Published in Calcif Tissue Int on October 14, 2014
Animal models of osteoarthritis: classification, update, and measurement of outcomes. J Orthop Surg Res (2016) 0.90
Conditional Deletion of the Phd2 Gene in Articular Chondrocytes Accelerates Differentiation and Reduces Articular Cartilage Thickness. Sci Rep (2017) 0.75
Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis. Orthop J Sports Med (2017) 0.75
Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R. Hum Cell (2017) 0.75
Increased 15-lipoxygenase-1 expression in chondrocytes contributes to the pathogenesis of osteoarthritis. Cell Death Dis (2017) 0.75
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell (1997) 18.91
Developmental regulation of the growth plate. Nature (2003) 11.53
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science (2002) 8.27
Dickkopf-1 is a master regulator of joint remodeling. Nat Med (2007) 7.29
Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum (2004) 6.46
Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991-94. J Rheumatol (2006) 6.03
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature (2005) 5.71
Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial. Ann Intern Med (2004) 5.69
Osteoarthritis. J Cell Physiol (2007) 5.55
Clinical practice. Osteoarthritis of the knee. N Engl J Med (2006) 4.69
Epidemiology of hip and knee osteoarthritis. Epidemiol Rev (1988) 4.45
A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet (2007) 4.31
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature (2005) 4.24
Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature (1994) 3.99
Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum (1995) 3.89
The impact of osteoarthritis: implications for research. Clin Orthop Relat Res (2004) 3.63
Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res (2009) 3.61
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum (2009) 3.61
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med (2010) 3.59
Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med (2010) 3.55
Biochemical characterization of human collagenase-3. J Biol Chem (1996) 3.52
The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis. Arthritis Rheum (2006) 3.51
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (2004) 3.45
Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn (1999) 3.33
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A (2004) 3.27
Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum (2000) 3.23
TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol (2001) 3.22
Effect of collagen turnover on the accumulation of advanced glycation end products. J Biol Chem (2000) 3.17
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest (2001) 2.90
Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells (2002) 2.85
Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat Med (2009) 2.81
Minimally invasive total knee arthroplasty for osteoarthritis. N Engl J Med (2009) 2.79
Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med (2013) 2.74
Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci (2010) 2.73
Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol (1997) 2.72
Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum (2007) 2.45
Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther (2009) 2.44
Cbfa1 is a positive regulatory factor in chondrocyte maturation. J Biol Chem (2000) 2.38
E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. J Biol Chem (2003) 2.34
The role of growth factors in cartilage repair. Clin Orthop Relat Res (2011) 2.20
Cartilage proteoglycans. Semin Cell Dev Biol (2001) 2.17
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A (2004) 2.16
Bone morphogenetic protein-2 stimulates Runx2 acetylation. J Biol Chem (2006) 2.15
Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study). Ann Rheum Dis (2004) 2.10
Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem (2005) 2.04
Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis (2007) 2.01
MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum (2009) 1.99
HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J Cell Sci (2003) 1.93
Mechanisms of synovial joint and articular cartilage formation: recent advances, but many lingering mysteries. Birth Defects Res C Embryo Today (2005) 1.93
Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study. Osteoarthritis Cartilage (2009) 1.90
Regulation of metabolism by hypoxia-inducible factor 1. Cold Spring Harb Symp Quant Biol (2011) 1.85
Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional study. J Rheumatol (2007) 1.84
Expression of MicroRNA-146a in osteoarthritis cartilage. Arthritis Rheum (2009) 1.84
Mechanisms of GDF-5 action during skeletal development. Development (1999) 1.83
Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum (2005) 1.83
Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo. J Biol Chem (2003) 1.81
Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development (2008) 1.79
MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum (2010) 1.78
Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum (2008) 1.77
The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm (2014) 1.76
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J Biol Chem (1996) 1.72
TGF-beta and osteoarthritis. Osteoarthritis Cartilage (2007) 1.66
The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem (2002) 1.66
A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair. Osteoarthritis Cartilage (2006) 1.66
Economics of osteoarthritis: a global perspective. Baillieres Clin Rheumatol (1997) 1.65
Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol Chem (2005) 1.60
Osteoarthritis year 2010 in review: pathomechanisms. Osteoarthritis Cartilage (2011) 1.58
Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis. Arthritis Rheum (2009) 1.58
TIMP-2: an endogenous inhibitor of angiogenesis. Trends Mol Med (2005) 1.55
Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis. Osteoarthritis Cartilage (2005) 1.53
A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet (2000) 1.53
Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis. Arthritis Rheum (2007) 1.52
Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice. Arthritis Res Ther (2012) 1.52
Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. Mech Dev (1998) 1.50
Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. Arthritis Rheum (2009) 1.50
A single residue of GDF-5 defines binding specificity to BMP receptor IB. J Mol Biol (2005) 1.49
A current review of molecular mechanisms regarding osteoarthritis and pain. Gene (2013) 1.48
Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. J Biol Chem (2006) 1.45
Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis. Gene (2008) 1.45
Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis. Eur J Biochem (2000) 1.44
Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation. J Biol Chem (2005) 1.44
The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses. Cell Mol Life Sci (2003) 1.40
Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation. Ann Rheum Dis (2006) 1.39
The matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) genes. Transcriptional and posttranscriptional regulation, signal transduction and cell-type-specific expression. Methods Mol Biol (2001) 1.38
Requisite roles of Runx2 and Cbfb in skeletal development. J Bone Miner Metab (2003) 1.36
FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Dev Biol (2006) 1.36
Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension. Osteoarthritis Cartilage (2002) 1.35
Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci (2011) 1.34
Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism. Arthritis Rheum (2009) 1.34
Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases. Crit Rev Eukaryot Gene Expr (1997) 1.33
Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum (2005) 1.32
Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions. J Cell Physiol (2007) 1.32
MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther (2013) 1.31
Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways. J Biol Chem (2007) 1.30
Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum (2010) 1.29
Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases. Pathol Int (2010) 1.29
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum (2012) 1.67
Chondrocyte BMP2 signaling plays an essential role in bone fracture healing. Gene (2012) 1.56
BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci (2011) 1.44
Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci (2011) 1.34
MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Res Ther (2013) 1.31
Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice. Arthritis Rheum (2013) 1.23
Study on injectable and degradable cement of calcium sulphate and calcium phosphate for bone repair. J Mater Sci Mater Med (2009) 1.16
Development and assessment of a complete-detoxication strategy for Fuzi (lateral root of Aconitum carmichaeli) and its application in rheumatoid arthritis therapy. J Ethnopharmacol (2013) 0.99
Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility. Sci Rep (2013) 0.92
Antibacterial hemostatic dressings with nanoporous bioglass containing silver. Int J Nanomedicine (2012) 0.92
Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of osteoclast formation in a murine model. Arthritis Rheumatol (2014) 0.91
The effects of autologous bone marrow mesenchymal stem cell arterial perfusion on vascular repair and angiogenesis in osteonecrosis of the femoral head in dogs. Int Orthop (2012) 0.87
Combination treatment of biomechanical support and targeted intra-arterial infusion of peripheral blood stem cells mobilized by granulocyte-colony stimulating factor for the osteonecrosis of the femoral head: a randomized controlled clinical trial. J Bone Miner Res (2015) 0.79
Gene expression profile of steroid-induced necrosis of femoral head of rats. Calcif Tissue Int (2011) 0.77
Functional Restriction for the Fear of Falling In Family Caregivers. Medicine (Baltimore) (2015) 0.75
Administration of enoxaparin 24 h after total knee arthroplasty: safer for bleeding and equally effective for deep venous thrombosis prevention. Arch Orthop Trauma Surg (2014) 0.75
Plasma metabonomic profiling of lumbar disc herniation and its traditional Chinese medicine subtypes in patients by using gas chromatography coupled with mass spectrometry. Mol Biosyst (2014) 0.75