Published in Science on April 01, 2005
Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science (2009) 4.14
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. J Cell Biol (2006) 2.38
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor. Mol Syst Biol (2009) 2.10
A noisy paracrine signal determines the cellular NF-kappaB response to lipopolysaccharide. Sci Signal (2009) 1.91
Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles. PLoS One (2009) 1.81
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Minimal model of spiky oscillations in NF-kappaB signaling. Proc Natl Acad Sci U S A (2006) 1.68
Population robustness arising from cellular heterogeneity. Proc Natl Acad Sci U S A (2010) 1.66
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Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells. J Cell Sci (2010) 1.38
Stochastic regulation in early immune response. Biophys J (2005) 1.31
High content cell screening in a microfluidic device. Mol Cell Proteomics (2008) 1.29
Lessons from mathematically modeling the NF-κB pathway. Immunol Rev (2012) 1.22
Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription. PLoS Biol (2013) 1.08
High-throughput and single-cell imaging of NF-kappaB oscillations using monoclonal cell lines. BMC Cell Biol (2010) 1.06
Integrating computational and biochemical studies to explore mechanisms in NF-{kappa}B signaling. J Biol Chem (2008) 0.95
Oscillatory signaling processes: the how, the why and the where. Curr Opin Genet Dev (2010) 0.92
Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module. PLoS Comput Biol (2013) 0.90
Identification of a ligand-induced transient refractory period in nuclear factor-kappaB signaling. J Biol Chem (2008) 0.89
Dynamic effect of bortezomib on nuclear factor-kappaB activity and gene expression in tumor cells. Mol Pharmacol (2008) 0.89
Spontaneous NF-κB activation by autocrine TNFα signaling: a computational analysis. PLoS One (2013) 0.89
Using a microfluidic device for high-content analysis of cell signaling. Sci Signal (2009) 0.88
Single-cell variation leads to population invariance in NF-κB signaling dynamics. Mol Biol Cell (2014) 0.84
Wires in the soup: quantitative models of cell signaling. Trends Cell Biol (2008) 0.83
Roles of spatial parameters on the oscillation of nuclear NF-κB: computer simulations of a 3D spherical cell. PLoS One (2012) 0.82
Observing single cell NF-κB dynamics under stimulant concentration gradient. Anal Chem (2012) 0.82
Models at the single cell level. Wiley Interdiscip Rev Syst Biol Med (2010) 0.81
High-content screening in microfluidic devices. Expert Opin Drug Discov (2010) 0.78
Regulation of nuclear NF-κB oscillation by a diffusion coefficient and its biological implications. PLoS One (2014) 0.78
Statistical ensemble analysis for simulating extrinsic noise-driven response in NF-κB signaling networks. BMC Syst Biol (2013) 0.76
Clathrin complexes with the inhibitor kappa B kinase signalosome: imaging the interactome. Physiol Rep (2014) 0.75
IkappaB, NF-kappaB regulation model: simulation analysis of small number of molecules. EURASIP J Bioinform Syst Biol (2007) 0.75
Demystifying the cytokine network: Mathematical models point the way. Cytokine (2016) 0.75
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science (2004) 8.44
Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet (2004) 8.30
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J (2003) 3.93
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Oscillatory nucleocytoplasmic shuttling of the general stress response transcriptional activators Msn2 and Msn4 in Saccharomyces cerevisiae. J Cell Biol (2003) 1.81
Amplitude control of cell-cycle waves by nuclear import. Nat Cell Biol (2004) 1.07
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell (2009) 6.26
Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science (2005) 5.14
One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell (2004) 4.53
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell (2005) 4.30
A fourth IkappaB protein within the NF-kappaB signaling module. Cell (2007) 3.34
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature (2007) 3.23
Information transduction capacity of noisy biochemical signaling networks. Science (2011) 2.95
A microfluidic chemostat for experiments with bacterial and yeast cells. Nat Methods (2005) 2.91
Dynamic properties of network motifs contribute to biological network organization. PLoS Biol (2005) 2.58
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity (2005) 2.56
Fluorescence resonance energy transfer over approximately 130 basepairs in hyperstable lac repressor-DNA loops. Biophys J (2003) 2.42
IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. J Cell Biol (2006) 2.38
Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes Dev (2008) 2.29
Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev (2010) 2.26
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. Proc Natl Acad Sci U S A (2009) 2.25
CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Mol Cell (2003) 2.23
Matrix nanotopography as a regulator of cell function. J Cell Biol (2012) 2.20
Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc Natl Acad Sci U S A (2008) 2.20
Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol (2005) 2.18
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Mol Syst Biol (2007) 2.13
Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. J Biol Chem (2005) 2.08
Microengineered platforms for cell mechanobiology. Annu Rev Biomed Eng (2009) 2.02
Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem (2005) 2.01
A single NFκB system for both canonical and non-canonical signaling. Cell Res (2010) 1.88
NF-kappaB dictates the degradation pathway of IkappaBalpha. EMBO J (2008) 1.81
Understanding NF-kappaB signaling via mathematical modeling. Mol Syst Biol (2008) 1.79
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest (2012) 1.71
NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα. Mol Cell (2012) 1.68
Modeling the cell's guidance system. Sci STKE (2002) 1.68
IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature (2010) 1.68
Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell (2013) 1.61
Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet (2011) 1.58
Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity. Proc Natl Acad Sci U S A (2009) 1.56
Mechanosensitivity of fibroblast cell shape and movement to anisotropic substratum topography gradients. Biomaterials (2009) 1.53
Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations. Bioinformatics (2003) 1.53
Self-organization in high-density bacterial colonies: efficient crowd control. PLoS Biol (2007) 1.52
UV as an amplifier rather than inducer of NF-kappaB activity. Mol Cell (2008) 1.52
Use of MR cell tracking to evaluate targeting of glial precursor cells to inflammatory tissue by exploiting the very late antigen-4 docking receptor. Radiology (2012) 1.51
Focal epileptiform activity in the brain: detection with spike-related functional MR imaging--preliminary results. Radiology (2002) 1.50
Understanding the temporal codes of intra-cellular signals. Curr Opin Genet Dev (2010) 1.48
Crosstalk via the NF-kappaB signaling system. Cytokine Growth Factor Rev (2008) 1.48
Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. Nat Immunol (2012) 1.48
Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. J Biol Chem (2013) 1.48
Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol (2012) 1.47
A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues. Lab Chip (2008) 1.46
GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes Dev (2003) 1.46
Generation and activation of multiple dimeric transcription factors within the NF-kappaB signaling system. Mol Cell Biol (2008) 1.46
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev (2005) 1.45
The dynamics of signaling as a pharmacological target. Cell (2013) 1.45
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A (2009) 1.43
Human cerebrospinal fluid regulates proliferation and migration of stem cells through insulin-like growth factor-1. Stem Cells Dev (2015) 1.42
Diverse sensitivity thresholds in dynamic signaling responses by social amoebae. Sci Signal (2012) 1.41
Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proc Natl Acad Sci U S A (2009) 1.39
Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proc Natl Acad Sci U S A (2004) 1.39
Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy. Adv Funct Mater (2009) 1.39
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nat Chem Biol (2010) 1.35
A 3D Monte Carlo analysis of the role of dyadic space geometry in spark generation. Biophys J (2005) 1.34
Classification systems for tibial plateau fractures; does computed tomography scanning improve their reliability? Injury (2009) 1.33
ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK. PLoS One (2012) 1.29
Multiple signaling pathways regulate yeast cell death during the response to mating pheromones. Mol Biol Cell (2006) 1.29
High content cell screening in a microfluidic device. Mol Cell Proteomics (2008) 1.29
Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biol (2012) 1.29
Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis. Curr Biol (2008) 1.27
The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol Cell (2009) 1.26
Negative autoregulation by FAS mediates robust fetal erythropoiesis. PLoS Biol (2007) 1.25
Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures. Lab Chip (2009) 1.25
Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules. Proc Natl Acad Sci U S A (2011) 1.24
Lessons from mathematically modeling the NF-κB pathway. Immunol Rev (2012) 1.22
Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB. J Biol Chem (2013) 1.21
Stabilization of RelB requires multidomain interactions with p100/p52. J Biol Chem (2008) 1.21
Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proc Natl Acad Sci U S A (2010) 1.20
Lab-on-a-chip devices as an emerging platform for stem cell biology. Lab Chip (2010) 1.20
Synergistically enhanced osteogenic differentiation of human mesenchymal stem cells by culture on nanostructured surfaces with induction media. Biomacromolecules (2010) 1.18
The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50. Sci Signal (2011) 1.18
Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires. Nat Nanotechnol (2010) 1.18
A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. Sci Signal (2013) 1.17
Cell motility of neural stem cells is reduced after SPIO-labeling, which is mitigated after exocytosis. Magn Reson Med (2012) 1.16
Immortalized fibroblasts from NF-kappaB RelA knockout mice show phenotypic heterogeneity and maintain increased sensitivity to tumor necrosis factor alpha after transformation by v-Ras. Oncogene (2005) 1.15
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14
Robust and sensitive control of a quorum-sensing circuit by two interlocked feedback loops. Mol Syst Biol (2008) 1.14
The regulatory logic of the NF-kappaB signaling system. Cold Spring Harb Perspect Biol (2010) 1.13
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci U S A (2002) 1.13
The systems biology of glycosylation. Chembiochem (2004) 1.09
Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription. PLoS Biol (2013) 1.08
Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration. Integr Biol (Camb) (2012) 1.08
Systems biology. How information theory handles cell signaling and uncertainty. Science (2012) 1.08
Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Sci Signal (2012) 1.08