Published in J Physiol on October 11, 2007
TRPV1 structures in distinct conformations reveal activation mechanisms. Nature (2013) 3.62
Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc Natl Acad Sci U S A (2010) 2.15
Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci (2008) 2.13
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nat Neurosci (2010) 1.98
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell (2010) 1.82
A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron (2008) 1.79
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc Natl Acad Sci U S A (2008) 1.78
Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels. Proc Natl Acad Sci U S A (2011) 1.65
Inorganic polyphosphate modulates TRPM8 channels. PLoS One (2009) 1.64
Molecular mechanism of TRP channels. Compr Physiol (2013) 1.58
Kinetic and energetic analysis of thermally activated TRPV1 channels. Biophys J (2010) 1.51
The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol (2008) 1.48
Activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol 4,5-bisphosphate. J Biol Chem (2008) 1.47
Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations. J Biol Chem (2008) 1.35
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc Natl Acad Sci U S A (2009) 1.33
Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium (2009) 1.29
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther (2011) 1.24
Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol (2009) 1.22
Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. J Gen Physiol (2012) 1.21
A linkage analysis toolkit for studying allosteric networks in ion channels. J Gen Physiol (2012) 1.15
Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314. J Neurophysiol (2013) 1.14
Molecular modeling of the full-length human TRPV1 channel in closed and desensitized states. J Membr Biol (2008) 1.11
Ligand stoichiometry of the cold- and menthol-activated channel TRPM8. J Physiol (2011) 1.10
Molecular and cellular limits to somatosensory specificity. Mol Pain (2008) 1.09
A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1. Pain (2009) 1.08
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
Scraping through the ice: uncovering the role of TRPM8 in cold transduction. Am J Physiol Regul Integr Comp Physiol (2011) 1.06
Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. Neuron (2014) 1.05
The role of allosteric coupling on thermal activation of thermo-TRP channels. Biophys J (2013) 1.04
Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. Pflugers Arch (2010) 1.02
Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels. J Biol Chem (2010) 1.02
Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis. J Gen Physiol (2011) 0.99
TRPA1 is a polyunsaturated fatty acid sensor in mammals. PLoS One (2012) 0.99
Voltage- and cold-dependent gating of single TRPM8 ion channels. J Gen Physiol (2011) 0.95
Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of α-hydroxyl acids on keratinocytes. J Biol Chem (2012) 0.94
Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold. J Gen Physiol (2013) 0.93
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1. Biochem J (2011) 0.92
Distinct modulations of human capsaicin receptor by protons and magnesium through different domains. J Biol Chem (2010) 0.91
The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1). J Physiol (2013) 0.90
Mechanisms of eosinophil major basic protein-induced hyperexcitability of vagal pulmonary chemosensitive neurons. Am J Physiol Lung Cell Mol Physiol (2009) 0.89
Modulation of thermoreceptor TRPM8 by cooling compounds. ACS Chem Neurosci (2012) 0.88
Effect of a temperature increase in the non-noxious range on proton-evoked ASIC and TRPV1 activity. Pflugers Arch (2010) 0.87
Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation. J Gen Physiol (2014) 0.87
High temperature sensitivity is intrinsic to voltage-gated potassium channels. Elife (2014) 0.85
Species-specific temperature sensitivity of TRPA1. Temperature (Austin) (2015) 0.84
Molecular determinants of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) binding to transient receptor potential V1 (TRPV1) channels. J Biol Chem (2014) 0.83
Hill coefficients of a polymodal Monod-Wyman-Changeux model for ion channel gating. Biophys J (2010) 0.82
Lack of potentiating effect of increasing temperature on responses to chemical activators in vagal sensory neurons isolated from TRPV1-null mice. Am J Physiol Lung Cell Mol Physiol (2008) 0.82
Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog. Proc Natl Acad Sci U S A (2011) 0.80
Pore size matters for potassium channel conductance. J Gen Physiol (2016) 0.80
Temperature and voltage coupling to channel opening in transient receptor potential melastatin 8 (TRPM8). J Biol Chem (2014) 0.80
Understanding the role of voltage gating of polymodal TRP channels. J Physiol (2007) 0.80
An external sodium ion binding site controls allosteric gating in TRPV1 channels. Elife (2016) 0.80
The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating. Biophys J (2015) 0.79
The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation. J Biol Chem (2014) 0.79
Use Dependence of Heat Sensitivity of Vanilloid Receptor TRPV2. Biophys J (2016) 0.79
Agonist-induced sensitisation of the irritant receptor ion channel TRPA1. J Physiol (2016) 0.78
TRPM8: a potential target for cancer treatment. J Cancer Res Clin Oncol (2016) 0.78
Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain. Curr Neuropharmacol (2013) 0.78
Engineering vanilloid-sensitivity into the rat TRPV2 channel. Elife (2016) 0.76
KCa1.1 channels regulate β1 integrin function and cell adhesion in rheumatoid arthritis fibroblast-like synoviocytes. FASEB J (2017) 0.76
Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. Elife (2016) 0.75
Biophysical analysis of thermosensitive TRP channels with a special focus on the cold receptor TRPM8. Temperature (Austin) (2015) 0.75
Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. Protein Cell (2017) 0.75
Trafficking of Na+/Ca2+ exchanger to the site of persistent inflammation in nociceptive afferents. J Neurosci (2015) 0.75
Full-Spectral Multiplexing of Bioluminescence Resonance Energy Transfer in Three TRPV Channels. Biophys J (2017) 0.75
Hypersensitivity Induced by Activation of Spinal Cord PAR2 Receptors Is Partially Mediated by TRPV1 Receptors. PLoS One (2016) 0.75
Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening. Sci Rep (2016) 0.75
Single-residue molecular switch for high-temperature dependence of vanilloid receptor TRPV3. Proc Natl Acad Sci U S A (2017) 0.75
The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59
The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron (1998) 13.03
TRP channels as cellular sensors. Nature (2003) 12.03
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature (1999) 10.05
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature (2004) 5.76
Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol (2002) 5.18
Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell (2002) 4.57
Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A (2000) 4.53
Trp ion channels and temperature sensation. Annu Rev Neurosci (2006) 4.35
Induction of vanilloid receptor channel activity by protein kinase C. Nature (2001) 3.95
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br J Pharmacol (2000) 3.57
Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A (2000) 3.55
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci U S A (2002) 3.16
Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8. Proc Natl Acad Sci U S A (2004) 3.11
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol (2001) 2.88
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem (2002) 2.79
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature (2005) 2.52
Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br J Pharmacol (1992) 2.50
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat Chem Biol (2007) 2.48
A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels. J Neurosci (2006) 2.47
Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature (2006) 2.47
Gating of TRP channels: a voltage connection? J Physiol (2005) 2.30
Molecular determinants of vanilloid sensitivity in TRPV1. J Biol Chem (2004) 2.17
Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc Natl Acad Sci U S A (2007) 2.02
Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1. J Neurophysiol (2002) 1.76
Functional role of C-terminal cytoplasmic tail of rat vanilloid receptor 1. J Neurosci (2003) 1.65
A study of the voltage dependence of capsaicin-activated membrane currents in rat sensory neurones before and after acute desensitization. J Physiol (1999) 1.59
Activation of TRPV1 by the satiety factor oleoylethanolamide. J Biol Chem (2003) 1.59
Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J Neurosci (2005) 1.52
Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. J Biol Chem (2005) 1.39
Pharmacological differences between the human and rat vanilloid receptor 1 (VR1). Br J Pharmacol (2001) 1.35
Polyamines are potent ligands for the capsaicin receptor TRPV1. J Biol Chem (2006) 1.35
Voltage- and time-dependent properties of the recombinant rat vanilloid receptor (rVR1). J Physiol (2000) 1.32
TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. J Physiol (2006) 1.25
Contribution of the putative inner-pore region to the gating of the transient receptor potential vanilloid subtype 1 channel (TRPV1). J Neurosci (2007) 1.23
Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol Pharmacol (2005) 1.02
Voltage-dependent priming of rat vanilloid receptor: effects of agonist and protein kinase C activation. J Physiol (2002) 1.01
Inhibitory modulation of distal C-terminal on protein kinase C-dependent phospho-regulation of rat TRPV1 receptors. J Physiol (2004) 0.93
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc Natl Acad Sci U S A (2008) 1.78
General anesthetics sensitize the capsaicin receptor transient receptor potential V1. Mol Pharmacol (2008) 1.70
The emergence of neurotransmitters as immune modulators. Trends Immunol (2007) 1.57
A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells. Blood (2005) 1.57
Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood (2006) 1.29
TRPV1-null mice are protected from diet-induced obesity. FEBS Lett (2008) 1.27
TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. J Physiol (2006) 1.25
Oleoylethanolamide excites vagal sensory neurones, induces visceral pain and reduces short-term food intake in mice via capsaicin receptor TRPV1. J Physiol (2005) 1.18
TRPA1 is a polyunsaturated fatty acid sensor in mammals. PLoS One (2012) 0.99
Store-operated Ca²+ signaling in dendritic cells occurs independently of STIM1. J Leukoc Biol (2010) 0.96
Identification of functional type 1 ryanodine receptors in mouse dendritic cells. FEBS Lett (2002) 0.89
IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1. J Leukoc Biol (2006) 0.87
Dendritic cells do not transduce inflammatory stimuli via the capsaicin receptor TRPV1. FEBS Lett (2005) 0.86
TRPV1 and synaptic transmission. Curr Pharm Biotechnol (2011) 0.82