Published in Cancer on December 15, 2007
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. FEBS J (2010) 1.78
Significance of heparanase in cancer and inflammation. Cancer Microenviron (2011) 1.46
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. J Biol Chem (2010) 1.19
Tumorigenic and adhesive properties of heparanase. Semin Cancer Biol (2010) 1.10
Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget (2015) 0.94
Heparanase is overexpressed in lung cancer and correlates inversely with patient survival. Cancer (2008) 0.92
Prognostic value of heparanase expression and cellular localization in oral cancer. Head Neck (2010) 0.81
Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma. J Cell Mol Med (2013) 0.81
The prognostic role of phospho-Src family kinase analysis in tongue cancer. J Cancer Res Clin Oncol (2010) 0.80
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor. PLoS One (2015) 0.75
The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression. Neoplasia (2017) 0.75
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol (2006) 3.24
Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis. J Natl Cancer Inst (2004) 2.52
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis. J Biol Chem (2007) 2.25
Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate. Curr Pharm Des (2007) 2.14
Heparanase: busy at the cell surface. Trends Biochem Sci (2009) 2.07
Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res (2006) 2.02
Processing and activation of latent heparanase occurs in lysosomes. J Cell Sci (2004) 1.82
Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem (2004) 1.78
Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. FEBS J (2010) 1.78
Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest (2009) 1.73
Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Circ Res (2008) 1.64
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J (2004) 1.64
Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res (2003) 1.54
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood (2010) 1.53
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting. J Biol Chem (2005) 1.52
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy. Blood (2007) 1.49
Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J Biol Chem (2013) 1.49
Skp2 and salivary cancer. Cancer Biol Ther (2009) 1.47
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PLoS One (2009) 1.46
Significance of heparanase in cancer and inflammation. Cancer Microenviron (2011) 1.46
Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis. Proc Natl Acad Sci U S A (2002) 1.45
Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46. J Immunol (2004) 1.43
Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. J Biol Chem (2004) 1.43
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment. J Biol Chem (2008) 1.43
Heparanase promotes growth, angiogenesis and survival of primary breast tumors. Int J Cancer (2006) 1.42
Non-anticoagulant heparins and inhibition of cancer. Pathophysiol Haemost Thromb (2009) 1.41
Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice. Neurosci Lett (2011) 1.41
Heparanase mediates cell adhesion independent of its enzymatic activity. FASEB J (2003) 1.41
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development (2007) 1.40
SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis. Clin Cancer Res (2011) 1.40
The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma. Cancer (2005) 1.39
In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis. Proc Natl Acad Sci U S A (2005) 1.37
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res (2008) 1.35
Role of endothelial heparanase in delayed-type hypersensitivity. Blood (2005) 1.35
Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. Cancer Res (2009) 1.34
Cellular heparan sulfate participates in the metabolism of prions. J Biol Chem (2003) 1.34
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J (2005) 1.32
Heparan sulfate is a cellular receptor for purified infectious prions. J Biol Chem (2005) 1.32
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. J Clin Invest (2011) 1.32
Heparanase induces VEGF C and facilitates tumor lymphangiogenesis. Int J Cancer (2008) 1.31
The expression of the ubiquitin ligase subunit Cks1 in human breast cancer. Breast Cancer Res (2005) 1.30
Heparanase: one molecule with multiple functions in cancer progression. Connect Tissue Res (2008) 1.29
Heparanase is essential for the development of diabetic nephropathy in mice. Diabetes (2011) 1.29
The impact of heparanese and heparin on cancer metastasis and angiogenesis. Pathophysiol Haemost Thromb (2006) 1.29
Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival. Neoplasia (2006) 1.28
The heparanase system and tumor metastasis: is heparanase the seed and soil? Cancer Metastasis Rev (2011) 1.28
Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase. J Biol Chem (2005) 1.27
Heparin, heparan sulfate and heparanase in inflammatory reactions. Thromb Haemost (2009) 1.27
Function of heparanase in prostate tumorigenesis: potential for therapy. Clin Cancer Res (2008) 1.25
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate. Nat Chem Biol (2007) 1.25
The heparanase/syndecan-1 axis in cancer: mechanisms and therapies. FEBS J (2013) 1.24
Pathologic predictors of microsatellite instability in colorectal cancer. Am J Surg Pathol (2009) 1.23
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. J Biol Chem (2010) 1.19
Traumatic ulcerative granuloma with stromal eosinophilia: a reactive lesion of the oral mucosa. Am J Clin Pathol (2006) 1.19
Heterodimer formation is essential for heparanase enzymatic activity. Biochem Biophys Res Commun (2003) 1.17
Enzymatically quiescent heparanase augments T cell interactions with VCAM-1 and extracellular matrix components under versatile dynamic contexts. J Immunol (2004) 1.16
P-selectin- and heparanase-dependent antimetastatic activity of non-anticoagulant heparins. FASEB J (2007) 1.14
Heparanase facilitates cell adhesion and spreading by clustering of cell surface heparan sulfate proteoglycans. PLoS One (2008) 1.14
Site-directed mutagenesis, proteolytic cleavage, and activation of human proheparanase. J Biol Chem (2005) 1.13
A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics. FASEB J (2009) 1.13
Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. J Cell Sci (2002) 1.12
Role of promoter methylation in regulation of the mammalian heparanase gene. Oncogene (2003) 1.12
Heparanase is expressed in osteoblastic cells and stimulates bone formation and bone mass. J Cell Physiol (2006) 1.11
Tumorigenic and adhesive properties of heparanase. Semin Cancer Biol (2010) 1.10
Heparanase upregulation by colonic epithelium in inflammatory bowel disease. Mod Pathol (2006) 1.09
Regulation of heparanase gene expression by estrogen in breast cancer. Cancer Res (2003) 1.09
Characterization of mechanisms involved in secretion of active heparanase. J Biol Chem (2006) 1.08
The alopecias associated with vitamin D-dependent rickets type IIA and with hairless gene mutations: a comparative clinical, histologic, and immunohistochemical study. Arch Dermatol (2005) 1.07
Human heparanase is localized within lysosomes in a stable form. Exp Cell Res (2002) 1.07