Published in Bioorg Med Chem on October 10, 2007
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DNA damage-mediated apoptosis induced by selenium compounds. J Biol Chem (2003) 1.15
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. J Biol Chem (2011) 1.10
Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult. Biochem Pharmacol (2006) 1.10
Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast. J Biol Chem (2003) 1.08
Association of ORAI1 haplotypes with the risk of HLA-B27 positive ankylosing spondylitis. PLoS One (2011) 1.07
Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells. Biochem Pharmacol (2004) 1.06
Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. Biochem Pharmacol (2009) 1.06
Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents. Bioorg Med Chem (2003) 1.05
Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways. Biochem Pharmacol (2007) 1.03
Involvement of topoisomerase III in telomere-telomere recombination. J Biol Chem (2006) 1.02
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther (2008) 1.02
Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals. J Biol Chem (2003) 1.01
Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells. Cancer Lett (2006) 1.01
YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells. Mol Cancer Ther (2005) 1.00
How to standardize 3 finger positions of examiner for palpating radial pulses at wrist in traditional Chinese medicine. Acupunct Electrother Res (2007) 0.97
D:C-friedooleanane-type triterpenoids from Lagenaria siceraria and their cytotoxic activity. Chem Pharm Bull (Tokyo) (2008) 0.95
Serum uric acid is independently associated with metabolic syndrome in subjects with and without a low estimated glomerular filtration rate. J Rheumatol (2009) 0.95
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma. J Hepatol (2005) 0.94
Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res (2008) 0.94
Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells. Eur J Pharmacol (2006) 0.93
Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity. J Med Chem (2003) 0.93
Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells. J Nutr Biochem (2011) 0.93
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo. Carcinogenesis (2005) 0.92
Inhibitory effects of 16-hydroxycleroda-3,13(14)E-dien-15-oic acid on superoxide anion and elastase release in human neutrophils through multiple mechanisms. Eur J Pharmacol (2008) 0.92
Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.92
Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells. J Urol (2003) 0.92
On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs. Nucleic Acids Res (2013) 0.92
Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells. Biochem Pharmacol (2003) 0.92
Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Lett (2011) 0.92
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models. J Pharmacol Exp Ther (2005) 0.91
Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells. Eur J Pharmacol (2004) 0.91
Anti-angiogenic effects and mechanism of prazosin. Prostate (2010) 0.91
Distribution of gyrase and topoisomerase IV on bacterial nucleoid: implications for nucleoid organization. Nucleic Acids Res (2006) 0.91
Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes. Life Sci (2004) 0.90
Usage of the claim database of national health insurance programme for analysis of cisapride-erythromycin co-medication in Taiwan. Pharmacoepidemiol Drug Saf (2007) 0.90
A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways. Biochem Pharmacol (2011) 0.90
Psychometric evaluation of the WHOQOL-BREF in community-dwelling older people in Taiwan using Rasch analysis. Qual Life Res (2009) 0.89
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Eur J Pharmacol (2006) 0.89
Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses. DNA Repair (Amst) (2008) 0.89
YC-1 [3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl Indazole] exhibits a novel antiproliferative effect and arrests the cell cycle in G0-G1 in human hepatocellular carcinoma cells. J Pharmacol Exp Ther (2004) 0.89
Aminoglycoside complexation with a DNA.RNA hybrid duplex: the thermodynamics of recognition and inhibition of RNA processing enzymes. J Am Chem Soc (2003) 0.88
Propofol increases bone morphogenetic protein-7 and decreases oxidative stress in sepsis-induced acute kidney injury. Nephrol Dial Transplant (2010) 0.88
The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cells. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.88
An empirical comparison of the WHOQOL-BREF and the SGRQ among patients with COPD. Qual Life Res (2008) 0.88
TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells. Cancer Lett (2013) 0.87
EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells. J Biol Chem (2010) 0.87
Acidic pH induces topoisomerase II-mediated DNA damage. Proc Natl Acad Sci U S A (2003) 0.87
Multiple domains of the tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencing. Mol Plant Microbe Interact (2012) 0.87
Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo. Cancer Lett (2009) 0.87
Role of uric acid in the link between arterial stiffness and cardiac hypertrophy: a cross-sectional study. Rheumatology (Oxford) (2010) 0.87
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Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer. J Urol (2011) 0.86
Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia (2007) 0.86
Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine. J Urol (2005) 0.86
Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells. Shock (2010) 0.86
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits neointima formation in balloon-injured rat carotid through suppression of expressions and activities of matrix metalloproteinases 2 and 9. J Pharmacol Exp Ther (2005) 0.86
Mitoxantrone inhibits HIF-1α expression in a topoisomerase II-independent pathway. Clin Cancer Res (2011) 0.85
Genistein inversely affects tubulin-binding agent-induced apoptosis in human breast cancer cells. Biochem Pharmacol (2004) 0.85
Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity. J Biomed Sci (2005) 0.85
New prostanoids with cytotoxic activity from Taiwanese octocoral Clavularia viridis. J Nat Prod (2004) 0.84
A potential role of YC-1 on the inhibition of cytokine release in peripheral blood mononuclear leukocytes and endotoxemic mouse models. Thromb Haemost (2005) 0.84
CHM-1 inhibits hepatocyte growth factor-induced invasion of SK-Hep-1 human hepatocellular carcinoma cells by suppressing matrix metalloproteinase-9 expression. Cancer Lett (2007) 0.84
Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair. Cancer Lett (2012) 0.83
Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification. J Med Chem (2009) 0.83
Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.83
Potentiation of tumor necrosis factor-alpha expression by YC-1 in alveolar macrophages through a cyclic GMP-independent pathway. Biochem Pharmacol (2003) 0.83
Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication. J Virol (2006) 0.83
Two new cytotoxic clerodane diterpenoids from Casearia membranacea. Chem Pharm Bull (Tokyo) (2004) 0.82
New cytotoxic clerodane diterpenoids from the leaves and twigs of Casearia membranacea. J Nat Prod (2004) 0.82
Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435. Bioorg Med Chem Lett (2002) 0.82
Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.82
Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulation. Prostate (2012) 0.81
Cellular processing determinants for the activation of damage signals in response to topoisomerase I-linked DNA breakage. Cell Res (2010) 0.81
WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers. Biochem Pharmacol (2007) 0.81
Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats. Biochem Pharmacol (2003) 0.81
Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties. Bioorg Med Chem (2013) 0.81
Novel azulene-based derivatives as potent multi-receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett (2010) 0.81
Modulation of anti-adhesion molecule MUC-1 is associated with arctiin-induced growth inhibition in PC-3 cells. Prostate (2004) 0.80
Chemical modification and anticancer effect of prenylated flavanones from Taiwanese propolis. Nat Prod Res (2011) 0.80
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Inhibition of Ras-mediated cell proliferation by benzyloxybenzaldehyde. J Biomed Sci (2002) 0.80
QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells. Cancer Sci (2011) 0.80
Two new sesquiterpene lactones from Ixeris chinensis. Chem Pharm Bull (Tokyo) (2005) 0.79
A negative feedback of the HIF-1α pathway via interferon-stimulated gene 15 and ISGylation. Clin Cancer Res (2013) 0.79
Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.79
CIL-102 interacts with microtubule polymerization and causes mitotic arrest following apoptosis in the human prostate cancer PC-3 cell line. J Biol Chem (2004) 0.79