Published in Mol Cell Biol on January 03, 2011
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Essential role of mitochondrial energy metabolism in Foxp3⁺ T-regulatory cell function and allograft survival. FASEB J (2015) 0.87
SIRT1 deacetylates RORγt and enhances Th17 cell generation. J Exp Med (2015) 0.85
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Protective effects of SIRT1 in patients with proliferative diabetic retinopathy via the inhibition of IL-17 expression. Exp Ther Med (2015) 0.80
Immunometabolism of regulatory T cells. Nat Immunol (2016) 0.80
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Combination of isoform-selective histone/protein deacetylase inhibitors improves Foxp3+ T-regulatory cell function. Cell Cycle (2012) 0.78
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HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells. Int J Cancer (2016) 0.77
Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation. J Biol Chem (2015) 0.77
miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain. J Neuroinflammation (2016) 0.76
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Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology. Immunology (2015) 0.75
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The Effects of Tacrolimus on T-Cell Proliferation Are Short-Lived: A Pilot Analysis of Immune Function Testing. Transplant Direct (2017) 0.75
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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature (2007) 10.21
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity (2001) 9.45
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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol (1990) 6.57
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol (2008) 6.41
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Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab (2009) 5.02
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (2009) 4.80
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37
Aging and disease: connections to sirtuins. Aging Cell (2010) 3.15
Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity (2009) 2.84
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood (2009) 2.49
The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer Res (2009) 2.29
SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 2.25
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J Clin Invest (2009) 2.02
In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat Med (2010) 2.01
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat Rev Drug Discov (2009) 2.00
Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol Cell Biol (2010) 1.94
Mayday--integrative analytics for expression data. BMC Bioinformatics (2010) 1.91
Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology (2009) 1.81
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene (2008) 1.78
sirt1-null mice develop an autoimmune-like condition. Exp Cell Res (2008) 1.67
Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J Immunol (2005) 1.55
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem (2009) 1.39
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J Med Chem (2008) 1.31
Genome-wide identification of human FOXP3 target genes in natural regulatory T cells. J Immunol (2010) 1.28
Effect of short term calorie restriction on pro-inflammatory NF-kB and AP-1 in aged rat kidney. Inflamm Res (2009) 1.14
Transient local depletion of Foxp3+ regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death. J Immunol (2008) 1.09
Dynamics of peripheral tolerance and immune regulation mediated by Treg. Eur J Immunol (2009) 1.07
Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint. J Immunol (2005) 0.98
Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 6.61
Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N Engl J Med (2005) 5.02
Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med (2003) 4.12
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A (2007) 3.32
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med (2005) 3.17
Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer (2011) 2.56
Helios expression is a marker of T cell activation and proliferation. PLoS One (2011) 2.55
Cellular reservoirs of HIV-1 and their role in viral persistence. Curr HIV Res (2008) 2.40
TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36
Observed changes in winter wheat phenology in the North China Plain for 1981-2009. Int J Biometeorol (2012) 2.11
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat Rev Drug Discov (2009) 2.00
PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest (2006) 1.93
Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res (2010) 1.85
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. J Biol Chem (2006) 1.84
Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol (2011) 1.82
Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology (2009) 1.81
Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression. J Immunol (2009) 1.72
Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms. Sci Signal (2012) 1.71
Programmed death-1 targeting can promote allograft survival. J Immunol (2002) 1.68
Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet (2008) 1.66
TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A (2008) 1.65
Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J Immunol (2005) 1.55
BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice. J Leukoc Biol (2009) 1.53
Improved renal ischemia tolerance in females influences kidney transplantation outcomes. J Clin Invest (2016) 1.51
Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction. Am J Respir Crit Care Med (2014) 1.51
Accelerated memory cell homeostasis during T cell depletion and approaches to overcome it. J Immunol (2006) 1.51
Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet (2009) 1.48
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BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur J Immunol (2004) 1.44
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Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells. J Immunol (2003) 1.40
Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. Am J Pathol (2007) 1.38
Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol (2004) 1.33
Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J Clin Invest (2014) 1.33
B7-H3 promotes acute and chronic allograft rejection. Eur J Immunol (2005) 1.31
Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs. Clin Immunol (2010) 1.30
Mutant prenyltransferase-like mitochondrial protein (PLMP) and mitochondrial abnormalities in kd/kd mice. Kidney Int (2004) 1.24
MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. J Biol Chem (2011) 1.23
Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Curr Opin Immunol (2010) 1.23
Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis. Exp Mol Pathol (2009) 1.22
Prolongation of cardiac and islet allograft survival by a blocking hamster anti-mouse CXCR3 monoclonal antibody. Transplantation (2008) 1.22
Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant (2003) 1.21
Using histone deacetylase inhibitors to enhance Foxp3(+) regulatory T-cell function and induce allograft tolerance. Immunol Cell Biol (2009) 1.20
Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells. Curr Opin Immunol (2011) 1.17
Regulatory T cell expression of herpesvirus entry mediator suppresses the function of B and T lymphocyte attenuator-positive effector T cells. J Immunol (2008) 1.15
Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. J Immunol (2003) 1.15
Histone/protein deacetylases and T-cell immune responses. Blood (2012) 1.14
Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep (2012) 1.14
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Transplantation (2005) 1.13
Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood (2006) 1.12
Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol (2003) 1.12
Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival. J Exp Med (2002) 1.10
Programmed cell death 1 (PD-1) and its ligand PD-L1 are required for allograft tolerance. Eur J Immunol (2007) 1.10
Chemokines and their receptors as markers of allograft rejection and targets for immunosuppression. Curr Opin Immunol (2003) 1.09
Substrate rigidity regulates human T cell activation and proliferation. J Immunol (2012) 1.09
Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse. Diabetes (2006) 1.05
TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol (2003) 1.03
Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity. Nat Med (2013) 1.02
The mitochondrial and kidney disease phenotypes of kd/kd mice under germfree conditions. J Autoimmun (2005) 1.01
Multiple combination therapies involving blockade of ICOS/B7RP-1 costimulation facilitate long-term islet allograft survival. Am J Transplant (2004) 1.00
Differential expression of profibrotic and growth factors in chronic allograft nephropathy. Transplantation (2006) 0.99
Foxp3 processing by proprotein convertases and control of regulatory T cell function. J Biol Chem (2008) 0.97