PubRank

Wayne W Hancock

Author PubWeight™ 125.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 2007 6.61
2 Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005 5.02
3 Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med 2003 4.12
4 FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A 2007 3.32
5 Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med 2005 3.17
6 Helios expression is a marker of T cell activation and proliferation. PLoS One 2011 2.55
7 TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 2003 2.36
8 Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat Rev Drug Discov 2009 2.00
9 PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest 2006 1.93
10 Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J Biol Chem 2006 1.84
11 Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol 2011 1.82
12 Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology 2009 1.81
13 Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression. J Immunol 2009 1.72
14 Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Sci Signal 2012 1.71
15 Programmed death-1 targeting can promote allograft survival. J Immunol 2002 1.68
16 Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet 2008 1.66
17 TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A 2008 1.65
18 Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J Immunol 2005 1.55
19 Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol Cell Biol 2011 1.53
20 BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice. J Leukoc Biol 2009 1.53
21 Improved renal ischemia tolerance in females influences kidney transplantation outcomes. J Clin Invest 2016 1.51
22 Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction. Am J Respir Crit Care Med 2014 1.51
23 Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol 2006 1.51
24 Noninvasive detection of renal allograft inflammation by measurements of mRNA for IP-10 and CXCR3 in urine. Kidney Int 2004 1.48
25 Safety and efficacy of a calcineurin inhibitor avoidance regimen in pediatric renal transplantation. J Am Soc Nephrol 2006 1.45
26 BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol 2004 1.44
27 Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol 2008 1.41
28 Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells. J Immunol 2003 1.40
29 Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. Am J Pathol 2007 1.38
30 Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol 2004 1.33
31 Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J Clin Invest 2014 1.33
32 B7-H3 promotes acute and chronic allograft rejection. Eur J Immunol 2005 1.31
33 Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs. Clin Immunol 2010 1.30
34 Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice. Kidney Int 2004 1.24
35 Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Curr Opin Immunol 2010 1.23
36 Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis. Exp Mol Pathol 2009 1.22
37 Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibody. Transplantation 2008 1.22
38 Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant 2003 1.21
39 Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. Immunol Cell Biol 2009 1.20
40 Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells. Curr Opin Immunol 2011 1.17
41 Regulatory T cell expression of herpesvirus entry mediator suppresses the function of B and T lymphocyte attenuator-positive effector T cells. J Immunol 2008 1.15
42 Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. J Immunol 2003 1.15
43 Histone/protein deacetylases and T-cell immune responses. Blood 2012 1.14
44 Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep 2012 1.14
45 Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Transplantation 2005 1.13
46 Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood 2006 1.12
47 Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol 2003 1.12
48 Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival. J Exp Med 2002 1.10
49 Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance. Eur J Immunol 2007 1.10
50 Substrate rigidity regulates human T cell activation and proliferation. J Immunol 2012 1.09
51 Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse. Diabetes 2006 1.05
52 TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol 2003 1.03
53 Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity. Nat Med 2013 1.02
54 The mitochondrial and kidney disease phenotypes of kd/kd mice under germfree conditions. J Autoimmun 2005 1.01
55 Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival. Am J Transplant 2004 1.00
56 Differential expression of profibrotic and growth factors in chronic allograft nephropathy. Transplantation 2006 0.99
57 Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function. PLoS One 2012 0.97
58 Foxp3 processing by proprotein convertases and control of regulatory T cell function. J Biol Chem 2008 0.97
59 CXCR3+CD4+ T cells mediate innate immune function in the pathophysiology of liver ischemia/reperfusion injury. J Immunol 2006 0.97
60 Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression. Curr Opin Immunol 2007 0.94
61 Serum cytokine profiles associated with early allograft dysfunction in patients undergoing liver transplantation. Liver Transpl 2012 0.93
62 Mbd2 promotes foxp3 demethylation and T-regulatory-cell function. Mol Cell Biol 2013 0.92
63 Coinhibitory T-cell signaling in islet allograft rejection and tolerance. Cell Transplant 2006 0.92
64 Foxp3+ T-regulatory cells require DNA methyltransferase 1 expression to prevent development of lethal autoimmunity. Blood 2013 0.92
65 The cyclin-dependent kinase inhibitor p27kip1 is required for transplantation tolerance induced by costimulatory blockade. J Immunol 2006 0.91
66 Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells. J Med Chem 2012 0.91
67 Glomerular and tubular epithelial defects in kd/kd mice lead to progressive renal failure. Am J Nephrol 2005 0.91
68 Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2. Transplantation 2002 0.90
69 Enforced c-REL deficiency prolongs survival of islet allografts1. Transplantation 2002 0.89
70 FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest 2015 0.89
71 Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway. J Immunol 2005 0.89
72 Resistance of Foxp3+ regulatory T cells to Nur77-induced apoptosis promotes allograft survival. PLoS One 2008 0.89
73 Chemokines and transplant immunobiology. J Am Soc Nephrol 2002 0.89
74 Pirfenidone inhibits T-cell activation, proliferation, cytokine and chemokine production, and host alloresponses. Transplantation 2009 0.87
75 Regulating regulatory T cells to achieve transplant tolerance. Hepatobiliary Pancreat Dis Int 2007 0.87
76 Histone deacetylase inhibitors and transplantation. Curr Opin Immunol 2007 0.87
77 Cyclin-dependent kinase 2 controls peripheral immune tolerance. J Immunol 2012 0.86
78 Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J Clin Invest 2011 0.85
79 Normalization of brain death-induced injury to rat renal allografts by recombinant soluble P-selectin glycoprotein ligand. J Am Soc Nephrol 2002 0.85
80 Cyclophosphamide modulates CD4+ T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8+ T cells in secondary progressive multiple sclerosis. J Neuroimmunol 2004 0.83
81 Anti-CD28 monoclonal antibody therapy prevents chronic rejection of renal allografts in rats. J Am Soc Nephrol 2002 0.83
82 Negative and positive co-signaling with anti-BTLA (PJ196) and CTLA4Ig prolongs islet allograft survival. Transplantation 2007 0.81
83 Viral IL-10 gene transfer inhibits the expression of multiple chemokine and chemokine receptor genes induced by inflammatory or adaptive immune stimuli. Am J Transplant 2003 0.80
84 Selectin inhibitor bimosiamose prolongs survival of kidney allografts by reduction in intragraft production of cytokines and chemokines. J Am Soc Nephrol 2004 0.80
85 Indoleamine 2,3-dioxygenase and metabolites protect murine lung allografts and impair the calcium mobilization of T cells. Am J Respir Cell Mol Biol 2012 0.79
86 Regulatory allospecific T cell clones abrogate chronic allograft rejection. J Am Soc Nephrol 2009 0.78
87 Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function. Cell Cycle 2012 0.78
88 Selectin blockade plus therapy with low-dose sirolimus and cyclosporin a prevent brain death-induced renal allograft dysfunction. Am J Transplant 2005 0.78
89 Donor hypertension increases graft immunogenicity and intensifies chronic changes in long-surviving renal allografts. Transplantation 2004 0.78
90 Early and late injury to renal transplants from non-heart-beating donors. Transplantation 2002 0.77
91 Recipient hypertension potentiates chronic functional and structural injury of rat renal allografts. Transplantation 2002 0.77
92 Inhibitory effects of pirfenidone on dendritic cells and lung allograft rejection. Transplantation 2012 0.77
93 Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells. J Immunol 2006 0.77
94 Heat shock protein 70 is required for optimal liver regeneration after partial hepatectomy in mice. Liver Transpl 2014 0.76
95 Strategies to cure experimental autoimmune colitis using antigen-specific Foxp3+ regulatory T cells. Gastroenterology 2008 0.76
96 FOXP3⁺ regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest 2015 0.75
97 Immunogenetics and transplantation. Curr Opin Immunol 2011 0.75
98 Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop. JCI Insight 2017 0.75