Published in Naunyn Schmiedebergs Arch Pharmacol on July 08, 2008
Combined treatment with denbinobin and Fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma BxPC-3 cells. Br J Pharmacol (2009) 0.92
Antitumor activity of ethanolic extract of Dendrobium formosum in T-cell lymphoma: an in vitro and in vivo study. Biomed Res Int (2014) 0.89
Synthesis and biological evaluation of phenanthrenes as cytotoxic agents with pharmacophore modeling and ChemGPS-NP prediction as topo II inhibitors. PLoS One (2012) 0.75
Mitochondria and apoptosis. Science (1998) 23.41
Caspases: enemies within. Science (1998) 19.45
Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41
The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene (2007) 10.08
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science (2000) 8.74
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell (2005) 8.73
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
DNA damage-induced cell death by apoptosis. Trends Mol Med (2006) 4.67
The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol (2001) 3.66
Caspase-independent cell death. Nat Med (2005) 3.42
Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene (2004) 2.52
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell Death Differ (2002) 2.42
Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science (2002) 2.36
The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun (2005) 2.25
Mitochondria, the killer organelles and their weapons. J Cell Physiol (2002) 1.92
Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci (2002) 1.88
Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ (1999) 1.84
Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie (2002) 1.70
Cellular response to etoposide treatment. Cancer Lett (2006) 1.61
Caspase-independent cell deaths. Curr Opin Cell Biol (2002) 1.46
Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene (2001) 1.33
Regulation of AIF expression by p53. Cell Death Differ (2006) 1.31
Caspases: potential targets for regulating cell death. J Cell Mol Med (2004) 1.22
In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobile. Planta Med (1995) 1.17
Viruses and apoptosis. Int J Exp Pathol (2001) 1.03
Phase I trial and antitumor effects of BZL101 for patients with advanced breast cancer. Breast Cancer Res Treat (2006) 1.02
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res (2003) 0.98
Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. Carcinogenesis (2005) 0.98
Selenium activates p53 and p38 pathways and induces caspase-independent cell death in cervical cancer cells. Cell Biol Toxicol (2007) 0.97
Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways. Blood (2007) 0.95
Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells. World J Gastroenterol (2005) 0.91
4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ (2007) 0.89
Mechanisms of mitochondrial membrane permeabilization. Cell Death Differ (2000) 0.89
Caspases and apoptosis - biology and terminology. Cell Death Differ (1999) 0.87
Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia (2007) 0.86
Antioxidant principles from Ephemerantha lonchophylla. J Nat Prod (1999) 0.86
Antiproliferative effect in human prostatic smooth muscle cells by nitric oxide donor. Mol Pharmacol (1998) 0.85
Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity. J Biomed Sci (2005) 0.85
p53 can promote mitochondria- and caspase-independent apoptosis. Cell Death Differ (2004) 0.81
Flavone initiates a hierarchical activation of the caspase-cascade in colon cancer cells. Apoptosis (2005) 0.80
Regulation of apoptosis by modified naringenin derivatives in human colorectal carcinoma RKO cells. J Cell Biochem (2008) 0.79
Comparison of video laryngoscopes with direct laryngoscopy for tracheal intubation: a meta-analysis of randomised trials. Eur J Anaesthesiol (2011) 3.22
Enhancement of long-term potentiation by a potent nitric oxide-guanylyl cyclase activator, 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole. Mol Pharmacol (2003) 1.63
Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases. Mol Pharmacol (2010) 1.30
Long-term survival analysis of nasopharyngeal carcinoma by plasma Epstein-Barr virus DNA levels. Cancer (2012) 1.19
Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. J Med Chem (2010) 1.16
Soluble decoy receptor 3 induces angiogenesis by neutralization of TL1A, a cytokine belonging to tumor necrosis factor superfamily and exhibiting angiostatic action. Cancer Res (2004) 1.14
Accuracy of the EasyTouch blood glucose self-monitoring system: a study of 516 cases. Clin Chim Acta (2004) 1.12
Soluble guanylyl cyclase activator YC-1 inhibits human neutrophil functions through a cGMP-independent but cAMP-dependent pathway. Mol Pharmacol (2003) 1.11
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. J Biol Chem (2011) 1.10
Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult. Biochem Pharmacol (2006) 1.10
Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. J Med Chem (2007) 1.08
Comparison of the effects of PAR1 antagonists, PAR4 antagonists, and their combinations on thrombin-induced human platelet activation. Eur J Pharmacol (2006) 1.07
Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells. Biochem Pharmacol (2004) 1.06
Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. Biochem Pharmacol (2009) 1.06
Peptidoglycan induces nuclear factor-kappaB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages. J Biol Chem (2004) 1.06
Isolation of a natural antioxidant, dehydrozingerone from Zingiber officinale and synthesis of its analogues for recognition of effective antioxidant and antityrosinase agents. Arch Pharm Res (2005) 1.05
Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways. Biochem Pharmacol (2007) 1.03
Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction. Toxicol Lett (2007) 1.03
Ruptured left subclavian artery aneurysm presenting as upper airway obstruction in von Recklinghausen's disease. Resuscitation (2007) 1.03
CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther (2008) 1.02
Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells. Cancer Lett (2006) 1.01
Synthesis of N2-(substituted benzyl)-3-(4-methylphenyl)indazoles as novel anti-angiogenic agents. Bioorg Med Chem (2005) 1.01
Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-κB and JNK/p38 MAPK activation pathways. J Biomed Sci (2011) 1.00
YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells. Mol Cancer Ther (2005) 1.00
Enhancement of learning behaviour by a potent nitric oxide-guanylate cyclase activator YC-1. Eur J Neurosci (2005) 0.99
Antioxidant properties of scopoletin isolated from Sinomonium acutum. Phytother Res (2003) 0.99
Reactive oxygen species mediation of baizhu-induced apoptosis in human leukemia cells. J Ethnopharmacol (2004) 0.98
High risk of 'failure' among emergency physicians compared with other specialists: a nationwide cohort study. Emerg Med J (2013) 0.98
Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappaB induced oxidative stress and inflammation. Eur J Pharmacol (2009) 0.98
Plant Gene and Alternatively Spliced Variant Annotator. A plant genome annotation pipeline for rice gene and alternatively spliced variant identification with cross-species expressed sequence tag conservation from seven plant species. Plant Physiol (2007) 0.97
Chemical and anti-platelet constituents from Formosan Zanthoxylum simulans. Phytochemistry (2002) 0.96
Si-Wu-Tang and its constituents promote mammary duct cell proliferation by up-regulation of HER-2 signaling. Menopause (2006) 0.95
Relationships between respiratory muscle strength and daily living function in children with cerebral palsy. Res Dev Disabil (2012) 0.95
Risk factors for peritoneal dissemination of colorectal cancer. J Surg Oncol (2004) 0.95
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma. J Hepatol (2005) 0.94
Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice. Proteomics (2007) 0.94
Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways. PLoS One (2012) 0.94
Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226. Biochem Pharmacol (2007) 0.94
Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res (2008) 0.94
Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells. Eur J Pharmacol (2006) 0.93
Synthesis, DNA binding, and cytotoxicity of 1,4-bis(2-amino-ethylamino)anthraquinone-amino acid conjugates. Bioorg Med Chem (2007) 0.93
Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent. J Med Chem (2010) 0.93
Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways. Int Immunopharmacol (2011) 0.93
Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells. J Nutr Biochem (2011) 0.93
Baicalein attenuates intimal hyperplasia after rat carotid balloon injury through arresting cell-cycle progression and inhibiting ERK, Akt, and NF-kappaB activity in vascular smooth-muscle cells. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.92
Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo. Carcinogenesis (2005) 0.92
Identification of apoptotic and antiangiogenic activities of terazosin in human prostate cancer and endothelial cells. J Urol (2003) 0.92
Flavonoids isolated from Draconis Resina. Nat Prod Res (2007) 0.92
Age-associated decrease of oxidative repair enzymes, human 8-oxoguanine DNA glycosylases (hOgg1), in human aging. J Radiat Res (2003) 0.92
Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells. Biochem Pharmacol (2003) 0.92
Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species. PLoS One (2012) 0.92
Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Cancer Lett (2011) 0.92
Investigation of extrinsic and intrinsic apoptosis pathways of new clerodane diterpenoids in human prostate cancer PC-3 cells. Eur J Pharmacol (2004) 0.91
Structure-activity relationship studies on chalcone derivatives: potent inhibition of platelet aggregation. J Pharm Pharmacol (2004) 0.91
YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole] inhibits endothelial cell functions induced by angiogenic factors in vitro and angiogenesis in vivo models. J Pharmacol Exp Ther (2005) 0.91
Anti-angiogenic effects and mechanism of prazosin. Prostate (2010) 0.91
Subcapsular renal hematoma complicating acute pyelonephritis. J Emerg Med (2008) 0.91
Radiation-induced VEGF-C expression and endothelial cell proliferation in lung cancer. Strahlenther Onkol (2014) 0.90
Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells. Hepatology (2011) 0.90
A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells. Biochem Pharmacol (2003) 0.90
Induction of mitotic arrest and apoptosis by evodiamine in human leukemic T-lymphocytes. Life Sci (2004) 0.90
A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways. Biochem Pharmacol (2011) 0.90
Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway. Eur J Pharmacol (2006) 0.89