Published in Nucleosides Nucleotides Nucleic Acids on May 01, 2011
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. J Exp Med (2012) 1.16
Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation. J Biol Chem (2012) 1.12
Allosteric regulation of the human and mouse deoxyribonucleotide triphosphohydrolase sterile α-motif/histidine-aspartate domain-containing protein 1 (SAMHD1). J Biol Chem (2014) 0.91
Mitochondria and chloroplasts shared in animal and plant tissues: significance of communication. Med Sci Monit (2015) 0.87
Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications. Mol Cancer (2015) 0.86
Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine. Proc Natl Acad Sci U S A (2014) 0.81
Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1. J Antimicrob Chemother (2015) 0.77
Oxidative DNA damage stalls the human mitochondrial replisome. Sci Rep (2016) 0.76
Human Cytomegalovirus Can Procure Deoxyribonucleotides for Viral DNA Replication in the Absence of Retinoblastoma Protein Phosphorylation. J Virol (2016) 0.76
Heart mitochondrial TTP synthesis and the compartmentalization of TMP. J Biol Chem (2014) 0.76
Substrate Specificity of SAMHD1 Triphosphohydrolase Activity Is Controlled by Deoxyribonucleoside Triphosphates and Phosphorylation at Thr592. Biochemistry (2016) 0.75
A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells. Cell Death Differ (2017) 0.75
Effects of Zidovudine Treatment on Heart mRNA Expression and Mitochondrial DNA Copy Number Associated with Alterations in Deoxynucleoside Triphosphate Composition in a Neonatal Rat Model. Antimicrob Agents Chemother (2015) 0.75
Dual anti-HIV mechanism of clofarabine. Retrovirology (2016) 0.75
Correlated tissue expression of genes of cytoplasmic and mitochondrial nucleotide metabolisms in normal tissues is disrupted in transformed tissues. Nucleosides Nucleotides Nucleic Acids (2012) 0.75
Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA. PLoS Genet (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
On the origin of cancer cells. Science (1956) 49.55
Mitochondrial diseases in man and mouse. Science (1999) 11.67
Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature (2004) 11.59
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science (1999) 5.20
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet (2007) 4.99
Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Science (1999) 4.05
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet (1989) 3.69
Mitochondrial myopathy caused by long-term zidovudine therapy. N Engl J Med (1990) 3.52
Mitochondrial DNA in human malignancy. Mutat Res (2001) 2.87
Inherited mitochondrial diseases of DNA replication. Annu Rev Med (2008) 2.68
DNA precursor metabolism and genomic stability. FASEB J (2006) 2.25
Mitochondrial DNA polymerase-gamma and human disease. Hum Mol Genet (2006) 2.04
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci U S A (2001) 1.94
Myocardial density and composition: a basis for calculating intracellular metabolite concentrations. Am J Physiol Heart Circ Physiol (2003) 1.85
Quantitation of cellular deoxynucleoside triphosphates. Nucleic Acids Res (2009) 1.70
Mitochondrial DNA depletion syndromes--many genes, common mechanisms. Neuromuscul Disord (2010) 1.68
Toxicity of nucleoside analogues used to treat AIDS and the selectivity of the mitochondrial DNA polymerase. Biochemistry (2003) 1.67
DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity. Proc Natl Acad Sci U S A (2005) 1.67
Mitochondrial DNA depletion is a prevalent cause of multiple respiratory chain deficiency in childhood. J Pediatr (2007) 1.54
Deoxyribonucleotide pool imbalance stimulates deletions in HeLa cell mitochondrial DNA. J Biol Chem (2003) 1.52
Mitochondrial growth and division during the cell cycle in HeLa cells. J Cell Biol (1977) 1.45
Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy. J Biol Chem (2006) 1.35
Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate. Proc Natl Acad Sci U S A (2006) 1.34
Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases. Pharmacol Ther (2000) 1.32
Accumulation of point mutations in mitochondrial DNA of aging mice. Mutat Res (2003) 1.31
Mitochondrial deoxynucleotide pools in quiescent fibroblasts: a possible model for mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). J Biol Chem (2005) 1.31
Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells. J Biol Chem (1982) 1.28
Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance. Hum Mol Genet (2008) 1.26
Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity. Nucleic Acids Res (2008) 1.21
Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A (2006) 1.21
Mechanism of mitochondrial import of adenylate kinase isozymes. J Biochem (1998) 1.20
The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth. Mol Biol Cell (2007) 1.16
Characterization of a dCTP transport activity reconstituted from human mitochondria. J Biol Chem (1999) 1.14
Complications associated with NRTI therapy: update on clinical features and possible pathogenic mechanisms. Antivir Ther (2004) 1.11
Calcium content and distribution as a function of growth and transformation in the mouse 3T3 cell. J Cell Biol (1977) 1.09
Mitochondrial deoxyribonucleotides, pool sizes, synthesis, and regulation. J Biol Chem (2004) 1.08
Mitochondrial thymidine kinase and the enzymatic network regulating thymidine triphosphate pools in cultured human cells. J Biol Chem (2007) 1.03
3'-Azido-3'-deoxythymidine (AZT) is a competitive inhibitor of thymidine phosphorylation in isolated rat heart and liver mitochondria. Biochem Pharmacol (2006) 1.02
The nucleoside diphosphate kinase D (NM23-H4) binds the inner mitochondrial membrane with high affinity to cardiolipin and couples nucleotide transfer with respiration. J Biol Chem (2008) 1.02
Mitochondrial DNA depletion can be prevented by dGMP and dAMP supplementation in a resting culture of deoxyguanosine kinase-deficient fibroblasts. Hum Mol Genet (2003) 0.99
In vitro supplementation with dAMP/dGMP leads to partial restoration of mtDNA levels in mitochondrial depletion syndromes. Hum Mol Genet (2009) 0.97
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. J Biol Chem (2007) 0.95
Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency. Biochem Biophys Res Commun (2003) 0.95
Ribonucleotide reductase: evidence for specific association with HeLa cell mitochondria. Biochem Biophys Res Commun (1994) 0.92
Metabolic interrelations within guanine deoxynucleotide pools for mitochondrial and nuclear DNA maintenance. J Biol Chem (2008) 0.89
Interaction of NDPK-D with cardiolipin-containing membranes: Structural basis and implications for mitochondrial physiology. Biochimie (2009) 0.89
Mitochondrial deoxyribonucleotide pools in deoxyguanosine kinase deficiency. Mol Genet Metab (2008) 0.85
Effect of human basic fibroblast growth factor on fibroblast proliferation, cell volume, collagen lattice contraction: in comparison with acidic type. J Dermatol Sci (1996) 0.85
Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation. Genes Cells (2008) 0.84
Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts. FEBS J (2009) 0.84
Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion. Nucleosides Nucleotides Nucleic Acids (2010) 0.84
An analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitors. PLoS Comput Biol (2009) 0.83
Mitochondrial AZT metabolism. IUBMB Life (2006) 0.83
Growth dynamics of mitochondria in synchronized Chinese hamster cells. Biophys J (1972) 0.81
The role of mitochondrial dNTP levels in cells with reduced TK2 activity. Nucleosides Nucleotides Nucleic Acids (2006) 0.81
Deoxynucleoside salvage enzymes and tissue specific mitochondrial DNA depletion. Nucleosides Nucleotides Nucleic Acids (2010) 0.79
Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest (2003) 3.84
Pathogenic mitochondrial DNA mutations are common in the general population. Am J Hum Genet (2008) 3.56
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes. Nat Genet (2008) 2.82
What causes mitochondrial DNA deletions in human cells? Nat Genet (2008) 2.70
Universal heteroplasmy of human mitochondrial DNA. Hum Mol Genet (2012) 2.39
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet (2012) 1.94
Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations. Nat Genet (2011) 1.92
The diversity present in 5140 human mitochondrial genomes. Am J Hum Genet (2009) 1.90
Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model system. Hum Mutat (2011) 1.83
Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism? Lancet (2002) 1.65
Comparative study of exome copy number variation estimation tools using array comparative genomic hybridization as control. Biomed Res Int (2013) 1.61
Large scale comparison of gene expression levels by microarrays and RNAseq using TCGA data. PLoS One (2013) 1.61
Adult-onset spinocerebellar ataxia syndromes due to MTATP6 mutations. J Neurol Neurosurg Psychiatry (2012) 1.46
Epigenetics, epidemiology and mitochondrial DNA diseases. Int J Epidemiol (2012) 1.36
Depletion of mitochondrial DNA in leucocytes harbouring the 3243A->G mtDNA mutation. J Med Genet (2006) 1.34
The effect of strand bias in Illumina short-read sequencing data. BMC Genomics (2012) 1.34
Selection against pathogenic mtDNA mutations in a stem cell population leads to the loss of the 3243A-->G mutation in blood. Am J Hum Genet (2008) 1.32
MitoSeek: extracting mitochondria information and performing high-throughput mitochondria sequencing analysis. Bioinformatics (2013) 1.31
Three-stage quality control strategies for DNA re-sequencing data. Brief Bioinform (2013) 1.30
Comparing phylogeny and the predicted pathogenicity of protein variations reveals equal purifying selection across the global human mtDNA diversity. Am J Hum Genet (2011) 1.26
OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules. Hum Mol Genet (2010) 1.22
The distribution of mitochondrial DNA heteroplasmy due to random genetic drift. Am J Hum Genet (2008) 1.22
Previous estimates of mitochondrial DNA mutation level variance did not account for sampling error: comparing the mtDNA genetic bottleneck in mice and humans. Am J Hum Genet (2010) 1.10
A computational model of mitochondrial deoxynucleotide metabolism and DNA replication. Am J Physiol Cell Physiol (2005) 1.10
The use of next generation sequencing technology to study the effect of radiation therapy on mitochondrial DNA mutation. Mutat Res (2012) 1.09
Detecting new neurodegenerative disease genes: does phenotype accuracy limit the horizon? Trends Genet (2009) 1.07
A model of the nuclear control of mitochondrial DNA replication. J Theor Biol (2003) 1.07
Normal levels of wild-type mitochondrial DNA maintain cytochrome c oxidase activity for two pathogenic mitochondrial DNA mutations but not for m.3243A-->G. Am J Hum Genet (2007) 1.05
Mitochondrial DNA deletions are associated with non-B DNA conformations. Nucleic Acids Res (2012) 1.03
Evidence for variable selective pressures at a large secondary structure of the human mitochondrial DNA control region. Mol Biol Evol (2008) 1.02
What is influencing the phenotype of the common homozygous polymerase-γ mutation p.Ala467Thr? Brain (2012) 1.01
Mutation dependance of the mitochondrial DNA copy number in the first stages of human embryogenesis. Hum Mol Genet (2013) 0.96
Reassessing evidence for a postnatal mitochondrial genetic bottleneck. Nat Genet (2010) 0.94
Mitochondrial DNA rearrangements in health and disease--a comprehensive study. Hum Mutat (2013) 0.94
Poor correlations in the levels of pathogenic mitochondrial DNA mutations in polar bodies versus oocytes and blastomeres in humans. Am J Hum Genet (2011) 0.90
The evidence that the DNC (SLC25A19) is not the mitochondrial deoxyribonucleotide carrier. Mitochondrion (2008) 0.90
The length of cytochrome c oxidase-negative segments in muscle fibres in patients with mtDNA myopathy. Neuromuscul Disord (2002) 0.89
Evaluation of allele frequency estimation using pooled sequencing data simulation. ScientificWorldJournal (2013) 0.89
Discrete stochastic simulation methods for chemically reacting systems. Methods Enzymol (2009) 0.88
POLG mutations cause decreased mitochondrial DNA repopulation rates following induced depletion in human fibroblasts. Biochim Biophys Acta (2010) 0.87
No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Ann Rheum Dis (2012) 0.86
Alternative applications for distinct RNA sequencing strategies. Brief Bioinform (2014) 0.85
Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. J Neurovirol (2012) 0.85
Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384. J Acquir Immune Defic Syndr (2011) 0.85
Risk factors for symptomatic hyperlactatemia and lactic acidosis among combination antiretroviral therapy-treated adults in Botswana: results from a clinical trial. AIDS Res Hum Retroviruses (2012) 0.85
Evaluating purifying selection in the mitochondrial DNA of various mammalian species. PLoS One (2013) 0.85
Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication. PLoS Comput Biol (2011) 0.84
The other genome: a systematic review of studies of mitochondrial DNA haplogroups and outcomes of HIV infection and antiretroviral therapy. AIDS Rev (2013) 0.84
An analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitors. PLoS Comput Biol (2009) 0.83
Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected Black South Africans: a pilot study. AIDS Res Hum Retroviruses (2013) 0.82
Mitochondria sequence mapping strategies and practicability of mitochondria variant detection from exome and RNA sequencing data. Brief Bioinform (2015) 0.80
Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells. PLoS One (2012) 0.80
Epidermal nerve fiber density, oxidative stress, and mitochondrial haplogroups in HIV-infected Thais initiating therapy. AIDS (2014) 0.80
Polarization of superfluid turbulence. Phys Rev Lett (2002) 0.79
Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study. PLoS Comput Biol (2011) 0.79
A computational model of mitochondrial AZT metabolism. Biochem J (2005) 0.77
Multi-perspective quality control of Illumina RNA sequencing data analysis. Brief Funct Genomics (2016) 0.77
Analysis of enzyme kinetic data for mtDNA replication. Methods (2010) 0.77
T cell activation markers and African mitochondrial DNA haplogroups among non-Hispanic black participants in AIDS clinical trials group study 384. PLoS One (2012) 0.77
Unique mitochondrial DNA in highly inbred feral cattle. Mitochondrion (2012) 0.76
STRATEGIES FOR EQUITABLE PHARMACOGENOMIC-GUIDED WARFARIN DOSING AMONG EUROPEAN AND AFRICAN AMERICAN INDIVIDUALS IN A CLINICAL POPULATION. Pac Symp Biocomput (2016) 0.75
The effect of unhealthy β-cells on insulin secretion in pancreatic islets. BMC Med Genomics (2013) 0.75
Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble protein transcripts and ribosomal RNA are purine-rich. BMC Genomics (2005) 0.75
Correlated tissue expression of genes of cytoplasmic and mitochondrial nucleotide metabolisms in normal tissues is disrupted in transformed tissues. Nucleosides Nucleotides Nucleic Acids (2012) 0.75
Power and sample size calculations for high-throughput sequencing-based experiments. Brief Bioinform (2017) 0.75
Strategies for processing and quality control of Illumina genotyping arrays. Brief Bioinform (2017) 0.75
Evaporation of a packet of quantized vorticity. Phys Rev Lett (2002) 0.75