PubRank

Stephen F Traynelis

Author PubWeight™ 104.48‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structural basis for partial agonist action at ionotropic glutamate receptors. Nat Neurosci 2003 4.55
2 Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. J Physiol 2005 2.90
3 Activation of NR1/NR2B NMDA receptors. Nat Neurosci 2003 2.47
4 Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating. Nat Neurosci 2011 2.31
5 Glutamate receptor gating. Crit Rev Neurobiol 2004 2.31
6 Control of NMDA receptor function by the NR2 subunit amino-terminal domain. J Neurosci 2009 2.19
7 Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating. Mol Pharmacol 2003 1.91
8 Astrocytic control of synaptic NMDA receptors. J Physiol 2007 1.85
9 Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium. J Neurosci 2009 1.63
10 Activation of recombinant NR1/NR2C NMDA receptors. J Physiol 2008 1.57
11 Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Mol Pharmacol 2007 1.56
12 Adenosine A(2A) receptor mediates microglial process retraction. Nat Neurosci 2009 1.56
13 Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Mol Pharmacol 2003 1.55
14 Control of assembly and function of glutamate receptors by the amino-terminal domain. Mol Pharmacol 2010 1.54
15 P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2. Proc Natl Acad Sci U S A 2005 1.48
16 The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia. Proc Natl Acad Sci U S A 2003 1.40
17 A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat Commun 2010 1.38
18 Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proc Natl Acad Sci U S A 2007 1.36
19 Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. Exp Neurol 2004 1.36
20 Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. J Physiol 2007 1.34
21 Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog. J Neurosci 2005 1.33
22 New advances in NMDA receptor pharmacology. Trends Pharmacol Sci 2011 1.32
23 Structural aspects of AMPA receptor activation, desensitization and deactivation. Curr Opin Neurobiol 2007 1.30
24 Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3. J Biol Chem 2005 1.27
25 Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun 2011 1.26
26 Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. J Physiol 2007 1.24
27 Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J Neurosci 2012 1.22
28 Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes. J Neurosci 2009 1.22
29 Protons trap NR1/NR2B NMDA receptors in a nonconducting state. J Neurosci 2005 1.21
30 Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J Neurosci 2005 1.21
31 Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J Med Chem 2010 1.20
32 Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling. Mol Pharmacol 2005 1.20
33 Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors. J Neurosci 2010 1.18
34 Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors. J Physiol 2005 1.18
35 Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci 2011 1.18
36 Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol 2011 1.17
37 Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors. Mol Pharmacol 2013 1.15
38 Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Res 2010 1.14
39 Allosteric regulation and spatial distribution of kainate receptors bound to ancillary proteins. J Physiol 2003 1.09
40 Zinc inhibition of rat NR1/NR2A N-methyl-D-aspartate receptors. J Physiol 2007 1.09
41 Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1. J Biol Chem 2008 1.09
42 GluN1 splice variant control of GluN1/GluN2D NMDA receptors. J Physiol 2012 1.04
43 PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia. J Cereb Blood Flow Metab 2004 1.02
44 Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2. Proc Natl Acad Sci U S A 2005 1.02
45 The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity. J Biol Chem 2006 1.00
46 The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. J Biol Chem 2009 0.99
47 Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function. Exp Neurol 2009 0.97
48 PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol Pharmacol 2010 0.96
49 Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor. Protein Sci 2005 0.96
50 Molecular pharmacology of human NMDA receptors. Neurochem Int 2011 0.96
51 Differential regulation of microglial motility by ATP/ADP and adenosine. Parkinsonism Relat Disord 2009 0.94
52 Learning and memory deficits in mice lacking protease activated receptor-1. Neurobiol Learn Mem 2007 0.93
53 S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis. Proc Natl Acad Sci U S A 2012 0.93
54 Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. Mol Pharmacol 2012 0.92
55 Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors. J Biol Chem 2013 0.92
56 Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus. Mol Brain 2011 0.92
57 A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study. J Biol Chem 2005 0.92
58 Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. J Pharmacol Exp Ther 2010 0.92
59 Systemic inflammation regulates microglial responses to tissue damage in vivo. Glia 2014 0.90
60 Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cell Signal 2012 0.89
61 Contribution of the M1 transmembrane helix and pre-M1 region to positive allosteric modulation and gating of N-methyl-D-aspartate receptors. Mol Pharmacol 2013 0.89
62 N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands. J Med Chem 2008 0.88
63 Novel NMDA receptor modulators: an update. Expert Opin Ther Pat 2012 0.87
64 Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. J Med Chem 2013 0.86
65 Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. Bioorg Med Chem 2009 0.86
66 Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis. Mol Brain 2012 0.86
67 Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1. Mol Pharmacol 2007 0.85
68 Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery. Clin Neurosurg 2005 0.85
69 PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance. Channels (Austin) 2012 0.84
70 Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators. J Med Chem 2014 0.83
71 Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J Biol Chem 2013 0.83
72 NMDA receptor modulators: an updated patent review (2013-2014). Expert Opin Ther Pat 2014 0.82
73 Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. Mol Brain 2008 0.82
74 Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists. J Med Chem 2013 0.81
75 Modal gating of GluN1/GluN2D NMDA receptors. Neuropharmacology 2013 0.81
76 Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840. Mol Pharmacol 2014 0.81
77 The genetics of neuropsychiatric diseases: looking in and beyond the exome. Annu Rev Neurosci 2015 0.81
78 Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. J Med Chem 2008 0.81
79 Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol Brain 2015 0.79
80 L-type calcium channel activity in osteoblast cells is regulated by the actin cytoskeleton independent of protein trafficking. J Bone Miner Metab 2011 0.79
81 Neuroscience: an intrusive chaperone. Nature 2005 0.78
82 Glutamate receptors: variation in structure-function coupling. Trends Pharmacol Sci 2006 0.78
83 How glutamate receptor subunits mix and match: details uncovered. Neuron 2011 0.77
84 Correction to Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-d-aspartate Receptors. J Med Chem 2014 0.77
85 NMDA receptor permeation: a light in the tunnel. Nat Neurosci 2012 0.76
86 Malevolent lurkers no more: NMDA receptors come of age. J Physiol 2006 0.76
87 Glutamate receptors: mechanistic twists and turns. Nat Chem Biol 2014 0.76
88 Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors. ChemMedChem 2009 0.75
89 Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists. J Med Chem 2013 0.75
90 Neuroscience: Excitatory view of a receptor. Nature 2009 0.75
91 A novel negative allosteric modulator selective for GluN2C/2D-containing NMDA receptors inhibits synaptic transmission in hippocampal interneurons. ACS Chem Neurosci 2017 0.75
92 Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators". J Med Chem 2015 0.75
93 Editor's note: technological advances and a molecular understanding of pharmacology. Mol Pharmacol 2012 0.75