Published in J Mol Biol on August 23, 2007
Inhibition of transcription by platinum antitumor compounds. Metallomics (2009) 1.88
Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease. DNA Repair (Amst) (2008) 1.37
KRAS mutations in primary tumours and post-FOLFOX metastatic lesions in cases of colorectal cancer. Br J Cancer (2012) 1.16
Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models. J Ovarian Res (2013) 0.84
Non-specificity and synergy at the binding site of the carboplatin-induced DNA adduct via molecular dynamics simulations of the MutSα-DNA recognition complex. J Biomol Struct Dyn (2013) 0.83
Structural basis for the sequence-dependent effects of platinum-DNA adducts. Nucleic Acids Res (2009) 0.83
Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links. PLoS One (2011) 0.79
Sequence-specific recognition of cancer drug-DNA adducts by HMGB1a repair protein. Biophys J (2012) 0.78
Differences in conformational dynamics of [Pt3(HPTAB)]6+-DNA adducts with various cross-linking modes. Nucleic Acids Res (2009) 0.78
Oxaliplatin: pre-clinical perspectives on the mechanisms of action, response and resistance. Ecancermedicalscience (2009) 0.76
Atomic level rendering of DNA-drug encounter. Biophys J (2014) 0.75
Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells. Cancer Chemother Pharmacol (2011) 0.75
Changes in the in vitro activity of platinum drugs when administered in two aliquots. BMC Cancer (2016) 0.75
Disturbance of DNA conformation by the binding of testosterone-based platinum drugs via groove-face and intercalative interactions: a molecular dynamics simulation study. BMC Struct Biol (2013) 0.75
Investigations of the binding of [Pt2(DTBPA)Cl2](II) and [Pt2(TPXA)Cl2](II) to DNA via various cross-linking modes. Int J Mol Sci (2013) 0.75
Empirical force field for cisplatin based on quantum dynamics data: case study of new parameterization scheme for coordination compounds. J Mol Model (2015) 0.75
The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature (2000) 6.10
A modified version of the Cornell et al. force field with improved sugar pucker phases and helical repeat. J Biomol Struct Dyn (1999) 5.14
Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA. Nature (2000) 4.63
Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry (1997) 4.55
Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J (2000) 3.46
The role of DNA mismatch repair in platinum drug resistance. Cancer Res (1996) 2.88
Risk of second malignant neoplasms among long-term survivors of testicular cancer. J Natl Cancer Inst (1997) 2.83
Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res (1996) 2.37
Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins. Nature (1999) 2.35
HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. Proc Natl Acad Sci U S A (1994) 2.12
Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta. Biochemistry (2000) 1.75
2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex. Inorg Chem (2001) 1.71
hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents. Oncogene (1997) 1.67
In vitro and in vivo resistance to cisplatin in cells that have lost DNA mismatch repair. Cancer Res (1997) 1.50
Sequence- and region-specificity of oxaliplatin adducts in naked and cellular DNA. Mol Pharmacol (1998) 1.50
NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin. Biochemistry (1998) 1.48
The role of hMLH1, hMSH3, and hMSH6 defects in cisplatin and oxaliplatin resistance: correlation with replicative bypass of platinum-DNA adducts. Cancer Res (1998) 1.39
The role of DNA polymerase eta in translesion synthesis past platinum-DNA adducts in human fibroblasts. Cancer Res (2004) 1.30
Spectrum of cisplatin-induced mutations in Escherichia coli. Proc Natl Acad Sci U S A (1987) 1.28
Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor). Proc Natl Acad Sci U S A (1994) 1.22
Effect of the diaminocyclohexane carrier ligand on platinum adduct formation, repair, and lethality. Biochemistry (1990) 1.22
The efficiency and fidelity of translesion synthesis past cisplatin and oxaliplatin GpG adducts by human DNA polymerase beta. J Biol Chem (2000) 1.20
Effect of DNA polymerases and high mobility group protein 1 on the carrier ligand specificity for translesion synthesis past platinum-DNA adducts. Biochemistry (1999) 1.20
Structure and isomerization of an intrastrand cisplatin-cross-linked octamer DNA duplex by NMR analysis. Biochemistry (1995) 1.15
Is cisplatin a human carcinogen? J Natl Cancer Inst (1992) 1.11
The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast. Mutat Res (1996) 1.11
Molecular modeling of the intrastrand guanine-guanine DNA adducts produced by cisplatin and oxaliplatin. Mol Pharmacol (1999) 1.08
DNA sequence context and protein composition modulate HMG-domain protein recognition of cisplatin-modified DNA. Biochemistry (1997) 1.04
Mismatch extension ability of yeast and human DNA polymerase eta. J Biol Chem (2000) 1.03
Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases beta and eta in vitro. Biochemistry (2003) 1.01
Effects of spectator ligands on the specific recognition of intrastrand platinum-DNA cross-links by high mobility group box and TATA-binding proteins. J Biol Chem (2001) 1.01
Cisplatin-DNA adducts inhibit ribosomal RNA synthesis by hijacking the transcription factor human upstream binding factor. Biochemistry (1998) 1.00
MutS preferentially recognizes cisplatin- over oxaliplatin-modified DNA. J Biol Chem (2001) 0.99
Relationship of solution and protein-bound structures of DNA duplexes with the major intrastrand cross-link lesions formed on cisplatin binding to DNA. J Am Chem Soc (2001) 0.97
Characterization of adducts produced in DNA by isomeric 1,2-diaminocyclohexaneplatinum(II) complexes. Chem Biol Interact (1989) 0.96
NMR solution structure of an oxaliplatin 1,2-d(GG) intrastrand cross-link in a DNA dodecamer duplex. J Mol Biol (2004) 0.96
HMG-domain protein recognition of cisplatin 1,2-intrastrand d(GpG) cross-links in purine-rich sequence contexts. Biochemistry (2000) 0.95
Mutagenicity and genotoxicity of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum(II). Biochemistry (1993) 0.94
Solution structures of a DNA dodecamer duplex with and without a cisplatin 1,2-d(GG) intrastrand cross-link: comparison with the same DNA duplex containing an oxaliplatin 1,2-d(GG) intrastrand cross-link. Biochemistry (2007) 0.91
Spectrum of cis-diamminedichloroplatinum(II)-induced mutations in a shuttle vector propagated in human cells. Mol Carcinog (1991) 0.89
Comparative analysis of the mutagenic activity of oxaliplatin and cisplatin in the Hprt gene of CHO cells. Environ Mol Mutagen (2005) 0.87
Unrestrained 5 ns molecular dynamics simulation of a cisplatin-DNA 1,2-GG adduct provides a rationale for the NMR features and reveals increased conformational flexibility at the platinum binding site. J Mol Biol (2001) 0.87
TATA binding protein discriminates between different lesions on DNA, resulting in a transcription decrease. Mol Cell Biol (1998) 0.86
HMG1 protein inhibits the translesion synthesis of the major DNA cisplatin adduct by cell extracts. J Mol Biol (1997) 0.83
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell (2006) 3.11
Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function. Proc Natl Acad Sci U S A (2008) 3.08
Ab initio RNA folding by discrete molecular dynamics: from structure prediction to folding mechanisms. RNA (2008) 2.86
Eris: an automated estimator of protein stability. Nat Methods (2007) 2.78
Engineered allosteric activation of kinases in living cells. Nat Biotechnol (2010) 2.44
Spatial analysis of hemorrhagic fever with renal syndrome in China. BMC Infect Dis (2006) 2.42
The beta-subunit of the Arabidopsis G protein negatively regulates auxin-induced cell division and affects multiple developmental processes. Plant Cell (2003) 2.41
Emergence of protein fold families through rational design. PLoS Comput Biol (2006) 2.35
Ab initio folding of proteins with all-atom discrete molecular dynamics. Structure (2008) 2.22
Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J Mol Biol (2005) 2.19
Environmental factors contributing to the spread of H5N1 avian influenza in mainland China. PLoS One (2008) 2.14
The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission. Cell Host Microbe (2010) 2.13
Female-specific insect lethality engineered using alternative splicing. Nat Biotechnol (2007) 2.13
Use of mobile phones in an emergency reporting system for infectious disease surveillance after the Sichuan earthquake in China. Bull World Health Organ (2009) 2.11
Outcome of a workshop on applications of protein models in biomedical research. Structure (2009) 2.05
iFoldRNA: three-dimensional RNA structure prediction and folding. Bioinformatics (2008) 2.03
RNA-Puzzles: a CASP-like evaluation of RNA three-dimensional structure prediction. RNA (2012) 1.88
Brillouin corrosion expansion sensors for steel reinforced concrete structures using a fiber optic coil winding method. Sensors (Basel) (2011) 1.84
Spatio-temporal distribution of malaria in Yunnan Province, China. Am J Trop Med Hyg (2009) 1.81
Functional fingerprints of folds: evidence for correlated structure-function evolution. J Mol Biol (2003) 1.80
Texture analysis for mapping Tamarix parviflora using aerial photographs along the Cache Creek, California. Environ Monit Assess (2006) 1.75
The impacts of climate change and human activities on biogeochemical cycles on the Qinghai-Tibetan Plateau. Glob Chang Biol (2013) 1.69
Molecular dynamics simulation of the SH3 domain aggregation suggests a generic amyloidogenesis mechanism. J Mol Biol (2002) 1.66
Modeling backbone flexibility improves protein stability estimation. Structure (2007) 1.65
Automated minimization of steric clashes in protein structures. Proteins (2011) 1.64
Multiscale modeling of nucleosome dynamics. Biophys J (2006) 1.63
Multiple membrane-cytoplasmic domain contacts in the cystic fibrosis transmembrane conductance regulator (CFTR) mediate regulation of channel gating. J Biol Chem (2008) 1.62
On the significance of an RNA tertiary structure prediction. RNA (2010) 1.61
Mapping global cropland and field size. Glob Chang Biol (2015) 1.55
Direct molecular dynamics observation of protein folding transition state ensemble. Biophys J (2002) 1.55
The interface of protein structure, protein biophysics, and molecular evolution. Protein Sci (2012) 1.54
Mechanism for the alpha-helix to beta-hairpin transition. Proteins (2003) 1.51
Computational design of a PAK1 binding protein. J Mol Biol (2010) 1.51
Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Eukaryot Cell (2005) 1.50
Oxaliplatin: a review of evolving concepts. Cancer Invest (2002) 1.47
The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2004) 1.46
Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis. J Biol Chem (2009) 1.46
p53 and p21 regulate error-prone DNA repair to yield a lower mutation load. Mol Cell (2006) 1.44
Can contact potentials reliably predict stability of proteins? J Mol Biol (2004) 1.44
Simple but predictive protein models. Trends Biotechnol (2005) 1.39
RACK1 mediates multiple hormone responsiveness and developmental processes in Arabidopsis. J Exp Bot (2006) 1.37
MedusaScore: an accurate force field-based scoring function for virtual drug screening. J Chem Inf Model (2008) 1.37
Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface. PLoS Pathog (2013) 1.36
Native-like RNA tertiary structures using a sequence-encoded cleavage agent and refinement by discrete molecular dynamics. J Am Chem Soc (2009) 1.33
Coxsackievirus B3 mutator strains are attenuated in vivo. Proc Natl Acad Sci U S A (2012) 1.32
Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR. J Mol Biol (2010) 1.31
Design and implementation of a wireless sensor network-based remote water-level monitoring system. Sensors (Basel) (2011) 1.31
The role of DNA polymerase eta in translesion synthesis past platinum-DNA adducts in human fibroblasts. Cancer Res (2004) 1.30
Folding Trp-cage to NMR resolution native structure using a coarse-grained protein model. Biophys J (2004) 1.29
Spatial analysis of plague in California: niche modeling predictions of the current distribution and potential response to climate change. Int J Health Geogr (2009) 1.27
The Exo70 subunit of the exocyst is an effector for both Cdc42 and Rho3 function in polarized exocytosis. Mol Biol Cell (2009) 1.27
Fast complementation of split fluorescent protein triggered by DNA hybridization. Proc Natl Acad Sci U S A (2006) 1.26
Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse Cu, Zn superoxide dismutase mutants. Proc Natl Acad Sci U S A (2006) 1.25
Imprint of evolution on protein structures. Proc Natl Acad Sci U S A (2004) 1.24
Dynamical roles of metal ions and the disulfide bond in Cu, Zn superoxide dismutase folding and aggregation. Proc Natl Acad Sci U S A (2008) 1.23
Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP. J Am Chem Soc (2010) 1.23
The path of DNA in the kinetochore. Curr Biol (2006) 1.22
Rapid flexible docking using a stochastic rotamer library of ligands. J Chem Inf Model (2010) 1.21
Three-dimensional RNA structure refinement by hydroxyl radical probing. Nat Methods (2012) 1.20
Reconstruction of the src-SH3 protein domain transition state ensemble using multiscale molecular dynamics simulations. J Mol Biol (2005) 1.18
Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR. J Mol Biol (2012) 1.18
Protein folding: then and now. Arch Biochem Biophys (2007) 1.18
BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics. Mol Cell Proteomics (2008) 1.17
Folding of Cu, Zn superoxide dismutase and familial amyotrophic lateral sclerosis. J Mol Biol (2003) 1.17
Molecular origin of polyglutamine aggregation in neurodegenerative diseases. PLoS Comput Biol (2005) 1.17
Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences. PLoS Comput Biol (2010) 1.17
Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein. FASEB J (2012) 1.17
A monitoring system for vegetable greenhouses based on a wireless sensor network. Sensors (Basel) (2010) 1.16
Principles for understanding the accuracy of SHAPE-directed RNA structure modeling. Biochemistry (2013) 1.16
Arabidopsis N-MYC DOWNREGULATED-LIKE1, a positive regulator of auxin transport in a G protein-mediated pathway. Plant Cell (2009) 1.16
Hyperspectral characteristics of canopy components and structure for phenological assessment of an invasive weed. Environ Monit Assess (2006) 1.15
iFold: a platform for interactive folding simulations of proteins. Bioinformatics (2006) 1.15
Topological determinants of protein domain swapping. Structure (2006) 1.15
Discrete molecular dynamics: an efficient and versatile simulation method for fine protein characterization. J Phys Chem B (2012) 1.14
Robust and generic RNA modeling using inferred constraints: a structure for the hepatitis C virus IRES pseudoknot domain. Biochemistry (2010) 1.13
Deciphering protein dynamics from NMR data using explicit structure sampling and selection. Biophys J (2007) 1.13
Active nuclear receptors exhibit highly correlated AF-2 domain motions. PLoS Comput Biol (2008) 1.12
New insights into FAK signaling and localization based on detection of a FAT domain folding intermediate. Structure (2004) 1.11
The coordinated evolution of yeast proteins is constrained by functional modularity. Trends Genet (2006) 1.10
Combining spatial-temporal and phylogenetic analysis approaches for improved understanding on global H5N1 transmission. PLoS One (2010) 1.10
Diminished self-chaperoning activity of the DeltaF508 mutant of CFTR results in protein misfolding. PLoS Comput Biol (2008) 1.08
Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases. Pflugers Arch (2010) 1.08
Rational design of a ligand-controlled protein conformational switch. Proc Natl Acad Sci U S A (2013) 1.08
Fidelity of the protein structure reconstruction from inter-residue proximity constraints. J Phys Chem B (2007) 1.06
The complex molecular biology of amyotrophic lateral sclerosis (ALS). Prog Mol Biol Transl Sci (2012) 1.05
Fast screening of protein surfaces using geometric invariant fingerprints. Proc Natl Acad Sci U S A (2009) 1.05
Structural and dynamic determinants of protein-peptide recognition. Structure (2011) 1.04
Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles. Mol Ther (2012) 1.04
Structural determinants of skeletal muscle ryanodine receptor gating. J Biol Chem (2013) 1.03
Forest cover classification by optimal segmentation of high resolution satellite imagery. Sensors (Basel) (2011) 1.03
Insights into allosteric control of vinculin function from its large scale conformational dynamics. J Biol Chem (2006) 1.03
Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR. J Mol Biol (2008) 1.01
A single disulfide bond differentiates aggregation pathways of beta2-microglobulin. J Mol Biol (2005) 1.01
Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases beta and eta in vitro. Biochemistry (2003) 1.01
Topological and conformational analysis of the initiation and elongation complex of t7 RNA polymerase suggests a new twist. Biochemistry (2004) 1.01
Identification of a consensus motif in substrates bound by a Type I Hsp40. Proc Natl Acad Sci U S A (2009) 1.00
Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers. Biochemistry (2011) 1.00
Scaling behavior and structure of denatured proteins. Structure (2005) 1.00
Protein interactions with platinum-DNA adducts: from structure to function. J Inorg Biochem (2004) 1.00