal dominant progressive external ophthalmoplegia. Am J Hum Genet (1999) 0.85

Mitochondrial deoxyguanosine kinase mutations and mitochondrial DNA depletion syndrome. FEBS Lett (2003) 0.84