Published in Bioinformatics on January 19, 2006
ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res (2009) 7.34
Walking the interactome for prioritization of candidate disease genes. Am J Hum Genet (2008) 7.03
Disease candidate gene identification and prioritization using protein interaction networks. BMC Bioinformatics (2009) 3.03
Disease gene identification strategies for exome sequencing. Eur J Hum Genet (2012) 2.89
PhenomeNET: a whole-phenome approach to disease gene discovery. Nucleic Acids Res (2011) 2.67
Improved human disease candidate gene prioritization using mouse phenotype. BMC Bioinformatics (2007) 2.56
Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network. Genome Biol (2009) 2.43
ENDEAVOUR update: a web resource for gene prioritization in multiple species. Nucleic Acids Res (2008) 2.31
Analysis of protein sequence and interaction data for candidate disease gene prediction. Nucleic Acids Res (2006) 2.30
Bioinformatics challenges for personalized medicine. Bioinformatics (2011) 2.28
Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes. Nucleic Acids Res (2006) 1.95
TargetMine, an integrated data warehouse for candidate gene prioritisation and target discovery. PLoS One (2011) 1.89
Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. Bioinformatics (2008) 1.85
GeneDistiller--distilling candidate genes from linkage intervals. PLoS One (2008) 1.77
FunSimMat: a comprehensive functional similarity database. Nucleic Acids Res (2007) 1.75
Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information. BMC Med Genomics (2010) 1.57
Candidate gene identification approach: progress and challenges. Int J Biol Sci (2007) 1.51
Bioinformatics for personal genome interpretation. Brief Bioinform (2012) 1.51
A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a case. Bioinformatics (2009) 1.50
DADA: Degree-Aware Algorithms for Network-Based Disease Gene Prioritization. BioData Min (2011) 1.44
Update of the G2D tool for prioritization of gene candidates to inherited diseases. Nucleic Acids Res (2007) 1.42
Improving disease gene prioritization using the semantic similarity of Gene Ontology terms. Bioinformatics (2010) 1.37
Prioritization of disease microRNAs through a human phenome-microRNAome network. BMC Syst Biol (2010) 1.37
CANDID: a flexible method for prioritizing candidate genes for complex human traits. Genet Epidemiol (2008) 1.36
PGMapper: a web-based tool linking phenotype to genes. Bioinformatics (2008) 1.34
Advances in translational bioinformatics: computational approaches for the hunting of disease genes. Brief Bioinform (2009) 1.27
Gene-network analysis identifies susceptibility genes related to glycobiology in autism. PLoS One (2009) 1.23
Identification of candidate disease genes by integrating Gene Ontologies and protein-interaction networks: case study of primary immunodeficiencies. Nucleic Acids Res (2008) 1.23
PosMed (Positional Medline): prioritizing genes with an artificial neural network comprising medical documents to accelerate positional cloning. Nucleic Acids Res (2009) 1.19
Disease gene characterization through large-scale co-expression analysis. PLoS One (2009) 1.15
Conserved co-expression for candidate disease gene prioritization. BMC Bioinformatics (2008) 1.15
In silico gene prioritization by integrating multiple data sources. PLoS One (2011) 1.10
A knowledge-based weighting framework to boost the power of genome-wide association studies. PLoS One (2010) 1.08
Commonality of functional annotation: a method for prioritization of candidate genes from genome-wide linkage studies. Nucleic Acids Res (2008) 1.07
Approaches for recognizing disease genes based on network. Biomed Res Int (2014) 1.06
Chapter 15: disease gene prioritization. PLoS Comput Biol (2013) 1.05
Bioinformatic tools for identifying disease gene and SNP candidates. Methods Mol Biol (2010) 1.01
Vavien: an algorithm for prioritizing candidate disease genes based on topological similarity of proteins in interaction networks. J Comput Biol (2011) 0.99
Improving disease gene prioritization by comparing the semantic similarity of phenotypes in mice with those of human diseases. PLoS One (2012) 0.98
Outcome of array CGH analysis for 255 subjects with intellectual disability and search for candidate genes using bioinformatics. Hum Genet (2010) 0.97
Overexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer. Radiat Oncol (2013) 0.95
Revealing and avoiding bias in semantic similarity scores for protein pairs. BMC Bioinformatics (2010) 0.95
Biomarker identification for prostate cancer and lymph node metastasis from microarray data and protein interaction network using gene prioritization method. ScientificWorldJournal (2012) 0.93
A bivariate whole genome linkage study identified genomic regions influencing both BMD and bone structure. J Bone Miner Res (2008) 0.93
Computational selection and prioritization of candidate genes for fetal alcohol syndrome. BMC Genomics (2007) 0.92
A literature-based similarity metric for biological processes. BMC Bioinformatics (2006) 0.91
Gene prioritization and clustering by multi-view text mining. BMC Bioinformatics (2010) 0.91
Integrating computational biology and forward genetics in Drosophila. PLoS Genet (2009) 0.91
Integration of multiple data sources to prioritize candidate genes using discounted rating system. BMC Bioinformatics (2010) 0.90
PosMed-plus: an intelligent search engine that inferentially integrates cross-species information resources for molecular breeding of plants. Plant Cell Physiol (2009) 0.89
Comparison of automated candidate gene prediction systems using genes implicated in type 2 diabetes by genome-wide association studies. BMC Bioinformatics (2009) 0.89
Disease gene identification by random walk on multigraphs merging heterogeneous genomic and phenotype data. BMC Genomics (2012) 0.89
Gene prioritization in Type 2 Diabetes using domain interactions and network analysis. BMC Genomics (2010) 0.88
Assessment of protein set coherence using functional annotations. BMC Bioinformatics (2008) 0.88
Retracted Candidate gene prioritization. Mol Genet Genomics (2012) 0.88
Text mining in cancer gene and pathway prioritization. Cancer Inform (2014) 0.85
Prioritization of candidate disease genes by topological similarity between disease and protein diffusion profiles. BMC Bioinformatics (2013) 0.85
Predicting candidate genes based on combined network topological features: a case study in coronary artery disease. PLoS One (2012) 0.83
ProphNet: a generic prioritization method through propagation of information. BMC Bioinformatics (2014) 0.82
BICEPP: an example-based statistical text mining method for predicting the binary characteristics of drugs. BMC Bioinformatics (2011) 0.82
Gene-disease relationship discovery based on model-driven data integration and database view definition. Bioinformatics (2008) 0.82
Gene prioritization of resistant rice gene against Xanthomas oryzae pv. oryzae by using text mining technologies. Biomed Res Int (2013) 0.81
A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis. Biol Direct (2011) 0.81
A vertex similarity-based framework to discover and rank orphan disease-related genes. BMC Syst Biol (2012) 0.81
Whole exome sequencing identifies mutation of EDNRA involved in ACTH-independent macronodular adrenal hyperplasia. Fam Cancer (2013) 0.80
OVA: integrating molecular and physical phenotype data from multiple biomedical domain ontologies with variant filtering for enhanced variant prioritization. Bioinformatics (2015) 0.80
Inference of gene-phenotype associations via protein-protein interaction and orthology. PLoS One (2013) 0.79
Gentrepid V2.0: a web server for candidate disease gene prediction. BMC Bioinformatics (2013) 0.79
Disease gene prioritization using network and feature. J Comput Biol (2015) 0.79
Prioritizing genes of potential relevance to diseases affected by sex hormones: an example of myasthenia gravis. BMC Genomics (2008) 0.78
PhenUMA: a tool for integrating the biomedical relationships among genes and diseases. BMC Bioinformatics (2014) 0.77
In silico prioritisation of candidate genes for prokaryotic gene function discovery: an application of phylogenetic profiles. BMC Bioinformatics (2009) 0.77
An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardio-cerebral ischemic diseases. Acta Pharmacol Sin (2015) 0.77
Candidate gene identification for systemic lupus erythematosus using network centrality measures and gene ontology. PLoS One (2013) 0.76
An algorithm for network-based gene prioritization that encodes knowledge both in nodes and in links. PLoS One (2013) 0.76
Predicting diabetes mellitus genes via protein-protein interaction and protein subcellular localization information. BMC Genomics (2016) 0.76
Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome 8p22-8p21.1 in an Extended Belgian Family. Dis Markers (2015) 0.76
EnRICH: Extraction and Ranking using Integration and Criteria Heuristics. BMC Syst Biol (2013) 0.75
MOBAS: identification of disease-associated protein subnetworks using modularity-based scoring. EURASIP J Bioinform Syst Biol (2015) 0.75
Analysis of susceptible genes and chromosome loci for lung cancers by automated gene prediction tools and genome scanning meta-analysis. Int J Clin Exp Pathol (2015) 0.75
CARDIO-PRED: an in silico tool for predicting cardiovascular-disorder associated proteins. Syst Synth Biol (2015) 0.75
Understanding the molecular mechanisms of human microtia via a pig model of HOXA1 syndrome. Dis Model Mech (2015) 0.75
A Novel Prioritization Method in Identifying Recurrent Venous Thromboembolism-Related Genes. PLoS One (2016) 0.75
The RNA component of human telomerase. Science (1995) 9.86
Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet (2000) 7.16
Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet (2001) 4.77
Preparation of antiserum to enteroviruses in large animals. J Immunol (1965) 4.20
Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry (2011) 4.16
The DISC locus in psychiatric illness. Mol Psychiatry (2007) 3.46
WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A (2001) 2.79
Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation. J Biol Chem (2001) 2.54
Splinkerettes--improved vectorettes for greater efficiency in PCR walking. Nucleic Acids Res (1995) 2.51
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene (1999) 2.34
Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis. Thorax (2007) 1.93
Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia. Mol Psychiatry (2001) 1.81
High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered. Genomics (1992) 1.74
The effects of a neuregulin 1 variant on white matter density and integrity. Mol Psychiatry (2007) 1.68
A locus for bipolar affective disorder on chromosome 4p. Nat Genet (1996) 1.67
Candidate gene polymorphisms for behavioural adaptations during urbanization in blackbirds. Mol Ecol (2013) 1.59
INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow. Exp Cell Res (2001) 1.59
A demonstration using mouse models that successful gene therapy for cystic fibrosis requires only partial gene correction. Gene Ther (1996) 1.49
Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. Mol Psychiatry (2005) 1.41
A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D. Cancer Res (2000) 1.39
Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens. Nat Genet (1995) 1.37
Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria. Mol Cell Neurosci (2004) 1.35
Control of the flux in the arginine pathway of Neurospora crassa. Modulations of enzyme activity and concentration. Biochem J (1981) 1.35
Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder. Psychiatr Genet (2001) 1.30
Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder. Mol Psychiatry (2008) 1.27
Peripheral nerve-conduction block by high muscle-compartment pressure. J Bone Joint Surg Am (1979) 1.26
Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population. Mol Psychiatry (2006) 1.23
Molecular analysis of chromosome 11 deletions in aniridia-Wilms tumor syndrome. Proc Natl Acad Sci U S A (1985) 1.22
CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse. Am J Physiol (1994) 1.20
Molecular and physical arrangements of human DNA in HRAS1-selected, chromosome-mediated transfectants. Mol Cell Biol (1986) 1.17
Quantitation of skeletal-muscle necrosis in a model compartment syndrome. J Bone Joint Surg Am (1981) 1.17
Control of the flux in the arginine pathway of Neurospora crassa. The flux from citrulline to arginine. Biochem J (1980) 1.16
Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. Neurosci Lett (2005) 1.15
Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum. Gene Ther (1998) 1.14
Rethinking the genetic architecture of schizophrenia. Psychol Med (2010) 1.13
Sendai virus-mediated CFTR gene transfer to the airway epithelium. Gene Ther (2007) 1.13
Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations. EMBO J (1996) 1.13
Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability. Am J Med Genet B Neuropsychiatr Genet (2005) 1.13
Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. Mol Psychiatry (2006) 1.12
Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection. J Immunol (2001) 1.11
HRAS1-selected chromosome transfer generates markers that colocalize aniridia- and genitourinary dysplasia-associated translocation breakpoints and the Wilms tumor gene within band 11p13. Proc Natl Acad Sci U S A (1987) 1.11
Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung. Gene Ther (2011) 1.10
A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42. Mol Psychiatry (2004) 1.08
Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. Mol Psychiatry (2005) 1.07
Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression. Mamm Genome (1994) 1.06
Restriction fragment length polymorphism analysis and assignment of the metalloproteinases stromelysin and collagenase to the long arm of chromosome 11. Genomics (1988) 1.02
Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site. Mol Cell Neurosci (2005) 1.01
Nuts and bolts of psychiatric genetics: building on the Human Genome Project. Trends Genet (2001) 1.01
Serine proteases in rodent hippocampus. J Biol Chem (1998) 1.01
Non-viral vectors in cystic fibrosis gene therapy: progress and challenges. Trends Biotechnol (2004) 1.00
Definition and refinement of a region of loss of heterozygosity at 11q23.3-q24.3 in epithelial ovarian cancer associated with poor prognosis. Cancer Res (1996) 0.99
A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc Natl Acad Sci U S A (1999) 0.98
Partial deletion of chromosome 11p in breast cancer correlates with size of primary tumour and oestrogen receptor level. Br J Cancer (1988) 0.97
Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3. Mol Psychiatry (2011) 0.96
A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder. Proc Natl Acad Sci U S A (2008) 0.96
Quantification of intracompartmental pressure and volume under plaster casts. J Bone Joint Surg Am (1981) 0.96
Some principles and practices of genetic biobanking studies. Eur Respir J (2009) 0.95
Association of DISC1 variants with age of onset in a population-based sample of recurrent major depression. Mol Psychiatry (2012) 0.94
Selection for precise chromosomal targeting of a dominant marker by homologous recombination. Science (1989) 0.94
BARX2 induces cadherin 6 expression and is a functional suppressor of ovarian cancer progression. Cancer Res (2001) 0.94
GWAS for psychiatric disease: is the framework built on a solid foundation? Mol Psychiatry (2009) 0.93
Gene mapping and physical arrangements of human chromatin in transformed, hybrid cells: fluorescent and autoradiographic in situ hybridization compared. Somat Cell Mol Genet (1986) 0.93
Hitch-hiking from HRAS1 to the WAGR locus with CMGT markers. Nucleic Acids Res (1988) 0.93
The genomic organisation of the metabotropic glutamate receptor subtype 5 gene, and its association with schizophrenia. Mol Psychiatry (2001) 0.92
A screening protocol used for the detection of acoustic neuromas: a clinical evaluation. Clin Otolaryngol Allied Sci (1988) 0.92
A 6.9-Mb high-resolution BAC/PAC contig of human 4p15.3-p16.1, a candidate region for bipolar affective disorder. Genomics (2001) 0.91
Regulation of adenovirus-mediated elafin transgene expression by bacterial lipopolysaccharide. Hum Gene Ther (2001) 0.91
Correlation between nasal potential difference measurements, genotype and clinical condition in patients with cystic fibrosis. Eur Respir J (1997) 0.91
The effects of syntactic structure on discourse comprehension in patients with parsing impairments. Brain Lang (1990) 0.91
Fluid balance within the canine anterolateral compartment and its relationship to compartment syndromes. J Bone Joint Surg Am (1978) 0.91
Chromosomal abnormalities and mental illness. Mol Psychiatry (2003) 0.90
Identification of genes from a schizophrenia-linked translocation breakpoint region. Genomics (2001) 0.90
Heritability of chronic pain in 2195 extended families. Eur J Pain (2012) 0.90
Formyl peptide receptor chimeras define domains involved in ligand binding. J Biol Chem (1993) 0.89
Mapping of retrotransposon sequences in the unstable region surrounding the spinal muscular atrophy locus in 5q13. Genomics (1995) 0.89
Bioelectric characteristics of exon 10 insertional cystic fibrosis mouse: comparison with humans. Am J Physiol (1995) 0.89
Variation in DISC1 is associated with anxiety, depression and emotional stability in elderly women. Mol Psychiatry (2010) 0.87
The Input Signal Step Function (ISSF), a standard method to encode input signals in SBML models with software support, applied to circadian clock models. J Biol Rhythms (2012) 0.87
CpG islands surround a DNA segment located between translocation breakpoints associated with genitourinary dysplasia and aniridia. Genomics (1989) 0.87
Bacterial DNA is implicated in the inflammatory response to delivery of DNA/DOTAP to mouse lungs. Gene Ther (2000) 0.87
Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. Mol Psychiatry (2007) 0.86
Plasmid DNA molecules complexed with cationic liposomes are protected from degradation by nucleases and shearing by aerosolisation. Gene Ther (1996) 0.86
YAC mapping by FISH using Alu-PCR-generated probes. Genomics (1992) 0.85
Synaptic modulators Nrxn1 and Nrxn3 are disregulated in a Disc1 mouse model of schizophrenia. Mol Psychiatry (2011) 0.85
Insertion of natural intron 6a-6b into a human cDNA-derived gene therapy vector for cystic fibrosis improves plasmid stability and permits facile RNA/DNA discrimination. J Gene Med (2000) 0.84
Identification and characterization of a homozygous deletion found in ovarian ascites by representational difference analysis. Genome Res (1999) 0.84
Co-ordinated action of DISC1, PDE4B and GSK3β in modulation of cAMP signalling. Mol Psychiatry (2011) 0.84