Published in Biochimie on September 22, 2007
Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85
Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov (2010) 2.90
A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43
The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates. EMBO Rep (2009) 1.42
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A (2008) 1.39
Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms. Cell Death Differ (2011) 1.39
Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat Commun (2014) 1.31
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin. EMBO J (2014) 1.20
The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling. Mol Cell Biol (2011) 1.17
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth. Oncotarget (2014) 1.08
The proteasome of malaria parasites: A multi-stage drug target for chemotherapeutic intervention? Int J Parasitol Drugs Drug Resist (2012) 1.06
USP8 is a novel target for overcoming gefitinib resistance in lung cancer. Clin Cancer Res (2013) 1.04
USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis (2013) 0.96
Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells. Curr Biol (2009) 0.95
Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer. Int J Med Sci (2008) 0.88
Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells. PLoS One (2011) 0.87
Strategies for the identification of ubiquitin ligase inhibitors. Biochem Soc Trans (2010) 0.85
Ataxin-3 and its e3 partners: implications for machado-joseph disease. Front Neurol (2013) 0.83
Cell death and deubiquitinases: perspectives in cancer. Biomed Res Int (2014) 0.83
Regulation of ErbB2 receptor status by the proteasomal DUB POH1. PLoS One (2009) 0.82
Targeting ubiquitination for cancer therapies. Future Med Chem (2015) 0.82
Computational methods for de novo protein design and its applications to the human immunodeficiency virus 1, purine nucleoside phosphorylase, ubiquitin specific protease 7, and histone demethylases. Curr Drug Targets (2010) 0.81
Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth. PLoS One (2014) 0.80
Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells. J Periodontal Res (2010) 0.79
USP8 modulates ubiquitination of LRIG1 for Met degradation. Sci Rep (2014) 0.79
Novel use of old drug: Anti-rheumatic agent auranofin overcomes imatinib-resistance of chronic myeloid leukemia cells. Cancer Cell Microenviron (2014) 0.79
Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Growth of Gefitinib-resistant Non-small Cell Lung Cancer Cells by Inducing Apoptosis. J Cancer Prev (2015) 0.78
Deubiquitinases in cancer. Oncotarget (2015) 0.78
Ubiquitin-specific protease 4 controls metastatic potential through β-catenin stabilization in brain metastatic lung adenocarcinoma. Sci Rep (2016) 0.77
A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases. Exp Biol Med (Maywood) (2014) 0.77
Characterization of the transcriptome of fast and slow muscle myotomal fibres in the pacu (Piaractus mesopotamicus). BMC Genomics (2015) 0.77
Isopeptidases in anticancer therapy: looking for inhibitors. Am J Transl Res (2010) 0.76
BLAP-Tags, TUBEs and DUB-Chips: Combined Novel Technologies will Advance Molecular Epithelial Physiology. Front Physiol (2012) 0.75
Regulation of pluripotency and differentiation by deubiquitinating enzymes. Cell Death Differ (2016) 0.75
Ubiquitin-specific protease 2 decreases p53-dependent apoptosis in cutaneous T-cell lymphoma. Oncotarget (2016) 0.75
The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators. Oncotarget (2017) 0.75
Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis. J Mol Histol (2015) 0.75
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat Cell Biol (2006) 4.14
Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell (2009) 2.40
Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme. Chem Biol (2012) 1.82
The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor. J Cell Biol (2007) 1.38
Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori. Appl Environ Microbiol (2008) 1.21
Patented small molecule inhibitors in the ubiquitin proteasome system. BMC Biochem (2007) 1.19
The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}. Proc Natl Acad Sci U S A (2010) 1.11
ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion. Nat Cell Biol (2005) 1.06
Ubiquitin-specific proteases as cancer drug targets. Future Oncol (2011) 0.98
Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem (2010) 0.97
Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori. Mol Microbiol (2011) 0.91
Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling. EMBO J (2008) 0.90
Identification of PHRF1 as a tumor suppressor that promotes the TGF-β cytostatic program through selective release of TGIF-driven PML inactivation. Cell Rep (2013) 0.84
Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase. Exp Cell Res (2009) 0.81