Published in J Biol Chem on March 02, 2004
TRPV1 structures in distinct conformations reveal activation mechanisms. Nature (2013) 3.62
Voltage is a partial activator of rat thermosensitive TRP channels. J Physiol (2007) 2.16
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. Nat Neurosci (2010) 1.98
Structure and function of TRPV1. Pflugers Arch (2005) 1.91
A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell (2010) 1.82
Molecular mechanism of TRP channels. Compr Physiol (2013) 1.58
The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol (2008) 1.48
Nociceptors: a phylogenetic view. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2009) 1.44
Acid-sensitive ion channels and receptors. Handb Exp Pharmacol (2009) 1.43
Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr (2008) 1.43
Nicotinic acid activates the capsaicin receptor TRPV1: Potential mechanism for cutaneous flushing. Arterioscler Thromb Vasc Biol (2014) 1.43
The expanding field of cannabimimetic and related lipid mediators. Br J Pharmacol (2005) 1.38
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest (2008) 1.34
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol (2005) 1.33
TRPV1: on the road to pain relief. Curr Mol Pharmacol (2008) 1.26
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature (2016) 1.19
Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin. J Physiol (2005) 1.18
Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel. Nat Chem Biol (2015) 1.11
Molecular modeling of the full-length human TRPV1 channel in closed and desensitized states. J Membr Biol (2008) 1.11
The biophysical and molecular basis of TRPV1 proton gating. EMBO J (2011) 1.05
Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons. Proc Natl Acad Sci U S A (2012) 1.03
Conserved residues within the putative S4-S5 region serve distinct functions among thermosensitive vanilloid transient receptor potential (TRPV) channels. J Biol Chem (2010) 1.02
Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational data. Mol Pain (2013) 1.01
Drug-induced mild therapeutic hypothermia obtained by administration of a transient receptor potential vanilloid type 1 agonist. BMC Cardiovasc Disord (2010) 0.99
Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies. J Comput Aided Mol Des (2011) 0.99
TRPV1: a stress response protein in the central nervous system. Am J Neurodegener Dis (2012) 0.98
TRPC channels and diacylglycerol dependent calcium signaling in rat sensory neurons. Histochem Cell Biol (2008) 0.97
Physiology and pharmacology of the vanilloid receptor. Curr Neuropharmacol (2006) 0.96
TRPV1: a target for next generation analgesics. Curr Neuropharmacol (2008) 0.95
Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate. Br J Pharmacol (2012) 0.94
Inhibitory modulation of distal C-terminal on protein kinase C-dependent phospho-regulation of rat TRPV1 receptors. J Physiol (2004) 0.93
A structural view of ligand-dependent activation in thermoTRP channels. Front Physiol (2014) 0.92
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1. Biochem J (2011) 0.92
Distinct modulations of human capsaicin receptor by protons and magnesium through different domains. J Biol Chem (2010) 0.91
Exploring structure-function relationships between TRP and Kv channels. Sci Rep (2013) 0.90
The zebrafish ortholog of TRPV1 is required for heat-induced locomotion. J Neurosci (2013) 0.89
Intact microtubules preserve transient receptor potential vanilloid 1 (TRPV1) functionality through receptor binding. J Biol Chem (2012) 0.88
Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity. J Pharmacol Exp Ther (2011) 0.88
The chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation. J Biol Chem (2011) 0.88
Transient receptor potential channels as targets for phytochemicals. ACS Chem Neurosci (2014) 0.88
Metabolism of capsaicinoids by P450 enzymes: a review of recent findings on reaction mechanisms, bio-activation, and detoxification processes. Drug Metab Rev (2006) 0.86
Acidification of rat TRPV1 alters the kinetics of capsaicin responses. Mol Pain (2005) 0.86
ThermoTRPs and Pain. Neuroscientist (2015) 0.86
Unveiling TRPV1 spatio-temporal organization in live cell membranes. PLoS One (2015) 0.85
TRPV1 and SP: key elements for sepsis outcome? Br J Pharmacol (2013) 0.85
Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist. J Biol Chem (2014) 0.85
Differential effects of transient receptor vanilloid one (TRPV1) antagonists in acid-induced excitation of esophageal vagal afferent fibers of rats. Neuroscience (2009) 0.85
Epidermal keratinocyte polarity and motility require Ca²⁺ influx through TRPV1. J Cell Sci (2013) 0.84
Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels. Mol Pain (2009) 0.84
Structural insight into tetrameric hTRPV1 from homology modeling, molecular docking, molecular dynamics simulation, virtual screening, and bioassay validations. J Chem Inf Model (2015) 0.84
The cough reflex in animals: relevance to human cough research. Lung (2007) 0.83
Desensitization of transient receptor potential ankyrin 1 (TRPA1) by the TRP vanilloid 1-selective cannabinoid arachidonoyl-2 chloroethanolamine. Mol Pharmacol (2011) 0.83
Capsaicin interaction with TRPV1 channels in a lipid bilayer: molecular dynamics simulation. Biophys J (2015) 0.83
Lack of potentiating effect of increasing temperature on responses to chemical activators in vagal sensory neurons isolated from TRPV1-null mice. Am J Physiol Lung Cell Mol Physiol (2008) 0.82
Modality-specific mechanisms of protein kinase C-induced hypersensitivity of TRPV1: S800 is a polymodal sensitization site. Pain (2015) 0.82
Role of the transient receptor potential vanilloid 1 in inflammation and sepsis. J Inflamm Res (2011) 0.82
Binding mode pediction of evodiamine within vanilloid receptor TRPV1. Int J Mol Sci (2012) 0.82
TRP channels in schistosomes. Int J Parasitol Drugs Drug Resist (2016) 0.82
Cross-talk between neural and immune receptors provides a potential mechanism of homeostatic regulation in the gut mucosa. Mucosal Immunol (2014) 0.81
Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor. Br J Pharmacol (2005) 0.80
TRP Channels as Therapeutic Targets in Diabetes and Obesity. Pharmaceuticals (Basel) (2016) 0.79
Targeting the transient receptor potential vanilloid type 1 (TRPV1) assembly domain attenuates inflammation-induced hypersensitivity. J Biol Chem (2014) 0.79
Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8. J Physiol Sci (2015) 0.79
Evolutionary dynamics of metazoan TRP channels. Pflugers Arch (2015) 0.78
Role of transient receptor potential vanilloid 1 in inflammation and autoimmune diseases. Pharmaceuticals (Basel) (2012) 0.78
Rational design and validation of a vanilloid-sensitive TRPV2 ion channel. Proc Natl Acad Sci U S A (2016) 0.78
High-resolution views of TRPV1 and their implications for the TRP channel superfamily. Handb Exp Pharmacol (2014) 0.78
Differential Activation of TRP Channels in the Adult Rat Spinal Substantia Gelatinosa by Stereoisomers of Plant-Derived Chemicals. Pharmaceuticals (Basel) (2016) 0.78
Extensive Admixture and Selective Pressure Across the Sahel Belt. Genome Biol Evol (2015) 0.77
Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels. Br J Pharmacol (2014) 0.77
Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni. PLoS Negl Trop Dis (2015) 0.77
The pain receptor TRPV1 displays agonist-dependent activation stoichiometry. Sci Rep (2015) 0.77
Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain. Biochemistry (2015) 0.77
TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats. Temperature (Austin) (2015) 0.77
Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study. PLoS One (2016) 0.76
Engineering vanilloid-sensitivity into the rat TRPV2 channel. Elife (2016) 0.76
Divalent heavy metal cations block the TRPV1 Ca(2+) channel. Biol Trace Elem Res (2012) 0.76
Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch. Nat Commun (2016) 0.76
Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches. J Biol Chem (2016) 0.76
Metabolism of N-acylated-dopamine. PLoS One (2014) 0.75
Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening. Sci Rep (2016) 0.75
Understand spiciness: mechanism of TRPV1 channel activation by capsaicin. Protein Cell (2017) 0.75
A new electro-optical approach for conductance measurement: an assay for the study of drugs acting on ligand-gated ion channels. Sci Rep (2017) 0.75
Tyrosine Residue in the TRPV1 Vanilloid Binding Pocket Regulates Deactivation Kinetics. J Biol Chem (2016) 0.75
Integrating TRPV1 Receptor Function with Capsaicin Psychophysics. Adv Pharmacol Sci (2016) 0.75
Evolutionary tuning of TRPA1 and TRPV1 thermal and chemical sensitivity in vertebrates. Temperature (Austin) (2017) 0.75
Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1. Sci Rep (2017) 0.75
TRPV1 properties in thoracic dorsal root ganglia neurons are modulated by intraperitoneal capsaicin administration in the late phase of type-1 autoimmune diabetes. Cell Mol Neurobiol (2012) 0.75
Receptor Mechanisms Mediating the Pro-Nociceptive Action of Hydrogen Sulfide in Rat Trigeminal Neurons and Meningeal Afferents. Front Cell Neurosci (2017) 0.75
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans. Pain (2008) 2.91
Unmasking the tonic-aversive state in neuropathic pain. Nat Neurosci (2009) 2.77
Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci (2007) 2.57
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A (2005) 2.36
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A (2003) 2.29
Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain (2002) 2.24
Dynorphin A activates bradykinin receptors to maintain neuropathic pain. Nat Neurosci (2006) 2.23
A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther (2004) 2.21
Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain. Brain Res Mol Brain Res (2005) 2.18
Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet (2009) 2.15
Central modulation of pain. J Clin Invest (2010) 2.12
Multiple actions of systemic artemin in experimental neuropathy. Nat Med (2003) 2.12
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther (2004) 2.08
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci (2007) 2.07
Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci (2002) 2.00
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology (2007) 1.96
Antinociceptive and nociceptive actions of opioids. J Neurobiol (2004) 1.93
Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol (2004) 1.93
Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. J Neurosci (2003) 1.89
Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer. Pain (2007) 1.88
Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers (2005) 1.83
Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain. Pain (2011) 1.82
Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance? Neurosignals (2005) 1.80
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70
Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. Anesthesiology (2002) 1.63
Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. Mol Cell Biol (2002) 1.60
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology (2003) 1.60
The role of sodium channels in chronic inflammatory and neuropathic pain. J Pain (2006) 1.59
Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. J Neurosci (2002) 1.58
Wnts induce migration and invasion of myeloma plasma cells. Blood (2005) 1.58
Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain (2010) 1.58
Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. J Biol Chem (2006) 1.58
Peripheral mechanisms of pain and analgesia. Brain Res Rev (2008) 1.55
Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis. PLoS Genet (2010) 1.54
Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues. Biopolymers (2005) 1.54
Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance. Anesth Analg (2005) 1.53
Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function. J Am Chem Soc (2008) 1.52
An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons. Mol Pain (2005) 1.49
Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain (2005) 1.49
Medullary pain facilitating neurons mediate allodynia in headache-related pain. Ann Neurol (2009) 1.48
CB2 cannabinoid receptor mediation of antinociception. Pain (2006) 1.47
Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nat Neurosci (2008) 1.47
Reversal of experimental neuropathic pain by T-type calcium channel blockers. Pain (2003) 1.46
Cardiac magnetic resonance imaging in children with chronic kidney disease and renal transplantation. Pediatr Transplant (2012) 1.44
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry. Proc Natl Acad Sci U S A (2012) 1.44
Beneficial effects of SR33805 in failing myocardium. Cardiovasc Res (2011) 1.43
Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins. Arterioscler Thromb Vasc Biol (2005) 1.42
Hematocrit and the risk of cardiovascular disease--the Framingham study: a 34-year follow-up. Am Heart J (1994) 1.42
A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes. Exp Cell Res (2009) 1.41
Differences in the prevalence of asthma and current wheeze between Jews and Arabs: results from a national survey of schoolchildren in Israel. Ann Allergy Asthma Immunol (2002) 1.40
Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem (2006) 1.40
CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? Curr Opin Pharmacol (2003) 1.39
Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance. Cancer Res (2003) 1.38
The epidemiology of impaired glucose tolerance and hypertension. Am Heart J (1991) 1.38
Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. J Clin Invest (2007) 1.37
Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. J Neurosci (2006) 1.37
Lesion of the rostral anterior cingulate cortex eliminates the aversiveness of spontaneous neuropathic pain following partial or complete axotomy. Pain (2011) 1.37
Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids. Anesthesiology (2011) 1.35
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
Descending facilitation from the rostral ventromedial medulla maintains visceral pain in rats with experimental pancreatitis. Gastroenterology (2006) 1.34
Characterization of the interaction of ingenol 3-angelate with protein kinase C. Cancer Res (2004) 1.33
Endovanilloid signaling in pain. Curr Opin Neurobiol (2002) 1.32
A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain. Bone (2009) 1.31
The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model. PLoS One (2008) 1.31
Descending pain modulation and chronification of pain. Curr Opin Support Palliat Care (2014) 1.30
Spinal protein kinase M ζ underlies the maintenance mechanism of persistent nociceptive sensitization. J Neurosci (2011) 1.30
Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance. J Neurosci (2005) 1.29
Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg Med Chem Lett (2006) 1.29
Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorg Med Chem (2009) 1.28