Towards a mechanism-based approach to pain management in osteoarthritis.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMC 4151882)

Published in Nat Rev Rheumatol on September 17, 2013

Authors

Anne-Marie Malfait1, Thomas J Schnitzer

Author Affiliations

1: Department of Medicine, Section of Rheumatology, and Department of Biochemistry, Rush University Medical Center, 1611 W. Harrison Street, Chicago, IL 60612, USA.

Associated clinical trials:

Molecular Pathways Involved in Knee Pain | NCT04443452

Articles citing this

Chemogenetic inhibition of pain neurons in a mouse model of osteoarthritis. Arthritis Rheumatol (2017) 1.38

Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol (2014) 1.15

Pain phenotype in patients with knee osteoarthritis: classification and measurement properties of painDETECT and self-report Leeds assessment of neuropathic symptoms and signs scale in a cross-sectional study. Arthritis Care Res (Hoboken) (2015) 0.95

Osteoarthritis joint pain: the cytokine connection. Cytokine (2014) 0.92

Osteoarthritis year in review 2015: biology. Osteoarthritis Cartilage (2016) 0.92

Animal models of osteoarthritis: classification, update, and measurement of outcomes. J Orthop Surg Res (2016) 0.90

Sleep, Pain Catastrophizing, and Central Sensitization in Knee Osteoarthritis Patients With and Without Insomnia. Arthritis Care Res (Hoboken) (2015) 0.89

Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis: A Pilot Study. Biomed Res Int (2016) 0.85

Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat. Neuroscience (2015) 0.82

Antinociceptive effects of lacosamide on spinal neuronal and behavioural measures of pain in a rat model of osteoarthritis. Arthritis Res Ther (2014) 0.80

Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis. Syst Rev (2016) 0.79

Abnormal Subcortical Brain Morphology in Patients with Knee Osteoarthritis: A Cross-sectional Study. Front Aging Neurosci (2016) 0.79

Damage-Associated Molecular Patterns Generated in Osteoarthritis Directly Excite Murine Nociceptive Neurons Through Toll-like Receptor 4. Arthritis Rheumatol (2015) 0.77

Emerging Targets for the Management of Osteoarthritis Pain. Curr Osteoporos Rep (2016) 0.77

The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain. Curr Osteoporos Rep (2015) 0.76

The Interface of Mechanics and Nociception in Joint Pathophysiology: Insights from the Facet & Temporomandibular Joints. J Biomech Eng (2017) 0.75

OsteoRheumatology: a new discipline? RMD Open (2015) 0.75

Unique spatiotemporal and dynamic gait compensations in the rat monoiodoacetate injection and medial meniscus transection models of knee osteoarthritis. Osteoarthritis Cartilage (2016) 0.75

Spinal microglial activation in a murine surgical model of knee osteoarthritis. Osteoarthritis Cartilage (2016) 0.75

Cerebral Cortical Thickness in Chronic Pain Due to Knee Osteoarthritis: The Effect of Pain Duration and Pain Sensitization. PLoS One (2016) 0.75

A novel method to detect articular chondrocyte death during early stages of osteoarthritis using a non-invasive ApoPep-1 probe. Arthritis Res Ther (2015) 0.75

A Mechanism-Based Approach to the Management of Osteoarthritis Pain. Curr Osteoporos Rep (2015) 0.75

Duloxetine in OsteoArthritis (DOA) study: study protocol of a pragmatic open-label randomised controlled trial assessing the effect of preoperative pain treatment on postoperative outcome after total hip or knee arthroplasty. BMJ Open (2016) 0.75

The effect of lateral wedge insoles in patients with medial compartment knee osteoarthritis: balancing biomechanics with pain neuroscience. Clin Rheumatol (2014) 0.75

Efficacy of CR4056, a first-in-class imidazoline-2 analgesic drug, in comparison with naproxen in two rat models of osteoarthritis. J Pain Res (2017) 0.75

Articles cited by this

(truncated to the top 100)

Cellular and molecular mechanisms of pain. Cell (2009) 9.36

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) (2012) 9.25

Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. J Pain (2007) 8.89

Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med (1999) 8.60

EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis (2003) 7.95

Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ (2006) 7.80

OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage (2010) 7.52

Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci (2003) 7.44

Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain (2009) 7.11

Central sensitization: implications for the diagnosis and treatment of pain. Pain (2010) 6.88

Differences between men and women in the rate of use of hip and knee arthroplasty. N Engl J Med (2000) 6.29

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature (2001) 6.26

Descending control of pain. Prog Neurobiol (2002) 6.20

Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. CMAJ (2006) 6.12

Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med (2001) 5.96

A capsaicin-receptor homologue with a high threshold for noxious heat. Nature (1999) 5.85

Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53

EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis (2004) 4.94

A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature (1996) 4.63

Outcomes of total hip and knee replacement: preoperative functional status predicts outcomes at six months after surgery. Arthritis Rheum (1999) 4.46

Pharmacological management of persistent pain in older persons. J Am Geriatr Soc (2009) 4.43

Pathogenesis and management of pain in osteoarthritis. Lancet (2005) 4.35

Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum (2012) 4.28

p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron (2002) 4.27

Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med (2010) 4.15

OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthritis Cartilage (2004) 4.01

Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies. BMJ (2009) 3.99

The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage (2007) 3.86

Predicting the outcome of total knee arthroplasty. J Bone Joint Surg Am (2004) 3.70

Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol (2000) 3.63

Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci (2006) 3.44

Sensitization in patients with painful knee osteoarthritis. Pain (2010) 3.18

The innervation of the knee joint. An anatomical and histological study in the cat. J Anat (1967) 3.16

Interactions between the immune and nervous systems in pain. Nat Med (2010) 2.91

The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskelet Disord (2008) 2.81

Towards a theory of chronic pain. Prog Neurobiol (2008) 2.76

Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum (2012) 2.71

SNRIs: their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants. CNS Spectr (2005) 2.71

Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial. Pain (2009) 2.69

National Ambulatory Medical Care Survey: 2004 summary. Adv Data (2006) 2.57

Corticostriatal functional connectivity predicts transition to chronic back pain. Nat Neurosci (2012) 2.51

Interpreting the clinical importance of group differences in chronic pain clinical trials: IMMPACT recommendations. Pain (2009) 2.49

Conscious neurosensory mapping of the internal structures of the human knee without intraarticular anesthesia. Am J Sports Med (1999) 2.41

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis (2013) 2.39

Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience (1994) 2.36

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med (2012) 2.25

Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging. Arthritis Rheum (2011) 2.17

A phase III placebo- and oxycodone-controlled study of tanezumab in adults with osteoarthritis pain of the hip or knee. Pain (2013) 2.14

Central modulation of pain. J Clin Invest (2010) 2.12

Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain (2000) 2.12

Novel class of pain drugs based on antagonism of NGF. Trends Pharmacol Sci (2005) 2.06

Understanding the pain experience in hip and knee osteoarthritis--an OARSI/OMERACT initiative. Osteoarthritis Cartilage (2008) 2.05

Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review. Ann Rheum Dis (2010) 2.01

A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain. Arthritis Rheum (2009) 1.94

Effects of an experimental arthritis on the sensory properties of fine articular afferent units. J Neurophysiol (1985) 1.81

Pain perception is altered by a nucleotide polymorphism in SCN9A. Proc Natl Acad Sci U S A (2010) 1.79

Developments in the clinical understanding of osteoarthritis. Arthritis Res Ther (2009) 1.74

Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage (2012) 1.74

Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. Arthritis Rheum (2011) 1.74

Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Ann Rheum Dis (2007) 1.73

Cytokine and chemokine regulation of sensory neuron function. Handb Exp Pharmacol (2009) 1.70

Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2. Mol Cell Neurosci (2000) 1.69

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound? Curr Opin Rheumatol (2008) 1.64

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol (2012) 1.62

Emerging role of Toll-like receptors in the control of pain and itch. Neurosci Bull (2012) 1.60

Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum (2010) 1.57

Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment. Eur J Pain (2000) 1.54

Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study. Pain (2001) 1.51

Pain mechanisms in osteoarthritis of the knee: effect of intraarticular anesthetic. J Rheumatol (1996) 1.51

A double-blind, randomized, placebo-controlled study of the efficacy and safety of duloxetine for the treatment of chronic pain due to osteoarthritis of the knee. Pain Pract (2011) 1.50

Symptoms and radiographic osteoarthritis: not as discordant as they are made out to be? Ann Rheum Dis (2006) 1.49

Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial. Ann Rheum Dis (2012) 1.49

Genetic architecture of human pain perception. Trends Genet (2007) 1.48

Arthritic pain is processed in brain areas concerned with emotions and fear. Arthritis Rheum (2007) 1.47

The role of proinflammatory cytokines in the generation and maintenance of joint pain. Ann N Y Acad Sci (2010) 1.46

Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain. Arthritis Rheum (2007) 1.44

Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization. Arthritis Rheum (2013) 1.41

The nerve of osteoarthritis pain. Arthritis Care Res (Hoboken) (2010) 1.39

Proprioceptive impairment in knee osteoarthritis. Rheum Dis Clin North Am (1999) 1.39

American Academy of Orthopaedic Surgeons clinical practice guideline on the treatment of osteoarthritis (OA) of the knee. J Bone Joint Surg Am (2010) 1.38

Inflammatory pain: the cellular basis of heat hyperalgesia. Curr Neuropharmacol (2006) 1.37

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain (2010) 1.37

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A (2012) 1.34

The effects of impaired joint position sense on the development and progression of pain and structural damage in knee osteoarthritis. Arthritis Rheum (2009) 1.33

Osteochondral alterations in osteoarthritis. Bone (2011) 1.31

Mode of action of aspirin-like drugs. Adv Intern Med (1979) 1.30

Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis. Arthritis Res Ther (2009) 1.29

Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials. BMC Neurol (2008) 1.28

Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain. Eur J Pain (2007) 1.27

What are the factors of residual pain after uncomplicated TKA? Knee Surg Sports Traumatol Arthrosc (2011) 1.26

Efficacy and safety of duloxetine in patients with chronic low back pain. Spine (Phila Pa 1976) (2010) 1.24

Neuropathic pain symptoms in a community knee OA cohort. Osteoarthritis Cartilage (2011) 1.21

Arthritis and pain. Neurogenic origin of joint pain. Arthritis Res Ther (2006) 1.21

Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons. J Neurosci Res (2008) 1.20

Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis. Pain (2005) 1.20

Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis. Ann Rheum Dis (2010) 1.19

Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes. Rheumatology (Oxford) (2002) 1.19

Duloxetine for treating painful neuropathy or chronic pain. Cochrane Database Syst Rev (2009) 1.19

COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest (2009) 1.18

Reduced lower extremity vibratory perception in osteoarthritis of the knee. Arthritis Rheum (2008) 1.17

Articles by these authors

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med (2006) 10.95

Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med (2010) 7.39

Tanezumab for the treatment of pain from osteoarthritis of the knee. N Engl J Med (2010) 4.15

Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. JAMA (2002) 3.61

Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial. Lancet (2004) 3.57

Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum (2005) 3.31

Corticostriatal functional connectivity predicts transition to chronic back pain. Nat Neurosci (2012) 2.51

Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use. Gastroenterology (2003) 2.00

Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits. Brain (2013) 1.77

Brain morphological signatures for chronic pain. PLoS One (2011) 1.63

Brain white matter structural properties predict transition to chronic pain. Pain (2013) 1.41

Pins and plaster aren't enough: a call for the evaluation and treatment of patients with osteoporotic fractures. J Clin Endocrinol Metab (2003) 1.30

A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis. Mol Pain (2008) 1.24

Alendronate improves bone mineral density in elderly women with osteoporosis residing in long-term care facilities. A randomized, double-blind, placebo-controlled trial. Ann Intern Med (2002) 1.12

Brain activity for chronic knee osteoarthritis: dissociating evoked pain from spontaneous pain. Eur J Pain (2011) 1.07

Reorganization of hippocampal functional connectivity with transition to chronic back pain. J Neurophysiol (2013) 1.05

A comparison of the efficacy and safety of nonsteroidal antiinflammatory agents versus acetaminophen in the treatment of osteoarthritis: a meta-analysis. Arthritis Rheum (2004) 1.00

Pain characteristic differences between subacute and chronic back pain. J Pain (2011) 0.96

Brain networks predicting placebo analgesia in a clinical trial for chronic back pain. Pain (2012) 0.93

The effect of eszopiclone in patients with insomnia and coexisting rheumatoid arthritis: a pilot study. Prim Care Companion J Clin Psychiatry (2009) 0.89

Once-weekly oral alendronate 70 mg in patients with glucocorticoid-induced bone loss: a 12-month randomized, placebo-controlled clinical trial. J Rheumatol (2009) 0.88

Efficacy, safety, and tolerability of the cyclooxygenase-inhibiting nitric oxide donator naproxcinod in treating osteoarthritis of the hip or knee. J Rheumatol (2009) 0.88

Prevalence of 25-hydroxyvitamin D deficiency in the outpatient rehabilitation population. Am J Phys Med Rehabil (2010) 0.85

Severity of joint pain and Kellgren-Lawrence grade at baseline are better predictors of joint space narrowing than bone scintigraphy in obese women with knee osteoarthritis. J Rheumatol (2005) 0.85

Effects of the cyclooxygenase inhibiting nitric oxide donator naproxcinod versus naproxen on systemic blood pressure in patients with osteoarthritis. Am J Cardiol (2009) 0.84

Effect of parathyroid hormone combined with gait training on bone density and bone architecture in people with chronic spinal cord injury. PM R (2013) 0.84

Does knee osteoarthritis differentially modulate proprioceptive acuity in the frontal and sagittal planes of the knee? Arthritis Rheum (2011) 0.83

Torsional stiffness and strength of the proximal tibia are better predicted by finite element models than DXA or QCT. J Biomech (2013) 0.83

Need for common internal controls when assessing the relative efficacy of pharmacologic agents using a meta-analytic approach: case study of cyclooxygenase 2-selective inhibitors for the treatment of osteoarthritis. Arthritis Rheum (2005) 0.83

Rofecoxib 12.5 mg, rofecoxib 25 mg, and celecoxib 200 mg in the treatment of symptomatic osteoarthritis: results of two similarly designed studies. Curr Med Res Opin (2006) 0.82

Subject retention and adherence in a randomized placebo-controlled trial of a disease-modifying osteoarthritis drug. Arthritis Rheum (2004) 0.82

Reduction in proximal femoral strength in patients with acute spinal cord injury. J Bone Miner Res (2014) 0.81

Response to expression of concern regarding VIGOR study. N Engl J Med (2006) 0.80

Prevalence of 25-hydroxyvitamin D deficiency in the acute inpatient rehabilitation population and its effect on function. Arch Phys Med Rehabil (2011) 0.79

Smoking increases risk of pain chronification through shared corticostriatal circuitry. Hum Brain Mapp (2014) 0.78

Means, responders, and meaning: evaluation of clinical trials in osteoarthritis. Arthritis Rheum (2003) 0.77

Effects of naproxcinod on blood pressure in patients with osteoarthritis. Am J Cardiol (2011) 0.77

Management of osteoporosis after spinal cord injury: what can be done? Point/counterpoint. PM R (2010) 0.77

Sensitivity of single-domain versus multiple-domain outcome measures to identify responders in chronic low-back pain: pooled analysis of 2 placebo-controlled trials of etoricoxib. Clin J Pain (2012) 0.76

Rofecoxib and clinically significant gastrointestinal events. Am J Med Sci (2011) 0.75

Estrogen therapy in postmenopausal women. Curr Rheumatol Rep (2003) 0.75

Reply: High Risk of Gastrointestinal Bleeding on Dual Antiplatelet Treatment. J Am Coll Cardiol (2016) 0.75

Osteoporosis treatment for patients with stroke. Top Stroke Rehabil (2007) 0.75

Intra-articular hylastan versus steroid for knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc (2013) 0.75

Pain management today - optimising the benefit/risk ratio: defining the role of weak opioids and combination analgesics. Clin Rheumatol (2006) 0.75

Bone Imaging and Fracture Risk after Spinal Cord Injury. Curr Osteoporos Rep (2015) 0.75

The Efficacy of Nonsteroidal Anti-inflammatory Drugs for Acute Pain. Cancer Control (2002) 0.75