Fronto-limbic functioning in children and adolescents with and without autism.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMC 2785231)

Published in Neuropsychologia on August 31, 2007

Authors

Katherine A Loveland1, Jocelyne Bachevalier, Deborah A Pearson, David M Lane

Author Affiliations

1: Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston 77030, United States. katherine.a.loveland@uth.tmc.edu

Articles citing this

Changes in prefrontal axons may disrupt the network in autism. J Neurosci (2010) 1.95

Neuropsychological profile of autism and the broad autism phenotype. Arch Gen Psychiatry (2009) 1.85

Recognition of emotions in autism: a formal meta-analysis. J Autism Dev Disord (2013) 1.46

Set-shifting in children with autism spectrum disorders: reversal shifting deficits on the Intradimensional/Extradimensional Shift Test correlate with repetitive behaviors. Autism (2009) 1.25

Neuropsychological endophenotype approach to genome-wide linkage analysis identifies susceptibility loci for ADHD on 2q21.1 and 13q12.11. Am J Hum Genet (2008) 1.23

Altered neural connectivity in excitatory and inhibitory cortical circuits in autism. Front Hum Neurosci (2013) 1.20

Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation. Front Psychiatry (2011) 0.94

Atomoxetine facilitates attentional set shifting in adolescent rats. Dev Cogn Neurosci (2011) 0.91

The serotonergic system: its role in pathogenesis and early developmental treatment of autism. Curr Neuropharmacol (2009) 0.91

Multiple list learning in adults with autism spectrum disorder: parallels with frontal lobe damage or further evidence of diminished relational processing? J Autism Dev Disord (2009) 0.90

Failure is not an option: Risk-taking is moderated by anxiety and also by cognitive ability in children and adolescents diagnosed with an autism spectrum disorder. J Autism Dev Disord (2011) 0.89

Behavioral outcomes of late-onset or early-onset orbital frontal cortex (areas 11/13) lesions in rhesus monkeys. Ann N Y Acad Sci (2011) 0.88

Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder. Front Hum Neurosci (2014) 0.86

Volumetric and voxel-based morphometry findings in autism subjects with and without macrocephaly. Dev Neuropsychol (2010) 0.85

Rule learning in autism: the role of reward type and social context. Dev Neuropsychol (2013) 0.85

Different verbal learning strategies in autism spectrum disorder: evidence from the Rey Auditory Verbal Learning Test. J Autism Dev Disord (2009) 0.82

Transitive inference in adults with autism spectrum disorders. Cogn Affect Behav Neurosci (2011) 0.81

Brief report: accuracy and response time for the recognition of facial emotions in a large sample of children with autism spectrum disorders. J Autism Dev Disord (2014) 0.75

Role of parental occupation in autism spectrum disorder diagnosis and severity. Res Autism Spectr Disord (2014) 0.75

Postsynaptic nicotinic acetylcholine receptors facilitate excitation of developing CA1 pyramidal neurons. J Neurophysiol (2016) 0.75

Understanding One's Own Emotions in Cognitively-Able Preadolescents with Autism Spectrum Disorder. J Autism Dev Disord (2016) 0.75

Articles cited by this

(truncated to the top 100)

Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord (1994) 42.80

Insensitivity to future consequences following damage to human prefrontal cortex. Cognition (1994) 14.92

The medial temporal lobe and recognition memory. Annu Rev Neurosci (2007) 10.37

Intellectual ability and cortical development in children and adolescents. Nature (2006) 8.41

Gaze fixation and the neural circuitry of face processing in autism. Nat Neurosci (2005) 6.56

Differential effects of early hippocampal pathology on episodic and semantic memory. Science (1997) 6.21

Automatic and intentional brain responses during evaluation of trustworthiness of faces. Nat Neurosci (2002) 5.29

Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency. J Neurosci (2004) 4.88

Lateral prefrontal cortex: architectonic and functional organization. Philos Trans R Soc Lond B Biol Sci (2005) 4.67

Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area. Int J Dev Neurosci (2005) 4.67

Topography of cognition: parallel distributed networks in primate association cortex. Annu Rev Neurosci (1988) 4.59

Abnormal ventral temporal cortical activity during face discrimination among individuals with autism and Asperger syndrome. Arch Gen Psychiatry (2000) 4.49

Brain structural abnormalities in young children with autism spectrum disorder. Neurology (2002) 4.20

Social intelligence in the normal and autistic brain: an fMRI study. Eur J Neurosci (1999) 3.94

Functional connectivity in an fMRI working memory task in high-functioning autism. Neuroimage (2004) 3.81

Conjunctive representations in learning and memory: principles of cortical and hippocampal function. Psychol Rev (2001) 3.64

Understanding the nature of face processing impairment in autism: insights from behavioral and electrophysiological studies. Dev Neuropsychol (2005) 3.58

Anatomic basis of cognitive-emotional interactions in the primate prefrontal cortex. Neurosci Biobehav Rev (1995) 3.28

Executive function deficits in high-functioning autistic individuals: relationship to theory of mind. J Child Psychol Psychiatry (1991) 3.18

Hippocampal-neocortical interaction: a hierarchy of associativity. Hippocampus (2000) 3.02

Amygdala-frontal interactions and reward expectancy. Curr Opin Neurobiol (2004) 2.83

Abnormal processing of social information from faces in autism. J Cogn Neurosci (2001) 2.76

Structure and function of declarative and nondeclarative memory systems. Proc Natl Acad Sci U S A (1996) 2.73

Neural correlates of face and object recognition in young children with autism spectrum disorder, developmental delay, and typical development. Child Dev (2002) 2.62

The hippocampus and declarative memory: cognitive mechanisms and neural codes. Behav Brain Res (2001) 2.43

The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain (2004) 2.42

The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning. Brain Cogn (2004) 2.19

The role of the fusiform face area in social cognition: implications for the pathobiology of autism. Philos Trans R Soc Lond B Biol Sci (2003) 2.19

Event-related brain potentials reveal anomalies in temporal processing of faces in autism spectrum disorder. J Child Psychol Psychiatry (2004) 2.18

Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism. Neurology (1999) 2.07

Enhanced and diminished visuo-spatial information processing in autism depends on stimulus complexity. Brain (2005) 2.05

Intact and impaired memory functions in autism. Child Dev (1996) 2.00

How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder? Behav Brain Res (2002) 2.00

Adolescents' performance on the Iowa Gambling Task: implications for the development of decision making and ventromedial prefrontal cortex. Dev Psychol (2004) 1.99

The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism. Neurosci Biobehav Rev (2005) 1.96

Under what conditions is recognition spared relative to recall after selective hippocampal damage in humans? Hippocampus (2002) 1.88

The cerebral metabolic landscape in autism. Intercorrelations of regional glucose utilization. Arch Neurol (1988) 1.86

Neuropsychological correlates of early symptoms of autism. Child Dev (1998) 1.81

Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. Am J Psychiatry (2000) 1.81

Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network. J Autism Dev Disord (2004) 1.79

Cerebral correlates of preserved cognitive skills in autism: a functional MRI study of embedded figures task performance. Brain (1999) 1.75

Neuroanatomical substrates of social cognition dysfunction in autism. Ment Retard Dev Disabil Res Rev (2004) 1.74

Neurocognitive function and joint attention ability in young children with autism spectrum disorder versus developmental delay. Child Dev (2002) 1.74

Social interest and the development of cortical face specialization: what autism teaches us about face processing. Dev Psychobiol (2002) 1.73

Abstract reasoning in autism: a dissociation between concept formation and concept identification. Neuropsychology (2002) 1.72

Abnormal regional cerebral blood flow in childhood autism. Brain (2000) 1.69

Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism. Neuroreport (2000) 1.68

Hippocampal formation lesions produce memory impairment in the rhesus monkey. Hippocampus (1999) 1.67

Neocortical system abnormalities in autism: an fMRI study of spatial working memory. Neurology (2002) 1.67

Hierarchical organization of cognitive memory. Philos Trans R Soc Lond B Biol Sci (1997) 1.66

Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans. Eur J Neurosci (2004) 1.63

Adaptive skills and executive function in autism spectrum disorders. Child Neuropsychol (2002) 1.61

Executive function and social communication deficits in young autistic children. J Child Psychol Psychiatry (1993) 1.60

Impaired face processing in autism: fact or artifact? J Autism Dev Disord (2006) 1.57

Normal and anomalous development of visual motion processing: motion coherence and 'dorsal-stream vulnerability'. Neuropsychologia (2003) 1.57

Charting the maturation of the frontal lobe: an electrophysiological strategy. Brain Cogn (2004) 1.51

Motion processing in autism: evidence for a dorsal stream deficiency. Neuroreport (2000) 1.48

Language, social, and executive functions in high functioning autism: a continuum of performance. J Autism Dev Disord (2005) 1.48

A biological perspective on empathy. Am J Psychiatry (1989) 1.47

Young children with autism show atypical brain responses to fearful versus neutral facial expressions of emotion. Dev Sci (2004) 1.47

The development of face processing in autism. J Autism Dev Disord (2006) 1.47

The profile of memory function in children with autism. Neuropsychology (2006) 1.45

Executive functions in young children with autism. Child Dev (1999) 1.45

Further evidence of intact working memory in autism. J Autism Dev Disord (2001) 1.43

Abnormal global processing along the dorsal visual pathway in autism: a possible mechanism for weak visuospatial coherence? Neuropsychologia (2004) 1.42

Executive functioning in high-functioning children with autism. J Child Psychol Psychiatry (2001) 1.40

Inverse correlation between frontal lobe and cerebellum sizes in children with autism. Brain (2000) 1.36

Medial temporal lobe structures and autism: a review of clinical and experimental findings. Neuropsychologia (1994) 1.35

Verbal and spatial working memory in autism. J Autism Dev Disord (2005) 1.30

The pattern of intact and impaired memory functions in autism. J Child Psychol Psychiatry (2001) 1.30

Delayed maturation of the frontal cortex in childhood autism. Am J Psychiatry (1995) 1.26

Executive functions in autism and Asperger's disorder: flexibility, fluency, and inhibition. Dev Neuropsychol (2005) 1.24

Is the human amygdala specialized for processing social information? Ann N Y Acad Sci (2003) 1.22

The representation of information about faces in the temporal and frontal lobes. Neuropsychologia (2006) 1.19

Impaired memory for faces and social scenes in autism: clinical implications of memory dysfunction. Arch Clin Neuropsychol (2005) 1.15

Structural and functional magnetic resonance imaging of autism. Int J Dev Neurosci (2002) 1.14

Spatial reversal as a measure of executive functioning in children with autism. J Genet Psychol (2003) 1.12

Episodic memory and remembering in adults with Asperger syndrome. J Autism Dev Disord (2000) 1.10

Facial expression processing after amygdalotomy. Neuropsychologia (1996) 1.08

The perception of four basic emotions in human and nonhuman faces by children with autism and other developmental disabilities. J Abnorm Child Psychol (2004) 1.08

Decoding of emotion through facial expression, prosody and verbal content in children and adolescents with Asperger's syndrome. J Autism Dev Disord (2006) 1.06

Memory deficits in early infantile autism: some similarities to the amnesic syndrome. Br J Psychol (1976) 1.06

Volumetric alterations of the orbitofrontal cortex in autism. Prog Neuropsychopharmacol Biol Psychiatry (2006) 1.04

The maturation of form and motion perception in school age children. Vision Res (2005) 1.03

A deficit in shifting attention present in high-functioning autism but not Asperger's disorder. Autism (2001) 1.00

Recall for self and other in autism: children's memory for events experienced by themselves and their peers. J Autism Dev Disord (2000) 0.99

Methodological issues for experiments on autistic individuals' perception and understanding of emotion. J Child Psychol Psychiatry (1991) 0.98

Magnetic resonance imaging study of the orbitofrontal cortex in autism. J Child Neurol (2006) 0.98

Memory in autism: review and synthesis. Cortex (2003) 0.97

Long-term memory in high-functioning autism: controversy on episodic memory in autism reconsidered. J Autism Dev Disord (2003) 0.96

Autism, amnesia, hippocampus, and learning. Neurosci Biobehav Rev (1992) 0.95

Memory for recent events in autistic children. J Autism Dev Disord (1981) 0.95

Memory impairments and communication in relatively able autistic children. J Child Psychol Psychiatry (1989) 0.92

Implicit and explicit memory in autism: is autism an amnesic disorder? J Autism Dev Disord (2000) 0.92

Creativity and imagination in autism and Asperger syndrome. J Autism Dev Disord (1999) 0.90

Eye movement abnormality suggestive of a spatial working memory deficit is present in parents of autistic probands. J Autism Dev Disord (2002) 0.90

A combined clinical, neuropsychological, and neuroanatomical study of adults with high functioning autism. Cogn Neuropsychiatry (2005) 0.88

Brief report: electroencephalographic paroxysmal activities in the frontal area emerged in middle childhood and during adolescence in a follow-up study of autism. J Autism Dev Disord (1997) 0.88

Subgroups of autistic children based on social behavior display distinct patterns of brain activity. J Abnorm Child Psychol (1995) 0.87

QEEG assisted neuropsychological evaluation of autism. Int J Neurosci (1998) 0.77

Articles by these authors

Towards a transgenic model of Huntington's disease in a non-human primate. Nature (2008) 4.47

The hippocampal/parahippocampal regions and recognition memory: insights from visual paired comparison versus object-delayed nonmatching in monkeys. J Neurosci (2004) 1.99

The effects of selective amygdala, orbital frontal cortex or hippocampal formation lesions on reward assessment in nonhuman primates. Eur J Neurosci (2007) 1.89

Multiresolution 3-D reconstruction from side-scan sonar images. IEEE Trans Image Process (2007) 1.78

The impact of selective amygdala, orbital frontal cortex, or hippocampal formation lesions on established social relationships in rhesus monkeys (Macaca mulatta). Behav Neurosci (2006) 1.74

Frontal and temporal morphometric findings on MRI in children after moderate to severe traumatic brain injury. J Neurotrauma (2005) 1.56

Long-term effects of neonatal medial temporal ablations on socioemotional behavior in monkeys (Macaca mulatta). Behav Neurosci (2010) 1.55

Impaired safety signal learning may be a biomarker of PTSD. Neuropharmacology (2011) 1.52

Mechanisms of same/different abstract-concept learning by rhesus monkeys (Macaca mulatta). J Exp Psychol Anim Behav Process (2002) 1.37

Maturation of the hippocampal formation and amygdala in Macaca mulatta: a volumetric magnetic resonance imaging study. Hippocampus (2010) 1.32

Impact of amygdala, orbital frontal, or hippocampal lesions on threat avoidance and emotional reactivity in nonhuman primates. Emotion (2009) 1.29

Social attachment in juvenile monkeys with neonatal lesion of the hippocampus, amygdala and orbital frontal cortex. Behav Brain Res (2006) 1.21

Assessment of locus and extent of neurotoxic lesions in monkeys using neuroimaging techniques: a replication. J Neurosci Methods (2002) 1.20

Behavioral and hormonal reactivity to threat: effects of selective amygdala, hippocampal or orbital frontal lesions in monkeys. Psychoneuroendocrinology (2008) 1.18

Selective aspiration or neurotoxic lesions of orbital frontal areas 11 and 13 spared monkeys' performance on the object discrimination reversal task. J Neurosci (2009) 1.17

Peripherally administered non-peptide oxytocin antagonist, L368,899, accumulates in limbic brain areas: a new pharmacological tool for the study of social motivation in non-human primates. Horm Behav (2007) 1.14

Developmental trajectory of object recognition memory in infant rhesus macaques with and without neonatal hippocampal lesions. J Neurosci (2010) 1.13

Measuring anxiety as a treatment endpoint in youth with autism spectrum disorder. J Autism Dev Disord (2014) 1.12

Improving the reliability of autism diagnoses: examining the utility of adaptive behavior. J Autism Dev Disord (2007) 1.11

Non-human primate models of childhood psychopathology: the promise and the limitations. J Child Psychol Psychiatry (2003) 1.11

Comparison of the effects of damage to the perirhinal and parahippocampal cortex on transverse patterning and location memory in rhesus macaques. J Neurosci (2005) 1.07

Altered brain activation during cognitive control in patients with moderate to severe traumatic brain injury. Neurorehabil Neural Repair (2006) 1.06

Hippocampus, amygdala, and basal ganglia morphometrics in children after moderate-to-severe traumatic brain injury. Dev Med Child Neurol (2007) 1.04

Abstract-concept learning and list-memory processing by capuchin and rhesus monkeys. J Exp Psychol Anim Behav Process (2003) 1.03

Treatment effects of methylphenidate on behavioral adjustment in children with mental retardation and ADHD. J Am Acad Child Adolesc Psychiatry (2003) 1.00

A comparison of behavioral and emotional functioning in children and adolescents with Autistic Disorder and PDD-NOS. Child Neuropsychol (2006) 0.99

How somatic cortical maps differ in autistic and typical brains. Neuroreport (2009) 0.95

Seafood consumption and blood mercury concentrations in Jamaican children with and without autism spectrum disorders. Neurotox Res (2012) 0.95

Object and spatial relational memory in adult rhesus monkeys is impaired by neonatal lesions of the hippocampal formation but not the amygdaloid complex. Hippocampus (2002) 0.95

Sex-dependent role of the amygdala in the development of emotional and neuroendocrine reactivity to threatening stimuli in infant and juvenile rhesus monkeys. Horm Behav (2013) 0.94

Selective neurotoxic damage to the hippocampal formation impairs performance of the transverse patterning and location memory tasks in rhesus macaques. Hippocampus (2005) 0.94

Bio-inspired wideband sonar signals based on observations of the bottlenose dolphin (Tursiops truncatus). J Acoust Soc Am (2007) 0.93

Effects of selective neonatal hippocampal lesions on tests of object and spatial recognition memory in monkeys. Behav Neurosci (2011) 0.92

Maternal and paternal age are jointly associated with childhood autism in Jamaica. J Autism Dev Disord (2012) 0.91

Outcome measures for clinical drug trials in autism. CNS Spectr (2004) 0.90

Neonatal amygdala lesions alter basal cortisol levels in infant rhesus monkeys. Psychoneuroendocrinology (2012) 0.90

Neonatal hippocampal damage impairs specific food/place associations in adult macaques. Behav Neurosci (2013) 0.89

Pervasive alterations of emotional and neuroendocrine responses to an acute stressor after neonatal amygdala lesions in rhesus monkeys. Psychoneuroendocrinology (2012) 0.89

A two years longitudinal study of a transgenic Huntington disease monkey. BMC Neurosci (2014) 0.89

Social orienting: reflexive versus voluntary control. Vision Res (2010) 0.89

Neonatal hippocampal lesions in rhesus macaques alter the monitoring, but not maintenance, of information in working memory. Behav Neurosci (2011) 0.89

High concordance of parent and teacher attention-deficit/hyperactivity disorder ratings in medicated and unmedicated children with autism spectrum disorders. J Child Adolesc Psychopharmacol (2012) 0.89

Increased response variability in autistic brains? Neuroreport (2009) 0.88

Reactions to familiar and novel objects in infant monkeys with neonatal temporal lesions. Hippocampus (2003) 0.88

Social communication in young children with traumatic brain injury: relations with corpus callosum morphometry. Int J Dev Neurosci (2011) 0.87

Working memory for temporal order is impaired after selective neonatal hippocampal lesions in adult rhesus macaques. Behav Brain Res (2012) 0.87

Neonatal amygdala lesions alter mother-infant interactions in rhesus monkeys living in a species-typical social environment. Dev Psychobiol (2014) 0.87

Effects of neonatal amygdala lesions on fear learning, conditioned inhibition, and extinction in adult macaques. Behav Neurosci (2012) 0.87

The role of drinking water sources, consumption of vegetables and seafood in relation to blood arsenic concentrations of Jamaican children with and without Autism Spectrum Disorders. Sci Total Environ (2012) 0.86

Comparison of emotional responses in monkeys with rhinal cortex or amygdala lesions. Emotion (2002) 0.86

Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions. Learn Mem (2011) 0.86

Accentuated Virchow-Robin spaces in the centrum semiovale in children with autistic disorder. J Comput Assist Tomogr (2004) 0.85

Development of memory for spatial locations and object/place associations in infant rhesus macaques with and without neonatal hippocampal lesions. J Int Neuropsychol Soc (2013) 0.84

Crossmodal integration of conspecific vocalizations in rhesus macaques. PLoS One (2013) 0.84

Responses to affective stimuli in monkeys with entorhinal or perirhinal cortex lesions. J Neurosci (2006) 0.84

Mother recognition and preference after neonatal amygdala lesions in rhesus macaques (Macaca mulatta) raised in a semi-naturalistic environment. Dev Psychobiol (2014) 0.83

Effects of extended release methylphenidate treatment on ratings of attention-deficit/hyperactivity disorder (ADHD) and associated behavior in children with autism spectrum disorders and ADHD symptoms. J Child Adolesc Psychopharmacol (2013) 0.83

Long-term effects of neonatal hippocampal lesions on novelty preference in monkeys. Hippocampus (2013) 0.82

Functional assays of local connectivity in the somatosensory cortex of individuals with autism. Autism Res (2013) 0.82

Impact of medications prescribed for treatment of attention-deficit hyperactivity disorder on physical growth in children and adolescents with HIV. J Dev Behav Pediatr (2009) 0.82

Blood manganese concentrations in Jamaican children with and without autism spectrum disorders. Environ Health (2014) 0.82

Are 'leaky gut' and behavior associated with gluten and dairy containing diet in children with autism spectrum disorders? Nutr Neurosci (2014) 0.81

Effects of methylphenidate treatment in children with mental retardation and ADHD: individual variation in medication response. J Am Acad Child Adolesc Psychiatry (2004) 0.81

The use of second-generation antipsychotics and the changes in physical growth in children and adolescents with perinatally acquired HIV. AIDS Patient Care STDS (2009) 0.80

Treatment effects of methylphenidate on cognitive functioning in children with mental retardation and ADHD. J Am Acad Child Adolesc Psychiatry (2004) 0.80

The effects of selective hippocampal damage on tests of oddity in rhesus macaques. Hippocampus (2010) 0.79

Judgments of auditory-visual affective congruence in adolescents with and without autism: a pilot study of a new task using fMRI. Percept Mot Skills (2008) 0.79

Behavioral toxicology of cognition: extrapolation from experimental animal models to humans: behavioral toxicology symposium overview. Neurotoxicol Teratol (2012) 0.79

Interaction of finger representations in the cortex of individuals with autism: a functional window into cortical inhibition. Autism Res (2013) 0.79

Preserved stimulus-reward and reversal learning after selective neonatal orbital frontal areas 11/13 or amygdala lesions in monkeys. Dev Cogn Neurosci (2012) 0.79

Detecting social and non-social changes in natural scenes: performance of children with and without autism spectrum disorders and typical adults. J Autism Dev Disord (2011) 0.78

A novel AX+/BX- paradigm to assess fear learning and safety-signal processing with repeated-measure designs. J Neurosci Methods (2013) 0.78

Stimulant Medications and Cognition, Behavior and Quality of Life in Children and Youth with HIV. Pediatr Infect Dis J (2016) 0.77

Relationships between the use of second-generation antipsychotics and changes in total cholesterol levels in children and adolescents perinatally infected with HIV. Neurobehav HIV Med (2010) 0.75

There Is Time for Calculation in Speed Chess, and Calculation Accuracy Increases With Expertise. Am J Psychol (2016) 0.75