Published in Front Neuroendocrinol on August 29, 2007
A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia. PLoS One (2010) 1.72
Association of short sleep duration with weight gain and obesity at 1-year follow-up: a large-scale prospective study. Sleep (2010) 1.66
Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men. Sleep (2013) 1.35
Sweet talk in the brain: glucosensing, neural networks, and hypoglycemic counterregulation. Front Neuroendocrinol (2009) 1.25
Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness. J Physiol (2009) 1.18
Ghrelin in central neurons. Curr Neuropharmacol (2009) 1.17
Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement. Psychopharmacology (Berl) (2010) 1.08
Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br J Pharmacol (2009) 1.07
Abnormal sleep-cardiovascular system interaction in narcolepsy with cataplexy: effects of hypocretin deficiency in humans. Sleep (2012) 1.06
The brain hypocretins and their receptors: mediators of allostatic arousal. Curr Opin Pharmacol (2009) 1.03
Central chemoreception in wakefulness and sleep: evidence for a distributed network and a role for orexin. J Appl Physiol (1985) (2010) 1.02
Practical use and risk of modafinil, a novel waking drug. Environ Health Toxicol (2012) 0.98
The pharmacology and molecular mechanisms underlying temperature regulation and torpor. Biochem Pharmacol (2008) 0.98
Molecular mechanisms of appetite regulation. Diabetes Metab J (2012) 0.97
The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle. Respir Physiol Neurobiol (2009) 0.97
Reconstructing mammalian sleep dynamics with data assimilation. PLoS Comput Biol (2012) 0.96
Elevated sleep quality and orexin receptor mRNA in obesity-resistant rats. Int J Obes (Lond) (2010) 0.95
Sleep and obesity: a focus on animal models. Neurosci Biobehav Rev (2012) 0.93
Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists. Bioorg Med Chem Lett (2011) 0.90
Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness. Sleep (2010) 0.89
A1 receptor mediated adenosinergic regulation of perifornical-lateral hypothalamic area neurons in freely behaving rats. Neuroscience (2010) 0.88
Integrating GHS into the Ghrelin System. Int J Pept (2010) 0.88
Projections of the suprachiasmatic nucleus and ventral subparaventricular zone in the Nile grass rat (Arvicanthis niloticus). Brain Res (2010) 0.86
Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor. J Med Chem (2013) 0.86
CSF levels of hypocretin-1 (orexin-A) peak during early infancy in humans. Sleep (2012) 0.86
Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep. Genetics (2012) 0.85
Orexin-A inputs onto visuomotor cell groups in the monkey brainstem. Neuroscience (2009) 0.85
Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation. Stroke (2013) 0.84
Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant. Psychopharmacology (Berl) (2010) 0.84
Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period. Behav Brain Res (2011) 0.84
A Path to Sleep Is through the Eye(1,2,3). eNeuro (2015) 0.83
Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol. Neurosci Lett (2008) 0.82
Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators. Front Neurosci (2013) 0.82
Cerebral and peripheral changes occurring in nitric oxide (NO) synthesis in a rat model of sleeping sickness: identification of brain iNOS expressing cells. PLoS One (2010) 0.82
Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil. Addict Biol (2015) 0.81
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol (2016) 0.81
Role of orexin in central regulation of gastrointestinal functions. J Gastroenterol (2008) 0.80
A physiologically based model of orexinergic stabilization of sleep and wake. PLoS One (2014) 0.80
Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism. Exp Mol Med (2016) 0.80
Objective assessment of drowsiness and reaction time during intermittent Ramadan fasting in young men: a case-crossover study. Behav Brain Funct (2013) 0.79
Endogenous orexin-A in the brain mediates 2-deoxy-D-glucose-induced stimulation of gastric motility in freely moving conscious rats. J Gastroenterol (2011) 0.79
Energy expenditure: role of orexin. Vitam Horm (2012) 0.79
Peptidomics methods for the identification of peptidase-substrate interactions. Curr Opin Chem Biol (2013) 0.78
Lack of hypocretin attenuates behavioral changes produced by glutamatergic activation of the perifornical-lateral hypothalamic area. Sleep (2014) 0.78
The effect of enteral and parenteral feeding on secretion of orexigenic peptides in infants. BMC Gastroenterol (2009) 0.78
GABAergic regulation of the perifornical-lateral hypothalamic neurons during non-rapid eye movement sleep in rats. Neuroscience (2010) 0.78
Hypocretin (orexin) regulates glutamate input to fast-spiking interneurons in layer V of the Fr2 region of the murine prefrontal cortex. Cereb Cortex (2013) 0.78
Nitric oxide production in the perifornical-lateral hypothalamic area and its influences on the modulation of perifornical-lateral hypothalamic area neurons. Neuroscience (2011) 0.76
Orexinergic system in the locus coeruleus modulates the CO2 ventilatory response. Pflugers Arch (2016) 0.76
Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep. eNeuro (2016) 0.75
Early improvement in obstructive sleep apnea and increase in orexin levels after bariatric surgery in adolescents and young adults. Surg Obes Relat Dis (2016) 0.75
Morphological and Physiological Interactions Between GnRH3 and Hypocretin/Orexin Neuronal Systems in Zebrafish (Danio rerio). Endocrinology (2016) 0.75
Fixed drug eruptions with modafinil. Indian J Pharmacol (2015) 0.75
Toll-Like Receptor 2 Is a Regulator of Circadian Active and Inactive State Consolidation in C57BL/6 Mice. Front Aging Neurosci (2017) 0.75
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Insect sex-pheromone signals mediated by specific combinations of olfactory receptors. Science (2005) 3.76
Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron (2003) 3.61
Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron (2003) 3.39
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci (2006) 2.84
Behavioral state instability in orexin knock-out mice. J Neurosci (2004) 2.56
Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci (2004) 2.13
Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron (2002) 2.08
Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev (2009) 2.02
Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. Cell Metab (2009) 1.88
The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders. Trends Neurosci (2009) 1.84
A role for Nr-CAM in the patterning of binocular visual pathways. Neuron (2006) 1.79
Elevated body temperature during sleep in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol (2006) 1.71
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology (2006) 1.67
Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice. PLoS One (2011) 1.66
Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Neurosci Lett (2005) 1.64
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat Genet (2011) 1.63
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A (2004) 1.61
Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. Neuron (2007) 1.58
Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. J Neurosci (2004) 1.55
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J Pharmacol Sci (2003) 1.48
Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A (2009) 1.44
Identification of receptors of main sex-pheromone components of three Lepidopteran species. Eur J Neurosci (2008) 1.42
Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology (2003) 1.39
Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury. J Clin Invest (2005) 1.39
Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia. Prog Neurobiol (2010) 1.36
Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. J Neurosci (2004) 1.35
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc Natl Acad Sci U S A (2003) 1.33
Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun (2002) 1.33
Identification of a population of sleep-active cerebral cortex neurons. Proc Natl Acad Sci U S A (2008) 1.32
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy. J Physiol (2007) 1.30
Ankyrin binding mediates L1CAM interactions with static components of the cytoskeleton and inhibits retrograde movement of L1CAM on the cell surface. J Cell Biol (2003) 1.30
Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ. J Neurosci (2012) 1.28
NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. Neuropsychopharmacology (2006) 1.24
Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci (2011) 1.23
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci (2004) 1.21
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. Biochem Biophys Res Commun (2004) 1.20
Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor. J Neurosci (2005) 1.20
Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem Biophys Res Commun (2003) 1.19
Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice. Eur J Neurosci (2004) 1.19
Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor. J Neurosci (2004) 1.17
Characterization of coronary fibrin thrombus in patients with acute coronary syndrome using dye-staining angioscopy. Arterioscler Thromb Vasc Biol (2011) 1.16
New developments in sleep research: molecular genetics, gene expression, and systems neurobiology. J Neurosci (2008) 1.14
IGFBP3 colocalizes with and regulates hypocretin (orexin). PLoS One (2009) 1.11
Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome. J Clin Invest (2010) 1.09
Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing. Neuron (2012) 1.08
Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function. J Neurosci (2014) 1.08
Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner. J Neurophysiol (2006) 1.08
The role of the ankyrin-binding protein NrCAM in node of Ranvier formation. J Neurosci (2003) 1.07
GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. J Physiol (2006) 1.06
Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status. CNS Drugs (2013) 1.06
Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice. J Neurosci (2011) 1.05
Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice. Am J Physiol Regul Integr Comp Physiol (2006) 1.04
MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth. Mol Biol Cell (2006) 1.03
NrCAM deletion causes topographic mistargeting of thalamocortical axons to the visual cortex and disrupts visual acuity. J Neurosci (2011) 1.02
Role of orexin in modulating arousal, feeding, and motivation. Front Behav Neurosci (2013) 1.01
Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice. PLoS One (2012) 1.01
Orexin neurons are indispensable for stress-induced thermogenesis in mice. J Physiol (2010) 1.01
A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc Natl Acad Sci U S A (2006) 1.01
Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice. Eur J Neurosci (2008) 1.01
Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. J Clin Invest (2008) 1.00
Linking white and grey matter in schizophrenia: oligodendrocyte and neuron pathology in the prefrontal cortex. Front Neuroanat (2009) 0.99
Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest (2014) 0.99
The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation. Cancer Res (2005) 0.97
Structure and function of the engineered multicopper oxidase CueO from Escherichia coli--deletion of the methionine-rich helical region covering the substrate-binding site. J Mol Biol (2007) 0.97
Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain. Brain Res (2006) 0.97
Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice. Brain Res (2008) 0.96
Primary structure of a Japanese lacquer tree laccase as a prototype enzyme of multicopper oxidases. J Inorg Biochem (2002) 0.96
Roles of glial cells in schizophrenia: possible targets for therapeutic approaches. Neurobiol Dis (2012) 0.96
Displays of paternal mouse pup retrieval following communicative interaction with maternal mates. Nat Commun (2013) 0.95
Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation. Biochem Biophys Res Commun (2007) 0.95
Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation. J Neurosci (2013) 0.95
The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus. J Biol Chem (2002) 0.95
Pheromone responsiveness threshold depends on temporal integration by antennal lobe projection neurons. Proc Natl Acad Sci U S A (2013) 0.93
Hypocretin/orexin neurons contribute to hippocampus-dependent social memory and synaptic plasticity in mice. J Neurosci (2013) 0.93
The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity. Mamm Genome (2012) 0.93
Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A (2009) 0.92
Bmal1 in the nervous system is essential for normal adaptation of circadian locomotor activity and food intake to periodic feeding. J Neurosci (2011) 0.91
Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1. J Biol Chem (2006) 0.91
Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity. Am J Med Genet B Neuropsychiatr Genet (2004) 0.91
Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis. Brain Res (2009) 0.90
Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. Sleep (2008) 0.90
Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons. J Neurosci (2009) 0.90
Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse. Biochem Biophys Res Commun (2008) 0.90
Monoaminergic neuronal changes in orexin deficient mice. Neuropharmacology (2009) 0.89
The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion. Results Probl Cell Differ (2008) 0.89
Vasopressin increases locomotion through a V1a receptor in orexin/hypocretin neurons: implications for water homeostasis. J Neurosci (2008) 0.89
Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models. Peptides (2006) 0.89
Attenuated phrenic long-term facilitation in orexin neuron-ablated mice. Respir Physiol Neurobiol (2009) 0.89
Neurotensin co-expressed in orexin-producing neurons in the lateral hypothalamus plays an important role in regulation of sleep/wakefulness states. PLoS One (2013) 0.89
Four-electron reduction of dioxygen by a multicopper oxidase, CueO, and roles of Asp112 and Glu506 located adjacent to the trinuclear copper center. J Biol Chem (2009) 0.87
Studies of interaction of homo-dimeric ferredoxin-NAD(P)+ oxidoreductases of Bacillus subtilis and Rhodopseudomonas palustris, that are closely related to thioredoxin reductases in amino acid sequence, with ferredoxins and pyridine nucleotide coenzymes. Biochim Biophys Acta (2008) 0.87
F3/contactin and TAG1 play antagonistic roles in the regulation of sonic hedgehog-induced cerebellar granule neuron progenitor proliferation. Development (2011) 0.87
Activation of orexin neurones after noxious but not conditioned fear stimuli in rats. Neuroreport (2002) 0.87
Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues. Biochem Biophys Res Commun (2005) 0.86
Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory. PLoS One (2011) 0.86
Loss of function studies in mice and genetic association link receptor protein tyrosine phosphatase α to schizophrenia. Biol Psychiatry (2011) 0.85
Enzymatic and spectroscopic studies on the activation or inhibition effects by substituted phenolic compounds in the oxidation of aryldiamines and catechols catalyzed by Rhus vernicifera laccase. J Inorg Biochem (2006) 0.85
GFP labeling of neurosecretory cells with the GAL4/UAS system in the silkmoth brain enables selective intracellular staining of neurons. Zoolog Sci (2008) 0.85