Published in Peptides on April 19, 2006
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy. J Physiol (2007) 1.30
Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls. Sleep (2009) 1.16
Food for thought: the role of appetitive peptides in age-related cognitive decline. Ageing Res Rev (2013) 0.97
Sleep and obesity: a focus on animal models. Neurosci Biobehav Rev (2012) 0.93
Animal models of narcolepsy. CNS Neurol Disord Drug Targets (2009) 0.85
Cerebrospinal fluid hypocretin 1 deficiency, overweight, and metabolic dysregulation in patients with narcolepsy. J Clin Sleep Med (2011) 0.84
Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested. BMC Med Genet (2008) 0.83
Animal models of sleep disorders. Comp Med (2013) 0.82
Sleep disorders, obesity, and aging: the role of orexin. Ageing Res Rev (2014) 0.81
Role of orexin receptors in obesity: from cellular to behavioral evidence. Int J Obes (Lond) (2012) 0.80
Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency. PLoS One (2015) 0.78
The impact of gender on timeliness of narcolepsy diagnosis. J Clin Sleep Med (2014) 0.77
Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice. PLoS One (2017) 0.75
Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 38.85
Leptin and the regulation of body weight in mammals. Nature (1998) 14.84
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell (1998) 12.66
Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci (1998) 9.88
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell (1999) 9.84
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell (1999) 7.99
Hypocretin (orexin) deficiency in human narcolepsy. Lancet (2000) 7.92
Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med (1995) 5.45
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron (2001) 5.09
Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron (2003) 3.61
Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci U S A (1999) 3.42
Molecular and anatomical determinants of central leptin resistance. Nat Neurosci (2005) 2.98
To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci (2001) 2.84
Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol (2001) 2.47
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci U S A (1999) 2.39
Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. J Neuroendocrinol (2003) 2.35
Increased body-mass index in patients with narcolepsy. Lancet (2000) 1.78
Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Neurosci Lett (2005) 1.64
Increased prevalence of obesity in narcoleptic patients and relatives. Eur Arch Psychiatry Clin Neurosci (2001) 1.36
The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol (1999) 1.28
The role of leptin in human physiology and pathophysiology. Physiol Res (2001) 1.22
Increased frequency of non-insulin-dependent diabetes mellitus among narcoleptic patients. Sleep (1986) 1.13
Reduction of plasma leptin levels and loss of its circadian rhythmicity in hypocretin (orexin)-deficient narcoleptic humans. J Clin Endocrinol Metab (2002) 1.11
Regulation of leptin production. Rev Endocr Metab Disord (2001) 1.01
Reduced leptin levels in human narcolepsy. Neuroendocrinology (2000) 0.95
Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus. Peptides (2002) 0.90
Serum leptin in obesity is related to gender and body fat topography but does not predict successful weight loss. Eur J Endocrinol (1997) 0.87
Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. Int J Mol Med (2002) 0.82
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science (2009) 4.92
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A (2008) 4.45
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci U S A (2003) 4.03
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol (2002) 4.03
Insect sex-pheromone signals mediated by specific combinations of olfactory receptors. Science (2005) 3.76
Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Med (2011) 3.66
Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron (2003) 3.61
Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature (2002) 3.60
Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci (2010) 3.50
Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron (2003) 3.39
The transcriptional repressor DEC2 regulates sleep length in mammals. Science (2009) 3.12
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A (2002) 2.93
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci (2006) 2.84
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron (2003) 2.73
Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention. J Clin Invest (2004) 2.66
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci (2008) 2.64
CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res (2002) 2.60
Behavioral state instability in orexin knock-out mice. J Neurosci (2004) 2.56
Attenuated defense response and low basal blood pressure in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol (2003) 2.45
Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models. J Neurosci (2009) 2.35
An essential role for orexins in emergence from general anesthesia. Proc Natl Acad Sci U S A (2008) 2.27
SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice. PLoS One (2008) 2.27
Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci (2004) 2.13
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance. J Clin Invest (2003) 2.11
Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron (2005) 2.11
The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker. Proc Natl Acad Sci U S A (2006) 2.11
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A (2013) 2.10
Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron (2002) 2.08
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A (2004) 2.08
Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol (2005) 2.04
Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev (2009) 2.02
Low blood pressure in endothelial cell-specific endothelin 1 knockout mice. Hypertension (2010) 1.91
Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci (2003) 1.89
Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. Cell Metab (2009) 1.88
Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner. Biol Psychiatry (2009) 1.87
The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders. Trends Neurosci (2009) 1.84
A role for Nr-CAM in the patterning of binocular visual pathways. Neuron (2006) 1.79
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy. Neuron (2012) 1.78
Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. Circulation (2010) 1.72
The narcoleptic borderland: a multimodal diagnostic approach including cerebrospinal fluid levels of hypocretin-1 (orexin A). Sleep Med (2003) 1.72
Elevated body temperature during sleep in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol (2006) 1.71
Endothelin: 20 years from discovery to therapy. Can J Physiol Pharmacol (2008) 1.69
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology (2006) 1.67
COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis. Proc Natl Acad Sci U S A (2009) 1.67
Pharmacogenetic modulation of orexin neurons alters sleep/wakefulness states in mice. PLoS One (2011) 1.66
Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Neurosci Lett (2005) 1.64
Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. Sleep (2010) 1.64
Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat Genet (2011) 1.63
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A (2004) 1.61
Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell (2013) 1.59
Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases. Neuron (2007) 1.58
Orexin neuronal circuitry: role in the regulation of sleep and wakefulness. Front Neuroendocrinol (2007) 1.57
Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology (2013) 1.55
Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. J Neurosci (2004) 1.55
Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion. Pain (2009) 1.54
Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature (2008) 1.54
Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide. J Clin Invest (2005) 1.53
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metab (2009) 1.51
Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. Am J Physiol Renal Physiol (2005) 1.49
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J Pharmacol Sci (2003) 1.48
Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A (2009) 1.44
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest (2003) 1.43
Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nat Neurosci (2002) 1.43
Identification of receptors of main sex-pheromone components of three Lepidopteran species. Eur J Neurosci (2008) 1.42
Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice. J Appl Physiol (1985) (2006) 1.42
Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology (2003) 1.39
Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury. J Clin Invest (2005) 1.39
Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia. Prog Neurobiol (2010) 1.36
Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. J Neurosci (2004) 1.35
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc Natl Acad Sci U S A (2003) 1.33
Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun (2002) 1.33
Identification of a population of sleep-active cerebral cortex neurons. Proc Natl Acad Sci U S A (2008) 1.32
Ankyrin binding mediates L1CAM interactions with static components of the cytoskeleton and inhibits retrograde movement of L1CAM on the cell surface. J Cell Biol (2003) 1.30
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy. J Physiol (2007) 1.30
Relationship between CSF hypocretin levels and hypocretin neuronal loss. Exp Neurol (2003) 1.28
Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy. Sleep (2012) 1.28
Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ. J Neurosci (2012) 1.28
Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects. Biol Psychiatry (2003) 1.27
Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications. Arch Neurol (2009) 1.27
Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt. Hypertension (2006) 1.26
NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice. Neuropsychopharmacology (2006) 1.24
A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2. J Biol Chem (2004) 1.24
Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci (2011) 1.23