Published in J Neurosci on October 03, 2007
Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One (2009) 1.53
The role of cytokines in UbD promoter regulation and Mallory-Denk body-like aggresomes. Exp Mol Pathol (2010) 1.18
Genome-wide analysis of gene expression in primate taste buds reveals links to diverse processes. PLoS One (2009) 1.11
Inflammation and taste disorders: mechanisms in taste buds. Ann N Y Acad Sci (2009) 1.02
Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences. J Comp Neurol (2009) 1.01
Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells. BMC Neurosci (2010) 1.00
Heterotrimeric G protein subunit Gγ13 is critical to olfaction. J Neurosci (2013) 0.94
Defects in the peripheral taste structure and function in the MRL/lpr mouse model of autoimmune disease. PLoS One (2012) 0.92
Taste bud homeostasis in health, disease, and aging. Chem Senses (2013) 0.90
Taste bud regeneration and the search for taste progenitor cells. Arch Ital Biol (2010) 0.89
Mechanisms of taste bud cell loss after head and neck irradiation. J Neurosci (2012) 0.89
Immune cells of the human peripheral taste system: dominant dendritic cells and CD4 T cells. Brain Behav Immun (2009) 0.86
Neutrophil responses to injury or inflammation impair peripheral gustatory function. Neuroscience (2010) 0.83
Expression and secretion of TNF-α in mouse taste buds: a novel function of a specific subset of type II taste cells. PLoS One (2012) 0.82
Functional role for interleukin-1 in the injured peripheral taste system. J Neurosci Res (2012) 0.82
Transcription profiling reveals potential mechanisms of dysbiosis in the oral microbiome of rhesus macaques with chronic untreated SIV infection. PLoS One (2013) 0.82
The T cells in peripheral taste tissue of healthy human adults: predominant memory T cells and Th-1 cells. Chem Senses (2010) 0.80
Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice. Neuroscience (2013) 0.79
Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds. J Neurosci (2014) 0.79
Regulation of bitter taste responses by tumor necrosis factor. Brain Behav Immun (2015) 0.79
Bmi1 essentially mediates podocalyxin-enhanced Cisplatin chemoresistance in oral tongue squamous cell carcinoma. PLoS One (2015) 0.77
AP1 transcription factors are required to maintain the peripheral taste system. Cell Death Dis (2016) 0.75
The effect of imiquimod on taste bud calcium transients and transmitter secretion. Br J Pharmacol (2016) 0.75
Symposium overview: Impact of oronasal inflammation on taste and smell. Ann N Y Acad Sci (2009) 0.75
β-catenin signaling induces the osteoblastogenic differentiation of human pre-osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression. Int J Mol Med (2015) 0.75
Anosmia and hypogeusia in Churg-Strauss syndrome. BMJ Case Rep (2014) 0.75
Associations Between Inflammation and Physical Function in African Americans and European Americans with Prevalent Cardiovascular Risk Factors. J Am Geriatr Soc (2016) 0.75
Whole transcriptome profiling of taste bud cells. Sci Rep (2017) 0.75
Cellular mechanisms of cyclophosphamide-induced taste loss in mice. PLoS One (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Inflammation and cancer. Nature (2002) 53.78
Inflammation and insulin resistance. J Clin Invest (2006) 18.76
STATs and gene regulation. Science (1997) 16.55
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (1995) 15.07
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A (1998) 13.39
Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature (2002) 12.09
Points of control in inflammation. Nature (2002) 10.61
A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry (1993) 7.78
Type I interferons (alpha/beta) in immunity and autoimmunity. Annu Rev Immunol (2005) 7.74
Type I interferons in host defense. Immunity (2006) 7.32
Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity (2006) 5.47
Complex modulation of cell type-specific signaling in response to type I interferons. Immunity (2006) 4.48
ATP signaling is crucial for communication from taste buds to gustatory nerves. Science (2005) 4.13
The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci U S A (2007) 4.01
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis (2003) 3.73
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell (1994) 3.56
Prevalence of olfactory impairment in older adults. JAMA (2002) 3.46
A weak signal for strong responses: interferon-alpha/beta revisited. Nat Rev Mol Cell Biol (2001) 3.39
The interferon system. A bird's eye view of its biochemistry. J Biol Chem (1992) 3.39
A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci (2002) 3.35
Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Immunity (2000) 3.07
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol Cell Biol (1997) 2.71
Renewal of cells within taste buds. J Cell Biol (1965) 2.54
Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock. Biochem Biophys Res Commun (2003) 2.37
Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg (1991) 2.34
"Type III" cells of rat taste buds: immunohistochemical and ultrastructural studies of neuron-specific enolase, protein gene product 9.5, and serotonin. J Comp Neurol (2001) 2.28
Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat Neurosci (1999) 2.23
Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain. Proc Natl Acad Sci U S A (2000) 2.20
Prevalence of olfactory dysfunction: the skövde population-based study. Laryngoscope (2004) 2.06
Smell and taste disorders: a primary care approach. Am Fam Physician (2000) 1.93
The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci (2006) 1.68
A study on the frequency of olfactory dysfunction. Laryngoscope (2004) 1.64
Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J (1995) 1.61
Geriatric cachexia: the role of cytokines. Am J Clin Nutr (1999) 1.54
Effect of inflammation on central nervous system development and vulnerability. Curr Opin Neurol (2005) 1.42
Interferon-gamma receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death. J Leukoc Biol (2001) 1.39
The effects of interferon-gamma on the central nervous system. Mol Neurobiol (1997) 1.35
The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases. Virology (1997) 1.26
Ultrastructure of mouse vallate taste buds. I. Taste cells and their associated synapses. J Comp Neurol (1985) 1.24
Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor. J Neurosci (2004) 1.23
Analysis of cell lineage relationships in taste buds. J Neurosci (2002) 1.23
Viral double-stranded RNA, cytokines, and the flu. J Interferon Cytokine Res (2000) 1.22
Biologic effects of interferons. J Invest Dermatol (1990) 1.20
Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 disability supplement to the National Health Interview Survey (NHIS). Ann N Y Acad Sci (1998) 1.20
Taste and smell perception affect appetite and immunity in the elderly. Eur J Clin Nutr (2000) 1.19
Alternate interferon signaling pathways. Pharmacol Ther (2003) 1.19
Interferon and the central nervous system. Eur J Pharmacol (2005) 1.17
Radiation and aging effect on taste structure and function. Radiat Res (1969) 1.15
Caspase-dependent and caspase-independent oligodendrocyte death mediated by AMPA and kainate receptors. J Neurosci (2003) 1.13
Clinical evaluation and symptoms of chemosensory impairment: one thousand consecutive cases from the Nasal Dysfunction Clinic in San Diego. Am J Rhinol (2006) 1.09
Prevalence and causes of severe taste loss in a chemosensory clinic population. Ann Otol Rhinol Laryngol (2003) 1.09
Safety and tolerance of recombinant interferon alfa-2a (Roferon-A) in cancer patients. Cancer (1986) 1.08
Cell types and lineages in taste buds. Chem Senses (2005) 1.08
Alpha-interferon and its effects on signal transduction pathways. J Cell Physiol (2005) 1.07
Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1. J Neurosci (2003) 1.06
Management of smell and taste problems. Cleve Clin J Med (2002) 1.04
Inhibition of E2F-mediated transcription by p202. EMBO J (1996) 1.02
Double-stranded RNA and interferon action. J Interferon Res (1987) 1.02
A review of drug-induced oral reactions. J Contemp Dent Pract (2003) 1.01
Biology of taste buds and the clinical problem of taste loss. Anat Rec (1998) 1.00
Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1. J Immunol (2002) 1.00
Gustatory function in chronic inflammatory middle ear diseases. Laryngoscope (2005) 0.99
Pathology of the olfactory mucosa: implications for the treatment of olfactory dysfunction. Laryngoscope (2004) 0.98
Hypogeusia, dysgeusia, hyposmia, and dysosmia following influenza-like infection. Ann Otol Rhinol Laryngol (1976) 0.97
Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis. J Biol Chem (2002) 0.97
Cloning and characterization of soluble and transmembrane isoforms of a novel component of the murine type I interferon receptor, IFNAR 2. J Biol Chem (1997) 0.95
The interferon receptors. Semin Oncol (1997) 0.94
Switching on of the proliferation or apoptosis of activated human T lymphocytes by IFN-gamma is correlated with the differential expression of the alpha- and beta-chains of its receptor. J Immunol (1996) 0.94
Quinine and citric acid elicit distinctive Fos-like immunoreactivity in the rat nucleus of the solitary tract. Am J Physiol Regul Integr Comp Physiol (2002) 0.93
Interferons and cell growth control. Histol Histopathol (2000) 0.91
Taste and smell complaints in HIV-infected patients. AIDS (1998) 0.90
Interferon (IFN)-gamma is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-gamma and tumour necrosis factor-alpha production. Br J Dermatol (2005) 0.90
Interferon-gamma and its functional receptors overexpression in benign prostatic hyperplasia and prostatic carcinoma: parallelism with c-myc and p53 expression. Eur Cytokine Netw (2000) 0.90
Diverse bitter stimuli elicit highly similar patterns of Fos-like immunoreactivity in the nucleus of the solitary tract. Chem Senses (2004) 0.90
Taste dysfunction in patients receiving radiotherapy. Head Neck (2006) 0.89
Endotoxin and mammalian host responses during experimental disease. J Comp Pathol (2006) 0.89
Aging effects on anatomy and neurophysiology of taste and smell. Gerodontology (1984) 0.88
The taste of sickness: lipopolysaccharide-induced finickiness in rats. Physiol Behav (2005) 0.87
Taste and smell losses in HIV infected patients. Physiol Behav (1995) 0.87
The interferon- and differentiation-inducible p202a protein inhibits the transcriptional activity of c-Myc by blocking its association with Max. J Biol Chem (2000) 0.86
p53 and Bax: putative death factors in taste cell turnover. J Comp Neurol (1999) 0.86
Early induction of proinflammatory cytokine and type I interferon mRNAs following Newcastle disease virus, poly [rI:rC], or low-dose LPS challenge of the mouse. J Interferon Cytokine Res (1997) 0.86
Disorders of smell and taste. Med Clin North Am (1999) 0.85
Synaptic proteins in rat taste bud cells: appearance in the Golgi apparatus and relationship to alpha-gustducin and the Lewis(b) and A antigens. J Comp Neurol (2000) 0.84
Odorant-dependent, spatially restricted induction of c-fos in the olfactory epithelium of the mouse. J Neurochem (2005) 0.83
Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells. J Biol Chem (2005) 0.82
The role of double-stranded RNA in induction of the acute-phase response in an abortive influenza virus infection model. J Infect Dis (1992) 0.82
Type I interferon and autoimmune disease. Autoimmunity (2003) 0.81
Anosmia induced with alpha interferon in a patient with chronic hepatitis C. Int J Clin Pharmacol Ther (2000) 0.81
Chemosensory dysfunction. Clinical evaluation results from a taste and smell clinic. Postgrad Med (1987) 0.81
Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression. Biochem J (2002) 0.80
Localization and functional investigation of the transcription factor CREB in taste receptor cells. Neuroreport (2002) 0.79
The increase in levels of interferon-inducible proteins p202a and p202b and RNA-dependent protein kinase (PKR) during myoblast differentiation is due to transactivation by MyoD: their tissue distribution in uninfected mice does not depend on interferons. J Interferon Cytokine Res (2002) 0.79
Histological and ultrastructural changes of the murine taste bud following ionizing irradiation. Ear Nose Throat J (1988) 0.79
Combined interferon and vinblastine treatment of advanced melanoma: evaluation of the treatment results and the effects of the treatment on immunological functions. Cancer Immunol Immunother (1989) 0.78
Interferon-gamma regulates apoptosis by releasing soluble tumor necrosis factor receptors in a gastric epithelial cell line. J Gastroenterol Hepatol (2002) 0.78
A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci (2002) 3.35
Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet (2005) 1.49
Human taste: peripheral anatomy, taste transduction, and coding. Adv Otorhinolaryngol (2006) 1.22
Inflammation and taste disorders: mechanisms in taste buds. Ann N Y Acad Sci (2009) 1.02
Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences. J Comp Neurol (2009) 1.01
Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells. BMC Neurosci (2010) 1.00
Bitter peptides activate hTAS2Rs, the human bitter receptors. Biochem Biophys Res Commun (2007) 0.99
Heterotrimeric G protein subunit Gγ13 is critical to olfaction. J Neurosci (2013) 0.94
No relationship between sequence variation in protein coding regions of the Tas1r3 gene and saccharin preference in rats. Chem Senses (2005) 0.94
Defects in the peripheral taste structure and function in the MRL/lpr mouse model of autoimmune disease. PLoS One (2012) 0.92
Cats lack a sweet taste receptor. J Nutr (2006) 0.91
Taste bud homeostasis in health, disease, and aging. Chem Senses (2013) 0.90
Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice. Mol Hum Reprod (2012) 0.90
Functional characterization of bitter-taste receptors expressed in mammalian testis. Mol Hum Reprod (2012) 0.90
Recent advances in olfactory receptor-based biosensors. Biosens Bioelectron (2012) 0.85
Expression and secretion of TNF-α in mouse taste buds: a novel function of a specific subset of type II taste cells. PLoS One (2012) 0.82
Bioengineered olfactory sensory neuron-based biosensor for specific odorant detection. Biosens Bioelectron (2012) 0.79
Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds. J Neurosci (2014) 0.79
Sarco/Endoplasmic reticulum Ca2+-ATPases (SERCA) contribute to GPCR-mediated taste perception. PLoS One (2011) 0.78
Tools for Investigating Functional Interactions Between Lipid-Derived Autacoids and their Receptors. Am J Ther (1996) 0.77
Symposium overview: Impact of oronasal inflammation on taste and smell. Ann N Y Acad Sci (2009) 0.75
A biomimetic bitter receptor-based biosensor with high efficiency immobilization and purification using self-assembled aptamers. Analyst (2013) 0.75
Characterization and expressional analysis of Dleu7 during Xenopus tropicalis embryogenesis. Gene (2012) 0.75