Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 3124846)

Published in J Invest Dermatol on October 18, 2007

Authors

Ling Zhu1, Chaya Brodie, Sivaprakasam Balasubramanian, Richard L Eckert

Author Affiliations

1: Department of Physiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Articles cited by this

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (1992) 12.18

Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: activation of the cross-linking by calcium ions. Cell (1979) 4.38

Regulation of protein kinase C. Curr Opin Cell Biol (1997) 3.45

Structure and evolution of the human involucrin gene. Cell (1986) 2.76

Distinctive activation mechanisms and functions for protein kinase Cdelta. Biochem J (2004) 2.70

Regulation of cell apoptosis by protein kinase c delta. Apoptosis (2003) 2.60

The dynamics of postmitotic reassembly of the nucleolus. J Cell Biol (2000) 2.41

Bricks and mortar of the epidermal barrier. Exp Mol Med (1999) 2.37

A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem (1990) 2.12

The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev (1997) 1.91

Phosphorylation sites of protein kinase C delta in H2O2-treated cells and its activation by tyrosine kinase in vitro. Proc Natl Acad Sci U S A (2001) 1.74

Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. Mol Cell Biol (2002) 1.60

Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. J Biol Chem (1995) 1.49

Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. J Biol Chem (1998) 1.47

Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes. J Biol Chem (2004) 1.43

Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C delta. J Biol Chem (1993) 1.37

Tyrosine phosphorylation of protein kinase C-delta in response to its activation. J Biol Chem (1994) 1.36

Regulation of involucrin gene expression. J Invest Dermatol (2004) 1.36

Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta. J Biol Chem (1996) 1.34

A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation. J Biol Chem (2003) 1.33

Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res (2001) 1.30

Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions. J Biol Chem (2000) 1.26

Involucrin expression in normal and neoplastic human skin: a marker for keratinocyte differentiation. J Invest Dermatol (1984) 1.23

Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells. J Biol Chem (2005) 1.22

Regulation of human involucrin promoter activity by novel protein kinase C isoforms. J Biol Chem (2000) 1.17

Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Mol Cell Biol (2004) 1.17

Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKCdelta in platelets. Blood (2005) 1.16

Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex. J Biol Chem (2004) 1.14

Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha. J Biol Chem (2002) 1.14

Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes. J Biol Chem (2005) 1.14

Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways. J Immunol (2003) 1.13

Involucrin--structure and role in envelope assembly. J Invest Dermatol (1993) 1.12

The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. Oncogene (2006) 1.11

Protein kinase Cdelta is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes. J Biol Chem (1998) 1.10

Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells. Mol Cell Biol (2001) 1.09

Differential expression of the fos and jun family members c-fos, fosB, Fra-1, Fra-2, c-jun, junB and junD during human epidermal keratinocyte differentiation. Oncogene (1995) 1.08

Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. J Biol Chem (2005) 1.07

Identification of tyrosine 187 as a protein kinase C-delta phosphorylation site. J Biol Chem (1996) 1.06

Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. J Biol Chem (2002) 1.05

Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. Cell Growth Differ (1995) 1.04

Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells. Biochem Biophys Res Commun (1995) 1.02

A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis. Cell Death Differ (2005) 1.02

Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)alpha and PKCdelta. J Biol Chem (2002) 1.01

Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes. J Biol Chem (2002) 0.97

Transcripts encoding protein kinase C-alpha, -delta, -epsilon, -zeta, and -eta are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells. Mol Carcinog (1992) 0.97

Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts. Carcinogenesis (2000) 0.97

Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells. Biochem Biophys Res Commun (2006) 0.93

Both the catalytic and regulatory domains of protein kinase C chimeras modulate the proliferative properties of NIH 3T3 cells. J Biol Chem (1997) 0.92

Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes. Exp Dermatol (2000) 0.92

Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin: reduced expression of protein kinase C-beta II in psoriasis. J Invest Dermatol (1993) 0.91

Involucrin is a covalently crosslinked constituent of highly purified epidermal corneocytes: evidence for a common pattern of involucrin crosslinking in vivo and in vitro. J Invest Dermatol (1996) 0.90

Role of oncogenes and tumor suppressor genes in multistage carcinogenesis. J Invest Dermatol (1994) 0.90

Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-alpha in normal human skin fibroblasts and keratinocytes. Biochem J (1993) 0.89

Protein kinase C regulates keratinocyte transglutaminase (TGK) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calcium. J Invest Dermatol (1994) 0.89

Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis. Arch Dermatol Res (2007) 0.89

Protein kinase C in normal human epidermal keratinocytes during proliferation and calcium-induced differentiation. J Invest Dermatol (1992) 0.88

Protein kinase C mRNA levels and activity in reconstituted normal human epidermis: relationships to cell differentiation. Biochem Biophys Res Commun (1992) 0.87

Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311. J Biol Chem (2006) 0.86

Antioxidants regulate normal human keratinocyte differentiation. Biochem Pharmacol (2004) 0.85

Opposing action of curcumin and green tea polyphenol in human keratinocytes. Mol Nutr Food Res (2006) 0.84

Immunoblotting PKC-delta: a cautionary note from the bench. Am J Physiol Cell Physiol (2005) 0.83

Articles by these authors

Altered adenosine-to-inosine RNA editing in human cancer. Genome Res (2007) 2.38

The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int J Cancer (2009) 1.98

MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1. Oncotarget (2013) 1.64

PKC-delta and -eta, MEKK-1, MEK-6, MEK-3, and p38-delta are essential mediators of the response of normal human epidermal keratinocytes to differentiating agents. J Invest Dermatol (2010) 1.64

De-differentiation of mouse interfollicular keratinocytes by the embryonic transcription factor Oct-4. J Invest Dermatol (2006) 1.62

Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide. Mol Cell Biol (2002) 1.60

S100 protein subcellular localization during epidermal differentiation and psoriasis. J Histochem Cytochem (2003) 1.58

Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. J Invest Dermatol (2004) 1.47

Keratinocyte survival, differentiation, and death: many roads lead to mitogen-activated protein kinase. J Investig Dermatol Symp Proc (2002) 1.41

Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency. Int J Cancer (2009) 1.39

Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta. Mol Cell Biol (2009) 1.37

Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases. J Biol Chem (2003) 1.37

Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells. J Clin Invest (2005) 1.36

Regulation of involucrin gene expression. J Invest Dermatol (2004) 1.36

Protein kinase C-epsilon regulates the apoptosis and survival of glioma cells. Cancer Res (2005) 1.33

A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation. J Biol Chem (2003) 1.33

Transglutaminase regulation of cell function. Physiol Rev (2014) 1.28

Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis. J Invest Dermatol (2007) 1.28

Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal. Oncotarget (2013) 1.22

FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway. Neoplasia (2008) 1.21

Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. J Biol Chem (2010) 1.19

Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Mol Cell Biol (2004) 1.17

Related to testes-specific, vespid, and pathogenesis protein-1 (RTVP-1) is overexpressed in gliomas and regulates the growth, survival, and invasion of glioma cells. Cancer Res (2006) 1.17

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis. Neuro Oncol (2008) 1.17

S100A7 (Psoriasin)--mechanism of antibacterial action in wounds. J Invest Dermatol (2006) 1.16

An essential role of ERK signalling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus. J Gen Virol (2006) 1.16

MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor. PLoS One (2013) 1.15

(-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis (2011) 1.14

Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha. J Biol Chem (2002) 1.14

h2-Calponin is regulated by mechanical tension and modifies the function of actin cytoskeleton. J Biol Chem (2005) 1.13

P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis. Cell Mol Neurobiol (2003) 1.11

A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase. J Biol Chem (2003) 1.08

Polycomb group proteins are key regulators of keratinocyte function. J Invest Dermatol (2010) 1.08

Keratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, EGCG and apigenin. Toxicol Appl Pharmacol (2007) 1.08

Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis. J Biol Chem (2005) 1.07

Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor. Am J Physiol Cell Physiol (2005) 1.07

Caspase-8: a key role in the pathogenesis of diabetic embryopathy. Birth Defects Res B Dev Reprod Toxicol (2009) 1.07

The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival. Carcinogenesis (2009) 1.06

p38 Mitogen-activated protein kinases on the body surface--a function for p38 delta. J Invest Dermatol (2003) 1.06

SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion. Int J Cancer (2008) 1.06

TGF-beta-regulated collagen type I accumulation: role of Src-based signals. Am J Physiol Cell Physiol (2006) 1.06

Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. J Biol Chem (2002) 1.05

Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects. Sci Signal (2013) 1.04

The distal and proximal regulatory regions of the involucrin gene promoter have distinct functions and are required for in vivo involucrin expression. J Invest Dermatol (2006) 1.03

Cilengitide induces autophagy-mediated cell death in glioma cells. Neuro Oncol (2011) 1.03

Activation of keratinocyte protein kinase C zeta in psoriasis plaques. J Invest Dermatol (2008) 1.02

cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes. J Physiol (2007) 1.02

Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)alpha and PKCdelta. J Biol Chem (2002) 1.01

HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion. Glia (2008) 1.01

Regulation of involucrin expression in normal human corneal epithelial cells: a role for activator protein one. Invest Ophthalmol Vis Sci (2004) 1.00

A novel transglutaminase activator forms a complex with type 1 transglutaminase. Oncogene (2005) 1.00

Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J Biol Chem (2001) 0.99

The localization of protein kinase Cdelta in different subcellular sites affects its proapoptotic and antiapoptotic functions and the activation of distinct downstream signaling pathways. Mol Cancer Res (2007) 0.99

Insulin-like growth factor binding protein 7 mediates glioma cell growth and migration. Neoplasia (2008) 0.99

Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells. Mol Pharmacol (2011) 0.99

Protein kinase C δ increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes. J Biol Chem (2013) 0.98

Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes. J Biol Chem (2006) 0.98

Evidence for 1,25-dihydroxyvitamin D3-independent transactivation by the vitamin D receptor: uncoupling the receptor and ligand in keratinocytes. J Biol Chem (2007) 0.97

The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation. Oncogene (2002) 0.96

Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanism. J Biol Chem (2011) 0.96

Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol (2004) 0.96

Localization of the TIG3 transglutaminase interaction domain and demonstration that the amino-terminal region is required for TIG3 function as a keratinocyte differentiation regulator. J Invest Dermatol (2007) 0.96

Suppression of AP1 transcription factor function in keratinocyte suppresses differentiation. PLoS One (2012) 0.95

Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent. J Biol Chem (2012) 0.94

A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level. J Biol Chem (2012) 0.94

Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions. Cell Signal (2011) 0.93

Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. J Biol Chem (2004) 0.93

Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells. Biochem Biophys Res Commun (2006) 0.93

Retinoids suppress epidermal growth factor-associated cell proliferation by inhibiting epidermal growth factor receptor-dependent ERK1/2 activation. J Biol Chem (2002) 0.92

Barrier function in transgenic mice overexpressing K16, involucrin, and filaggrin in the suprabasal epidermis. J Invest Dermatol (2004) 0.92

Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells. Biochem Biophys Res Commun (2007) 0.91

Synergistic activation of human involucrin gene expression by Fra-1 and p300--evidence for the presence of a multiprotein complex. J Invest Dermatol (2007) 0.91

Mesenchymal stem cells deliver exogenous miRNAs to neural cells and induce their differentiation and glutamate transporter expression. Stem Cells Dev (2014) 0.90

Human epidermal keratinocytes undergo (-)-epigallocatechin-3-gallate-dependent differentiation but not apoptosis. Carcinogenesis (2005) 0.90

The phosphorylation of tyrosine 332 is necessary for the caspase 3-dependent cleavage of PKCdelta and the regulation of cell apoptosis. Cell Signal (2007) 0.90

An involucrin promoter AP1 transcription factor binding site is required for expression of involucrin in the corneal epithelium in vivo. Invest Ophthalmol Vis Sci (2005) 0.89

S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes. J Invest Dermatol (2003) 0.89

Increased matriptase zymogen activation in inflammatory skin disorders. Am J Physiol Cell Physiol (2010) 0.89

The Bmi-1 polycomb group gene in skin cancer: regulation of function by (-)-epigallocatechin-3-gallate. Nutr Rev (2008) 0.89

Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis. Arch Dermatol Res (2007) 0.89

Biochemistry of epidermal stem cells. Biochim Biophys Acta (2012) 0.88

TRAIL conjugated to nanoparticles exhibits increased anti-tumor activities in glioma cells and glioma stem cells in vitro and in vivo. Neuro Oncol (2012) 0.88

Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival. Mol Cancer (2012) 0.88

Involucrin expression in the corneal epithelium: an essential role for Sp1 transcription factors. Invest Ophthalmol Vis Sci (2005) 0.87

Differential role of PKC isoforms in GnRH and phorbol 12-myristate 13-acetate activation of extracellular signal-regulated kinase and Jun N-terminal kinase. Endocrinology (2010) 0.87

Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon. Biochim Biophys Acta (2011) 0.87

Protein arginine methyltransferase 5 (PRMT5) signaling suppresses protein kinase Cδ- and p38δ-dependent signaling and keratinocyte differentiation. J Biol Chem (2011) 0.86

Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311. J Biol Chem (2006) 0.86

TIG3 interaction at the centrosome alters microtubule distribution and centrosome function. J Cell Sci (2012) 0.86

PKCepsilon induces astrocytic differentiation of multipotential neural precursor cells. Glia (2007) 0.86

TIG3 tumor suppressor-dependent organelle redistribution and apoptosis in skin cancer cells. PLoS One (2011) 0.85

Antioxidants regulate normal human keratinocyte differentiation. Biochem Pharmacol (2004) 0.85

Bone marrow stromal cell therapy reduces proNGF and p75 expression in mice with experimental autoimmune encephalomyelitis. J Neurol Sci (2009) 0.85

Opposing action of curcumin and green tea polyphenol in human keratinocytes. Mol Nutr Food Res (2006) 0.84

RTVP-1 expression is regulated by SRF downstream of protein kinase C and contributes to the effect of SRF on glioma cell migration. Cell Signal (2011) 0.82

DeltaNp63alpha promotes apoptosis of human epidermal keratinocytes. J Invest Dermatol (2007) 0.82

Suppression of human pancreatic cancer cell proliferation by AGN194204, an RXR-selective retinoid. Carcinogenesis (2004) 0.81