Neural drive to human genioglossus in obstructive sleep apnoea.

PubWeight™: 1.28‹?› | Rank: Top 10%

🔗 View Article (PMC 2375464)

Published in J Physiol on October 04, 2007

Authors

Julian P Saboisky1, Jane E Butler, David K McKenzie, Robert B Gorman, John A Trinder, David P White, Simon C Gandevia

Author Affiliations

1: Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW, 2031, Australia.

Articles citing this

Neurogenic changes in the upper airway of patients with obstructive sleep apnea. Am J Respir Crit Care Med (2011) 1.77

Metabolic activity of the tongue in obstructive sleep apnea. A novel application of FDG positron emission tomography imaging. Am J Respir Crit Care Med (2014) 1.43

Effects of aging on genioglossus motor units in humans. PLoS One (2014) 1.38

Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea. J Appl Physiol (1985) (2011) 1.24

Respiratory Movement of Upper Airway Tissue in Obstructive Sleep Apnea. Sleep (2013) 1.18

Discharge patterns of human genioglossus motor units during sleep onset. Sleep (2008) 1.16

Central and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol (2013) 1.10

The output from human inspiratory motoneurone pools. J Physiol (2007) 1.02

Recruitment and rate-coding strategies of the human genioglossus muscle. J Appl Physiol (1985) (2010) 1.01

Discharge patterns of human genioglossus motor units during arousal from sleep. Sleep (2010) 1.01

Hypoglossal nerve conduction findings in obstructive sleep apnea. Muscle Nerve (2010) 0.99

Activities of human genioglossus motor units. Respir Physiol Neurobiol (2011) 0.94

Potential therapeutic targets in obstructive sleep apnoea. Expert Opin Ther Targets (2009) 0.92

Upper Airway Stimulation for Obstructive Sleep Apnea: Past, Present, and Future. Sleep (2015) 0.90

Intermittent hypoxia, respiratory plasticity and sleep apnea in humans: present knowledge and future investigations. Respir Physiol Neurobiol (2013) 0.88

Functional role of neural injury in obstructive sleep apnea. Front Neurol (2012) 0.86

C/EBP homologous binding protein (CHOP) underlies neural injury in sleep apnea model. Sleep (2013) 0.86

Physiological mechanisms of upper airway hypotonia during REM sleep. Sleep (2014) 0.86

Corticomotor control of the genioglossus in awake OSAS patients: a transcranial magnetic stimulation study. Respir Res (2009) 0.83

Accurate and representative decoding of the neural drive to muscles in humans with multi-channel intramuscular thin-film electrodes. J Physiol (2015) 0.82

Human hypoglossal motor unit activities in exercise. J Physiol (2013) 0.82

A mechanism for upper airway stability during slow wave sleep. Sleep (2013) 0.81

Discharge patterns of human tensor palatini motor units during sleep onset. Sleep (2012) 0.79

Sleep-wake control of the upper airway by noradrenergic neurons, with and without intermittent hypoxia. Prog Brain Res (2014) 0.78

Pathophysiology & genetics of obstructive sleep apnoea. Indian J Med Res (2010) 0.77

Healthy humans with a narrow upper airway maintain patency during quiet breathing by dilating the airway during inspiration. J Physiol (2014) 0.77

Developmental changes in the morphology of mouse hypoglossal motor neurons. Brain Struct Funct (2015) 0.77

A comprehensive assessment of genioglossus electromyographic activity in healthy adults. J Neurophysiol (2015) 0.77

Lingual muscle activity across sleep-wake States in rats with surgically altered upper airway. Front Neurol (2014) 0.75

Tongue stiffness is lower in patients with obstructive sleep apnea during wakefulness compared with matched control subjects. Sleep (2015) 0.75

Catecholaminergic A1/C1 neurons contribute to the maintenance of upper airway muscle tone but may not participate in NREM sleep-related depression of these muscles. Respir Physiol Neurobiol (2017) 0.75

Articles cited by this

The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med (1993) 35.93

Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep (1999) 23.64

Pathogenesis of upper airway occlusion during sleep. J Appl Physiol Respir Environ Exerc Physiol (1978) 5.48

Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea. Am J Respir Crit Care Med (2003) 3.80

Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J Clin Invest (1992) 2.94

Insomnia with sleep apnea: a new syndrome. Science (1973) 2.62

Specificity of rabies virus as a transneuronal tracer of motor networks: transfer from hypoglossal motoneurons to connected second-order and higher order central nervous system cell groups. J Comp Neurol (1995) 2.45

Models of recruitment and rate coding organization in motor-unit pools. J Neurophysiol (1993) 2.41

Prevalence of sleep-disordered breathing in middle-aged Korean men and women. Am J Respir Crit Care Med (2004) 2.24

The human tongue during sleep: electromyographic activity of the genioglossus muscle. Exp Neurol (1976) 2.19

Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea. Am Rev Respir Dis (1991) 2.16

Coordination of intrinsic and extrinsic tongue muscles during spontaneous breathing in the rat. J Appl Physiol (1985) (2003) 2.16

Polygraphic study of the episodic diurnal and nocturnal (hypnic and respiratory) manifestations of the Pickwick syndrome. Brain Res (1966) 2.06

Genioglossal activation in patients with obstructive sleep apnea versus control subjects. Mechanisms of muscle control. Am J Respir Crit Care Med (2001) 1.98

Upper airway muscle inflammation and denervation changes in obstructive sleep apnea. Am J Respir Crit Care Med (2004) 1.75

Sleep-related breathing disorders, loud snoring and excessive daytime sleepiness in obese subjects. Int J Obes Relat Metab Disord (2001) 1.70

Pathological changes observed in the finger biopsy of patients with vibration-induced white finger. Scand J Work Environ Health (1986) 1.67

A neuromuscular mechanism maintaining extrathoracic airway patency. J Appl Physiol Respir Environ Exerc Physiol (1979) 1.62

Effect of co-activation of tongue protrudor and retractor muscles on tongue movements and pharyngeal airflow mechanics in the rat. J Physiol (1999) 1.60

Motor unit and muscle activity in voluntary motor control. Physiol Rev (1983) 1.55

Morphological analyses of the human tongue musculature for three-dimensional modeling. J Speech Lang Hear Res (2001) 1.55

Tonic and phasic respiratory drives to human genioglossus motoneurons during breathing. J Neurophysiol (2005) 1.51

Influence of sleep on genioglossus muscle activation by negative pressure in normal men. Am Rev Respir Dis (1993) 1.49

Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med (2000) 1.46

Motor control of the pharyngeal musculature and implications for the pathogenesis of obstructive sleep apnea. Sleep (1996) 1.46

Respiratory-related hypoglossal nerve activity: influence of anesthetics. J Appl Physiol Respir Environ Exerc Physiol (1983) 1.40

Heterogeneous activity of the human genioglossus muscle assessed by multiple bipolar fine-wire electrodes. J Appl Physiol (1985) (2003) 1.37

Patients with obstructive sleep apnea exhibit genioglossus dysfunction that is normalized after treatment with continuous positive airway pressure. Am J Respir Crit Care Med (1999) 1.37

Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea. Arch Otolaryngol Head Neck Surg (2001) 1.32

The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls. J Physiol (2005) 1.31

Muscle fibre type and habitual snoring. Lancet (1991) 1.30

Genioglossus premotoneurons and the negative pressure reflex in rats. J Physiol (2006) 1.28

Electrical stimulation of the lingual musculature in obstructive sleep apnea. J Appl Physiol (1985) (1996) 1.27

Differential activation among five human inspiratory motoneuron pools during tidal breathing. J Appl Physiol (1985) (2006) 1.24

Pharyngeal pressure and flow effects on genioglossus activation in normal subjects. Am J Respir Crit Care Med (2002) 1.24

Upper airway muscle activation is augmented in patients with obstructive sleep apnea compared with that in normal subjects. Am Rev Respir Dis (1988) 1.21

Histopathologic changes in snoring and obstructive sleep apnea syndrome. Laryngoscope (1991) 1.20

Phasic mechanoreceptor stimuli can induce phasic activation of upper airway muscles in humans. J Physiol (2001) 1.18

Activation of XII motoneurons and premotor neurons during various oropharyngeal behaviors. Respir Physiol Neurobiol (2005) 1.16

Respiratory pre-motor control of hypoglossal motoneurons in the rat. Neuroscience (2002) 1.14

Firing patterns of human genioglossus motor units during voluntary tongue movement. J Neurophysiol (2006) 1.13

Impact of obstructive apnea syndrome on upper airway respiratory muscles. Respir Physiol Neurobiol (2005) 1.12

Morphological features and activation patterns of motor units. J Clin Neurophysiol (1995) 1.12

The neural regulation of tongue movements. Prog Neurobiol (1980) 1.12

Discharge properties and recruitment of human diaphragmatic motor units during voluntary inspiratory tasks. J Physiol (1999) 1.09

Fluctuation in timing of upper airway and chest wall inspiratory muscle activity in obstructive sleep apnea. J Appl Physiol (1985) (1990) 1.09

Effects of increased ventilatory drive on motor unit firing rates in human inspiratory muscles. Am J Respir Crit Care Med (1999) 1.07

The effect of neuromuscular stimulation of the genioglossus on the hypopharyngeal airway. Laryngoscope (2002) 1.06

Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA. J Appl Physiol (1985) (2000) 1.05

A contribution to the study of the movements of the tongue in animals, with special reference to the cat. J Anat (1938) 1.03

Physiologic, metabolic, and muscle fiber type characteristics of musculus uvulae in sleep apnea hypopnea syndrome and in snorers. J Clin Invest (1995) 1.03

Amplitude cancellation reduces the size of motor unit potentials averaged from the surface EMG. J Appl Physiol (1985) (2006) 0.98

Characteristics of the genioglossus and musculus uvulae in sleep apnea hypopnea syndrome and in snorers. Am J Respir Crit Care Med (1996) 0.96

Sublingual electrical stimulation of the tongue during wakefulness and sleep. Respir Physiol (2001) 0.87

Pressure-diameter relationships of the upper airway in awake supine subjects. J Appl Physiol (1985) (1991) 0.86

Localization and contractile properties of intrinsic longitudinal motor units of the rat tongue. J Neurophysiol (2000) 0.86

New display of the timing and firing frequency of single motor units. J Neurosci Methods (2007) 0.83

Pattern of simulated snoring is different through mouth and nose. J Appl Physiol (1985) (1991) 0.82

Respiratory-related genioglossus electromyographic activity in response to head rotation and changes in body position. Angle Orthod (2000) 0.81

Nonvagal modulation of hypoglossal neural activity. Respiration (1992) 0.80

Articles by these authors

A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med (2003) 9.24

A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care (2003) 7.40

Obstructive sleep apnoea. Lancet (2002) 6.37

A prospective study of sleep duration and mortality risk in women. Sleep (2004) 6.11

Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation (2008) 5.87

Correlates of long sleep duration. Sleep (2006) 5.67

Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. J Am Coll Cardiol (2008) 4.78

Association between reduced sleep and weight gain in women. Am J Epidemiol (2006) 4.59

An algorithm for the safety of costal diaphragm electromyography derived from ultrasound. Muscle Nerve (2012) 4.46

History of the development of sleep medicine in the United States. J Clin Sleep Med (2005) 4.22

Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care Med (2013) 3.98

Neurobiology of exercise. Obesity (Silver Spring) (2006) 3.39

Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis. Arch Intern Med (2003) 2.95

Ventilatory control and airway anatomy in obstructive sleep apnea. Am J Respir Crit Care Med (2004) 2.70

The proprioceptive senses: their roles in signaling body shape, body position and movement, and muscle force. Physiol Rev (2012) 2.62

Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea. Am J Respir Crit Care Med (2005) 2.35

Retracted Anatomic and physiologic predictors of apnea severity in morbidly obese subjects. Sleep (2003) 2.34

A simplified method for determining phenotypic traits in patients with obstructive sleep apnea. J Appl Physiol (1985) (2013) 2.27

Sleep disorders, health, and safety in police officers. JAMA (2011) 2.16

Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold. Clin Sci (Lond) (2011) 2.08

A method for measuring and modeling the physiological traits causing obstructive sleep apnea. J Appl Physiol (1985) (2011) 2.01

The kinaesthetic senses. J Physiol (2009) 1.92

Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea. Am J Respir Crit Care Med (2014) 1.91

Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: The Apnea Positive Pressure Long-term Efficacy Study (APPLES). Sleep (2012) 1.91

Effect of oxygen in obstructive sleep apnea: role of loop gain. Respir Physiol Neurobiol (2008) 1.90

A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions. J Appl Physiol (1985) (2007) 1.90

Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea. J Physiol (2012) 1.85

Experimental muscle pain changes feedforward postural responses of the trunk muscles. Exp Brain Res (2003) 1.83

Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea. Am J Respir Crit Care Med (2014) 1.83

Supraspinal fatigue does not explain the sex difference in muscle fatigue of maximal contractions. J Appl Physiol (1985) (2006) 1.77

Neurogenic changes in the upper airway of patients with obstructive sleep apnea. Am J Respir Crit Care Med (2011) 1.77

Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation. Sleep (2004) 1.75

The male predisposition to pharyngeal collapse: importance of airway length. Am J Respir Crit Care Med (2002) 1.70

Cost-effectiveness of continuous positive airway pressure therapy for moderate to severe obstructive sleep apnea/hypopnea. Arch Intern Med (2006) 1.68

Resistance training for strength: effect of number of sets and contraction speed. Med Sci Sports Exerc (2005) 1.67

Depression is associated with worse objectively and subjectively measured sleep, but not more frequent awakenings, in women with vasomotor symptoms. Menopause (2009) 1.67

Abdominal muscle training can enhance cough after spinal cord injury. Neurorehabil Neural Repair (2013) 1.67

The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep. Sleep (2003) 1.64

Use of motor cortex stimulation to measure simultaneously the changes in dynamic muscle properties and voluntary activation in human muscles. J Appl Physiol (1985) (2007) 1.63

Panic attacks and perception of inspiratory resistive loads in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 1.62

Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis. Sleep (2004) 1.62

Genioglossus muscle responsiveness to chemical and mechanical stimuli during non-rapid eye movement sleep. Am J Respir Crit Care Med (2002) 1.60

Intra-abdominal pressure increases stiffness of the lumbar spine. J Biomech (2005) 1.60

Contralateral effects of unilateral strength training: evidence and possible mechanisms. J Appl Physiol (1985) (2006) 1.58

Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans. Thorax (2007) 1.58

Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable. Proc Am Thorac Soc (2007) 1.56

Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse. Am J Med (2006) 1.56

The influence of aging on pharyngeal collapsibility during sleep. Chest (2007) 1.55

Adverse effects of induced hot flashes on objectively recorded and subjectively reported sleep: results of a gonadotropin-releasing hormone agonist experimental protocol. Menopause (2013) 1.54

Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea. Sleep (2009) 1.54

The response to paired motor cortical stimuli is abolished at a spinal level during human muscle fatigue. J Physiol (2009) 1.53

The Apnea Positive Pressure Long-term Efficacy Study (APPLES): rationale, design, methods, and procedures. J Clin Sleep Med (2006) 1.52

Deep and superficial fibers of the lumbar multifidus muscle are differentially active during voluntary arm movements. Spine (Phila Pa 1976) (2002) 1.52

Water-based exercise in COPD with physical comorbidities: a randomised controlled trial. Eur Respir J (2012) 1.52

Tonic and phasic respiratory drives to human genioglossus motoneurons during breathing. J Neurophysiol (2005) 1.51

The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility. J Appl Physiol (1985) (2009) 1.48

The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol (2004) 1.47

High-frequency submaximal stimulation over muscle evokes centrally generated forces in human upper limb skeletal muscles. J Appl Physiol (1985) (2008) 1.47

Termination of respiratory events with and without cortical arousal in obstructive sleep apnea. Am J Respir Crit Care Med (2011) 1.46

Changes in segmental and motor cortical output with contralateral muscle contractions and altered sensory inputs in humans. J Neurophysiol (2003) 1.43

A novel adaptive wrist actigraphy algorithm for sleep-wake assessment in sleep apnea patients. Sleep (2004) 1.42

Evidence for a supraspinal contribution to human muscle fatigue. Clin Exp Pharmacol Physiol (2006) 1.42

Assessment of a wrist-worn device in the detection of obstructive sleep apnea. Sleep Med (2003) 1.42

Interrater reliability of drug-induced sleep endoscopy. Arch Otolaryngol Head Neck Surg (2010) 1.39

Continuous positive airway pressure versus the mandibular advancing splint: are they equally effective in obstructive sleep apnea management? Am J Respir Crit Care Med (2013) 1.38

The current prevalence of sleep disordered breathing in congestive heart failure patients treated with beta-blockers. J Clin Sleep Med (2008) 1.37

Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea. J Appl Physiol (1985) (2005) 1.37

Serotonin receptor subtypes required for ventilatory long-term facilitation and its enhancement after chronic intermittent hypoxia in awake rats. Am J Physiol Regul Integr Comp Physiol (2003) 1.36

Hyperthermia: a failure of the motor cortex and the muscle. J Physiol (2004) 1.35

Constraints for control of the human hand. J Physiol (2011) 1.33

Genioglossus activity during sleep in normal control subjects and children with obstructive sleep apnea. Am J Respir Crit Care Med (2004) 1.33

Proprioceptive signals contribute to the sense of body ownership. J Physiol (2011) 1.32

The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls. J Physiol (2005) 1.31

Postural effects on pharyngeal protective reflex mechanisms. Sleep (2004) 1.30

Chronic intermittent hypoxia enhances ventilatory long-term facilitation in awake rats. J Appl Physiol (1985) (2003) 1.29

Genioglossus premotoneurons and the negative pressure reflex in rats. J Physiol (2006) 1.28

Resolving head rotation for human bipedalism. Curr Biol (2006) 1.27

The ipsilateral motor cortex contributes to cross-limb transfer of performance gains after ballistic motor practice. J Physiol (2009) 1.27

Behaviour of the motoneurone pool in a fatiguing submaximal contraction. J Physiol (2011) 1.24

Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing. Sleep (2004) 1.24

Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease. Mol Cancer Ther (2004) 1.24

Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea. J Appl Physiol (1985) (2011) 1.24

Differential activation among five human inspiratory motoneuron pools during tidal breathing. J Appl Physiol (1985) (2006) 1.24

Pharyngeal pressure and flow effects on genioglossus activation in normal subjects. Am J Respir Crit Care Med (2002) 1.24

Fatigue-sensitive afferents inhibit extensor but not flexor motoneurons in humans. J Neurosci (2006) 1.22

Genioglossal muscle response to CO2 stimulation during NREM sleep. Sleep (2006) 1.21