Published in Eur J Pain on October 18, 2007
Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain? Mol Pain (2011) 1.23
Genetic tracing of Nav1.8-expressing vagal afferents in the mouse. J Comp Neurol (2011) 1.16
Role of acid-sensing ion channel 3 in sub-acute-phase inflammation. Mol Pain (2009) 1.14
Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn. Mol Pain (2012) 1.07
Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia. PLoS One (2013) 1.06
Towards a mechanism-based approach to pain management in osteoarthritis. Nat Rev Rheumatol (2013) 1.04
Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. Pflugers Arch (2010) 1.02
Nav1.9 channel contributes to mechanical and heat pain hypersensitivity induced by subacute and chronic inflammation. PLoS One (2011) 1.02
Pain related channels are differentially expressed in neuronal and non-neuronal cells of glabrous skin of fabry knockout male mice. PLoS One (2014) 0.91
RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors. PLoS One (2015) 0.89
Upregulation of cystathionine β-synthetase expression contributes to visceral hyperalgesia induced by heterotypic intermittent stress in rats. PLoS One (2012) 0.89
Colonic Hypersensitivity and Sensitization of Voltage-gated Sodium Channels in Primary Sensory Neurons in Rats with Diabetes. J Neurogastroenterol Motil (2016) 0.89
Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons. J Pain (2013) 0.89
Nociceptors as chronic drivers of pain and hyperreflexia after spinal cord injury: an adaptive-maladaptive hyperfunctional state hypothesis. Front Physiol (2012) 0.88
Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation. J Neuroinflammation (2014) 0.88
Tetrodotoxin (TTX) as a therapeutic agent for pain. Mar Drugs (2012) 0.87
Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis. Arthritis Res Ther (2012) 0.87
Sodium channel Na v 1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome. BMC Neurosci (2010) 0.84
Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. Elife (2015) 0.84
A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain. J Physiol (2013) 0.84
Hyperexcitability and sensitization of sodium channels of dorsal root ganglion neurons in a rat model of lumber disc herniation. Eur Spine J (2015) 0.83
Antinociceptive action of carbamazepine on thermal hypersensitive pain at spinal level in a rat model of adjuvant-induced chronic inflammation. J Anesth (2010) 0.83
Sensory innervation of the nonspecialized connective tissues in the low back of the rat. Cells Tissues Organs (2011) 0.82
Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat. Neuroscience (2015) 0.82
The role of sodium channels in chronic pain. Muscle Nerve (2012) 0.81
Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. Front Pharmacol (2015) 0.80
Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas. Mol Pain (2013) 0.80
Antinociceptive effects of lacosamide on spinal neuronal and behavioural measures of pain in a rat model of osteoarthritis. Arthritis Res Ther (2014) 0.80
Topical ambroxol for the treatment of neuropathic pain. An initial clinical observation. Schmerz (2015) 0.79
The search for novel analgesics: targets and mechanisms. F1000Prime Rep (2015) 0.79
MicroRNA-30b regulates expression of the sodium channel Nav1.7 in nerve injury-induced neuropathic pain in the rat. Mol Pain (2016) 0.79
Evaluation of behavior and expression of NaV1.7 in dorsal root ganglia after sciatic nerve compression and application of nucleus pulposus in rats. Eur Spine J (2013) 0.78
Targeting voltage gated sodium channels NaV1.7, Na V1.8, and Na V1.9 for treatment of pathological cough. Lung (2013) 0.78
Current Status and Future Directions of Botulinum Neurotoxins for Targeting Pain Processing. Toxins (Basel) (2015) 0.77
Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity. Future Med Chem (2014) 0.76
Sodium channel Nav1.7 expression is upregulated in the dorsal root ganglia in a rat model of paclitaxel-induced peripheral neuropathy. Springerplus (2016) 0.75
Chitosan Oligosaccharide Reduces Propofol Requirements and Propofol-Related Side Effects. Mar Drugs (2016) 0.75
Efficacy of Anti-NaV1.7 Antibody on the Sensory Nervous System in a Rat Model of Lumbar Intervertebral Disc Injury. Yonsei Med J (2016) 0.75
Targeting ASIC3 for Relieving Mice Fibromyalgia Pain: Roles of Electroacupuncture, Opioid, and Adenosine. Sci Rep (2017) 0.75
Antihyperalgesic effect of tetrodotoxin in rat models of persistent muscle pain. Neuroscience (2015) 0.75
A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol (2016) 0.75
Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition. Toxins (Basel) (2015) 0.75
Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach. J Neurogastroenterol Motil (2017) 0.75
[Topical ambroxol for the treatment of neuropathic pain : A first clinical observation. German version]. Schmerz (2015) 0.75
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 3.85
Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. J Neurosci (2008) 1.97
The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci (2006) 1.88
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol (2006) 1.87
eDrug: a dynamic interactive electronic drug formulary for medical students. Br J Clin Pharmacol (2006) 1.86
The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain. Pain (2008) 1.54
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol (2007) 1.51
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther (2008) 1.45
Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons. Pain (2008) 1.10
Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem (2007) 1.03
Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins. J Biol Chem (2012) 1.01
Functional regulation of P2X6 receptors by N-linked glycosylation: identification of a novel alpha beta-methylene ATP-sensitive phenotype. Mol Pharmacol (2004) 0.99
An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models. Eur J Pain (2005) 0.99
Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action. J Pain (2008) 0.98
Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders. BMC Urol (2006) 0.98
Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain. Pain (2007) 0.96
The role of P2X₇ in pain and inflammation. Purinergic Signal (2007) 0.93
Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2'-3'-O-(4-benzoylbenzoyl)-ATP. J Neurosci (2004) 0.92
Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol. Eur J Pain (2006) 0.91
Investigation into the role of P2X(3)/P2X(2/3) receptors in neuropathic pain following chronic constriction injury in the rat: an electrophysiological study. Br J Pharmacol (2006) 0.91
The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization. J Pharmacol Exp Ther (2004) 0.90
A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl. J Neurosci Methods (2007) 0.88
A robust model of adjuvant-induced chronic unilateral arthritis in two mouse strains. J Neurosci Methods (2004) 0.87
The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain. Bioorg Med Chem Lett (2006) 0.87
Demonstration of a novel technique to quantitatively assess inflammatory mediators and cells in rat knee joints. J Inflamm (Lond) (2007) 0.86
Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury. J Peripher Nerv Syst (2004) 0.86
The role of the cylooxygenase pathway in nociception and pain. Semin Cell Dev Biol (2006) 0.86
Voltage-gated ion channel Nav1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain). Neurosci Lett (2007) 0.85
Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study. BMC Neurol (2006) 0.85
Pyridine-3-carboxamides as novel CB(2) agonists for analgesia. Bioorg Med Chem Lett (2008) 0.84
GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Pain (2006) 0.83
Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain. J Med Chem (2009) 0.82
Pressure application measurement (PAM): a novel behavioural technique for measuring hypersensitivity in a rat model of joint pain. J Neurosci Methods (2007) 0.81
Missplicing resulting from a short deletion in the reelin gene causes reeler-like neuronal disorders in the mutant shaking rat Kawasaki. J Comp Neurol (2003) 0.80
Inflammation alters somatostatin mRNA expression in sensory neurons in the rat. Eur J Neurosci (2005) 0.79
Identification of novel glycine sulfonamide antagonists for the EP1 receptor. Bioorg Med Chem Lett (2006) 0.79
Localisation and modulation of prostanoid receptors EP1 and EP4 in the rat chronic constriction injury model of neuropathic pain. Eur J Pain (2006) 0.79
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives. Bioorg Med Chem Lett (2006) 0.79
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists. Bioorg Med Chem Lett (2012) 0.78
Transgenic models of pain: a brief review. Curr Opin Investig Drugs (2006) 0.76
Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett (2009) 0.76
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists. Bioorg Med Chem Lett (2006) 0.75
Emerging therapies for neuropathic pain. Expert Opin Emerg Drugs (2005) 0.75
Perivascular nerves induce cardiorespiratory reflexes in response to algogens in anaesthetised rats. Neurosci Res (2004) 0.75
Biologics: the next-generation therapeutics for analgesia? Expert Rev Neurother (2011) 0.75
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure-activity relationships of 4- and 5-substituted benzoic acid derivatives. Bioorg Med Chem Lett (2006) 0.75
Discovery of novel biaryl heterocyclic EP1 receptor antagonists. Bioorg Med Chem Lett (2006) 0.75
Biologic drugs for analgesia: redefining the opportunity. Curr Pharm Biotechnol (2011) 0.75
Structure-activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists. Bioorg Med Chem Lett (2006) 0.75
Identification of novel pyrazole acid antagonists for the EP1 receptor. Bioorg Med Chem Lett (2006) 0.75