Published in Arthritis Rheum on November 01, 2007
Animal models for cartilage regeneration and repair. Tissue Eng Part B Rev (2010) 2.22
Molecular analysis of age and sex-related gene expression in meniscal tears with and without a concomitant anterior cruciate ligament tear. J Bone Joint Surg Am (2012) 1.81
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum (2012) 1.67
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification. Osteoarthritis Cartilage (2015) 1.48
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci (2007) 1.36
MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther (2013) 1.31
Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice. Arthritis Rheum (2013) 1.23
Analysis of meniscal degeneration and meniscal gene expression. BMC Musculoskelet Disord (2010) 1.17
Post-traumatic osteoarthritis: from mouse models to clinical trials. Nat Rev Rheumatol (2013) 1.15
An introduction to proteoglycans and their localization. J Histochem Cytochem (2012) 1.08
Extracellular matrix and heart development. Birth Defects Res A Clin Mol Teratol (2011) 1.07
O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol (2010) 1.05
The role of ADAMTSs in arthritis. Protein Cell (2010) 1.03
Cartilage damage in osteoarthritis and rheumatoid arthritis-two unequal siblings. Nat Rev Rheumatol (2015) 1.03
The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease. Arthritis Res Ther (2009) 1.02
Effect of small interference RNA (siRNA) for ADAMTS5 on intervertebral disc degeneration in the rabbit anular needle-puncture model. Arthritis Res Ther (2009) 0.98
Role of ADAM and ADAMTS metalloproteinases in airway diseases. Respir Res (2009) 0.95
Establishment of an index with increased sensitivity for assessing murine arthritis. J Orthop Res (2011) 0.94
Biomechanical influence of cartilage homeostasis in health and disease. Arthritis (2011) 0.90
Bovine lactoferricin is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol (2013) 0.87
TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci (2013) 0.86
Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis. J Clin Invest (2016) 0.85
Region-dependent aggrecan degradation patterns in the rat intervertebral disc are affected by mechanical loading in vivo. Spine (Phila Pa 1976) (2011) 0.85
Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets. Curr Rheumatol Rep (2013) 0.84
Modifications of gait as predictors of natural osteoarthritis progression in STR/Ort mice. Arthritis Rheumatol (2014) 0.83
ADAMTS-12 metalloprotease is necessary for normal inflammatory response. J Biol Chem (2012) 0.83
Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with lumbar disc herniation. Eur Spine J (2010) 0.83
Osteoarthritis pathogenesis: a review of molecular mechanisms. Calcif Tissue Int (2014) 0.83
Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res (2014) 0.82
Effects of TGF-β1 and IL-1β on expression of ADAMTS enzymes and TIMP-3 in human intervertebral disc degeneration. Exp Ther Med (2013) 0.82
Activation of β-catenin signalling leads to temporomandibular joint defects. Eur Cell Mater (2014) 0.82
Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn (2011) 0.81
Matrix Metalloproteinases in Non-Neoplastic Disorders. Int J Mol Sci (2016) 0.81
Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo. Ann Rheum Dis (2013) 0.81
[Histopathological degeneration score of fibrous cartilage. Low- and high-grade meniscal degeneration]. Z Rheumatol (2010) 0.80
Emerging Roles of ADAMTSs in Angiogenesis and Cancer. Cancers (Basel) (2012) 0.80
Role of Sp1 transcription factor in Interleukin-1-induced ADAMTS-4 (aggrecanase-1) gene expression in human articular chondrocytes. Rheumatol Int (2011) 0.79
Chopping off the chondrocyte proteome. Biomarkers (2014) 0.78
ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury. Biomed Res Int (2014) 0.77
Treatment with SiMiaoFang, an anti-arthritis chinese herbal formula, inhibits cartilage matrix degradation in osteoarthritis rat model. Rejuvenation Res (2013) 0.76
CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci (2016) 0.75
The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases. Open Access Rheumatol (2009) 0.75
The Function and Roles of ADAMTS-7 in Inflammatory Diseases. Mediators Inflamm (2015) 0.75
Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy. Arthritis Res Ther (2013) 0.75
Identification of differentially expressed microRNAs in knee anterior cruciate ligament tissues surgically removed from patients with osteoarthritis. Int J Mol Med (2017) 0.75
Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes. Inflammation (2017) 0.75
Wnt/β-catenin Signaling in Osteoarthritis and in Other Forms of Arthritis. Curr Rheumatol Rep (2017) 0.75
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature (2005) 5.71
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum (2004) 2.01
Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum (2009) 1.94
Comparative proteomic characterization of articular cartilage tissue from normal donors and patients with osteoarthritis. Arthritis Rheum (2007) 1.48
Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites. J Biol Chem (2002) 1.39
Binding and localization of recombinant lubricin to articular cartilage surfaces. J Orthop Res (2007) 1.34
ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. Matrix Biol (2004) 1.24
Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. J Biol Chem (2009) 1.17
Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation. Am J Respir Cell Mol Biol (2006) 1.13
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes. J Biol Chem (2006) 1.11
Tumor necrosis factor alpha blockade exacerbates murine psoriasis-like disease by enhancing Th17 function and decreasing expansion of Treg cells. Arthritis Rheum (2010) 1.10
Chondral defect repair after the microfracture procedure: a nonhuman primate model. Am J Sports Med (2005) 1.06
Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18. Biochim Biophys Acta (2006) 1.06
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J Biol Chem (2002) 1.02
IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice. J Immunol (2012) 1.02
Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol (2010) 1.01
Involvement of protein kinase Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes. Arthritis Rheum (2007) 1.01
Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2). Arthritis Rheum (2004) 1.00
Disruption of G protein-coupled receptor 39 impairs insulin secretion in vivo. Endocrinology (2009) 0.99
LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model. Proc Natl Acad Sci U S A (2010) 0.91
Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage. BMC Musculoskelet Disord (2011) 0.91
N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg Med Chem Lett (2008) 0.89
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors. Bioorg Med Chem Lett (2009) 0.87
5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorg Med Chem Lett (2006) 0.85
Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg Med Chem Lett (2006) 0.80
The influence of enrichment devices on development of osteoarthritis in a surgically induced murine model. ILAR J (2008) 0.79
5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2). Bioorg Med Chem Lett (2007) 0.79
Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1. J Cell Physiol (2008) 0.78
Case descriptions of fibropapillomatosis in rehabilitating loggerhead sea turtles Caretta caretta in the southeastern USA. Dis Aquat Organ (2015) 0.77
Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytes. Int J Mol Med (2007) 0.77
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors. Bioorg Med Chem Lett (2005) 0.77
Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition. Bioorg Med Chem Lett (2011) 0.77
Bone morphogenetic protein 9 is a potent anabolic factor for juvenile bovine cartilage, but not adult cartilage. J Orthop Res (2005) 0.76
Synthesis and SAR of highly selective MMP-13 inhibitors. Bioorg Med Chem Lett (2005) 0.76
Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype. J Cell Physiol (2006) 0.75
In vitro-in vivo correlation on delivery of drug candidates to articular cartilage. Pharm Res (2008) 0.75
3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding. Bioorg Med Chem Lett (2009) 0.75
1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators. J Med Chem (2014) 0.75
HEALTH AND NUTRITIONAL ASSESSMENT OF FREE-RANGING EASTERN INDIGO SNAKES (DRYMARCHON COUPERI) IN GEORGIA, UNITED STATES. J Zoo Wildl Med (2016) 0.75
RETROSPECTIVE EVALUATION OF HISTOPATHOLOGIC FINDINGS IN CAPTIVE GAZELLE SPECIES. J Zoo Wildl Med (2016) 0.75
Endoscopic orchidectomy and salpingohysterectomy of pigeons (Columba livia): an avian model for minimally invasive endosurgery. J Avian Med Surg (2007) 0.75