Published in PLoS Biol on October 01, 2007
Erythroblastic islands: niches for erythropoiesis. Blood (2008) 2.93
Global DNA demethylation during mouse erythropoiesis in vivo. Science (2011) 1.73
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia. Blood (2008) 1.72
Stress erythropoiesis: new signals and new stress progenitor cells. Curr Opin Hematol (2011) 1.68
Stat5 signaling specifies basal versus stress erythropoietic responses through distinct binary and graded dynamic modalities. PLoS Biol (2012) 1.59
A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol (2010) 1.58
Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein. J Biol Chem (2011) 1.54
Cell-cell interaction networks regulate blood stem and progenitor cell fate. Mol Syst Biol (2009) 1.49
Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia. Hematol Oncol Clin North Am (2010) 1.14
Identification and analysis of mouse erythroid progenitors using the CD71/TER119 flow-cytometric assay. J Vis Exp (2011) 1.11
β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies. Haematologica (2015) 1.06
Sublethal radiation injury uncovers a functional transition during erythroid maturation. Exp Hematol (2011) 1.05
Ineffective erythropoiesis in β -thalassemia. ScientificWorldJournal (2013) 1.01
Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response. PLoS One (2011) 1.00
Contrasting dynamic responses in vivo of the Bcl-xL and Bim erythropoietic survival pathways. Blood (2011) 0.93
Hematopoiesis and its disorders: a systems biology approach. Blood (2010) 0.93
GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis. Mol Cell Biol (2012) 0.91
Temperature control of fimbriation circuit switch in uropathogenic Escherichia coli: quantitative analysis via automated model abstraction. PLoS Comput Biol (2010) 0.91
DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia. J Biol Chem (2008) 0.82
Exploring the erythroblastic island. Nat Med (2013) 0.80
Pregnancy-secreted Acid phosphatase, uteroferrin, enhances fetal erythropoiesis. Endocrinology (2014) 0.76
Mathematical modeling reveals differential effects of erythropoietin on proliferation and lineage commitment of human hematopoietic progenitors in early erythroid culture. Haematologica (2015) 0.76
Erythropoietin-induced erythroid precursor pool depletion causes erythropoietin hyporesponsiveness. Pharm Res (2012) 0.75
Causal protein-signaling networks derived from multiparameter single-cell data. Science (2005) 34.28
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Structure and function of the feed-forward loop network motif. Proc Natl Acad Sci U S A (2003) 12.50
Effects of an Rb mutation in the mouse. Nature (1992) 11.06
Biological robustness. Nat Rev Genet (2004) 9.98
Inferring cellular networks using probabilistic graphical models. Science (2004) 9.91
The segment polarity network is a robust developmental module. Nature (2000) 9.28
Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol (2002) 9.17
Inferring genetic networks and identifying compound mode of action via expression profiling. Science (2003) 9.10
Programmed cell death in animal development. Cell (1997) 8.95
Robustness of cellular functions. Cell (2004) 6.65
Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood (2001) 6.35
Evolvability. Proc Natl Acad Sci U S A (1998) 6.34
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell (1991) 6.14
Reverse engineering of biological complexity. Science (2002) 6.06
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science (1995) 5.65
The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks. J Mol Biol (2003) 5.20
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood (2003) 4.91
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell (1995) 4.73
Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell (1999) 4.69
A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell (1990) 4.23
Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature (2002) 4.21
Feedback control of intercellular signalling in development. Nature (2000) 4.04
Inferring subnetworks from perturbed expression profiles. Bioinformatics (2001) 3.93
The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Br J Haematol (2000) 3.31
Untangling the wires: a strategy to trace functional interactions in signaling and gene networks. Proc Natl Acad Sci U S A (2002) 3.18
Computer simulations reveal properties of the cell-cell signaling network at the shoot apex in Arabidopsis. Proc Natl Acad Sci U S A (2006) 2.88
Robustness as a measure of plausibility in models of biochemical networks. J Theor Biol (2002) 2.48
E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell (2000) 2.21
Systems biology: its practice and challenges. Cell (2005) 2.20
Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev (1996) 2.18
Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver. Science (2001) 2.17
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood (2006) 2.16
Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover. J Cell Biol (1996) 2.14
Determination of causal connectivities of species in reaction networks. Proc Natl Acad Sci U S A (2002) 2.07
Connecting proliferation and apoptosis in development and disease. Nat Rev Mol Cell Biol (2004) 1.97
Bayesian network approach to cell signaling pathway modeling. Sci STKE (2002) 1.96
BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood (2004) 1.93
Gene networks: how to put the function in genomics. Trends Biotechnol (2002) 1.84
Apoptotic role of Fas/Fas ligand system in the regulation of erythropoiesis. Blood (1999) 1.54
Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. Bioinformatics (2004) 1.52
Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. Development (2002) 1.47
Live and let die: regulatory mechanisms in Fas-mediated apoptosis. Cell Signal (2003) 1.47
Regulatory principles of developmental signaling. Annu Rev Cell Dev Biol (2002) 1.45
On the deduction of chemical reaction pathways from measurements of time series of concentrations. Chaos (2001) 1.42
The vertebrate segmentation clock. Curr Opin Genet Dev (2004) 1.40
Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A (1996) 1.39
Programmed cell death of embryonic motoneurons triggered through the Fas death receptor. J Cell Biol (1999) 1.37
Death in the third dimension: apoptosis regulation and tissue architecture. Curr Opin Genet Dev (2004) 1.26
Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis. J Exp Med (2004) 1.17
Apoptosis. Death of a T cell. Nature (1995) 1.06
Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB. J Neurosci (1999) 1.05
Biological significance of MAPK, AKT and JAK-STAT protein activation by various erythropoietic factors in normal human early erythroid cells. Br J Haematol (2001) 1.01
Fas ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon gamma to produce erythroid cell apoptosis. Blood (1998) 1.01
Intercellular coupling amplifies fate segregation during Caenorhabditis elegans vulval development. Proc Natl Acad Sci U S A (2006) 1.00
Fas/FasL-mediated apoptosis in perinatal murine lungs. Am J Physiol Lung Cell Mol Physiol (2004) 0.96
Identification of an erythroid active element in the transferrin receptor gene. J Biol Chem (2000) 0.92
Homotypic signalling regulates Gata1 activity in the erythroblastic island. Development (2004) 0.89
Apoptosis in human embryo development: 3. Fas-induced apoptosis in brain primary cultures. J Cell Mol Med (2002) 0.84
The cellular basis for the defect in haemopoiesis in flexed-tailed mice. I. The nature and persistance of the defect. Br J Haematol (1966) 0.84
Fas ligand expression coincides with alveolar cell apoptosis in late-gestation fetal lung development. Am J Physiol Lung Cell Mol Physiol (2000) 0.84
Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3. Blood (2002) 0.82
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nat Biotechnol (2006) 30.90
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
FaST linear mixed models for genome-wide association studies. Nat Methods (2011) 6.52
The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nat Genet (2005) 6.22
Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy. J Urol (2010) 6.01
The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron (2006) 4.13
Genomic alterations in cultured human embryonic stem cells. Nat Genet (2005) 3.89
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell (2011) 3.78
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature (2007) 3.23
Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim Biophys Acta (2006) 3.10
Trajectory of performance status and symptom scores for patients with cancer during the last six months of life. J Clin Oncol (2011) 3.05
Information transduction capacity of noisy biochemical signaling networks. Science (2011) 2.95
A microfluidic chemostat for experiments with bacterial and yeast cells. Nat Methods (2005) 2.91
Human embryonic stem cells have a unique epigenetic signature. Genome Res (2006) 2.89
An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity (2011) 2.77
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev (2012) 2.70
Structure and function of a transcriptional network activated by the MAPK Hog1. Nat Genet (2008) 2.67
Binding of blood proteins to carbon nanotubes reduces cytotoxicity. Proc Natl Acad Sci U S A (2011) 2.66
Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14. Nat Med (2010) 2.58
Dynamic properties of network motifs contribute to biological network organization. PLoS Biol (2005) 2.58
Increasing hospital admission rates for urological complications after transrectal ultrasound guided prostate biopsy. J Urol (2013) 2.53
Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nat Med (2005) 2.46
Anatomical traits associated with absorption and mycorrhizal colonization are linked to root branch order in twenty-three Chinese temperate tree species. New Phytol (2008) 2.43
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci (2012) 2.35
Proliferation of prenatal ultrasonography. CMAJ (2010) 2.33
IScore: a risk score to predict death early after hospitalization for an acute ischemic stroke. Circulation (2011) 2.29
Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival. Invest Ophthalmol Vis Sci (2004) 2.27
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. Proc Natl Acad Sci U S A (2009) 2.25
Matrix nanotopography as a regulator of cell function. J Cell Biol (2012) 2.20
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. PLoS Genet (2012) 2.19
A document clustering and ranking system for exploring MEDLINE citations. J Am Med Inform Assoc (2007) 2.18
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood (2006) 2.16
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Mol Syst Biol (2007) 2.13
Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. J Biol Chem (2005) 2.08
Corneal immunity is mediated by heterogeneous population of antigen-presenting cells. J Leukoc Biol (2003) 2.08
Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Kidney Int (2013) 2.05
The corneal stroma is endowed with a significant number of resident dendritic cells. Invest Ophthalmol Vis Sci (2003) 2.05
Microengineered platforms for cell mechanobiology. Annu Rev Biomed Eng (2009) 2.02
Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small (2011) 2.00
Bis(acetato-κO)[1,2-bis-(2-pyridylmeth-oxy)benzene-κN,O,O',N']copper(II) monohydrate. Acta Crystallogr Sect E Struct Rep Online (2010) 1.94
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One (2011) 1.93
The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc Natl Acad Sci U S A (2008) 1.90
A novel GATA6 mutation in patients with tetralogy of Fallot or atrial septal defect. J Hum Genet (2010) 1.89
Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration. Dev Cell (2013) 1.89
Comparison of adenoviruses from species B, C, E, and F after intravenous delivery. Mol Ther (2007) 1.88
Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. Proc Natl Acad Sci U S A (2010) 1.85
Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways. J Neurosci (2005) 1.81
Novel characterization of MHC class II-negative population of resident corneal Langerhans cell-type dendritic cells. Invest Ophthalmol Vis Sci (2002) 1.80
Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression". Science (2005) 1.79
Understanding NF-kappaB signaling via mathematical modeling. Mol Syst Biol (2008) 1.79
Evolution of multi-drug resistant hepatitis B virus during sequential therapy. Hepatology (2006) 1.76
Addiction related alteration in resting-state brain connectivity. Neuroimage (2009) 1.76
Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001. Stem Cells Dev (2004) 1.75
A subset of methylated CpG sites differentiate psoriatic from normal skin. J Invest Dermatol (2011) 1.73
Global DNA demethylation during mouse erythropoiesis in vivo. Science (2011) 1.73
A cryptographic approach to securely share and query genomic sequences. IEEE Trans Inf Technol Biomed (2008) 1.71
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest (2012) 1.71
Imaging MALDI mass spectrometry using an oscillating capillary nebulizer matrix coating system and its application to analysis of lipids in brain from a mouse model of Tay-Sachs/Sandhoff disease. Anal Chem (2008) 1.69
Modeling the cell's guidance system. Sci STKE (2002) 1.68
Exercise and the metabolic syndrome with weight regain. J Appl Physiol (1985) (2010) 1.66
Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature (2013) 1.66
Population based study of long-term rates of surgery for urinary incontinence after radical prostatectomy for prostate cancer. J Urol (2012) 1.66
A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells. J Virol (2006) 1.65
Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research. Stem Cells (2007) 1.62
Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline. Am J Pathol (2003) 1.62
The lexical constituency model: some implications of research on Chinese for general theories of reading. Psychol Rev (2005) 1.61
catena-Poly[[bis-(nitrato-κO)copper(II)]-bis-[μ-1,4-bis-(pyridin-3-ylmeth-oxy)benzene-κN:N']]. Acta Crystallogr Sect E Struct Rep Online (2011) 1.61
T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B. J Hepatol (2010) 1.60
Noninvasive evaluation of coronary distensibility in older adults: a feasibility study with MR angiography. Radiology (2011) 1.60
A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells. Stem Cells (2009) 1.59
Assessing self-renewal and differentiation in human embryonic stem cell lines. Stem Cells (2005) 1.58
A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol (2010) 1.58
Identification of a Kir3.4 mutation in congenital long QT syndrome. Am J Hum Genet (2010) 1.57
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A (2013) 1.57
The coexistence of superconductivity and topological order in the Bi₂Se₃ thin films. Science (2012) 1.56
Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO(2) nanoparticles. Toxicology (2008) 1.56
Changes in sexual problems over time in women with and without early-stage breast cancer. Menopause (2010) 1.56
Semantic Similarity and Relatedness between Clinical Terms: An Experimental Study. AMIA Annu Symp Proc (2010) 1.56
Efficacy of contrast-enhanced US and magnetic microbubbles targeted to vascular cell adhesion molecule-1 for molecular imaging of atherosclerosis. Radiology (2011) 1.55
Structure of C3PO and mechanism of human RISC activation. Nat Struct Mol Biol (2011) 1.55
Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase. J Biol Chem (2003) 1.54
Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein. J Biol Chem (2011) 1.54
Mechanosensitivity of fibroblast cell shape and movement to anisotropic substratum topography gradients. Biomaterials (2009) 1.53
Mutations in the AXIN1 gene in advanced prostate cancer. Eur Urol (2008) 1.53
Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations. Bioinformatics (2003) 1.53
Self-organization in high-density bacterial colonies: efficient crowd control. PLoS Biol (2007) 1.52
Exome sequencing and unrelated findings in the context of complex disease research: ethical and clinical implications. Discov Med (2011) 1.52
Impact of metabolic syndrome on benign prostatic hyperplasia in elderly Chinese men. Urol Int (2014) 1.51
Use of MR cell tracking to evaluate targeting of glial precursor cells to inflammatory tissue by exploiting the very late antigen-4 docking receptor. Radiology (2012) 1.51
Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity. PLoS One (2011) 1.50
Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice. Stem Cells Dev (2007) 1.50
Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res (2009) 1.49
Targeted genomic sequencing identifies PRRT2 mutations as a cause of paroxysmal kinesigenic choreoathetosis. J Med Genet (2011) 1.49
Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods. Biomaterials (2010) 1.48
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity. J Immunol (2012) 1.48
Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand. Biochemistry (2006) 1.48