The effects of a neuregulin 1 variant on white matter density and integrity.

PubWeight™: 1.68‹?› | Rank: Top 3%

🔗 View Article (PMID 17925794)

Published in Mol Psychiatry on October 09, 2007

Authors

A M McIntosh1, T W J Moorhead, D Job, G K S Lymer, S Muñoz Maniega, J McKirdy, J E D Sussmann, B J Baig, M E Bastin, D Porteous, K L Evans, E C Johnstone, S M Lawrie, J Hall

Author Affiliations

1: Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. andrew.mcintosh@ed.ac.uk

Articles citing this

Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci Biobehav Rev (2009) 2.44

Genetics of brain fiber architecture and intellectual performance. J Neurosci (2009) 2.42

From maps to mechanisms through neuroimaging of schizophrenia. Nature (2010) 2.28

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav (2014) 1.90

General and specific cognitive deficits in schizophrenia: Goliath defeats David? Biol Psychiatry (2008) 1.86

Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group. Neuroimage (2013) 1.78

Genetics of microstructure of cerebral white matter using diffusion tensor imaging. Neuroimage (2010) 1.70

Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol Psychiatry (2009) 1.59

A review of multivariate methods for multimodal fusion of brain imaging data. J Neurosci Methods (2011) 1.52

Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk. Schizophr Bull (2008) 1.52

A role for white matter abnormalities in the pathophysiology of bipolar disorder. Neurosci Biobehav Rev (2009) 1.49

Executive function, neural circuitry, and genetic mechanisms in schizophrenia. Neuropsychopharmacology (2010) 1.47

Discriminating schizophrenia and bipolar disorder by fusing fMRI and DTI in a multimodal CCA+ joint ICA model. Neuroimage (2011) 1.41

The neuregulin signaling pathway and schizophrenia: from genes to synapses and neural circuits. Brain Res Bull (2010) 1.34

Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. Neuron (2014) 1.30

Altered structural brain connectivity in healthy carriers of the autism risk gene, CNTNAP2. Brain Connect (2011) 1.29

Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci Biobehav Rev (2010) 1.24

White matter abnormalities in bipolar disorder: insights from diffusion tensor imaging studies. J Neural Transm (Vienna) (2010) 1.22

Systemic hypotheses for generalized cognitive deficits in schizophrenia: a new take on an old problem. Schizophr Bull (2008) 1.21

Schizophrenia as a disorder of disconnectivity. Eur Arch Psychiatry Clin Neurosci (2011) 1.18

Microstructural correlations of white matter tracts in the human brain. Neuroimage (2010) 1.17

Along-tract statistics allow for enhanced tractography analysis. Neuroimage (2011) 1.14

Signaling pathways in schizophrenia: emerging targets and therapeutic strategies. Trends Pharmacol Sci (2010) 1.09

Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. Am J Psychiatry (2014) 1.09

DISC1 in schizophrenia: genetic mouse models and human genomic imaging. Schizophr Bull (2010) 1.04

Premorbid cognitive deficits in young relatives of schizophrenia patients. Front Hum Neurosci (2010) 1.01

Schizophrenia, psychiatric genetics, and Darwinian psychiatry: an evolutionary framework. Schizophr Bull (2007) 1.01

Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap. Nat Rev Drug Discov (2012) 0.97

Oligodendrocyte genes, white matter tract integrity, and cognition in schizophrenia. Cereb Cortex (2012) 0.96

Genetic variants in the ErbB4 gene are associated with white matter integrity. Psychiatry Res (2011) 0.96

White matter microstructural abnormalities in bipolar disorder: A whole brain diffusion tensor imaging study. Neuroimage Clin (2013) 0.95

Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system. Bipolar Disord (2012) 0.93

Schizophrenia: susceptibility genes and oligodendroglial and myelin related abnormalities. Front Cell Neurosci (2014) 0.93

Mapping connectivity in the developing brain. Int J Dev Neurosci (2013) 0.92

Effects of the BDNF Val66Met polymorphism on white matter microstructure in healthy adults. Neuropsychopharmacology (2012) 0.90

Measurement and comparison of serum neuregulin 1 immunoreactivity in control subjects and patients with schizophrenia: an influence of its genetic polymorphism. J Neural Transm (Vienna) (2010) 0.90

Polygenic risk and white matter integrity in individuals at high risk of mood disorder. Biol Psychiatry (2013) 0.90

Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies. Eur Arch Psychiatry Clin Neurosci (2008) 0.87

Molecular and cellular characterization of Neuregulin-1 type IV isoforms. J Neurochem (2010) 0.87

Genetic influence on the working memory circuitry: behavior, structure, function and extensions to illness. Behav Brain Res (2011) 0.87

White matter development in the early stages of psychosis. Schizophr Res (2014) 0.86

Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample. Schizophr Res (2013) 0.86

Common genetic variants and gene expression associated with white matter microstructure in the human brain. Neuroimage (2014) 0.86

Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. J Psychiatry Neurosci (2009) 0.85

A diffusion tensor imaging study of the anterior limb of the internal capsule in schizophrenia. Psychiatry Res (2010) 0.84

CNTNAP2 polymorphisms and structural brain connectivity: a diffusion-tensor imaging study. J Psychiatr Res (2013) 0.84

Schizophrenia-related neuregulin-1 single-nucleotide polymorphisms lead to deficient smooth eye pursuit in a large sample of young men. Schizophr Bull (2009) 0.83

BDNF Val66Met polymorphism influences age differences in microstructure of the Corpus Callosum. Front Hum Neurosci (2009) 0.83

The effects of psychosis risk variants on brain connectivity: a review. Front Psychiatry (2012) 0.83

Genetic underpinnings of white matter 'connectivity': heritability, risk, and heterogeneity in schizophrenia. Schizophr Res (2014) 0.83

Imaging genetics of structural brain connectivity and neural integrity markers. Neuroimage (2009) 0.83

Molecular substrates of schizophrenia: homeostatic signaling to connectivity. Mol Psychiatry (2015) 0.82

White matter integrity, language, and childhood onset schizophrenia. Schizophr Res (2012) 0.82

Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia. Neuropsychopharmacology (2010) 0.81

Anterior limb of the internal capsule in schizotypal personality disorder: fiber-tract counting, volume, and anisotropy. Schizophr Res (2012) 0.81

Brain white matter development is associated with a human-specific haplotype increasing the synthesis of long chain fatty acids. J Neurosci (2014) 0.80

Neuroimaging, nutrition, and iron-related genes. Cell Mol Life Sci (2013) 0.80

Fusion of white and gray matter geometry: a framework for investigating brain development. Med Image Anal (2014) 0.80

Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Neuroimage (2013) 0.80

Heritability of the limbic networks. Soc Cogn Affect Neurosci (2015) 0.79

Reprint of: Mapping connectivity in the developing brain. Int J Dev Neurosci (2013) 0.79

The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives. Transl Psychiatry (2012) 0.79

White matter microstructure alterations in bipolar disorder. Funct Neurol (2012) 0.78

Neurogenetic effects on cognition in aging brains: a window of opportunity for intervention? Front Aging Neurosci (2010) 0.78

Diffusion tensor imaging in first degree relatives of schizophrenia and bipolar disorder patients. Schizophr Res (2014) 0.78

Neurobehavioral Differences Between Mice Receiving Distinct Neuregulin Variants as Neonates; Impact on Sensitivity to MK-801. Curr Mol Med (2015) 0.77

Diffuse abnormality of low to moderately organized white matter in schizophrenia. Brain Connect (2011) 0.77

Neuregulin-1 genotypes and eye movements in schizophrenia. Eur Arch Psychiatry Clin Neurosci (2009) 0.77

Sexually dimorphic white matter geometry abnormalities in adolescent onset schizophrenia. Cereb Cortex (2013) 0.77

Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia. Neuropsychobiology (2009) 0.77

Schizophrenia-risk variant rs6994992 in the neuregulin-1 gene on brain developmental trajectories in typically developing children. Transl Psychiatry (2014) 0.77

Frontotemporal White Matter in Adolescents with, and at-Risk for, Bipolar Disorder. J Clin Med (2014) 0.76

The 2nd Schizophrenia International Research Society Conference, 10-14 April 2010, Florence, Italy: summaries of oral sessions. Schizophr Res (2010) 0.76

Can common functional gene variants affect visual discrimination in metacontrast masking? PLoS One (2013) 0.76

Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth. Nat Commun (2015) 0.76

A Neuregulin-1 schizophrenia susceptibility variant causes perihippocampal fiber tract anomalies in healthy young subjects. Brain Behav (2014) 0.75

Neuregulin 1, brain region specificity and PI3K/Akt in schizophrenia: comment on "Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal area". Eur Arch Psychiatry Clin Neurosci (2009) 0.75

Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia. Ann Gen Psychiatry (2014) 0.75

BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia. Front Mol Neurosci (2017) 0.75

Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network. Eur Arch Psychiatry Clin Neurosci (2015) 0.75

Articles by these authors

Measuring the quality of life of cancer patients: a concise QL-index for use by physicians. J Chronic Dis (1981) 7.00

Serevent nationwide surveillance study: comparison of salmeterol with salbutamol in asthmatic patients who require regular bronchodilator treatment. BMJ (1993) 6.14

Genome sequence of Halobacterium species NRC-1. Proc Natl Acad Sci U S A (2000) 5.87

Psychological autopsy studies of suicide: a systematic review. Psychol Med (2003) 4.97

Effects of organizational change in the medical intensive care unit of a teaching hospital: a comparison of 'open' and 'closed' formats. JAMA (1996) 4.71

A mesoscale phytoplankton bloom in the polar Southern Ocean stimulated by iron fertilization. Nature (2000) 4.36

Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med (1998) 3.75

Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry (2000) 3.67

Rapid active transport of immunoglobulin A from blood to bile. J Exp Med (1978) 3.62

Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11. BMJ (1994) 3.33

Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis. N Engl J Med (1992) 3.23

Sex differences in brain maturation during childhood and adolescence. Cereb Cortex (2001) 3.17

Comparison of potency of inhaled beclomethasone and budesonide in New Zealand: retrospective study of computerised general practice records. BMJ (1998) 3.15

Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet (1976) 3.14

The candidate Wilms' tumour gene is involved in genitourinary development. Nature (1990) 3.13

SUSPECTS: enabling fast and effective prioritization of positional candidates. Bioinformatics (2006) 2.96

A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am J Hum Genet (1999) 2.88

Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics (1997) 2.81

The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1995) 2.74

Practical management of hyperinsulinism in infancy. Arch Dis Child Fetal Neonatal Ed (2000) 2.70

Improved survival in ARDS patients associated with a reduction in pulmonary capillary wedge pressure. Chest (1990) 2.61

Evaluation of anticoagulant control in a pharmacist operated anticoagulant clinic. J Clin Pathol (1995) 2.58

Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J Virol (1993) 2.58

The specific features of methionine biosynthesis and metabolism in plants. Proc Natl Acad Sci U S A (1998) 2.52

Magnetic resonance imaging of brain in people at high risk of developing schizophrenia. Lancet (1999) 2.47

Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. Br J Psychiatry (2009) 2.46

Occurrence of specific antibodies of the IgA class in the bile of rats. Int Arch Allergy Appl Immunol (1979) 2.46

Use of perioperative mupirocin to prevent methicillin-resistant Staphylococcus aureus (MRSA) orthopaedic surgical site infections. J Hosp Infect (2003) 2.40

Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study. Br J Psychiatry (2003) 2.31

Proteomic analysis of arabidopsis seed germination and priming. Plant Physiol (2001) 2.24

MR diffusion-weighted imaging and outcome prediction after ischemic stroke. Neurology (2006) 2.19

White matter integrity and cognition in childhood and old age. Neurology (2006) 2.14

The impact of course attendance on the practice of dentists. Br Dent J (2004) 2.08

Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther (2006) 2.07

Presenilin-I, presenilin-II, and VLDL-R associations in early onset Alzheimer's disease. Lancet (1997) 2.06

Septicemia caused by Pseudomonas paucimobilis. Am J Clin Pathol (1979) 2.06

Complications of pregnancy and delivery in relation to psychosis in adult life: data from the British perinatal mortality survey sample. BMJ (1991) 2.03

The management of oesophageal carcinoma: radiotherapy or surgery? Cost considerations. Eur J Cancer Clin Oncol (1989) 2.00

Implementing evidence-based psychiatry: whose responsibility? Br J Psychiatry (2001) 1.99

Obstetric complications and age at onset in schizophrenia: an international collaborative meta-analysis of individual patient data. Am J Psychiatry (1997) 1.94

Spatial separation of protein domains is not necessary for catalytic activity or substrate binding in a xylanase. Biochem J (1990) 1.93

Service provision for people with schizophrenia. II. Role of the general practitioner. Br J Psychiatry (1997) 1.88

Depression after stroke and lesion location: a systematic review. Lancet (2000) 1.87

Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users. Br J Psychiatry (1999) 1.86

The Northwick Park electroconvulsive therapy trial. Lancet (1981) 1.79

The dementia of dementia praecox. Acta Psychiatr Scand (1978) 1.79

Chronic fatigue syndrome: prevalence and outcome. BMJ (1994) 1.77

The N-terminal region of an endoglucanase from Pseudomonas fluorescens subspecies cellulosa constitutes a cellulose-binding domain that is distinct from the catalytic centre. Mol Microbiol (1990) 1.76

Working memory in schizophrenia: a meta-analysis. Psychol Med (2008) 1.76

Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Arch Gen Psychiatry (1986) 1.74

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ (2011) 1.74

Schizophrenic patients discharged from hospital--a follow-up study. Br J Psychiatry (1984) 1.71

Dangerous behaviour preceding first admissions for schizophrenia. Br J Psychiatry (1992) 1.71

Predisposition to and late onset of upper airway obstruction following angiotensin-converting enzyme inhibitor therapy. Chest (1992) 1.70

Biogeography and ecological setting of Indian Ocean hydrothermal vents. Science (2001) 1.69

Acetylator status and response to phenelzine in depressed patients. Lancet (1973) 1.67

Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis. Cancer Res (2001) 1.67

Neurotic illness and its response to anxiolytic and antidepressant treatment. Psychol Med (1980) 1.66

Spontaneous remission of primary hyperparathyroidism from parathyroid apoplexy. J Clin Endocrinol Metab (1996) 1.66

Evidence for a general role for non-catalytic thermostabilizing domains in xylanases from thermophilic bacteria. Biochem J (1995) 1.64

Elevated protease activities in human amnion and chorion correlate with preterm premature rupture of membranes. Am J Obstet Gynecol (1995) 1.62

Accumulation of delta 2-tubulin, a major tubulin variant that cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies. J Cell Sci (1994) 1.59

Characterization of microtubule protofilament numbers. How does the surface lattice accommodate? J Mol Biol (1990) 1.59

Candidate gene polymorphisms for behavioural adaptations during urbanization in blackbirds. Mol Ecol (2013) 1.59

Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia. Biol Psychiatry (2001) 1.59

Right amygdala volume in adolescent and young adult offspring from families at high risk for developing alcoholism. Biol Psychiatry (2001) 1.57

Dark matter search results from the CDMS II experiment. Science (2010) 1.57

Interactions between serine acetyltransferase and O-acetylserine (thiol) lyase in higher plants--structural and kinetic properties of the free and bound enzymes. Eur J Biochem (1998) 1.56

Using graded motor imagery for complex regional pain syndrome in clinical practice: failure to improve pain. Eur J Pain (2011) 1.56

New variant Creutzfeldt-Jakob disease: psychiatric features. Lancet (1997) 1.55

Hydrocephalus in achondroplasia: the possible role of intracranial venous hypertension. J Neurosurg (1989) 1.55

Early alterations in airway mucociliary clearance and inflammation of the lamina propria in CF mice. Am J Physiol (1997) 1.54

A MRI study of ocular hypertelorism in individuals at high risk of developing schizophrenia. Schizophr Res (2001) 1.54

Molecular cloning of multiple xylanase genes from Pseudomonas fluorescens subsp. cellulosa. J Gen Microbiol (1988) 1.53

Incremental change in the Australian health care system. Health Aff (Millwood) (1999) 1.52

Neuropsychological change in young people at high risk for schizophrenia: results from the first two neuropsychological assessments of the Edinburgh High Risk Study. Psychol Med (2000) 1.52

Concordance by sex in sibling pairs with schizophrenia is paternally inherited. Evidence for a pseudoautosomal locus. Br J Psychiatry (1989) 1.50

Recycling of cold-stable microtubules: evidence that cold stability is due to substoichiometric polymer blocks. Biochemistry (1982) 1.50

The blockade of Fc receptor-mediated clearance of immune complexes in vivo by a monoclonal antibody (2.4G2) directed against Fc receptors on murine leukocytes. J Immunol (1984) 1.48

Unsuspected organic disease in chronic schizophrenia demonstrated by computed tomography. J Neurol Neurosurg Psychiatry (1980) 1.48

Brain white matter tract integrity as a neural foundation for general intelligence. Mol Psychiatry (2012) 1.47

Mechanism of the antipsychotic effect in the treatment of acute schizophrenia. Lancet (1978) 1.47

DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol Psychiatry (2008) 1.47

The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial. Ann Oncol (2012) 1.46

A pilot longitudinal study of hippocampal volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry (2001) 1.46

Morphologic, distributional, volumetric, and intensity characterization of periventricular hyperintensities. AJNR Am J Neuroradiol (2013) 1.45

Lumbar spine surgery in the obese patient. J Spinal Disord (1997) 1.45

Generation of microtubule stability subclasses by microtubule-associated proteins: implications for the microtubule "dynamic instability" model. J Cell Biol (1985) 1.44

The polyglutamylated lateral chain of alpha-tubulin plays a key role in flagellar motility. J Cell Sci (1996) 1.44

Segregation of cognitive and emotional function in the prefrontal cortex: a stereotactic meta-analysis. Neuroimage (2004) 1.44

Accuracy of a portable interpretive ECG machine in diagnosis of acute evolving myocardial infarction. Aust N Z J Med (1992) 1.44

Spontaneous involuntary disorders of movement: their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics. Arch Gen Psychiatry (1982) 1.44

Mutations in the follicle-stimulating hormone receptor and familial dizygotic twinning. Lancet (2001) 1.43

Utilisation as a measure of equity: weighing heat? J Health Econ (1991) 1.43

A rapid method for screening inhibitor effects: determination of I50 and its standard deviation. Anal Biochem (1978) 1.43